Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q16643

- DREB_HUMAN

UniProt

Q16643 - DREB_HUMAN

Protein

Drebrin

Gene

DBN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 4 (25 Nov 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.1 Publication

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. profilin binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. actin filament organization Source: UniProtKB
    2. cell communication by chemical coupling Source: Ensembl
    3. cell communication by electrical coupling Source: Ensembl
    4. maintenance of protein location in cell Source: Ensembl
    5. neural precursor cell proliferation Source: Ensembl
    6. regulation of dendrite development Source: UniProtKB
    7. regulation of neuronal synaptic plasticity Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    SignaLinkiQ16643.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Drebrin
    Alternative name(s):
    Developmentally-regulated brain protein
    Gene namesi
    Name:DBN1
    Synonyms:D0S117E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:2695. DBN1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcell cortex 1 Publication. Cell junction 1 Publication
    Note: In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC).

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. actomyosin Source: UniProtKB
    3. cell cortex Source: UniProtKB-SubCell
    4. cytoplasm Source: UniProtKB
    5. dendrite Source: UniProtKB
    6. gap junction Source: Ensembl
    7. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27163.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 649648DrebrinPRO_0000080008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei141 – 1411Phosphoserine2 Publications
    Modified residuei142 – 1421Phosphoserine4 Publications
    Modified residuei331 – 3311Phosphothreonine2 Publications
    Modified residuei335 – 3351Phosphothreonine1 Publication
    Modified residuei337 – 3371Phosphoserine2 Publications
    Modified residuei339 – 3391Phosphoserine1 Publication
    Modified residuei346 – 3461Phosphothreonine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ16643.
    PaxDbiQ16643.
    PRIDEiQ16643.

    2D gel databases

    OGPiQ16643.

    PTM databases

    PhosphoSiteiQ16643.

    Expressioni

    Tissue specificityi

    Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ16643.
    BgeeiQ16643.
    CleanExiHS_DBN1.
    GenevestigatoriQ16643.

    Organism-specific databases

    HPAiCAB008367.
    HPA051452.

    Interactioni

    Subunit structurei

    Binds F-actin. Interacts with CXCR4; this interaction is enhanced by antigenic stimulation.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CXCR4P610735EBI-351394,EBI-489411
    DBN1Q16643-12EBI-351394,EBI-8757328
    MLLT4P551964EBI-351394,EBI-365875
    Mllt4O358893EBI-351394,EBI-6654073From a different organism.
    PTENP604845EBI-351394,EBI-696162

    Protein-protein interaction databases

    BioGridi107995. 54 interactions.
    IntActiQ16643. 35 interactions.
    MINTiMINT-1149054.
    STRINGi9606.ENSP00000292385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16643.
    SMRiQ16643. Positions 13-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 134132ADF-HPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ADF-H domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG329456.
    HOGENOMiHOG000015304.
    HOVERGENiHBG000823.
    OMAiCANLLNF.
    OrthoDBiEOG7X3QR9.
    PhylomeDBiQ16643.
    TreeFamiTF318935.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028438. Drebrin.
    [Graphical view]
    PANTHERiPTHR10829:SF1. PTHR10829:SF1. 1 hit.
    PfamiPF00241. Cofilin_ADF. 1 hit.
    [Graphical view]
    SMARTiSM00102. ADF. 1 hit.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16643-1) [UniParc]FASTAAdd to Basket

    Also known as: Drebrin E, drebrin E2, Embryonic drebrin

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG    50
    LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS 100
    HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL 150
    REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL 200
    DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ TLEAEEAKRR 250
    LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV 300
    ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE 350
    QIERALDEVT SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP 400
    MEEPPQAQAP PRGPGSPAED LMFMESAEQA VLAAPVEPAT ADATEIHDAA 450
    DTIETDTATA DTTVANNVPP AATSLIDLWP GNGEGASTLQ GEPRAPTPPS 500
    GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP ATFCDPEEVE 550
    GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ 600
    SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD 649
    Length:649
    Mass (Da):71,429
    Last modified:November 25, 2008 - v4
    Checksum:iA7DF1AE3776C0BEA
    GO
    Isoform 2 (identifier: Q16643-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4-29: VSFSGHRLELLAAYEEVIREESAADW → HPWHGTAALASSQAWRDGRERQALVSCR

    Note: No experimental confirmation available.

