Q16617 (NKG7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NKG7

Alternative name(s):
G-CSF-induced gene 1 protein
Short name=GIG-1 protein
Granule membrane protein of 17 kDa
Short name=GMP-17
Natural killer cell protein 7
p15-TIA-1

Gene names

Name:	NKG7
Synonyms:	GIG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note: Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils. Ref.5
Tissue specificity	Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.
Induction	By CSF3/G-CSF.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Protein NKG7		PRO_0000164667
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	133 – 153	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q16617 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CEE2901B6DC42A8C	FASTA	165	17,665
	10 20 30 40 50 60 MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI ISGYIHVTQT 70 80 90 100 110 120 FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA AAISMVVAMA VYTSERWDQP 130 140 150 160 PHPQIQTFFS WSFYLGWVSA ILLLCTGALS LGAHCGGPRP GYETL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells." Turman M.A., Yabe T., McSherry C., Bach F.H., Houchins J.P. Hum. Immunol. 36:34-40(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and characterization of G-CSF induced gene cDNA." Shimane M., Tani K., Maruyama K., Takahashi S., Ozawa K., Asano S. Biochem. Biophys. Res. Commun. 199:26-32(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Human chromosome 19q13.4 DNA sequence, including complete sequence for LIM2 and NKG7." Church R.L., Li X.L., Wang J.H. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[5]	"Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition." Medley Q.G., Kedersha N., O'Brien S., Tian Q., Schlossman S.F., Streuli M., Anderson P. Proc. Natl. Acad. Sci. U.S.A. 93:685-689(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-25, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09608 mRNA. Translation: AAA18209.1. S69115 mRNA. Translation: AAB30078.1. AF305941 Genomic DNA. Translation: AAG32329.1. BC015759 mRNA. Translation: AAH15759.1.
IPI	IPI00003355.
PIR	JC2081.
RefSeq	NP_005592.1. NM_005601.3.
UniGene	Hs.10306.
3D structure databases
ProteinModelPortal	Q16617.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16617. 1 interaction.
STRING	9606.ENSP00000221978.
Polymorphism databases
DMDM	3914144.
Proteomic databases
PRIDE	Q16617.
Protocols and materials databases
DNASU	4818.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221978; ENSP00000221978; ENSG00000105374.
GeneID	4818.
KEGG	hsa:4818.
UCSC	uc002pwj.3. human.
Organism-specific databases
CTD	4818.
GeneCards	GC19M051874.
HGNC	HGNC:7830. NKG7.
MIM	606008. gene.
neXtProt	NX_Q16617.
PharmGKB	PA31639.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45115.
HOGENOM	HOG000113791.
HOVERGEN	HBG000485.
InParanoid	Q16617.
OMA	IQTFFSW.
OrthoDB	EOG498V27.
PhylomeDB	Q16617.
Gene expression databases
Bgee	Q16617.
CleanEx	HS_NKG7.
Genevestigator	Q16617.
GermOnline	ENSG00000105374. Homo sapiens.
Family and domain databases
InterPro	IPR004031. PMP22/EMP/MP20/Claudin. IPR004032. PMP22_EMP_MP20. [Graphical view]
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PROSITE	PS01221. PMP22_1. 1 hit. PS01222. PMP22_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4818.
NextBio	18566.
SOURCE	Search...

Entry information

Entry name

NKG7_HUMAN

Accession

Primary (citable) accession number: Q16617

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.