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Q16627

- CCL14_HUMAN

UniProt

Q16627 - CCL14_HUMAN

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Protein

C-C motif chemokine 14

Gene
CCL14, NCC2, SCYA14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.1 Publication

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. cellular calcium ion homeostasis Source: ProtInc
  3. immune response Source: InterPro
  4. positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 14
Alternative name(s):
Chemokine CC-1/CC-3
Short name:
HCC-1/HCC-3
HCC-1(1-74)
NCC-2
Small-inducible cytokine A14
Cleaved into the following 3 chains:
Gene namesi
Name:CCL14
Synonyms:NCC2, SCYA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10612. CCL14.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19193 PublicationsAdd
BLAST
Chaini20 – 9374C-C motif chemokine 14PRO_0000005204Add
BLAST
Chaini22 – 9372HCC-1(3-74)PRO_0000005205Add
BLAST
Chaini23 – 9371HCC-1(4-74)PRO_0000005206Add
BLAST
Chaini28 – 9366HCC-1(9-74)PRO_0000005207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261O-linked (GalNAc...); partial1 Publication
Disulfide bondi35 ↔ 59
Disulfide bondi36 ↔ 75

Post-translational modificationi

The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ16627.
PRIDEiQ16627.

PTM databases

PhosphoSiteiQ16627.

Expressioni

Tissue specificityi

Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.1 Publication

Gene expression databases

BgeeiQ16627.
CleanExiHS_CCL14.
GenevestigatoriQ16627.

Organism-specific databases

HPAiCAB004423.
HPA030268.

Interactioni

Protein-protein interaction databases

BioGridi112261. 5 interactions.
DIPiDIP-5861N.
IntActiQ16627. 4 interactions.
STRINGi9606.ENSP00000409197.

Structurei

Secondary structure

1
93
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353
Helixi46 – 483
Beta strandi49 – 546
Beta strandi59 – 613
Beta strandi64 – 685
Beta strandi73 – 764
Helixi81 – 9010

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q8RX-ray1.82E/F/G/H28-93[»]
2Q8TX-ray2.23A/B/C/D20-93[»]
ProteinModelPortaliQ16627.
SMRiQ16627. Positions 28-93.

Miscellaneous databases

EvolutionaryTraceiQ16627.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG84308.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ16627.
KOiK05514.
OMAiVVKIQLK.
PhylomeDBiQ16627.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform HCC-1 (identifier: Q16627-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM   50
DYYETNSQCS KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN 93
Length:93
Mass (Da):10,678
Last modified:November 1, 1997 - v1
Checksum:iDDDB899DC9148836
GO
Isoform HCC-3 (identifier: Q16627-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: R → QTGGKPKVVKIQLKLVG

Note: No experimental confirmation available.

Show »
Length:109
Mass (Da):12,297
Checksum:i73591D5CFF6D3C28
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611K → E.
Corresponds to variant rs16971802 [ dbSNP | Ensembl ].
VAR_048707

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei27 – 271R → QTGGKPKVVKIQLKLVG in isoform HCC-3. VSP_001060

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49270 mRNA. Translation: CAA89264.1.
Z70292 mRNA. Translation: CAA94307.1.
Z70293 mRNA. Translation: CAA94309.1.
Z49269 Genomic DNA. Translation: CAA89263.1.
AF088219 Genomic DNA. Translation: AAC63329.1.
AF088219 Genomic DNA. Translation: AAF23982.1.
CH471147 Genomic DNA. Translation: EAW80105.1.
CH471147 Genomic DNA. Translation: EAW80106.1.
CH471147 Genomic DNA. Translation: EAW80107.1.
CH471147 Genomic DNA. Translation: EAW80108.1.
BC038289 mRNA. Translation: AAH38289.1.
BC045165 mRNA. Translation: AAH45165.1.
CCDSiCCDS32624.1. [Q16627-1]
CCDS45652.1. [Q16627-2]
RefSeqiNP_116738.1. NM_032962.4. [Q16627-2]
NP_116739.1. NM_032963.3. [Q16627-1]
UniGeneiHs.272493.
Hs.740501.

