Q16619 (CTF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cardiotrophin-1
Short name=CT-1

Gene names

Name:

CTF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Subcellular location	Secreted.
Tissue specificity	Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.
Sequence similarities	Belongs to the IL-6 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Cytokine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement PubMed 7738033. Source: ProtInc cell-cell signaling Traceable author statement PubMed 7862649. Source: ProtInc leukemia inhibitory factor signaling pathway Inferred from electronic annotation. Source: Compara muscle organ development Traceable author statement PubMed 7862649Ref.1. Source: ProtInc nervous system development Traceable author statement PubMed 7738033. Source: ProtInc neuron development Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Traceable author statement PubMed 7862649. Source: ProtInc
Cellular_component	extracellular region Traceable author statement PubMed 7862649. Source: ProtInc extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	leukemia inhibitory factor receptor binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q16619-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q16619-2)

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Cardiotrophin-1		PRO_0000058762
Natural variations
	Alternative sequence	9	1	Missing in isoform 2.		VSP_042725
	Natural variant	92	1	A → T. Corresponds to variant rs2234933 [ dbSNP | Ensembl ].		VAR_014938

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0235A7B5745F675F	FASTA	201	21,227
	10 20 30 40 50 60 MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS 70 80 90 100 110 120 FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR 130 140 150 160 170 180 RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL 190 200 YREWLSRTEG DLGQLLPGGS A
	Isoform 2 [UniParc]. Checksum: 8AF8E579EB779E1F	FASTA	200	21,098
	10 20 30 40 50 60 MSRREGSLDP QTDSSVSLLP HLEAKIRQTH SLAHLLTKYA EQLLQEYVQL QGDPFGLPSF 70 80 90 100 110 120 SPPRLPVAGL SAPAPSHAGL PVHERLRLDA AALAALPPLL DAVCRRQAEL NPRAPRLLRR 130 140 150 160 170 180 LEDAARQARA LGAAVEALLA ALGAANRGPR AEPPAATASA ASATGVFPAK VLGLRVCGLY 190 200 REWLSRTEGD LGQLLPGGSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization." Pennica D., Swanson T.A., Shaw K.J., Kuang W.-J., Gray C.L., Beatty B.G., Wood W.I. Cytokine 8:183-189(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). Tissue: Heart.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43033, U43031, U43032 Genomic DNA. Translation: AAD12173.1. U43030 mRNA. Translation: AAA85229.1. AC135048 Genomic DNA. No translation available. BC036787 mRNA. Translation: AAH36787.1. BC064416 mRNA. Translation: AAH64416.1.
IPI	IPI00003357. IPI00645899.
PIR	G02312.
RefSeq	NP_001136016.1. NM_001142544.1. NP_001321.1. NM_001330.3.
UniGene	Hs.483811.
3D structure databases
ProteinModelPortal	Q16619.
SMR	Q16619. Positions 27-192.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-394N.
STRING	9606.ENSP00000279804.
Polymorphism databases
DMDM	2498265.
Proteomic databases
PaxDb	Q16619.
PRIDE	Q16619.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000279804; ENSP00000279804; ENSG00000150281. ENST00000395019; ENSP00000378465; ENSG00000150281.
GeneID	1489.
KEGG	hsa:1489.
UCSC	uc002dzw.3. human.
Organism-specific databases
CTD	1489.
GeneCards	GC16P030910.
HGNC	HGNC:2499. CTF1.
HPA	CAB025853.
MIM	600435. gene.
neXtProt	NX_Q16619.
PharmGKB	PA27002.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44809.
HOGENOM	HOG000112040.
HOVERGEN	HBG000455.
InParanoid	Q16619.
KO	K05422.
OMA	REWVSRT.
OrthoDB	EOG4QC16M.
PhylomeDB	Q16619.
Gene expression databases
Bgee	Q16619.
CleanEx	HS_CTF1.
Genevestigator	Q16619.
GermOnline	ENSG00000150281. Homo sapiens.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR010681. PRF. [Graphical view]
PANTHER	PTHR21353. PTHR21353. 1 hit.
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	1489.
NextBio	6119.
SOURCE	Search...

Entry information

Entry name

CTF1_HUMAN

Accession

Primary (citable) accession number: Q16619
Secondary accession number(s): A8MVX4, Q5U5Y7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.