Q16653 (MOG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin-oligodendrocyte glycoprotein

Gene names

Name:

MOG

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates homophilic cell-cell adhesion By similarity. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
Subunit structure	Homodimer By similarity. May form heterodimers between the different isoforms.
Subcellular location	Isoform 1: Cell membrane; Multi-pass membrane protein Potential. Isoform 5: Cell membrane; Multi-pass membrane protein Potential. Isoform 2: Cell membrane; Single-pass type I membrane protein Potential. Isoform 3: Cell membrane; Single-pass type I membrane protein Potential. Isoform 4: Cell membrane; Single-pass type I membrane protein Potential. Isoform 6: Cell membrane; Single-pass type I membrane protein Potential. Isoform 7: Cell membrane; Single-pass type I membrane protein Potential. Isoform 8: Cell membrane; Single-pass type I membrane protein Potential. Isoform 9: Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Involvement in disease	Defects in MOG are the cause of narcolepsy type 7 (NRCLP7) [MIM:614250]. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Ref.9
Sequence similarities	Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Caution	Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW central nervous system development Traceable author statement. Source: ProtInc positive regulation of MyD88-dependent toll-like receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Non-traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q16653-1)

Also known as: Alpha-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q16653-2)

Also known as: Alpha-2;

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.

Isoform 3 (identifier: Q16653-3)

Also known as: Alpha-3;

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: DPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLA → ESFGVLGPQVKEPKKT

Isoform 4 (identifier: Q16653-4)

Also known as: Alpha-4;

The sequence of this isoform differs from the canonical sequence as follows:
     30-145: Missing.

Isoform 5 (identifier: Q16653-5)

Also known as: Beta-1;

The sequence of this isoform differs from the canonical sequence as follows:
     244-247: RNPF → LFHLEALSG

Isoform 6 (identifier: Q16653-6)

Also known as: Beta-2;

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.
     244-247: RNPF → LFHLEALSG

Isoform 7 (identifier: Q16653-7)

Also known as: Beta-3;

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: DPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLA → ESFGVLGPQVKEPKKT
     244-247: RNPF → LFHLEALSG

Isoform 8 (identifier: Q16653-8)

Also known as: Beta-4;

The sequence of this isoform differs from the canonical sequence as follows:
     198-243: Missing.
     244-247: RNPF → LFHLEALSG

Isoform 9 (identifier: Q16653-9)

The sequence of this isoform differs from the canonical sequence as follows:
     198-203: DPHFLR → GKFRHV
     204-247: Missing.

Note: Not functionally active. May be expressed at low level in the adult.

Isoform 10 (identifier: Q16653-10)

The sequence of this isoform differs from the canonical sequence as follows:
     146-171: DPFYWVSPGVLVLLAVLPVLLLQITV → VSHSVTQDWLQWHDHGSLQPPPPRLK
     172-247: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Potential

Chain

30 – 247

218

Myelin-oligodendrocyte glycoprotein

PRO_0000014888

Regions

Topological domain

30 – 154

125

Extracellular Potential

Transmembrane

155 – 175

21

Helical; Potential

Topological domain

176 – 210

35

Cytoplasmic Potential

Transmembrane

211 – 231

21

Helical; Potential

Topological domain

232 – 247

16

Extracellular Potential

Domain

32 – 145

114

Ig-like V-type

Amino acid modifications

Glycosylation

60

1

N-linked (GlcNAc...) Potential

Disulfide bond

53 ↔ 127

Potential

Natural variations

Alternative sequence

30 – 145

116

Missing in isoform 4.

VSP_002539

Alternative sequence

146 – 171

26

DPFYW…LQITV → VSHSVTQDWLQWHDHGSLQP PPPRLK in isoform 10.

VSP_040344

Alternative sequence

172 – 247

76

Missing in isoform 10.

VSP_040345

Alternative sequence

198 – 243

46

Missing in isoform 8.

VSP_002544

Alternative sequence

198 – 236

39

Missing in isoform 2 and isoform 6.

VSP_002543

Alternative sequence

198 – 236

39

DPHFL…HRRLA → ESFGVLGPQVKEPKKT in isoform 3 and isoform 7.

