Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cardiotrophin-1

Gene

CTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

GO - Molecular functioni

  • leukemia inhibitory factor receptor binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • leukemia inhibitory factor signaling pathway Source: Ensembl
  • muscle organ development Source: ProtInc
  • nervous system development Source: ProtInc
  • neuron development Source: Ensembl
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiQ16619.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotrophin-1
Short name:
CT-1
Gene namesi
Name:CTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2499. CTF1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: ProtInc
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27002.

Polymorphism and mutation databases

BioMutaiCTF1.
DMDMi2498265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Cardiotrophin-1PRO_0000058762Add
BLAST

Proteomic databases

PaxDbiQ16619.
PRIDEiQ16619.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Gene expression databases

BgeeiQ16619.
CleanExiHS_CTF1.
GenevestigatoriQ16619.

Organism-specific databases

HPAiCAB025853.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA6P433603EBI-10238077,EBI-1045155

Protein-protein interaction databases

BioGridi107871. 3 interactions.
DIPiDIP-394N.
IntActiQ16619. 1 interaction.
STRINGi9606.ENSP00000279804.

Structurei

3D structure databases

ProteinModelPortaliQ16619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Phylogenomic databases

eggNOGiNOG44809.
GeneTreeiENSGT00510000049046.
HOGENOMiHOG000112040.
HOVERGENiHBG000455.
InParanoidiQ16619.
KOiK05422.
OMAiLYREWVS.
OrthoDBiEOG7VHSZW.
PhylomeDBiQ16619.
TreeFamiTF333266.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16619-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ
60 70 80 90 100
LQGDPFGLPS FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL
110 120 130 140 150
LDAVCRRQAE LNPRAPRLLR RLEDAARQAR ALGAAVEALL AALGAANRGP
160 170 180 190 200
RAEPPAATAS AASATGVFPA KVLGLRVCGL YREWLSRTEG DLGQLLPGGS

A
Length:201
Mass (Da):21,227
Last modified:November 1, 1996 - v1
Checksum:i0235A7B5745F675F
GO
Isoform 2 (identifier: Q16619-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: Missing.

Note: No experimental confirmation available.

Show »
Length:200
Mass (Da):21,098
Checksum:i8AF8E579EB779E1F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921A → T.
Corresponds to variant rs2234933 [ dbSNP | Ensembl ].
VAR_014938

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei9 – 91Missing in isoform 2. 1 PublicationVSP_042725

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43033, U43031, U43032 Genomic DNA. Translation: AAD12173.1.
U43030 mRNA. Translation: AAA85229.1.
AC135048 Genomic DNA. No translation available.
BC036787 mRNA. Translation: AAH36787.1.
BC064416 mRNA. Translation: AAH64416.1.
CCDSiCCDS10694.1. [Q16619-1]
CCDS45464.1. [Q16619-2]
PIRiG02312.
RefSeqiNP_001136016.1. NM_001142544.1. [Q16619-2]
NP_001321.1. NM_001330.3. [Q16619-1]
UniGeneiHs.483811.

Genome annotation databases

EnsembliENST00000279804; ENSP00000279804; ENSG00000150281. [Q16619-1]
ENST00000395019; ENSP00000378465; ENSG00000150281. [Q16619-2]
GeneIDi1489.
KEGGihsa:1489.
UCSCiuc002dzw.3. human. [Q16619-1]
uc002dzx.3. human. [Q16619-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43033, U43031, U43032 Genomic DNA. Translation: AAD12173.1.
U43030 mRNA. Translation: AAA85229.1.
AC135048 Genomic DNA. No translation available.
BC036787 mRNA. Translation: AAH36787.1.
BC064416 mRNA. Translation: AAH64416.1.
CCDSiCCDS10694.1. [Q16619-1]
CCDS45464.1. [Q16619-2]
PIRiG02312.
RefSeqiNP_001136016.1. NM_001142544.1. [Q16619-2]
NP_001321.1. NM_001330.3. [Q16619-1]
UniGeneiHs.483811.

3D structure databases

ProteinModelPortaliQ16619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107871. 3 interactions.
DIPiDIP-394N.
IntActiQ16619. 1 interaction.
STRINGi9606.ENSP00000279804.

Polymorphism and mutation databases

BioMutaiCTF1.
DMDMi2498265.

Proteomic databases

PaxDbiQ16619.
PRIDEiQ16619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279804; ENSP00000279804; ENSG00000150281. [Q16619-1]
ENST00000395019; ENSP00000378465; ENSG00000150281. [Q16619-2]
GeneIDi1489.
KEGGihsa:1489.
UCSCiuc002dzw.3. human. [Q16619-1]
uc002dzx.3. human. [Q16619-2]

Organism-specific databases

CTDi1489.
GeneCardsiGC16P030910.
HGNCiHGNC:2499. CTF1.
HPAiCAB025853.
MIMi600435. gene.
neXtProtiNX_Q16619.
PharmGKBiPA27002.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44809.
GeneTreeiENSGT00510000049046.
HOGENOMiHOG000112040.
HOVERGENiHBG000455.
InParanoidiQ16619.
KOiK05422.
OMAiLYREWVS.
OrthoDBiEOG7VHSZW.
PhylomeDBiQ16619.
TreeFamiTF333266.

Enzyme and pathway databases

SignaLinkiQ16619.

Miscellaneous databases

GenomeRNAii1489.
NextBioi6119.
PROiQ16619.
SOURCEiSearch...

Gene expression databases

BgeeiQ16619.
CleanExiHS_CTF1.
GenevestigatoriQ16619.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization."
    Pennica D., Swanson T.A., Shaw K.J., Kuang W.-J., Gray C.L., Beatty B.G., Wood W.I.
    Cytokine 8:183-189(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Lung.

Entry informationi

Entry nameiCTF1_HUMAN
AccessioniPrimary (citable) accession number: Q16619
Secondary accession number(s): A8MVX4, Q5U5Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.