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Q16626

- MEA1_HUMAN

UniProt

Q16626 - MEA1_HUMAN

Protein

Male-enhanced antigen 1

Gene

MEA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    May play an important role in spermatogenesis and/or testis development.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. male gonad development Source: ProtInc
    3. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Male-enhanced antigen 1
    Short name:
    MEA-1
    Gene namesi
    Name:MEA1
    Synonyms:MEA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6986. MEA1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30726.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Male-enhanced antigen 1PRO_0000096341Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei114 – 1141Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ16626.
    PaxDbiQ16626.
    PRIDEiQ16626.

    PTM databases

    PhosphoSiteiQ16626.

    Expressioni

    Tissue specificityi

    Highly expressed in testis.

    Gene expression databases

    BgeeiQ16626.
    CleanExiHS_MEA1.
    GenevestigatoriQ16626.

    Organism-specific databases

    HPAiHPA017921.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AP2B1P630102EBI-744921,EBI-432924

    Protein-protein interaction databases

    BioGridi110365. 11 interactions.
    IntActiQ16626. 3 interactions.
    MINTiMINT-1484726.
    STRINGi9606.ENSP00000244711.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16626.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG41435.
    HOGENOMiHOG000082669.
    HOVERGENiHBG001597.
    InParanoidiQ16626.
    OMAiKMGPERI.
    OrthoDBiEOG73FQPB.
    PhylomeDBiQ16626.
    TreeFamiTF332365.

    Family and domain databases

    InterProiIPR009685. MEA1.
    [Graphical view]
    PfamiPF06910. MEA1. 1 hit.
    [Graphical view]
    ProDomiPD022082. PD022082. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q16626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS    50
    SEEPEEEQEE TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI 100
    QALGLHLPDP PLESEDEDEE GATALNNHSS IPMDPEHVEL VKRTMAGVSL 150
    PAPGVPAWAR EISDAQWEDV VQKALQARQA SPAWK 185
    Length:185
    Mass (Da):19,905
    Last modified:June 16, 2009 - v2
    Checksum:iF50E6892FBA7435C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti183 – 1831A → D.
    Corresponds to variant rs11751058 [ dbSNP | Ensembl ].
    VAR_058297

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27937 mRNA. Translation: AAA36208.1.
    L10400 mRNA. Translation: AAA36209.1.
    BT009831 mRNA. Translation: AAP88833.1.
    AL136304 Genomic DNA. Translation: CAI19794.2.
    BC001754 mRNA. Translation: AAH01754.1.
    CCDSiCCDS4879.1.
    PIRiA34421.
    RefSeqiNP_055438.1. NM_014623.2.
    UniGeneiHs.278362.

    Genome annotation databases

    EnsembliENST00000244711; ENSP00000244711; ENSG00000124733.
    GeneIDi4201.
    KEGGihsa:4201.
    UCSCiuc003otk.3. human.

    Polymorphism databases

    DMDMi239938667.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27937 mRNA. Translation: AAA36208.1 .
    L10400 mRNA. Translation: AAA36209.1 .
    BT009831 mRNA. Translation: AAP88833.1 .
    AL136304 Genomic DNA. Translation: CAI19794.2 .
    BC001754 mRNA. Translation: AAH01754.1 .
    CCDSi CCDS4879.1.
    PIRi A34421.
    RefSeqi NP_055438.1. NM_014623.2.
    UniGenei Hs.278362.

    3D structure databases

    ProteinModelPortali Q16626.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110365. 11 interactions.
    IntActi Q16626. 3 interactions.
    MINTi MINT-1484726.
    STRINGi 9606.ENSP00000244711.

    PTM databases

    PhosphoSitei Q16626.

    Polymorphism databases

    DMDMi 239938667.

    Proteomic databases

    MaxQBi Q16626.
    PaxDbi Q16626.
    PRIDEi Q16626.

    Protocols and materials databases

    DNASUi 4201.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000244711 ; ENSP00000244711 ; ENSG00000124733 .
    GeneIDi 4201.
    KEGGi hsa:4201.
    UCSCi uc003otk.3. human.

    Organism-specific databases

    CTDi 4201.
    GeneCardsi GC06M042979.
    HGNCi HGNC:6986. MEA1.
    HPAi HPA017921.
    MIMi 143170. gene.
    neXtProti NX_Q16626.
    PharmGKBi PA30726.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41435.
    HOGENOMi HOG000082669.
    HOVERGENi HBG001597.
    InParanoidi Q16626.
    OMAi KMGPERI.
    OrthoDBi EOG73FQPB.
    PhylomeDBi Q16626.
    TreeFami TF332365.

    Miscellaneous databases

    ChiTaRSi MEA1. human.
    GenomeRNAii 4201.
    NextBioi 16558.
    PROi Q16626.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16626.
    CleanExi HS_MEA1.
    Genevestigatori Q16626.

    Family and domain databases

    InterProi IPR009685. MEA1.
    [Graphical view ]
    Pfami PF06910. MEA1. 1 hit.
    [Graphical view ]
    ProDomi PD022082. PD022082. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis."
      Lau Y.-F.C., Chan K., Sparkes R.S.
      Proc. Natl. Acad. Sci. U.S.A. 86:8462-8466(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMEA1_HUMAN
    AccessioniPrimary (citable) accession number: Q16626
    Secondary accession number(s): Q5TC36, Q9BV01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be the H-Y antigen.Curated
    It is uncertain whether Met-1, Met-14 or Met-24 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3