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Protein

BDNF/NT-3 growth factors receptor

Gene

NTRK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei572ATPPROSITE-ProRule annotation1
Active sitei676Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi544 – 552ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • brain-derived neurotrophic factor-activated receptor activity Source: UniProtKB
  • brain-derived neurotrophic factor binding Source: UniProtKB
  • neurotrophin binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS07487-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-187024. NGF-independant TRKA activation.
SignaLinkiQ16620.
SIGNORiQ16620.

Names & Taxonomyi

Protein namesi
Recommended name:
BDNF/NT-3 growth factors receptor (EC:2.7.10.1)
Alternative name(s):
GP145-TrkB
Short name:
Trk-B
Neurotrophic tyrosine kinase receptor type 2
TrkB tyrosine kinase
Tropomyosin-related kinase B
Gene namesi
Name:NTRK2
Synonyms:TRKB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8032. NTRK2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 430ExtracellularSequence analysisAdd BLAST399
Transmembranei431 – 454HelicalSequence analysisAdd BLAST24
Topological domaini455 – 822CytoplasmicSequence analysisAdd BLAST368

GO - Cellular componenti

  • cytosol Source: Ensembl
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl
  • postsynaptic membrane Source: Ensembl
  • receptor complex Source: MGI
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Obesity, hyperphagia, and developmental delay (OBHD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language.
See also OMIM:613886
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065890706Y → C in OBHD; expressed normally on the cell surface; results in markedly impaired ligand-induced phosphorylation as well as impaired downstream MAPK1 phosphorylation. 1 PublicationCorresponds to variant rs121434633dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Obesity

Organism-specific databases

DisGeNETi4915.
MalaCardsiNTRK2.
MIMi613886. phenotype.
OpenTargetsiENSG00000148053.
Orphaneti251612. Pilocytic astrocytoma.
PharmGKBiPA31818.

Chemistry databases

ChEMBLiCHEMBL4898.
DrugBankiDB00321. Amitriptyline.
GuidetoPHARMACOLOGYi1818.

Polymorphism and mutation databases

BioMutaiNTRK2.
DMDMi2497560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Add BLAST31
ChainiPRO_000001672732 – 822BDNF/NT-3 growth factors receptorAdd BLAST791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 38PROSITE-ProRule annotation1 Publication
Disulfide bondi36 ↔ 45PROSITE-ProRule annotation1 Publication
Glycosylationi67N-linked (GlcNAc...)2 Publications1
Glycosylationi95N-linked (GlcNAc...)1 Publication1
Glycosylationi121N-linked (GlcNAc...)2 Publications1
Disulfide bondi152 ↔ 176PROSITE-ProRule annotation1 Publication
Disulfide bondi154 ↔ 194PROSITE-ProRule annotation1 Publication
Glycosylationi178N-linked (GlcNAc...)1 Publication1
Glycosylationi205N-linked (GlcNAc...)1 Publication1
Disulfide bondi218 ↔ 266PROSITE-ProRule annotation1 Publication
Glycosylationi241N-linked (GlcNAc...)1 Publication1
Glycosylationi254N-linked (GlcNAc...)2 Publications1
Glycosylationi280N-linked (GlcNAc...)1 Publication1
Disulfide bondi302 ↔ 345PROSITE-ProRule annotation1 Publication
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi338N-linked (GlcNAc...)1 Publication1
Glycosylationi412N-linked (GlcNAc...)1 Publication1
Modified residuei516Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei702Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei706Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei707Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei817Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.1 Publication
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ16620.
PeptideAtlasiQ16620.
PRIDEiQ16620.

PTM databases

iPTMnetiQ16620.
PhosphoSitePlusiQ16620.

Expressioni

Tissue specificityi

Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.2 Publications

Developmental stagei

Widely expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000148053.
CleanExiHS_NTRK2.
ExpressionAtlasiQ16620. baseline and differential.
GenevisibleiQ16620. HS.

Organism-specific databases

HPAiCAB010346.
HPA007637.

Interactioni

Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor. Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei516Interaction with SHC1By similarity1
Sitei706Interaction with SH2D1ABy similarity1
Sitei817Interaction with PLCG1By similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110970. 24 interactors.
DIPiDIP-5720N.
IntActiQ16620. 8 interactors.
MINTiMINT-156841.
STRINGi9606.ENSP00000277120.

Chemistry databases

BindingDBiQ16620.

Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi286 – 292Combined sources7
Beta strandi300 – 308Combined sources9
Beta strandi314 – 319Combined sources6
Beta strandi322 – 324Combined sources3
Beta strandi328 – 337Combined sources10
Beta strandi339 – 350Combined sources12
Helixi353 – 355Combined sources3
Beta strandi357 – 364Combined sources8
Beta strandi369 – 376Combined sources8
Beta strandi500 – 503Combined sources4
Beta strandi506 – 512Combined sources7
Turni515 – 517Combined sources3
Helixi535 – 537Combined sources3
Beta strandi538 – 545Combined sources8
Beta strandi552 – 557Combined sources6
Beta strandi567 – 574Combined sources8
Helixi579 – 592Combined sources14
Beta strandi603 – 607Combined sources5
Beta strandi609 – 618Combined sources10
Helixi625 – 631Combined sources7
Helixi634 – 638Combined sources5
Beta strandi641 – 643Combined sources3
Helixi650 – 669Combined sources20
Helixi679 – 681Combined sources3
Beta strandi682 – 684Combined sources3
Helixi686 – 688Combined sources3
Beta strandi690 – 692Combined sources3
Helixi698 – 701Combined sources4
Helixi703 – 705Combined sources3
Beta strandi707 – 709Combined sources3
Turni710 – 712Combined sources3
Beta strandi713 – 715Combined sources3
Helixi717 – 719Combined sources3
Helixi722 – 727Combined sources6
Helixi732 – 747Combined sources16
Turni748 – 750Combined sources3
Turni753 – 756Combined sources4
Helixi759 – 768Combined sources10
Helixi780 – 789Combined sources10
Helixi794 – 796Combined sources3
Helixi800 – 813Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HCFX-ray2.70X/Y286-383[»]
1WWBX-ray2.10X283-385[»]
2MFQNMR-B497-519[»]
4ASZX-ray1.70A527-822[»]
4AT3X-ray1.77A527-822[»]
4AT4X-ray2.36A527-822[»]
4AT5X-ray1.71A527-822[»]
ProteinModelPortaliQ16620.
SMRiQ16620.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16620.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 61LRRNTAdd BLAST30
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 137LRR 2Add BLAST22
Domaini148 – 196LRRCTAdd BLAST49
Domaini197 – 282Ig-like C2-type 1Add BLAST86
Domaini295 – 365Ig-like C2-type 2Add BLAST71
Domaini538 – 807Protein kinasePROSITE-ProRule annotationAdd BLAST270

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000264255.
HOVERGENiHBG056735.
InParanoidiQ16620.
KOiK04360.
OMAiCSCEIMW.
PhylomeDBiQ16620.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR000372. LRRNT.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020455. Tyr_kin_neurotrophic_rcpt_2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01941. NTKRECEPTOR2.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform TrkB (identifier: Q16620-1) [UniParc]FASTAAdd to basket
Also known as: gp145-TrkB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP
60 70 80 90 100
GIVAFPRLEP NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD
110 120 130 140 150
SGLKFVAHKA FLKNSNLQHI NFTRNKLTSL SRKHFRHLDL SELILVGNPF
160 170 180 190 200
TCSCDIMWIK TLQEAKSSPD TQDLYCLNES SKNIPLANLQ IPNCGLPSAN
210 220 230 240 250
LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM NETSHTQGSL
260 270 280 290 300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
310 320 330 340 350
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN
360 370 380 390 400
PTHMNNGDYT LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY
410 420 430 440 450
GTAANDIGDT TNRSNEIPST DVTDKTGREH LSVYAVVVIA SVVGFCLLVM
460 470 480 490 500
LFLLKLARHS KFGMKGPASV ISNDDDSASP LHHISNGSNT PSSSEGGPDA
510 520 530 540 550
VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL KRELGEGAFG
560 570 580 590 600
KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI
610 620 630 640 650
VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ
660 670 680 690 700
SQMLHIAQQI AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD
710 720 730 740 750
VYSTDYYRVG GHTMLPIRWM PPESIMYRKF TTESDVWSLG VVLWEIFTYG
760 770 780 790 800
KQPWYQLSNN EVIECITQGR VLQRPRTCPQ EVYELMLGCW QREPHMRKNI
810 820
KGIHTLLQNL AKASPVYLDI LG
Length:822
Mass (Da):91,999
Last modified:November 1, 1996 - v1
Checksum:i2FEB9159948F0D13
GO
Isoform TrkB-T1 (identifier: Q16620-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-477: PASVISNDDDS → FVLFHKIPLDG
     478-822: Missing.

Note: Non-catalytic isoform.
Show »
Length:477
Mass (Da):53,051
Checksum:iC4A7F565BC88372F
GO
Isoform TrkB-T-Shc (identifier: Q16620-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-537: FVQHIKRHN → WPRGSPKTA
     538-822: Missing.

Show »
Length:537
Mass (Da):59,167
Checksum:i5A8FA252A3871CC1
GO
Isoform 4 (identifier: Q16620-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-465: K → KDFSWFGFGKVKSRQGV

Show »
Length:838
Mass (Da):93,826
Checksum:i130C95A9D8895432
GO
Isoform 5 (identifier: Q16620-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-465: K → KDFSWFGFGKVKSRQGV
     529-537: FVQHIKRHN → WPRGSPKTA
     538-822: Missing.

Show »
Length:553
Mass (Da):60,994
Checksum:iBD98221B9EE1A6C1
GO
Isoform TrkB-T-TK (identifier: Q16620-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-735: GGHTMLPIRWMPPESIMYRKFTTESD → SSCADQRPQGPLSLRDPCCICLLRLS
     736-822: Missing.

Show »
Length:735
Mass (Da):81,569
Checksum:i5E0746BCCA281069
GO
Isoform TrkB-N-T1 (identifier: Q16620-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     467-477: PASVISNDDDS → FVLFHKIPLDG
     478-822: Missing.

Show »
Length:321
Mass (Da):35,332
Checksum:i64C146AAB494744E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041470138L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_016320309G → R.1 Publication1
Natural variantiVAR_011973338N → Y.Corresponds to variant rs1047856dbSNPEnsembl.1
Natural variantiVAR_049715545G → V.Corresponds to variant rs1075108dbSNPEnsembl.1
Natural variantiVAR_046518697M → I in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046519699R → G in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_065890706Y → C in OBHD; expressed normally on the cell surface; results in markedly impaired ligand-induced phosphorylation as well as impaired downstream MAPK1 phosphorylation. 1 PublicationCorresponds to variant rs121434633dbSNPEnsembl.1
Natural variantiVAR_046520718R → C in a lung carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0421771 – 156Missing in isoform TrkB-N-T1. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_041942465K → KDFSWFGFGKVKSRQGV in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_002901467 – 477PASVISNDDDS → FVLFHKIPLDG in isoform TrkB-T1 and isoform TrkB-N-T1. 6 PublicationsAdd BLAST11
Alternative sequenceiVSP_002902478 – 822Missing in isoform TrkB-T1 and isoform TrkB-N-T1. 6 PublicationsAdd BLAST345
Alternative sequenceiVSP_002903529 – 537FVQHIKRHN → WPRGSPKTA in isoform TrkB-T-Shc and isoform 5. 1 Publication9
Alternative sequenceiVSP_002904538 – 822Missing in isoform TrkB-T-Shc and isoform 5. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_042178710 – 735GGHTM…TTESD → SSCADQRPQGPLSLRDPCCI CLLRLS in isoform TrkB-T-TK. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_042179736 – 822Missing in isoform TrkB-T-TK. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12140 mRNA. Translation: AAC51371.1.
S76473 mRNA. Translation: AAB33109.1.
S76474 mRNA. Translation: AAB33110.1.
X75958 mRNA. Translation: CAA53571.1.
AF410899 mRNA. Translation: AAL67965.1.
AF410900 mRNA. Translation: AAL67966.1.
AF410901 mRNA. Translation: AAL67967.1.
AF508964 mRNA. Translation: AAM77876.1.
AB209118 mRNA. Translation: BAD92355.1.
AK294285 mRNA. Translation: BAG57570.1.
AL445532, AL390777, AL596132 Genomic DNA. Translation: CAH71816.1.
AL390777, AL596132 Genomic DNA. Translation: CAH72193.1.
AL390777, AL596132 Genomic DNA. Translation: CAH72194.1.
AL390777, AL445532, AL596132 Genomic DNA. Translation: CAH72195.1.
AL596132, AL390777 Genomic DNA. Translation: CAH72313.1.
AL596132, AL390777 Genomic DNA. Translation: CAH72314.1.
AL596132, AL390777, AL445532 Genomic DNA. Translation: CAH72316.1.
CH471089 Genomic DNA. Translation: EAW62688.1.
BC031835 mRNA. Translation: AAH31835.1.
CCDSiCCDS35050.1. [Q16620-1]
CCDS35051.1. [Q16620-5]
CCDS35052.1. [Q16620-3]
CCDS35053.1. [Q16620-2]
CCDS6671.1. [Q16620-4]
PIRiA56853.
I73631.
RefSeqiNP_001007098.1. NM_001007097.2. [Q16620-2]
NP_001018074.1. NM_001018064.2. [Q16620-1]
NP_001018075.1. NM_001018065.2. [Q16620-5]
NP_001018076.1. NM_001018066.2. [Q16620-3]
NP_006171.2. NM_006180.4. [Q16620-4]
XP_005252058.1. XM_005252001.2. [Q16620-4]
XP_005252060.1. XM_005252003.2. [Q16620-4]
XP_005252061.1. XM_005252004.2. [Q16620-4]
XP_005252063.1. XM_005252006.3. [Q16620-5]
XP_005252064.1. XM_005252007.3. [Q16620-2]
XP_011517020.1. XM_011518718.2. [Q16620-1]
XP_011517022.1. XM_011518720.2. [Q16620-3]
XP_016870240.1. XM_017014751.1. [Q16620-4]
XP_016870241.1. XM_017014752.1. [Q16620-1]
XP_016870242.1. XM_017014753.1. [Q16620-1]
XP_016870243.1. XM_017014754.1. [Q16620-1]
XP_016870244.1. XM_017014755.1. [Q16620-5]
XP_016870245.1. XM_017014756.1. [Q16620-5]
XP_016870246.1. XM_017014757.1. [Q16620-3]
XP_016870247.1. XM_017014758.1. [Q16620-2]
XP_016870248.1. XM_017014759.1. [Q16620-2]
XP_016870249.1. XM_017014760.1. [Q16620-2]
XP_016870250.1. XM_017014761.1. [Q16620-2]
UniGeneiHs.494312.
Hs.712776.

Genome annotation databases

EnsembliENST00000277120; ENSP00000277120; ENSG00000148053. [Q16620-4]
ENST00000304053; ENSP00000306167; ENSG00000148053. [Q16620-5]
ENST00000323115; ENSP00000314586; ENSG00000148053. [Q16620-1]
ENST00000359847; ENSP00000352906; ENSG00000148053. [Q16620-2]
ENST00000376208; ENSP00000365381; ENSG00000148053. [Q16620-3]
ENST00000376213; ENSP00000365386; ENSG00000148053. [Q16620-1]
ENST00000376214; ENSP00000365387; ENSG00000148053. [Q16620-4]
ENST00000395882; ENSP00000379221; ENSG00000148053. [Q16620-2]
GeneIDi4915.
KEGGihsa:4915.
UCSCiuc004anz.1. human. [Q16620-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12140 mRNA. Translation: AAC51371.1.
S76473 mRNA. Translation: AAB33109.1.
S76474 mRNA. Translation: AAB33110.1.
X75958 mRNA. Translation: CAA53571.1.
AF410899 mRNA. Translation: AAL67965.1.
AF410900 mRNA. Translation: AAL67966.1.
AF410901 mRNA. Translation: AAL67967.1.
AF508964 mRNA. Translation: AAM77876.1.
AB209118 mRNA. Translation: BAD92355.1.
AK294285 mRNA. Translation: BAG57570.1.
AL445532, AL390777, AL596132 Genomic DNA. Translation: CAH71816.1.
AL390777, AL596132 Genomic DNA. Translation: CAH72193.1.
AL390777, AL596132 Genomic DNA. Translation: CAH72194.1.
AL390777, AL445532, AL596132 Genomic DNA. Translation: CAH72195.1.
AL596132, AL390777 Genomic DNA. Translation: CAH72313.1.
AL596132, AL390777 Genomic DNA. Translation: CAH72314.1.
AL596132, AL390777, AL445532 Genomic DNA. Translation: CAH72316.1.
CH471089 Genomic DNA. Translation: EAW62688.1.
BC031835 mRNA. Translation: AAH31835.1.
CCDSiCCDS35050.1. [Q16620-1]
CCDS35051.1. [Q16620-5]
CCDS35052.1. [Q16620-3]
CCDS35053.1. [Q16620-2]
CCDS6671.1. [Q16620-4]
PIRiA56853.
I73631.
RefSeqiNP_001007098.1. NM_001007097.2. [Q16620-2]
NP_001018074.1. NM_001018064.2. [Q16620-1]
NP_001018075.1. NM_001018065.2. [Q16620-5]
NP_001018076.1. NM_001018066.2. [Q16620-3]
NP_006171.2. NM_006180.4. [Q16620-4]
XP_005252058.1. XM_005252001.2. [Q16620-4]
XP_005252060.1. XM_005252003.2. [Q16620-4]
XP_005252061.1. XM_005252004.2. [Q16620-4]
XP_005252063.1. XM_005252006.3. [Q16620-5]
XP_005252064.1. XM_005252007.3. [Q16620-2]
XP_011517020.1. XM_011518718.2. [Q16620-1]
XP_011517022.1. XM_011518720.2. [Q16620-3]
XP_016870240.1. XM_017014751.1. [Q16620-4]
XP_016870241.1. XM_017014752.1. [Q16620-1]
XP_016870242.1. XM_017014753.1. [Q16620-1]
XP_016870243.1. XM_017014754.1. [Q16620-1]
XP_016870244.1. XM_017014755.1. [Q16620-5]
XP_016870245.1. XM_017014756.1. [Q16620-5]
XP_016870246.1. XM_017014757.1. [Q16620-3]
XP_016870247.1. XM_017014758.1. [Q16620-2]
XP_016870248.1. XM_017014759.1. [Q16620-2]
XP_016870249.1. XM_017014760.1. [Q16620-2]
XP_016870250.1. XM_017014761.1. [Q16620-2]
UniGeneiHs.494312.
Hs.712776.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HCFX-ray2.70X/Y286-383[»]
1WWBX-ray2.10X283-385[»]
2MFQNMR-B497-519[»]
4ASZX-ray1.70A527-822[»]
4AT3X-ray1.77A527-822[»]
4AT4X-ray2.36A527-822[»]
4AT5X-ray1.71A527-822[»]
ProteinModelPortaliQ16620.
SMRiQ16620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110970. 24 interactors.
DIPiDIP-5720N.
IntActiQ16620. 8 interactors.
MINTiMINT-156841.
STRINGi9606.ENSP00000277120.

