ID NKG7_HUMAN Reviewed; 165 AA. AC Q16617; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 24-JAN-2024, entry version 158. DE RecName: Full=Protein NKG7; DE AltName: Full=G-CSF-induced gene 1 protein; DE Short=GIG-1 protein; DE AltName: Full=Granule membrane protein of 17 kDa; DE Short=GMP-17; DE AltName: Full=Natural killer cell protein 7; DE AltName: Full=p15-TIA-1; GN Name=NKG7; Synonyms=GIG1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8458737; DOI=10.1016/0198-8859(93)90006-m; RA Turman M.A., Yabe T., McSherry C., Bach F.H., Houchins J.P.; RT "Characterization of a novel gene (NKG7) on human chromosome 19 that is RT expressed in natural killer cells and T cells."; RL Hum. Immunol. 36:34-40(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION. RX PubMed=7510105; DOI=10.1006/bbrc.1994.1187; RA Shimane M., Tani K., Maruyama K., Takahashi S., Ozawa K., Asano S.; RT "Molecular cloning and characterization of G-CSF induced gene cDNA."; RL Biochem. Biophys. Res. Commun. 199:26-32(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Church R.L., Li X.L., Wang J.H.; RT "Human chromosome 19q13.4 DNA sequence, including complete sequence for RT LIM2 and NKG7."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Blood; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PROTEIN SEQUENCE OF 1-25, AND SUBCELLULAR LOCATION. RX PubMed=8570616; DOI=10.1073/pnas.93.2.685; RA Medley Q.G., Kedersha N., O'Brien S., Tian Q., Schlossman S.F., Streuli M., RA Anderson P.; RT "Characterization of GMP-17, a granule membrane protein that moves to the RT plasma membrane of natural killer cells following target cell RT recognition."; RL Proc. Natl. Acad. Sci. U.S.A. 93:685-689(1996). RN [6] RP INDUCTION. RX PubMed=32839608; DOI=10.1038/s41590-020-0758-6; RA Ng S.S., De Labastida Rivera F., Yan J., Corvino D., Das I., Zhang P., RA Kuns R., Chauhan S.B., Hou J., Li X.Y., Frame T.C.M., McEnroe B.A., RA Moore E., Na J., Engel J.A., Soon M.S.F., Singh B., Kueh A.J., Herold M.J., RA Montes de Oca M., Singh S.S., Bunn P.T., Aguilera A.R., Casey M., Braun M., RA Ghazanfari N., Wani S., Wang Y., Amante F.H., Edwards C.L., Haque A., RA Dougall W.C., Singh O.P., Baxter A.G., Teng M.W.L., Loukas A., Daly N.L., RA Cloonan N., Degli-Esposti M.A., Uzonna J., Heath W.R., Bald T., Tey S.K., RA Nakamura K., Hill G.R., Kumar R., Sundar S., Smyth M.J., Engwerda C.R.; RT "The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis RT and inflammation."; RL Nat. Immunol. 21:1205-1218(2020). CC -!- FUNCTION: Regulates cytotoxic granule exocytosis in effector CC lymphocytes, thus acting as a critical mediator of inflammation in a CC broad range of infectious and non-infectious diseases (By similarity). CC Essential for cytotoxic degranulation of natural killer (NK) cells and CC CD8(+) T-cells and for the activation of CD4(+) T-cells following CC infection (By similarity). Plays a critical role in CD8(+) T-cell and CC NK cell-mediated cytolysis of target cells and contributes to the CC cytolytic activity via the perforin/granzyme pathway by enhancing CC exocytosis of LAMP1-carrying lytic granules (By similarity). CC Contributes to NK cell-mediated control of cancer metastasis (By CC similarity). {ECO:0000250|UniProtKB:Q99PA5}. CC -!- INTERACTION: CC Q16617; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-3919611, EBI-741181; CC Q16617; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-3919611, EBI-11522760; CC Q16617; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-3919611, EBI-19125216; CC Q16617; Q13520: AQP6; NbExp=3; IntAct=EBI-3919611, EBI-13059134; CC Q16617; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-3919611, EBI-11343438; CC Q16617; O75787: ATP6AP2; NbExp=3; IntAct=EBI-3919611, EBI-2512037; CC Q16617; Q13145: BAMBI; NbExp=3; IntAct=EBI-3919611, EBI-742991; CC Q16617; P19397: CD53; NbExp=3; IntAct=EBI-3919611, EBI-6657396; CC Q16617; P11912: CD79A; NbExp=3; IntAct=EBI-3919611, EBI-7797864; CC Q16617; O95471: CLDN7; NbExp=3; IntAct=EBI-3919611, EBI-740744; CC Q16617; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-3919611, EBI-11749983; CC Q16617; Q9ULY5: CLEC4E; NbExp=4; IntAct=EBI-3919611, EBI-12807010; CC Q16617; Q9BQT9: CLSTN3; NbExp=3; IntAct=EBI-3919611, EBI-11291074; CC Q16617; Q15125: EBP; NbExp=3; IntAct=EBI-3919611, EBI-3915253; CC Q16617; Q9HAV5: EDA2R; NbExp=3; IntAct=EBI-3919611, EBI-526033; CC Q16617; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-3919611, EBI-781551; CC Q16617; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-3919611, EBI-18938272; CC Q16617; O15552: FFAR2; NbExp=3; IntAct=EBI-3919611, EBI-2833872; CC Q16617; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-3919611, EBI-12142257; CC Q16617; P36382: GJA5; NbExp=3; IntAct=EBI-3919611, EBI-750433; CC Q16617; Q8TED1: GPX8; NbExp=3; IntAct=EBI-3919611, EBI-11721746; CC Q16617; Q6UXK2: ISLR2; NbExp=3; IntAct=EBI-3919611, EBI-1266923; CC Q16617; P26715: KLRC1; NbExp=3; IntAct=EBI-3919611, EBI-9018187; CC Q16617; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-3919611, EBI-2820517; CC Q16617; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-3919611, EBI-2858252; CC Q16617; O14880: MGST3; NbExp=3; IntAct=EBI-3919611, EBI-724754; CC Q16617; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-3919611, EBI-12806656; CC Q16617; P21757: MSR1; NbExp=7; IntAct=EBI-3919611, EBI-1776976; CC Q16617; P15941-11: MUC1; NbExp=3; IntAct=EBI-3919611, EBI-17263240; CC Q16617; P41145: OPRK1; NbExp=3; IntAct=EBI-3919611, EBI-925028; CC Q16617; O00623: PEX12; NbExp=3; IntAct=EBI-3919611, EBI-594836; CC Q16617; O60894: RAMP1; NbExp=3; IntAct=EBI-3919611, EBI-962893; CC Q16617; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-3919611, EBI-13044680; CC Q16617; Q05940: SLC18A2; NbExp=3; IntAct=EBI-3919611, EBI-18036244; CC Q16617; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-3919611, EBI-10262251; CC Q16617; P27105: STOM; NbExp=5; IntAct=EBI-3919611, EBI-1211440; CC Q16617; Q16623: STX1A; NbExp=4; IntAct=EBI-3919611, EBI-712466; CC Q16617; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-3919611, EBI-12947623; CC Q16617; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-3919611, EBI-2821497; CC Q16617; Q8N3G9: TMEM130; NbExp=3; IntAct=EBI-3919611, EBI-19763514; CC Q16617; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-3919611, EBI-7238458; CC Q16617; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-3919611, EBI-11742770; CC Q16617; Q6PEY1: TMEM88; NbExp=3; IntAct=EBI-3919611, EBI-17198826; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8570616}; CC Multi-pass membrane protein {ECO:0000269|PubMed:8570616}. Cytolytic CC granule membrane {ECO:0000269|PubMed:8570616}; Multi-pass membrane CC protein {ECO:0000269|PubMed:8570616}. CC -!- TISSUE SPECIFICITY: Expressed in activated T-cells, in kidney, liver, CC lung and pancreas. Not expressed in brain, heart, or skeletal muscle. CC Expressed at high levels in TCR gamma delta-expressing CTL clones, and CC in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but CC is not expressed in other TCR alpha beta-expressing CTL clones and in CC cell lines representing B-cells, monocytes, and myeloid cells. CC -!