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Q16619

- CTF1_HUMAN

UniProt

Q16619 - CTF1_HUMAN

Protein

Cardiotrophin-1

Gene

CTF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

    GO - Molecular functioni

    1. leukemia inhibitory factor receptor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. leukemia inhibitory factor signaling pathway Source: Ensembl
    4. muscle organ development Source: ProtInc
    5. nervous system development Source: ProtInc
    6. neuron development Source: Ensembl
    7. positive regulation of cell proliferation Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    SignaLinkiQ16619.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cardiotrophin-1
    Short name:
    CT-1
    Gene namesi
    Name:CTF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:2499. CTF1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ProtInc
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27002.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Cardiotrophin-1PRO_0000058762Add
    BLAST

    Proteomic databases

    PaxDbiQ16619.
    PRIDEiQ16619.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

    Gene expression databases

    BgeeiQ16619.
    CleanExiHS_CTF1.
    GenevestigatoriQ16619.

    Organism-specific databases

    HPAiCAB025853.

    Interactioni

    Protein-protein interaction databases

    BioGridi107871. 2 interactions.
    DIPiDIP-394N.
    STRINGi9606.ENSP00000279804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16619.
    SMRiQ16619. Positions 27-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-6 superfamily.Curated

    Phylogenomic databases

    eggNOGiNOG44809.
    HOGENOMiHOG000112040.
    HOVERGENiHBG000455.
    InParanoidiQ16619.
    KOiK05422.
    OMAiRENMAKL.
    OrthoDBiEOG7VHSZW.
    PhylomeDBiQ16619.
    TreeFamiTF333266.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010681. PRF.
    [Graphical view]
    PANTHERiPTHR21353. PTHR21353. 1 hit.
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16619-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ    50
    LQGDPFGLPS FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL 100
    LDAVCRRQAE LNPRAPRLLR RLEDAARQAR ALGAAVEALL AALGAANRGP 150
    RAEPPAATAS AASATGVFPA KVLGLRVCGL YREWLSRTEG DLGQLLPGGS 200
    A 201
    Length:201
    Mass (Da):21,227
    Last modified:November 1, 1996 - v1
    Checksum:i0235A7B5745F675F
    GO
    Isoform 2 (identifier: Q16619-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         9-9: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:200
    Mass (Da):21,098
    Checksum:i8AF8E579EB779E1F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921A → T.
    Corresponds to variant rs2234933 [ dbSNP | Ensembl ].
    VAR_014938

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei9 – 91Missing in isoform 2. 1 PublicationVSP_042725

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43033, U43031, U43032 Genomic DNA. Translation: AAD12173.1.
    U43030 mRNA. Translation: AAA85229.1.
    AC135048 Genomic DNA. No translation available.
    BC036787 mRNA. Translation: AAH36787.1.
    BC064416 mRNA. Translation: AAH64416.1.
    CCDSiCCDS10694.1. [Q16619-1]
    CCDS45464.1. [Q16619-2]
    PIRiG02312.
    RefSeqiNP_001136016.1. NM_001142544.1. [Q16619-2]
    NP_001321.1. NM_001330.3. [Q16619-1]
    UniGeneiHs.483811.

    Genome annotation databases

    EnsembliENST00000279804; ENSP00000279804; ENSG00000150281. [Q16619-1]
    ENST00000395019; ENSP00000378465; ENSG00000150281. [Q16619-2]
    GeneIDi1489.
    KEGGihsa:1489.
    UCSCiuc002dzw.3. human. [Q16619-1]
    uc002dzx.3. human. [Q16619-2]

    Polymorphism databases

    DMDMi2498265.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43033 , U43031 , U43032 Genomic DNA. Translation: AAD12173.1 .
    U43030 mRNA. Translation: AAA85229.1 .
    AC135048 Genomic DNA. No translation available.
    BC036787 mRNA. Translation: AAH36787.1 .
    BC064416 mRNA. Translation: AAH64416.1 .
    CCDSi CCDS10694.1. [Q16619-1 ]
    CCDS45464.1. [Q16619-2 ]
    PIRi G02312.
    RefSeqi NP_001136016.1. NM_001142544.1. [Q16619-2 ]
    NP_001321.1. NM_001330.3. [Q16619-1 ]
    UniGenei Hs.483811.

    3D structure databases

    ProteinModelPortali Q16619.
    SMRi Q16619. Positions 27-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107871. 2 interactions.
    DIPi DIP-394N.
    STRINGi 9606.ENSP00000279804.

    Polymorphism databases

    DMDMi 2498265.

    Proteomic databases

    PaxDbi Q16619.
    PRIDEi Q16619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279804 ; ENSP00000279804 ; ENSG00000150281 . [Q16619-1 ]
    ENST00000395019 ; ENSP00000378465 ; ENSG00000150281 . [Q16619-2 ]
    GeneIDi 1489.
    KEGGi hsa:1489.
    UCSCi uc002dzw.3. human. [Q16619-1 ]
    uc002dzx.3. human. [Q16619-2 ]

    Organism-specific databases

    CTDi 1489.
    GeneCardsi GC16P030910.
    HGNCi HGNC:2499. CTF1.
    HPAi CAB025853.
    MIMi 600435. gene.
    neXtProti NX_Q16619.
    PharmGKBi PA27002.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44809.
    HOGENOMi HOG000112040.
    HOVERGENi HBG000455.
    InParanoidi Q16619.
    KOi K05422.
    OMAi RENMAKL.
    OrthoDBi EOG7VHSZW.
    PhylomeDBi Q16619.
    TreeFami TF333266.

    Enzyme and pathway databases

    SignaLinki Q16619.

    Miscellaneous databases

    GenomeRNAii 1489.
    NextBioi 6119.
    PROi Q16619.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16619.
    CleanExi HS_CTF1.
    Genevestigatori Q16619.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010681. PRF.
    [Graphical view ]
    PANTHERi PTHR21353. PTHR21353. 1 hit.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization."
      Pennica D., Swanson T.A., Shaw K.J., Kuang W.-J., Gray C.L., Beatty B.G., Wood W.I.
      Cytokine 8:183-189(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
      Tissue: Heart.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Lung.

    Entry informationi

    Entry nameiCTF1_HUMAN
    AccessioniPrimary (citable) accession number: Q16619
    Secondary accession number(s): A8MVX4, Q5U5Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3