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Q16626 (MEA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Male-enhanced antigen 1

Short name=MEA-1
Gene names
Name:MEA1
Synonyms:MEA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in spermatogenesis and/or testis development.

Tissue specificity

Highly expressed in testis.

Caution

Was originally thought to be the H-Y antigen.

It is uncertain whether Met-1, Met-14 or Met-24 is the initiator.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
   Coding sequence diversityPolymorphism
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

male gonad development

Traceable author statement Ref.1. Source: ProtInc

spermatogenesis

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 16189514. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AP2B1P630102EBI-744921,EBI-432924

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Male-enhanced antigen 1
PRO_0000096341

Amino acid modifications

Modified residue1141Phosphoserine Ref.5

Natural variations

Natural variant1831A → D.
Corresponds to variant rs11751058 [ dbSNP | Ensembl ].
VAR_058297

Sequences

Sequence LengthMass (Da)Tools
Q16626 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: F50E6892FBA7435C

FASTA18519,905
        10         20         30         40         50         60 
MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS SEEPEEEQEE 

        70         80         90        100        110        120 
TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI QALGLHLPDP PLESEDEDEE 

       130        140        150        160        170        180 
GATALNNHSS IPMDPEHVEL VKRTMAGVSL PAPGVPAWAR EISDAQWEDV VQKALQARQA 


SPAWK 

« Hide

References

« Hide 'large scale' references
[1]"Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis."
Lau Y.-F.C., Chan K., Sparkes R.S.
Proc. Natl. Acad. Sci. U.S.A. 86:8462-8466(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[5]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M27937 mRNA. Translation: AAA36208.1.
L10400 mRNA. Translation: AAA36209.1.
BT009831 mRNA. Translation: AAP88833.1.
AL136304 Genomic DNA. Translation: CAI19794.2.
BC001754 mRNA. Translation: AAH01754.1.
CCDSCCDS4879.1.
PIRA34421.
RefSeqNP_055438.1. NM_014623.2.
UniGeneHs.278362.

3D structure databases

ProteinModelPortalQ16626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110365. 11 interactions.
IntActQ16626. 3 interactions.
MINTMINT-1484726.
STRING9606.ENSP00000244711.

PTM databases

PhosphoSiteQ16626.

Polymorphism databases

DMDM239938667.

Proteomic databases

MaxQBQ16626.
PaxDbQ16626.
PRIDEQ16626.

Protocols and materials databases

DNASU4201.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244711; ENSP00000244711; ENSG00000124733.
GeneID4201.
KEGGhsa:4201.
UCSCuc003otk.3. human.

Organism-specific databases

CTD4201.
GeneCardsGC06M042979.
HGNCHGNC:6986. MEA1.
HPAHPA017921.
MIM143170. gene.
neXtProtNX_Q16626.
PharmGKBPA30726.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41435.
HOGENOMHOG000082669.
HOVERGENHBG001597.
InParanoidQ16626.
OMAKMGPERI.
OrthoDBEOG73FQPB.
PhylomeDBQ16626.
TreeFamTF332365.

Gene expression databases

BgeeQ16626.
CleanExHS_MEA1.
GenevestigatorQ16626.

Family and domain databases

InterProIPR009685. MEA1.
[Graphical view]
PfamPF06910. MEA1. 1 hit.
[Graphical view]
ProDomPD022082. PD022082. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

ChiTaRSMEA1. human.
GenomeRNAi4201.
NextBio16558.
PROQ16626.
SOURCESearch...

Entry information

Entry nameMEA1_HUMAN
AccessionPrimary (citable) accession number: Q16626
Secondary accession number(s): Q5TC36, Q9BV01
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM