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Protein

Protein NKG7

Gene

NKG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NKG7
Alternative name(s):
G-CSF-induced gene 1 protein
Short name:
GIG-1 protein
Granule membrane protein of 17 kDa
Short name:
GMP-17
Natural killer cell protein 7
p15-TIA-1
Gene namesi
Name:NKG7
Synonyms:GIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7830. NKG7.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic granule membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31639.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Protein NKG7PRO_0000164667Add
BLAST

Proteomic databases

PRIDEiQ16617.

Expressioni

Tissue specificityi

Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

Inductioni

By CSF3/G-CSF.

Gene expression databases

BgeeiQ16617.
CleanExiHS_NKG7.
ExpressionAtlasiQ16617. baseline and differential.
GenevestigatoriQ16617.

Interactioni

Protein-protein interaction databases

BioGridi110883. 3 interactions.
IntActiQ16617. 1 interaction.
STRINGi9606.ENSP00000221978.

Structurei

3D structure databases

ProteinModelPortaliQ16617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45115.
GeneTreeiENSGT00510000049212.
HOGENOMiHOG000113791.
HOVERGENiHBG000485.
InParanoidiQ16617.
OMAiIQTFFSW.
OrthoDBiEOG7XSTGC.
PhylomeDBiQ16617.
TreeFamiTF330587.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01221. PMP22_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI
60 70 80 90 100
ISGYIHVTQT FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA
110 120 130 140 150
AAISMVVAMA VYTSERWDQP PHPQIQTFFS WSFYLGWVSA ILLLCTGALS
160
LGAHCGGPRP GYETL
Length:165
Mass (Da):17,665
Last modified:October 31, 1996 - v1
Checksum:iCEE2901B6DC42A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09608 mRNA. Translation: AAA18209.1.
S69115 mRNA. Translation: AAB30078.1.
AF305941 Genomic DNA. Translation: AAG32329.1.
BC015759 mRNA. Translation: AAH15759.1.
CCDSiCCDS12830.1.
PIRiJC2081.
RefSeqiNP_005592.1. NM_005601.3.
UniGeneiHs.10306.

Genome annotation databases

EnsembliENST00000221978; ENSP00000221978; ENSG00000105374.
GeneIDi4818.
KEGGihsa:4818.
UCSCiuc002pwj.3. human.

Polymorphism databases

DMDMi3914144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09608 mRNA. Translation: AAA18209.1.
S69115 mRNA. Translation: AAB30078.1.
AF305941 Genomic DNA. Translation: AAG32329.1.
BC015759 mRNA. Translation: AAH15759.1.
CCDSiCCDS12830.1.
PIRiJC2081.
RefSeqiNP_005592.1. NM_005601.3.
UniGeneiHs.10306.

3D structure databases

ProteinModelPortaliQ16617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110883. 3 interactions.
IntActiQ16617. 1 interaction.
STRINGi9606.ENSP00000221978.

Polymorphism databases

DMDMi3914144.

Proteomic databases

PRIDEiQ16617.

Protocols and materials databases

DNASUi4818.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221978; ENSP00000221978; ENSG00000105374.
GeneIDi4818.
KEGGihsa:4818.
UCSCiuc002pwj.3. human.

Organism-specific databases

CTDi4818.
GeneCardsiGC19M051874.
HGNCiHGNC:7830. NKG7.
MIMi606008. gene.
neXtProtiNX_Q16617.
PharmGKBiPA31639.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45115.
GeneTreeiENSGT00510000049212.
HOGENOMiHOG000113791.
HOVERGENiHBG000485.
InParanoidiQ16617.
OMAiIQTFFSW.
OrthoDBiEOG7XSTGC.
PhylomeDBiQ16617.
TreeFamiTF330587.

Miscellaneous databases

GenomeRNAii4818.
NextBioi18566.
PROiQ16617.
SOURCEiSearch...

Gene expression databases

BgeeiQ16617.
CleanExiHS_NKG7.
ExpressionAtlasiQ16617. baseline and differential.
GenevestigatoriQ16617.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01221. PMP22_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells."
    Turman M.A., Yabe T., McSherry C., Bach F.H., Houchins J.P.
    Hum. Immunol. 36:34-40(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and characterization of G-CSF induced gene cDNA."
    Shimane M., Tani K., Maruyama K., Takahashi S., Ozawa K., Asano S.
    Biochem. Biophys. Res. Commun. 199:26-32(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Human chromosome 19q13.4 DNA sequence, including complete sequence for LIM2 and NKG7."
    Church R.L., Li X.L., Wang J.H.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition."
    Medley Q.G., Kedersha N., O'Brien S., Tian Q., Schlossman S.F., Streuli M., Anderson P.
    Proc. Natl. Acad. Sci. U.S.A. 93:685-689(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-25, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNKG7_HUMAN
AccessioniPrimary (citable) accession number: Q16617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: October 31, 1996
Last modified: February 3, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.