    Show »
    Length:651
    Mass (Da):71,599
    Checksum:i89DA14954246C0A3
    GO
    Isoform 3 (identifier: Q16643-3) [UniParc]FASTAAdd to Basket

    Also known as: Drebrin A

    The sequence of this isoform differs from the canonical sequence as follows:
         319-319: G → GRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPC

    Note: No experimental confirmation available.

    Show »
    Length:695
    Mass (Da):76,300
    Checksum:iC4E1FEC8D932603C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti278 – 2781E → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035910
    Natural varianti446 – 4461I → V.4 Publications
    Corresponds to variant rs2544809 [ dbSNP | Ensembl ].
    VAR_047365
    Natural varianti553 – 5531S → P.4 Publications
    Corresponds to variant rs28538572 [ dbSNP | Ensembl ].
    VAR_047366
    Natural varianti640 – 6401E → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035911

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei4 – 2926VSFSG…SAADW → HPWHGTAALASSQAWRDGRE RQALVSCR in isoform 2. 1 PublicationVSP_028175Add
    BLAST
    Alternative sequencei319 – 3191G → GRPYCPFIKASDSGPSSSSS SSSSPPRTPFPYITCHRTPN LSSSLPC in isoform 3. 1 PublicationVSP_053443

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17530 mRNA. Translation: BAA04480.1.
    U00802 mRNA. Translation: AAA16256.1.
    AK314645 mRNA. Translation: BAG37207.1.
    AL110225 mRNA. Translation: CAB53683.1.
    AC145098 Genomic DNA. No translation available.
    BC000283 mRNA. Translation: AAH00283.1.
    BC007281 mRNA. Translation: AAH07281.1.
    BC007567 mRNA. Translation: AAH07567.1.
    BC114553 mRNA. No translation available.
    CCDSiCCDS4420.1. [Q16643-1]
    CCDS4421.1. [Q16643-2]
    PIRiJN0809.
    T14763.
    RefSeqiNP_004386.2. NM_004395.3.
    NP_543157.1. NM_080881.2.
    XP_005265884.1. XM_005265827.2. [Q16643-3]
    UniGeneiHs.130316.

    Genome annotation databases

    EnsembliENST00000292385; ENSP00000292385; ENSG00000113758. [Q16643-2]
    ENST00000309007; ENSP00000308532; ENSG00000113758. [Q16643-1]
    ENST00000393565; ENSP00000377195; ENSG00000113758. [Q16643-3]
    GeneIDi1627.
    KEGGihsa:1627.
    UCSCiuc003mgx.2. human. [Q16643-2]
    uc003mgy.2. human. [Q16643-1]

    Polymorphism databases

    DMDMi215274247.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17530 mRNA. Translation: BAA04480.1 .
    U00802 mRNA. Translation: AAA16256.1 .
    AK314645 mRNA. Translation: BAG37207.1 .
    AL110225 mRNA. Translation: CAB53683.1 .
    AC145098 Genomic DNA. No translation available.
    BC000283 mRNA. Translation: AAH00283.1 .
    BC007281 mRNA. Translation: AAH07281.1 .
    BC007567 mRNA. Translation: AAH07567.1 .
    BC114553 mRNA. No translation available.
    CCDSi CCDS4420.1. [Q16643-1 ]
    CCDS4421.1. [Q16643-2 ]
    PIRi JN0809.
    T14763.
    RefSeqi NP_004386.2. NM_004395.3.
    NP_543157.1. NM_080881.2.
    XP_005265884.1. XM_005265827.2. [Q16643-3 ]
    UniGenei Hs.130316.

