ID   CTF1_HUMAN              Reviewed;         201 AA.
AC   Q16619; A8MVX4; Q5U5Y7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 170.
DE   RecName: Full=Cardiotrophin-1;
DE            Short=CT-1;
GN   Name=CTF1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RC   TISSUE=Heart;
RX   PubMed=8833032; DOI=10.1006/cyto.1996.0026;
RA   Pennica D., Swanson T.A., Shaw K.J., Kuang W.-J., Gray C.L., Beatty B.G.,
RA   Wood W.I.;
RT   "Human cardiotrophin-1: protein and gene structure, biological and binding
RT   activities, and chromosomal localization.";
RL   Cytokine 8:183-189(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   VARIANT THR-92.
RX   PubMed=11058912;
RX   DOI=10.1002/1098-1004(200011)16:5<448::aid-humu19>3.0.co;2-d;
RA   Erdmann J., Hassfeld S., Kallisch H., Fleck E., Regitz-Zagrose V.;
RT   "Genetic variants in the promoter (g983G>T) and coding region (A92T) of the
RT   human cardiotrophin-1 gene (CTF1) in patients with dilated
RT   cardiomyopathy.";
RL   Hum. Mutat. 16:448-448(2000).
CC   -!- FUNCTION: Induces cardiac myocyte hypertrophy in vitro. Binds to and
CC       activates the ILST/gp130 receptor.
CC   -!- INTERACTION:
CC       Q16619; P43360: MAGEA6; NbExp=3; IntAct=EBI-10238077, EBI-1045155;
CC       Q16619-2; P43360: MAGEA6; NbExp=3; IntAct=EBI-12276476, EBI-1045155;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q16619-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q16619-2; Sequence=VSP_042725;
CC   -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle,
CC       prostate and ovary. Lower levels in lung, kidney, pancreas, thymus,
CC       testis and small intestine. Little or no expression in brain, placenta,
CC       liver, spleen, colon or peripheral blood leukocytes.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; U43033; AAD12173.1; -; Genomic_DNA.
DR   EMBL; U43031; AAD12173.1; JOINED; Genomic_DNA.
DR   EMBL; U43032; AAD12173.1; JOINED; Genomic_DNA.
DR   EMBL; U43030; AAA85229.1; -; mRNA.
DR   EMBL; AC135048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC036787; AAH36787.1; -; mRNA.
DR   EMBL; BC064416; AAH64416.1; -; mRNA.
DR   CCDS; CCDS10694.1; -. [Q16619-1]
DR   CCDS; CCDS45464.1; -. [Q16619-2]
DR   PIR; G02312; G02312.
DR   RefSeq; NP_001136016.1; NM_001142544.1. [Q16619-2]
DR   RefSeq; NP_001321.1; NM_001330.3. [Q16619-1]
DR   AlphaFoldDB; Q16619; -.
DR   SMR; Q16619; -.
DR   BioGRID; 107871; 11.
DR   DIP; DIP-394N; -.
DR   IntAct; Q16619; 2.
DR   STRING; 9606.ENSP00000279804; -.
DR   iPTMnet; Q16619; -.
DR   PhosphoSitePlus; Q16619; -.
DR   BioMuta; CTF1; -.
DR   DMDM; 2498265; -.
DR   MassIVE; Q16619; -.
DR   PaxDb; 9606-ENSP00000279804; -.
DR   PeptideAtlas; Q16619; -.
DR   ProteomicsDB; 60953; -. [Q16619-1]
DR   ProteomicsDB; 60954; -. [Q16619-2]
DR   Pumba; Q16619; -.
DR   Antibodypedia; 27491; 537 antibodies from 32 providers.
DR   DNASU; 1489; -.
DR   Ensembl; ENST00000279804.3; ENSP00000279804.2; ENSG00000150281.7. [Q16619-1]
DR   Ensembl; ENST00000395019.3; ENSP00000378465.3; ENSG00000150281.7. [Q16619-2]
DR   GeneID; 1489; -.
DR   KEGG; hsa:1489; -.
DR   MANE-Select; ENST00000279804.3; ENSP00000279804.2; NM_001330.5; NP_001321.1.
DR   UCSC; uc002dzw.3; human. [Q16619-1]
DR   AGR; HGNC:2499; -.
DR   CTD; 1489; -.
DR   DisGeNET; 1489; -.
DR   GeneCards; CTF1; -.
DR   HGNC; HGNC:2499; CTF1.
DR   HPA; ENSG00000150281; Low tissue specificity.
DR   MIM; 600435; gene.
DR   neXtProt; NX_Q16619; -.
DR   OpenTargets; ENSG00000150281; -.
DR   PharmGKB; PA27002; -.
DR   VEuPathDB; HostDB:ENSG00000150281; -.
DR   eggNOG; ENOG502S5Z6; Eukaryota.
DR   GeneTree; ENSGT00510000048856; -.
DR   HOGENOM; CLU_117233_0_0_1; -.
DR   InParanoid; Q16619; -.
DR   OMA; CGLYHEW; -.
DR   OrthoDB; 5320932at2759; -.
DR   PhylomeDB; Q16619; -.
DR   TreeFam; TF333266; -.
DR   PathwayCommons; Q16619; -.
DR   Reactome; R-HSA-6788467; IL-6-type cytokine receptor ligand interactions.
DR   SignaLink; Q16619; -.
DR   SIGNOR; Q16619; -.
DR   BioGRID-ORCS; 1489; 8 hits in 1152 CRISPR screens.
DR   ChiTaRS; CTF1; human.
DR   GenomeRNAi; 1489; -.
DR   Pharos; Q16619; Tbio.
DR   PRO; PR:Q16619; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q16619; Protein.
DR   Bgee; ENSG00000150281; Expressed in apex of heart and 102 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005146; F:leukemia inhibitory factor receptor binding; TAS:ProtInc.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0007517; P:muscle organ development; TAS:ProtInc.
DR   GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR   GO; GO:0030182; P:neuron differentiation; TAS:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:CACAO.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR010681; PRF/CT.
DR   PANTHER; PTHR21353; -; 1.
DR   PANTHER; PTHR21353:SF2; CARDIOTROPHIN-1; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   Genevisible; Q16619; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytokine; Reference proteome; Secreted.
FT   CHAIN           1..201
FT                   /note="Cardiotrophin-1"
FT                   /id="PRO_0000058762"
FT   VAR_SEQ         9
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_042725"
FT   VARIANT         92
FT                   /note="A -> T (in dbSNP:rs2234933)"
FT                   /evidence="ECO:0000269|PubMed:11058912"
FT                   /id="VAR_014938"
SQ   SEQUENCE   201 AA;  21227 MW;  0235A7B5745F675F CRC64;
     MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS
     FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR
     RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL
     YREWLSRTEG DLGQLLPGGS A
//