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Protein

Male-enhanced antigen 1

Gene

MEA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in spermatogenesis and/or testis development.

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • male gonad development Source: ProtInc
  • spermatogenesis Source: ProtInc

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Male-enhanced antigen 1
Short name:
MEA-1
Gene namesi
Name:MEA1
Synonyms:MEA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6986. MEA1.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi4201.
OpenTargetsiENSG00000124733.
PharmGKBiPA30726.

Polymorphism and mutation databases

BioMutaiMEA1.
DMDMi239938667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963411 – 185Male-enhanced antigen 1Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16626.
MaxQBiQ16626.
PaxDbiQ16626.
PeptideAtlasiQ16626.
PRIDEiQ16626.

PTM databases

iPTMnetiQ16626.
PhosphoSitePlusiQ16626.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiENSG00000124733.
CleanExiHS_MEA1.
GenevisibleiQ16626. HS.

Organism-specific databases

HPAiHPA017921.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AP2B1P630102EBI-744921,EBI-432924

Protein-protein interaction databases

BioGridi110365. 9 interactors.
IntActiQ16626. 3 interactors.
MINTiMINT-1484726.
STRINGi9606.ENSP00000244711.

Structurei

3D structure databases

ProteinModelPortaliQ16626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWXB. Eukaryota.
ENOG41120JT. LUCA.
GeneTreeiENSGT00390000016927.
HOGENOMiHOG000082669.
HOVERGENiHBG001597.
InParanoidiQ16626.
OMAiKMGPERI.
OrthoDBiEOG090A0CRZ.
PhylomeDBiQ16626.
TreeFamiTF332365.

Family and domain databases

InterProiView protein in InterPro
IPR009685. MEA1.
PfamiView protein in Pfam
PF06910. MEA1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022082. PD022082. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS
60 70 80 90 100
SEEPEEEQEE TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI
110 120 130 140 150
QALGLHLPDP PLESEDEDEE GATALNNHSS IPMDPEHVEL VKRTMAGVSL
160 170 180
PAPGVPAWAR EISDAQWEDV VQKALQARQA SPAWK
Length:185
Mass (Da):19,905
Last modified:June 16, 2009 - v2
Checksum:iF50E6892FBA7435C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058297183A → D. Corresponds to variant dbSNP:rs11751058Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27937 mRNA. Translation: AAA36208.1.
L10400 mRNA. Translation: AAA36209.1.
BT009831 mRNA. Translation: AAP88833.1.
AL136304 Genomic DNA. Translation: CAI19794.2.
BC001754 mRNA. Translation: AAH01754.1.
CCDSiCCDS4879.1.
PIRiA34421.
RefSeqiNP_055438.1. NM_014623.3.
UniGeneiHs.278362.

Genome annotation databases

EnsembliENST00000244711; ENSP00000244711; ENSG00000124733.
GeneIDi4201.
KEGGihsa:4201.
UCSCiuc003otk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27937 mRNA. Translation: AAA36208.1.
L10400 mRNA. Translation: AAA36209.1.
BT009831 mRNA. Translation: AAP88833.1.
AL136304 Genomic DNA. Translation: CAI19794.2.
BC001754 mRNA. Translation: AAH01754.1.
CCDSiCCDS4879.1.
PIRiA34421.
RefSeqiNP_055438.1. NM_014623.3.
UniGeneiHs.278362.

3D structure databases

ProteinModelPortaliQ16626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110365. 9 interactors.
IntActiQ16626. 3 interactors.
MINTiMINT-1484726.
STRINGi9606.ENSP00000244711.

PTM databases

iPTMnetiQ16626.
PhosphoSitePlusiQ16626.

Polymorphism and mutation databases

BioMutaiMEA1.
DMDMi239938667.

Proteomic databases

EPDiQ16626.
MaxQBiQ16626.
PaxDbiQ16626.
PeptideAtlasiQ16626.
PRIDEiQ16626.

Protocols and materials databases

DNASUi4201.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244711; ENSP00000244711; ENSG00000124733.
GeneIDi4201.
KEGGihsa:4201.
UCSCiuc003otk.4. human.

Organism-specific databases

CTDi4201.
DisGeNETi4201.
GeneCardsiMEA1.
HGNCiHGNC:6986. MEA1.
HPAiHPA017921.
MIMi143170. gene.
neXtProtiNX_Q16626.
OpenTargetsiENSG00000124733.
PharmGKBiPA30726.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWXB. Eukaryota.
ENOG41120JT. LUCA.
GeneTreeiENSGT00390000016927.
HOGENOMiHOG000082669.
HOVERGENiHBG001597.
InParanoidiQ16626.
OMAiKMGPERI.
OrthoDBiEOG090A0CRZ.
PhylomeDBiQ16626.
TreeFamiTF332365.

Miscellaneous databases

ChiTaRSiMEA1. human.
GenomeRNAii4201.
PROiQ16626.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124733.
CleanExiHS_MEA1.
GenevisibleiQ16626. HS.

Family and domain databases

InterProiView protein in InterPro
IPR009685. MEA1.
PfamiView protein in Pfam
PF06910. MEA1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022082. PD022082. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMEA1_HUMAN
AccessioniPrimary (citable) accession number: Q16626
Secondary accession number(s): Q5TC36, Q9BV01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 16, 2009
Last modified: February 15, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be the H-Y antigen.Curated
It is uncertain whether Met-1, Met-14 or Met-24 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.