VSP_002542

Alternative sequence

198 – 203

6

DPHFLR → GKFRHV in isoform 9.

VSP_002540

Alternative sequence

204 – 247

44

Missing in isoform 9.

VSP_002541

Alternative sequence

244 – 247

4

RNPF → LFHLEALSG in isoform 5, isoform 6, isoform 7 and isoform 8.

VSP_002545

Natural variant

133

1

S → C in NRCLP7. Ref.9

VAR_066415

Natural variant

171

1

V → L. Ref.3 Ref.6
Corresponds to variant rs2857766 [ dbSNP | Ensembl ].

VAR_056056

Natural variant

174

1

I → V. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7
Corresponds to variant rs3130253 [ dbSNP | Ensembl ].

VAR_060215

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

247

Helix Strand Turn

Details...

Beta strand

42 – 44

3

Beta strand

66 – 69

4

Turn

71 – 73

3

Beta strand

74 – 80

7

Beta strand

82 – 85

4

Beta strand

87 – 92

6

Beta strand

96 – 100

5

Beta strand

104 – 109

6

Beta strand

112 – 114

3

Beta strand

125 – 128

4

Beta strand

131 – 133

3

Beta strand

138 – 140

3

Beta strand

143 – 145

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha-1) [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 846EBA5D412C080C	FASTA	247	28,193
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 210 220 230 240 RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL EELRNPF
	Isoform 2 (Alpha-2) [UniParc]. Checksum: 8053FA07957A1963	FASTA	208	23,627
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 RLRGKLRAEI ENLHRTFGQF LEELRNPF
	Isoform 3 (Alpha-3) [UniParc]. Checksum: EF7BA1567A69FB33	FASTA	224	25,353
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 210 220 RLRGKLRAEI ENLHRTFESF GVLGPQVKEP KKTGQFLEEL RNPF
	Isoform 4 (Alpha-4) [UniParc]. Checksum: 80B843738BF1ED47	FASTA	131	14,988
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAD PFYWVSPGVL VLLAVLPVLL LQITVGLIFL 70 80 90 100 110 120 CLQYRLRGKL RAEIENLHRT FDPHFLRVPC WKITLFVIVP VLGPLVALII CYNWLHRRLA 130 GQFLEELRNP F
	Isoform 5 (Beta-1) [UniParc]. Checksum: D41E3A6050BA9837	FASTA	252	28,647
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 210 220 230 240 RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL 250 EELLFHLEAL SG
	Isoform 6 (Beta-2) [UniParc]. Checksum: AD5788DAB32EA577	FASTA	213	24,081
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 210 RLRGKLRAEI ENLHRTFGQF LEELLFHLEA LSG
	Isoform 7 (Beta-3) [UniParc]. Checksum: DB6C018BA4418D2C	FASTA	229	25,807
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 210 220 RLRGKLRAEI ENLHRTFESF GVLGPQVKEP KKTGQFLEEL LFHLEALSG
	Isoform 8 (Beta-4) [UniParc]. Checksum: 54D1257CD963AD8E	FASTA	206	23,264
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 RLRGKLRAEI ENLHRTFLFH LEALSG
	Isoform 9 [UniParc]. Checksum: 33C38085A4D22627	FASTA	203	23,021
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 180 DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 190 200 RLRGKLRAEI ENLHRTFGKF RHV
	Isoform 10 [UniParc]. Checksum: E65BA3858848F8E8	FASTA	171	19,334
	10 20 30 40 50 60 MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 70 80 90 100 110 120 ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 130 140 150 160 170 DEGGFTCFFR DHSYQEEAAM ELKVEVSHSV TQDWLQWHDH GSLQPPPPRL K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein." Hilton A.A., Slavin A.J., Hilton D.J., Bernard C.C.A. J. Neurochem. 65:309-318(1995) [PubMed: 7790876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANT VAL-174.
[2]	"Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein." Pham-Dinh D., Allinquant B., Ruberg M., della Gaspera B., Nussbaum J.-L., Dautigny A. J. Neurochem. 63:2353-2356(1994) [PubMed: 7964757] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-174. Tissue: Brain.
[3]	"The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization." Roth M.-P., Malfroy L., Offer C., Sevin J., Enault G., Borot N., Pontarotti P., Coppin H. Genomics 28:241-250(1995) [PubMed: 8530032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-171 AND VAL-174.
[4]	"Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms." Pham-Dinh D., Della Gaspera B., de Rosbo N.K., Dautigny A. Genomics 29:345-352(1995) [PubMed: 8666381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANT VAL-174.
[5]	"Myelin/oligodendrocyte glycoprotein is alternatively spliced in humans but not mice." Ballenthin P.A., Gardinier M.V. J. Neurosci. Res. 46:271-281(1996) [PubMed: 8915905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, NUCLEOTIDE SEQUENCE [MRNA] OF 30-247 (ISOFORM 10), VARIANT VAL-174.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-171 AND VAL-174.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-174.
[8]	"A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55." Albouz-Abo S., Wilson J.C., Bernard C.C.A., von Itzstein M. Eur. J. Biochem. 246:59-70(1997) [PubMed: 9210466] [Abstract] Cited for: STRUCTURE BY NMR OF 64-84.
[9]	"A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy." Hor H., Bartesaghi L., Kutalik Z., Vicario J.L., de Andres C., Pfister C., Lammers G.J., Guex N., Chrast R., Tafti M., Peraita-Adrados R. Am. J. Hum. Genet. 89:474-479(2011) [PubMed: 21907016] [Abstract] Cited for: VARIANT NRCLP7 CYS-133.
+	Additional computationally mapped references.