Chemistry databases

BindingDBiQ16620.
ChEMBLiCHEMBL4898.
DrugBankiDB00321. Amitriptyline.
GuidetoPHARMACOLOGYi1818.

PTM databases

iPTMnetiQ16620.
PhosphoSitePlusiQ16620.

Polymorphism and mutation databases

BioMutaiNTRK2.
DMDMi2497560.

Proteomic databases

PaxDbiQ16620.
PeptideAtlasiQ16620.
PRIDEiQ16620.

Protocols and materials databases

DNASUi4915.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277120; ENSP00000277120; ENSG00000148053. [Q16620-4]
ENST00000304053; ENSP00000306167; ENSG00000148053. [Q16620-5]
ENST00000323115; ENSP00000314586; ENSG00000148053. [Q16620-1]
ENST00000359847; ENSP00000352906; ENSG00000148053. [Q16620-2]
ENST00000376208; ENSP00000365381; ENSG00000148053. [Q16620-3]
ENST00000376213; ENSP00000365386; ENSG00000148053. [Q16620-1]
ENST00000376214; ENSP00000365387; ENSG00000148053. [Q16620-4]
ENST00000395882; ENSP00000379221; ENSG00000148053. [Q16620-2]
GeneIDi4915.
KEGGihsa:4915.
UCSCiuc004anz.1. human. [Q16620-1]

Organism-specific databases

CTDi4915.
DisGeNETi4915.
GeneCardsiNTRK2.
HGNCiHGNC:8032. NTRK2.
HPAiCAB010346.
HPA007637.
MalaCardsiNTRK2.
MIMi600456. gene.
613886. phenotype.
neXtProtiNX_Q16620.
OpenTargetsiENSG00000148053.
Orphaneti251612. Pilocytic astrocytoma.
PharmGKBiPA31818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000264255.
HOVERGENiHBG056735.
InParanoidiQ16620.
KOiK04360.
OMAiCSCEIMW.
PhylomeDBiQ16620.
TreeFamiTF106465.

Enzyme and pathway databases

BioCyciZFISH:HS07487-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-187024. NGF-independant TRKA activation.
SignaLinkiQ16620.
SIGNORiQ16620.

Miscellaneous databases

ChiTaRSiNTRK2. human.
EvolutionaryTraceiQ16620.
GeneWikiiTrkB_receptor.
GenomeRNAii4915.
PROiQ16620.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148053.
CleanExiHS_NTRK2.
ExpressionAtlasiQ16620. baseline and differential.
GenevisibleiQ16620. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR000372. LRRNT.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020455. Tyr_kin_neurotrophic_rcpt_2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01941. NTKRECEPTOR2.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTRK2_HUMAN
AccessioniPrimary (citable) accession number: Q16620
Secondary accession number(s): B1ANZ4
, B4DFV9, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 192 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.