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Q16626

- MEA1_HUMAN

UniProt

Q16626 - MEA1_HUMAN

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Protein

Male-enhanced antigen 1

Gene

MEA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play an important role in spermatogenesis and/or testis development.

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. male gonad development Source: ProtInc
  3. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Male-enhanced antigen 1
Short name:
MEA-1
Gene namesi
Name:MEA1
Synonyms:MEA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6986. MEA1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Male-enhanced antigen 1PRO_0000096341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei114 – 1141Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ16626.
PaxDbiQ16626.
PRIDEiQ16626.

PTM databases

PhosphoSiteiQ16626.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiQ16626.
CleanExiHS_MEA1.
GenevestigatoriQ16626.

Organism-specific databases

HPAiHPA017921.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AP2B1P630102EBI-744921,EBI-432924

Protein-protein interaction databases

BioGridi110365. 11 interactions.
IntActiQ16626. 3 interactions.
MINTiMINT-1484726.
STRINGi9606.ENSP00000244711.

Structurei

3D structure databases

ProteinModelPortaliQ16626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG41435.
GeneTreeiENSGT00390000016927.
HOGENOMiHOG000082669.
HOVERGENiHBG001597.
InParanoidiQ16626.
OMAiKMGPERI.
OrthoDBiEOG73FQPB.
PhylomeDBiQ16626.
TreeFamiTF332365.

Family and domain databases

InterProiIPR009685. MEA1.
[Graphical view]
PfamiPF06910. MEA1. 1 hit.
[Graphical view]
ProDomiPD022082. PD022082. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q16626-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS
60 70 80 90 100
SEEPEEEQEE TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI
110 120 130 140 150
QALGLHLPDP PLESEDEDEE GATALNNHSS IPMDPEHVEL VKRTMAGVSL
160 170 180
PAPGVPAWAR EISDAQWEDV VQKALQARQA SPAWK
Length:185
Mass (Da):19,905
Last modified:June 16, 2009 - v2
Checksum:iF50E6892FBA7435C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831A → D.
Corresponds to variant rs11751058 [ dbSNP | Ensembl ].
VAR_058297

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27937 mRNA. Translation: AAA36208.1.
L10400 mRNA. Translation: AAA36209.1.
BT009831 mRNA. Translation: AAP88833.1.
AL136304 Genomic DNA. Translation: CAI19794.2.
BC001754 mRNA. Translation: AAH01754.1.
CCDSiCCDS4879.1.
PIRiA34421.
RefSeqiNP_055438.1. NM_014623.2.
UniGeneiHs.278362.

Genome annotation databases

EnsembliENST00000244711; ENSP00000244711; ENSG00000124733.
GeneIDi4201.
KEGGihsa:4201.
UCSCiuc003otk.3. human.

Polymorphism databases

DMDMi239938667.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27937 mRNA. Translation: AAA36208.1 .
L10400 mRNA. Translation: AAA36209.1 .
BT009831 mRNA. Translation: AAP88833.1 .
AL136304 Genomic DNA. Translation: CAI19794.2 .
BC001754 mRNA. Translation: AAH01754.1 .
CCDSi CCDS4879.1.
PIRi A34421.
RefSeqi NP_055438.1. NM_014623.2.
UniGenei Hs.278362.

3D structure databases

ProteinModelPortali Q16626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110365. 11 interactions.
IntActi Q16626. 3 interactions.
MINTi MINT-1484726.
STRINGi 9606.ENSP00000244711.

PTM databases

PhosphoSitei Q16626.

Polymorphism databases

DMDMi 239938667.

Proteomic databases

MaxQBi Q16626.
PaxDbi Q16626.
PRIDEi Q16626.

Protocols and materials databases

DNASUi 4201.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244711 ; ENSP00000244711 ; ENSG00000124733 .
GeneIDi 4201.
KEGGi hsa:4201.
UCSCi uc003otk.3. human.

Organism-specific databases

CTDi 4201.
GeneCardsi GC06M042979.
HGNCi HGNC:6986. MEA1.
HPAi HPA017921.
MIMi 143170. gene.
neXtProti NX_Q16626.
PharmGKBi PA30726.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41435.
GeneTreei ENSGT00390000016927.
HOGENOMi HOG000082669.
HOVERGENi HBG001597.
InParanoidi Q16626.
OMAi KMGPERI.
OrthoDBi EOG73FQPB.
PhylomeDBi Q16626.
TreeFami TF332365.

Miscellaneous databases

ChiTaRSi MEA1. human.
GenomeRNAii 4201.
NextBioi 16558.
PROi Q16626.
SOURCEi Search...

Gene expression databases

Bgeei Q16626.
CleanExi HS_MEA1.
Genevestigatori Q16626.

Family and domain databases

InterProi IPR009685. MEA1.
[Graphical view ]
Pfami PF06910. MEA1. 1 hit.
[Graphical view ]
ProDomi PD022082. PD022082. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis."
    Lau Y.-F.C., Chan K., Sparkes R.S.
    Proc. Natl. Acad. Sci. U.S.A. 86:8462-8466(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMEA1_HUMAN
AccessioniPrimary (citable) accession number: Q16626
Secondary accession number(s): Q5TC36, Q9BV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be the H-Y antigen.Curated
It is uncertain whether Met-1, Met-14 or Met-24 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3