- INDUCTION: By CSF3/G-CSF (PubMed:7510105). Up-regulated in CD4(+) T- CC cells from peripheral blood mononuclear cells of patients with visceral CC leishmaniasis (PubMed:32839608). {ECO:0000269|PubMed:32839608, CC ECO:0000269|PubMed:7510105}. CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U09608; AAA18209.1; -; mRNA. DR EMBL; S69115; AAB30078.1; -; mRNA. DR EMBL; AF305941; AAG32329.1; -; Genomic_DNA. DR EMBL; BC015759; AAH15759.1; -; mRNA. DR CCDS; CCDS12830.1; -. DR PIR; JC2081; JC2081. DR RefSeq; NP_005592.1; NM_005601.3. DR AlphaFoldDB; Q16617; -. DR SMR; Q16617; -. DR BioGRID; 110883; 46. DR IntAct; Q16617; 45. DR STRING; 9606.ENSP00000221978; -. DR PhosphoSitePlus; Q16617; -. DR BioMuta; NKG7; -. DR DMDM; 3914144; -. DR MassIVE; Q16617; -. DR PaxDb; 9606-ENSP00000221978; -. DR PeptideAtlas; Q16617; -. DR Antibodypedia; 76657; 35 antibodies from 11 providers. DR DNASU; 4818; -. DR Ensembl; ENST00000221978.10; ENSP00000221978.4; ENSG00000105374.10. DR GeneID; 4818; -. DR KEGG; hsa:4818; -. DR MANE-Select; ENST00000221978.10; ENSP00000221978.4; NM_005601.4; NP_005592.1. DR UCSC; uc002pwj.4; human. DR AGR; HGNC:7830; -. DR CTD; 4818; -. DR DisGeNET; 4818; -. DR GeneCards; NKG7; -. DR HGNC; HGNC:7830; NKG7. DR HPA; ENSG00000105374; Group enriched (bone marrow, lymphoid tissue). DR MIM; 606008; gene. DR neXtProt; NX_Q16617; -. DR OpenTargets; ENSG00000105374; -. DR PharmGKB; PA31639; -. DR VEuPathDB; HostDB:ENSG00000105374; -. DR eggNOG; ENOG502SUH4; Eukaryota. DR GeneTree; ENSGT01050000244814; -. DR HOGENOM; CLU_133330_0_0_1; -. DR InParanoid; Q16617; -. DR OMA; YIHVTQT; -. DR OrthoDB; 5323165at2759; -. DR PhylomeDB; Q16617; -. DR TreeFam; TF330587; -. DR PathwayCommons; Q16617; -. DR SignaLink; Q16617; -. DR BioGRID-ORCS; 4818; 6 hits in 1145 CRISPR screens. DR GenomeRNAi; 4818; -. DR Pharos; Q16617; Tdark. DR PRO; PR:Q16617; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q16617; Protein. DR Bgee; ENSG00000105374; Expressed in granulocyte and 103 other cell types or tissues. DR ExpressionAtlas; Q16617; baseline and differential. DR GO; GO:0044194; C:cytolytic granule; ISS:UniProtKB. DR GO; GO:0101004; C:cytolytic granule membrane; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0035710; P:CD4-positive, alpha-beta T cell activation; ISS:UniProtKB. DR GO; GO:0042832; P:defense response to protozoan; IDA:UniProtKB. DR GO; GO:0140507; P:granzyme-mediated programmed cell death signaling pathway; ISS:UniProtKB. DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW. DR GO; GO:0043320; P:natural killer cell degranulation; ISS:UniProtKB. DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; ISS:UniProtKB. DR GO; GO:0002420; P:natural killer cell mediated cytotoxicity directed against tumor cell target; ISS:UniProtKB. DR GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB. DR Gene3D; 1.20.140.150; -; 1. DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin. DR InterPro; IPR004032; PMP22_EMP_MP20. DR PANTHER; PTHR10671; EPITHELIAL MEMBRANE PROTEIN-RELATED; 1. DR PANTHER; PTHR10671:SF34; PROTEIN NKG7; 1. DR Pfam; PF00822; PMP22_Claudin; 1. DR PROSITE; PS01221; PMP22_1; 1. DR Genevisible; Q16617; HS. PE 1: Evidence at protein level; KW Cell membrane; Cytolysis; Direct protein sequencing; Inflammatory response; KW Lysosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..165 FT /note="Protein NKG7" FT /id="PRO_0000164667" FT TRANSMEM 9..29 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 61..81 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 92..112 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 133..153 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 165 AA; 17665 MW; CEE2901B6DC42A8C CRC64; MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI ISGYIHVTQT FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA AAISMVVAMA VYTSERWDQP PHPQIQTFFS WSFYLGWVSA ILLLCTGALS LGAHCGGPRP GYETL //