Web resources

Wikipedia

Myelin oligodendrocyte glycoprotein entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X74511 mRNA. Translation: CAA52617.1.
Z48051 Genomic DNA. Translation: CAA88109.1.
U18840 mRNA. Translation: AAC50361.1.
U18843 mRNA. Translation: AAC50362.1.
U18798 mRNA. Translation: AAC50876.1.
U18799 mRNA. Translation: AAC50877.1.
U18800 mRNA. Translation: AAB36870.1.
U18801 mRNA. Translation: AAC50878.1.
U18803 mRNA. Translation: AAC50879.1.
U64564 mRNA. Translation: AAB08088.1.
U64565 mRNA. Translation: AAB08089.1.
U64566 mRNA. Translation: AAB08090.1.
U64567 mRNA. Translation: AAB08091.1.
U64568 mRNA. Translation: AAB08092.1.
U64569 mRNA. Translation: AAB08093.1.
U64570 mRNA. Translation: AAB08094.1.
U64571 mRNA. Translation: AAB08095.1.
AL050328 Genomic DNA. Translation: CAB89267.1.
AL050328 Genomic DNA. Translation: CAB89268.1.
AL050328 Genomic DNA. Translation: CAB89269.1.
AL050328 Genomic DNA. Translation: CAB89270.1.
AL050328 Genomic DNA. Translation: CAB89271.1.
AL662826 Genomic DNA. Translation: CAI17395.2.
AL662826, AL669813 Genomic DNA. Translation: CAI17396.1.
AL662826, AL669813 Genomic DNA. Translation: CAI17397.1.
AL662826 Genomic DNA. Translation: CAI17400.3.
AL669813, AL662826 Genomic DNA. Translation: CAI17636.2.
AL669813, AL662826 Genomic DNA. Translation: CAI17637.1.
AL645936 Genomic DNA. Translation: CAI18020.1.
AL645936 Genomic DNA. Translation: CAI18021.1.
AL645936 Genomic DNA. Translation: CAI18022.2.
AL645936 Genomic DNA. Translation: CAI18023.1.
AL645936 Genomic DNA. Translation: CAI18024.1.
AL929591 Genomic DNA. Translation: CAI41911.2.
AL929591 Genomic DNA. Translation: CAI41914.2.
AL929591 Genomic DNA. Translation: CAI41917.1.
BX120002 Genomic DNA. Translation: CAI95560.2.
BX120002 Genomic DNA. Translation: CAI95564.1.
BX120002 Genomic DNA. Translation: CAI95565.1.
BX120002 Genomic DNA. Translation: CAI95568.2.
AL929591 Genomic DNA. Translation: CAM25818.1.
CR759766 Genomic DNA. Translation: CAQ06614.1.
CR388408 Genomic DNA. Translation: CAQ08208.1.
CR388408 Genomic DNA. Translation: CAQ08210.1.
CR388408 Genomic DNA. Translation: CAQ08212.1.
CR388408 Genomic DNA. Translation: CAQ08213.1.
CR936483 Genomic DNA. Translation: CAQ10086.1.
CR936483 Genomic DNA. Translation: CAQ10088.1.
CR936483 Genomic DNA. Translation: CAQ10090.1.
CR936483 Genomic DNA. Translation: CAQ10091.1.
BX927250 Genomic DNA. Translation: CAQ10709.1.
BX927250 Genomic DNA. Translation: CAQ10711.1.
BX927250 Genomic DNA. Translation: CAQ10713.1.
BX927250 Genomic DNA. Translation: CAQ10714.1.
CH471081 Genomic DNA. Translation: EAX03214.1.
CH471081 Genomic DNA. Translation: EAX03217.1.

