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Q16619 (CTF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cardiotrophin-1

Short name=CT-1
Gene names
Name:CTF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Subcellular location

Secreted.

Tissue specificity

Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Sequence similarities

Belongs to the IL-6 superfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q16619-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q16619-2)

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Cardiotrophin-1
PRO_0000058762

Natural variations

Alternative sequence91Missing in isoform 2.
VSP_042725
Natural variant921A → T.
Corresponds to variant rs2234933 [ dbSNP | Ensembl ].
VAR_014938

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0235A7B5745F675F

FASTA20121,227
        10         20         30         40         50         60 
MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS 

        70         80         90        100        110        120 
FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR 

       130        140        150        160        170        180 
RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL 

       190        200 
YREWLSRTEG DLGQLLPGGS A 

« Hide

Isoform 2 [UniParc].

Checksum: 8AF8E579EB779E1F
Show »

FASTA20021,098

References

« Hide 'large scale' references
[1]"Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization."
Pennica D., Swanson T.A., Shaw K.J., Kuang W.-J., Gray C.L., Beatty B.G., Wood W.I.
Cytokine 8:183-189(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
Tissue: Heart.
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43033, U43031, U43032 Genomic DNA. Translation: AAD12173.1.
U43030 mRNA. Translation: AAA85229.1.
AC135048 Genomic DNA. No translation available.
BC036787 mRNA. Translation: AAH36787.1.
BC064416 mRNA. Translation: AAH64416.1.
CCDSCCDS10694.1. [Q16619-1]
CCDS45464.1. [Q16619-2]
PIRG02312.
RefSeqNP_001136016.1. NM_001142544.1. [Q16619-2]
NP_001321.1. NM_001330.3. [Q16619-1]
UniGeneHs.483811.

3D structure databases

ProteinModelPortalQ16619.
SMRQ16619. Positions 27-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107871. 2 interactions.
DIPDIP-394N.
STRING9606.ENSP00000279804.

Polymorphism databases

DMDM2498265.

Proteomic databases

PaxDbQ16619.
PRIDEQ16619.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000279804; ENSP00000279804; ENSG00000150281. [Q16619-1]
ENST00000395019; ENSP00000378465; ENSG00000150281. [Q16619-2]
GeneID1489.
KEGGhsa:1489.
UCSCuc002dzw.3. human. [Q16619-1]
uc002dzx.3. human. [Q16619-2]

Organism-specific databases

CTD1489.
GeneCardsGC16P030910.
HGNCHGNC:2499. CTF1.
HPACAB025853.
MIM600435. gene.
neXtProtNX_Q16619.
PharmGKBPA27002.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44809.
HOGENOMHOG000112040.
HOVERGENHBG000455.
InParanoidQ16619.
KOK05422.
OMARENMAKL.
OrthoDBEOG7VHSZW.
PhylomeDBQ16619.
TreeFamTF333266.

Enzyme and pathway databases

SignaLinkQ16619.

Gene expression databases

BgeeQ16619.
CleanExHS_CTF1.
GenevestigatorQ16619.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERPTHR21353. PTHR21353. 1 hit.
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi1489.
NextBio6119.
PROQ16619.
SOURCESearch...

Entry information

Entry nameCTF1_HUMAN
AccessionPrimary (citable) accession number: Q16619
Secondary accession number(s): A8MVX4, Q5U5Y7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM