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Q16617

- NKG7_HUMAN

UniProt

Q16617 - NKG7_HUMAN

Protein

Protein NKG7

Gene

NKG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NKG7
    Alternative name(s):
    G-CSF-induced gene 1 protein
    Short name:
    GIG-1 protein
    Granule membrane protein of 17 kDa
    Short name:
    GMP-17
    Natural killer cell protein 7
    p15-TIA-1
    Gene namesi
    Name:NKG7
    Synonyms:GIG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:7830. NKG7.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic granule membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31639.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165Protein NKG7PRO_0000164667Add
    BLAST

    Proteomic databases

    PRIDEiQ16617.

    Expressioni

    Tissue specificityi

    Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

    Inductioni

    By CSF3/G-CSF.

    Gene expression databases

    ArrayExpressiQ16617.
    BgeeiQ16617.
    CleanExiHS_NKG7.
    GenevestigatoriQ16617.

    Interactioni

    Protein-protein interaction databases

    BioGridi110883. 1 interaction.
    IntActiQ16617. 1 interaction.
    STRINGi9606.ENSP00000221978.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16617.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45115.
    HOGENOMiHOG000113791.
    HOVERGENiHBG000485.
    InParanoidiQ16617.
    OMAiIQTFFSW.
    OrthoDBiEOG7XSTGC.
    PhylomeDBiQ16617.
    TreeFamiTF330587.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR004032. PMP22_EMP_MP20.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PROSITEiPS01221. PMP22_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16617-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI    50
    ISGYIHVTQT FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA 100
    AAISMVVAMA VYTSERWDQP PHPQIQTFFS WSFYLGWVSA ILLLCTGALS 150
    LGAHCGGPRP GYETL 165
    Length:165
    Mass (Da):17,665
    Last modified:November 1, 1996 - v1
    Checksum:iCEE2901B6DC42A8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09608 mRNA. Translation: AAA18209.1.
    S69115 mRNA. Translation: AAB30078.1.
    AF305941 Genomic DNA. Translation: AAG32329.1.
    BC015759 mRNA. Translation: AAH15759.1.
    CCDSiCCDS12830.1.
    PIRiJC2081.
    RefSeqiNP_005592.1. NM_005601.3.
    UniGeneiHs.10306.

    Genome annotation databases

    EnsembliENST00000221978; ENSP00000221978; ENSG00000105374.
    GeneIDi4818.
    KEGGihsa:4818.
    UCSCiuc002pwj.3. human.

    Polymorphism databases

    DMDMi3914144.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09608 mRNA. Translation: AAA18209.1 .
    S69115 mRNA. Translation: AAB30078.1 .
    AF305941 Genomic DNA. Translation: AAG32329.1 .
    BC015759 mRNA. Translation: AAH15759.1 .
    CCDSi CCDS12830.1.
    PIRi JC2081.
    RefSeqi NP_005592.1. NM_005601.3.
    UniGenei Hs.10306.

    3D structure databases

    ProteinModelPortali Q16617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110883. 1 interaction.
    IntActi Q16617. 1 interaction.
    STRINGi 9606.ENSP00000221978.

    Polymorphism databases

    DMDMi 3914144.

    Proteomic databases

    PRIDEi Q16617.

    Protocols and materials databases

    DNASUi 4818.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221978 ; ENSP00000221978 ; ENSG00000105374 .
    GeneIDi 4818.
    KEGGi hsa:4818.
    UCSCi uc002pwj.3. human.

    Organism-specific databases

    CTDi 4818.
    GeneCardsi GC19M051874.
    HGNCi HGNC:7830. NKG7.
    MIMi 606008. gene.
    neXtProti NX_Q16617.
    PharmGKBi PA31639.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45115.
    HOGENOMi HOG000113791.
    HOVERGENi HBG000485.
    InParanoidi Q16617.
    OMAi IQTFFSW.
    OrthoDBi EOG7XSTGC.
    PhylomeDBi Q16617.
    TreeFami TF330587.

    Miscellaneous databases

    GenomeRNAii 4818.
    NextBioi 18566.
    PROi Q16617.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16617.
    Bgeei Q16617.
    CleanExi HS_NKG7.
    Genevestigatori Q16617.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR004032. PMP22_EMP_MP20.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PROSITEi PS01221. PMP22_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells."
      Turman M.A., Yabe T., McSherry C., Bach F.H., Houchins J.P.
      Hum. Immunol. 36:34-40(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and characterization of G-CSF induced gene cDNA."
      Shimane M., Tani K., Maruyama K., Takahashi S., Ozawa K., Asano S.
      Biochem. Biophys. Res. Commun. 199:26-32(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Human chromosome 19q13.4 DNA sequence, including complete sequence for LIM2 and NKG7."
      Church R.L., Li X.L., Wang J.H.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    5. "Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition."
      Medley Q.G., Kedersha N., O'Brien S., Tian Q., Schlossman S.F., Streuli M., Anderson P.
      Proc. Natl. Acad. Sci. U.S.A. 93:685-689(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-25, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiNKG7_HUMAN
    AccessioniPrimary (citable) accession number: Q16617
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3