IPI

IPI00219664.
IPI00409587.
IPI00473134.
IPI00549656.
IPI00556079.
IPI00744638.
IPI00873156.
IPI00873317.
IPI00943197.
IPI00953473.

PIR

S58394.

RefSeq

NP_001008229.1. NM_001008228.2.
NP_001008230.1. NM_001008229.2.
NP_001163889.1. NM_001170418.1.
NP_002424.3. NM_002433.4.
NP_996532.2. NM_206809.3.
NP_996533.2. NM_206810.3.
NP_996534.2. NM_206811.3.
NP_996535.2. NM_206812.3.
NP_996537.3. NM_206814.5.

UniGene

Hs.141308.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Q70	model	-	A	31-149	[»]

ProteinModelPortal

Q16653.

SMR

Q16653. Positions 30-147.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q16653. 1 interaction.

STRING

Q16653.

PTM databases

PhosphoSite

Q16653.

Polymorphism databases

DMDM

2497312.

Proteomic databases

PRIDE

Q16653.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000383525; ENSP00000373017; ENSG00000237834.
ENST00000383630; ENSP00000373126; ENSG00000137345.
ENST00000417019; ENSP00000404537; ENSG00000234096.
ENST00000427289; ENSP00000414489; ENSG00000230885.
ENST00000432271; ENSP00000389221; ENSG00000234623.
ENST00000447285; ENSP00000401609; ENSG00000236561.
ENST00000452744; ENSP00000389022; ENSG00000232641.

GeneID

4340.

KEGG

hsa:4340.

Organism-specific databases

CTD

4340.

GeneCards

GC06P029624.

H-InvDB

HIX0025082.
HIX0058179.
HIX0166437.
HIX0166689.
HIX0166922.
HIX0167201.
HIX0167440.

HGNC

HGNC:7197. MOG.

HPA

HPA021873.

MIM

159465. gene.
614250. phenotype.

neXtProt

NX_Q16653.

PharmGKB

PA30905.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG004565.

OMA

VIGPGHP.

OrthoDB

EOG4W6NWX.

Gene expression databases

Genevestigator

Q16653.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

PANTHER

PTHR24100:SF31. PTHR24100:SF31. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

PIRSF

PIRSF016522. MOG. 1 hit.

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

17078.

SOURCE

Search...

Entry information

Entry name

MOG_HUMAN

Accession

Primary (citable) accession number: Q16653
Secondary accession number(s): A6NDR4 , A8MY31, B0UZR9, O00713, O00714, O00715, Q13054, Q13055, Q14855, Q5JNY1, Q5JNY4, Q5SSB5, Q5SSB6, Q5STM0, Q5STM5, Q5SUK7, Q5SUK8, Q5SUK9, Q5SUL0, Q5SUL1, Q92891, Q92892, Q92893, Q92894, Q92895, Q93053, Q96KU9, Q96KV0, Q96KV1, Q99605

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 11, 2011
Last modified:	January 25, 2012
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.