Genome annotation databases

EnsembliENST00000394509; ENSP00000378017; ENSG00000213494. [Q16627-1]
ENST00000435911; ENSP00000409197; ENSG00000213494. [Q16627-2]
ENST00000536149; ENSP00000441771; ENSG00000213494. [Q16627-2]
GeneIDi6358.
KEGGihsa:6358.
UCSCiuc010wcq.1. human. [Q16627-2]
uc010wcr.1. human. [Q16627-1]

Polymorphism databases

DMDMi2493670.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL14 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49270 mRNA. Translation: CAA89264.1 .
Z70292 mRNA. Translation: CAA94307.1 .
Z70293 mRNA. Translation: CAA94309.1 .
Z49269 Genomic DNA. Translation: CAA89263.1 .
AF088219 Genomic DNA. Translation: AAC63329.1 .
AF088219 Genomic DNA. Translation: AAF23982.1 .
CH471147 Genomic DNA. Translation: EAW80105.1 .
CH471147 Genomic DNA. Translation: EAW80106.1 .
CH471147 Genomic DNA. Translation: EAW80107.1 .
CH471147 Genomic DNA. Translation: EAW80108.1 .
BC038289 mRNA. Translation: AAH38289.1 .
BC045165 mRNA. Translation: AAH45165.1 .
CCDSi CCDS32624.1. [Q16627-1 ]
CCDS45652.1. [Q16627-2 ]
RefSeqi NP_116738.1. NM_032962.4. [Q16627-2 ]
NP_116739.1. NM_032963.3. [Q16627-1 ]
UniGenei Hs.272493.
Hs.740501.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Q8R X-ray 1.82 E/F/G/H 28-93 [» ]
2Q8T X-ray 2.23 A/B/C/D 20-93 [» ]
ProteinModelPortali Q16627.
SMRi Q16627. Positions 28-93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112261. 5 interactions.
DIPi DIP-5861N.
IntActi Q16627. 4 interactions.
STRINGi 9606.ENSP00000409197.

PTM databases

PhosphoSitei Q16627.

Polymorphism databases

DMDMi 2493670.

Proteomic databases

PaxDbi Q16627.
PRIDEi Q16627.

Protocols and materials databases

DNASUi 6358.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394509 ; ENSP00000378017 ; ENSG00000213494 . [Q16627-1 ]
ENST00000435911 ; ENSP00000409197 ; ENSG00000213494 . [Q16627-2 ]
ENST00000536149 ; ENSP00000441771 ; ENSG00000213494 . [Q16627-2 ]
GeneIDi 6358.
KEGGi hsa:6358.
UCSCi uc010wcq.1. human. [Q16627-2 ]
uc010wcr.1. human. [Q16627-1 ]

Organism-specific databases

CTDi 6358.
GeneCardsi GC17M034343.
H-InvDB HIX0039168.
HGNCi HGNC:10612. CCL14.
HPAi CAB004423.
HPA030268.
MIMi 601392. gene.
neXtProti NX_Q16627.
PharmGKBi PA35545.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84308.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q16627.
KOi K05514.
OMAi VVKIQLK.
PhylomeDBi Q16627.
TreeFami TF334888.

Miscellaneous databases

EvolutionaryTracei Q16627.
GenomeRNAii 6358.
NextBioi 24696.
PROi Q16627.
SOURCEi Search...

Gene expression databases

Bgeei Q16627.
CleanExi HS_CCL14.
Genevestigatori Q16627.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM HCC-1), PROTEIN SEQUENCE OF 20-93.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HCC-1 AND HCC-3), TISSUE SPECIFICITY.
    Tissue: Liver.
  3. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
    Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
    J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HCC-1).
    Tissue: Pancreas and Spleen.
  6. "Posttranslationally processed forms of the human chemokine HCC-1."
    Richter R., Schulz-Knappe P., John H., Forssmann W.-G.
    Biochemistry 39:10799-10805(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-32, IDENTIFICATION OF HCC-1(3-74) AND HCC-1(4-74), IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION AT SER-26.
  7. "Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties."
    Detheux M., Staendker L., Vakili J., Muench J., Forssmann U., Adermann K., Poehlmann S., Vassart G., Kirchhoff F., Parmentier M., Forssmann W.-G.
    J. Exp. Med. 192:1501-1508(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-48, IDENTIFICATION OF HCC-1(9-74), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 28-93.

Entry informationi

Entry nameiCCL14_HUMAN
AccessioniPrimary (citable) accession number: Q16627
Secondary accession number(s): E1P649, E1P650, Q13954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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