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Protein

C-C motif chemokine 14

Gene

CCL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:G66-32623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 14
Alternative name(s):
Chemokine CC-1/CC-3
Short name:
HCC-1/HCC-3
HCC-1(1-74)
NCC-2
Small-inducible cytokine A14
Cleaved into the following 3 chains:
Gene namesi
Name:CCL14
Synonyms:NCC2, SCYA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10612. CCL14.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6358.
OpenTargetsiENSG00000276409.
ENSG00000277236.
PharmGKBiPA35545.

Polymorphism and mutation databases

BioMutaiCCL14.
DMDMi2493670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 193 PublicationsAdd BLAST19
ChainiPRO_000000520420 – 93C-C motif chemokine 14Add BLAST74
ChainiPRO_000000520522 – 93HCC-1(3-74)Add BLAST72
ChainiPRO_000000520623 – 93HCC-1(4-74)Add BLAST71
ChainiPRO_000000520728 – 93HCC-1(9-74)Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26O-linked (GalNAc...); partial1 Publication1
Disulfide bondi35 ↔ 59
Disulfide bondi36 ↔ 75

Post-translational modificationi

The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ16627.
PRIDEiQ16627.

PTM databases

iPTMnetiQ16627.
PhosphoSitePlusiQ16627.

Expressioni

Tissue specificityi

Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.1 Publication

Gene expression databases

BgeeiENSG00000213494.
CleanExiHS_CCL14.
ExpressionAtlasiQ16627. baseline and differential.
GenevisibleiQ16627. HS.

Organism-specific databases

HPAiCAB004423.
HPA030268.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112261. 9 interactors.
DIPiDIP-5861N.
IntActiQ16627. 4 interactors.

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 35Combined sources3
Helixi46 – 48Combined sources3
Beta strandi49 – 54Combined sources6
Beta strandi59 – 61Combined sources3
Beta strandi64 – 68Combined sources5
Beta strandi73 – 76Combined sources4
Helixi81 – 90Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q8RX-ray1.82E/F/G/H28-93[»]
2Q8TX-ray2.23A/B/C/D20-93[»]
ProteinModelPortaliQ16627.
SMRiQ16627.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16627.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16627.
KOiK05514.
OMAiICANPRD.
OrthoDBiEOG091G14Y2.
PhylomeDBiQ16627.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform HCC-1 (identifier: Q16627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM
60 70 80 90
DYYETNSQCS KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN
Length:93
Mass (Da):10,678
Last modified:November 1, 1997 - v1
Checksum:iDDDB899DC9148836
GO
Isoform HCC-3 (identifier: Q16627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: R → QTGGKPKVVKIQLKLVG

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):12,297
Checksum:i73591D5CFF6D3C28
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04870761K → E.Corresponds to variant rs16971802dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00106027R → QTGGKPKVVKIQLKLVG in isoform HCC-3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49270 mRNA. Translation: CAA89264.1.
Z70292 mRNA. Translation: CAA94307.1.
Z70293 mRNA. Translation: CAA94309.1.
Z49269 Genomic DNA. Translation: CAA89263.1.
AF088219 Genomic DNA. Translation: AAC63329.1.
AF088219 Genomic DNA. Translation: AAF23982.1.
CH471147 Genomic DNA. Translation: EAW80105.1.
CH471147 Genomic DNA. Translation: EAW80106.1.
CH471147 Genomic DNA. Translation: EAW80107.1.
CH471147 Genomic DNA. Translation: EAW80108.1.
BC038289 mRNA. Translation: AAH38289.1.
BC045165 mRNA. Translation: AAH45165.1.
CCDSiCCDS32624.1. [Q16627-1]
CCDS45652.1. [Q16627-2]
RefSeqiNP_116738.1. NM_032962.4. [Q16627-2]
NP_116739.1. NM_032963.3. [Q16627-1]
UniGeneiHs.272493.
Hs.740501.

Genome annotation databases

EnsembliENST00000618404; ENSP00000481023; ENSG00000276409. [Q16627-1]
ENST00000619040; ENSP00000483302; ENSG00000277236. [Q16627-2]
ENST00000622526; ENSP00000479097; ENSG00000276409. [Q16627-2]
ENST00000632700; ENSP00000487948; ENSG00000277236. [Q16627-1]
GeneIDi6358.
KEGGihsa:6358.
UCSCiuc010wcq.2. human. [Q16627-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL14 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49270 mRNA. Translation: CAA89264.1.
Z70292 mRNA. Translation: CAA94307.1.
Z70293 mRNA. Translation: CAA94309.1.
Z49269 Genomic DNA. Translation: CAA89263.1.
AF088219 Genomic DNA. Translation: AAC63329.1.
AF088219 Genomic DNA. Translation: AAF23982.1.
CH471147 Genomic DNA. Translation: EAW80105.1.
CH471147 Genomic DNA. Translation: EAW80106.1.
CH471147 Genomic DNA. Translation: EAW80107.1.
CH471147 Genomic DNA. Translation: EAW80108.1.
BC038289 mRNA. Translation: AAH38289.1.
BC045165 mRNA. Translation: AAH45165.1.
CCDSiCCDS32624.1. [Q16627-1]
CCDS45652.1. [Q16627-2]
RefSeqiNP_116738.1. NM_032962.4. [Q16627-2]
NP_116739.1. NM_032963.3. [Q16627-1]
UniGeneiHs.272493.
Hs.740501.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q8RX-ray1.82E/F/G/H28-93[»]
2Q8TX-ray2.23A/B/C/D20-93[»]
ProteinModelPortaliQ16627.
SMRiQ16627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112261. 9 interactors.
DIPiDIP-5861N.
IntActiQ16627. 4 interactors.

PTM databases

iPTMnetiQ16627.
PhosphoSitePlusiQ16627.

Polymorphism and mutation databases

BioMutaiCCL14.
DMDMi2493670.

Proteomic databases

PeptideAtlasiQ16627.
PRIDEiQ16627.

Protocols and materials databases

DNASUi6358.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618404; ENSP00000481023; ENSG00000276409. [Q16627-1]
ENST00000619040; ENSP00000483302; ENSG00000277236. [Q16627-2]
ENST00000622526; ENSP00000479097; ENSG00000276409. [Q16627-2]
ENST00000632700; ENSP00000487948; ENSG00000277236. [Q16627-1]
GeneIDi6358.
KEGGihsa:6358.
UCSCiuc010wcq.2. human. [Q16627-1]

Organism-specific databases

CTDi6358.
DisGeNETi6358.
GeneCardsiCCL14.
H-InvDBHIX0039168.
HGNCiHGNC:10612. CCL14.
HPAiCAB004423.
HPA030268.
MIMi601392. gene.
neXtProtiNX_Q16627.
OpenTargetsiENSG00000276409.
ENSG00000277236.
PharmGKBiPA35545.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16627.
KOiK05514.
OMAiICANPRD.
OrthoDBiEOG091G14Y2.
PhylomeDBiQ16627.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:G66-32623-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ16627.
GenomeRNAii6358.
PROiQ16627.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213494.
CleanExiHS_CCL14.
ExpressionAtlasiQ16627. baseline and differential.
GenevisibleiQ16627. HS.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL14_HUMAN
AccessioniPrimary (citable) accession number: Q16627
Secondary accession number(s): E1P649, E1P650, Q13954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.