    3D structure databases

    ProteinModelPortali Q16643.
    SMRi Q16643. Positions 13-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107995. 54 interactions.
    IntActi Q16643. 35 interactions.
    MINTi MINT-1149054.
    STRINGi 9606.ENSP00000292385.

    PTM databases

    PhosphoSitei Q16643.

    Polymorphism databases

    DMDMi 215274247.

    2D gel databases

    OGPi Q16643.

    Proteomic databases

    MaxQBi Q16643.
    PaxDbi Q16643.
    PRIDEi Q16643.

    Protocols and materials databases

    DNASUi 1627.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292385 ; ENSP00000292385 ; ENSG00000113758 . [Q16643-2 ]
    ENST00000309007 ; ENSP00000308532 ; ENSG00000113758 . [Q16643-1 ]
    ENST00000393565 ; ENSP00000377195 ; ENSG00000113758 . [Q16643-3 ]
    GeneIDi 1627.
    KEGGi hsa:1627.
    UCSCi uc003mgx.2. human. [Q16643-2 ]
    uc003mgy.2. human. [Q16643-1 ]

    Organism-specific databases

    CTDi 1627.
    GeneCardsi GC05M176883.
    H-InvDB HIX0005464.
    HGNCi HGNC:2695. DBN1.
    HPAi CAB008367.
    HPA051452.
    MIMi 126660. gene.
    neXtProti NX_Q16643.
    PharmGKBi PA27163.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329456.
    HOGENOMi HOG000015304.
    HOVERGENi HBG000823.
    OMAi CANLLNF.
    OrthoDBi EOG7X3QR9.
    PhylomeDBi Q16643.
    TreeFami TF318935.

    Enzyme and pathway databases

    SignaLinki Q16643.

    Miscellaneous databases

    ChiTaRSi DBN1. human.
    GeneWikii DBN1.
    GenomeRNAii 1627.
    NextBioi 35464922.
    PROi Q16643.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16643.
    Bgeei Q16643.
    CleanExi HS_DBN1.
    Genevestigatori Q16643.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028438. Drebrin.
    [Graphical view ]
    PANTHERi PTHR10829:SF1. PTHR10829:SF1. 1 hit.
    Pfami PF00241. Cofilin_ADF. 1 hit.
    [Graphical view ]
    SMARTi SM00102. ADF. 1 hit.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene."
      Toda M., Shirao T., Minoshima S., Shimizu N., Toya S., Uyemura K.
      Biochem. Biophys. Res. Commun. 196:468-472(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-446 AND PRO-553.
      Tissue: Fetal brain.
    2. "Human drebrin: cDNA sequence, mRNA tissue distribution and chromosomal localization."
      Fisher L.W., McBride O.W., Filpula D., Ibaraki K., Young M.F.
      Neurosci. Res. Commun. 14:35-42(1994)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-446 AND PRO-553.
      Tissue: Osteoblast.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS VAL-446 AND PRO-553.
      Tissue: Testis.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-521 (ISOFORM 3), VARIANTS VAL-446 AND PRO-553.
      Tissue: Eye and Muscle.
    7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-10, ACETYLATION AT ALA-2.
      Tissue: Platelet.
    8. Bienvenut W.V., Dozynkiewicz M., Norman J.C.
      Submitted (JUN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-10; 43-62; 140-147; 150-165; 272-299 AND 328-390, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, PHOSPHORYLATION AT SER-142, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    9. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 80-94, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142; THR-331; THR-335; SER-337 AND THR-346, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331 AND THR-346, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. Cited for: FUNCTION, INTERACTION WITH CXCR4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 AND SER-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141; SER-142; SER-337 AND SER-339, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-278 AND GLN-640.

    Entry informationi

    Entry nameiDREB_HUMAN
    AccessioniPrimary (citable) accession number: Q16643
    Secondary accession number(s): A8MV58, B2RBG0, Q9UFZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 138 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3