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Q16617 (NKG7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NKG7
Alternative name(s):
G-CSF-induced gene 1 protein
Short name=GIG-1 protein
Granule membrane protein of 17 kDa
Short name=GMP-17
Natural killer cell protein 7
p15-TIA-1
Gene names
Name:NKG7
Synonyms:GIG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note: Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils. Ref.5

Tissue specificity

Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

Induction

By CSF3/G-CSF.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Protein NKG7
PRO_0000164667

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane133 – 15321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q16617 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CEE2901B6DC42A8C

FASTA16517,665
        10         20         30         40         50         60 
MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI ISGYIHVTQT 

        70         80         90        100        110        120 
FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA AAISMVVAMA VYTSERWDQP 

       130        140        150        160 
PHPQIQTFFS WSFYLGWVSA ILLLCTGALS LGAHCGGPRP GYETL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells."
Turman M.A., Yabe T., McSherry C., Bach F.H., Houchins J.P.
Hum. Immunol. 36:34-40(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and characterization of G-CSF induced gene cDNA."
Shimane M., Tani K., Maruyama K., Takahashi S., Ozawa K., Asano S.
Biochem. Biophys. Res. Commun. 199:26-32(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Human chromosome 19q13.4 DNA sequence, including complete sequence for LIM2 and NKG7."
Church R.L., Li X.L., Wang J.H.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[5]"Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition."
Medley Q.G., Kedersha N., O'Brien S., Tian Q., Schlossman S.F., Streuli M., Anderson P.
Proc. Natl. Acad. Sci. U.S.A. 93:685-689(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-25, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09608 mRNA. Translation: AAA18209.1.
S69115 mRNA. Translation: AAB30078.1.
AF305941 Genomic DNA. Translation: AAG32329.1.
BC015759 mRNA. Translation: AAH15759.1.
PIRJC2081.
RefSeqNP_005592.1. NM_005601.3.
UniGeneHs.10306.

3D structure databases

ProteinModelPortalQ16617.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110883. 1 interaction.
IntActQ16617. 1 interaction.
STRING9606.ENSP00000221978.

Polymorphism databases

DMDM3914144.

Proteomic databases

PRIDEQ16617.

Protocols and materials databases

DNASU4818.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221978; ENSP00000221978; ENSG00000105374.
GeneID4818.
KEGGhsa:4818.
UCSCuc002pwj.3. human.

Organism-specific databases

CTD4818.
GeneCardsGC19M051874.
HGNCHGNC:7830. NKG7.
MIM606008. gene.
neXtProtNX_Q16617.
PharmGKBPA31639.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45115.
HOGENOMHOG000113791.
HOVERGENHBG000485.
InParanoidQ16617.
OMAIQTFFSW.
OrthoDBEOG7XSTGC.
PhylomeDBQ16617.
TreeFamTF330587.

Gene expression databases

ArrayExpressQ16617.
BgeeQ16617.
CleanExHS_NKG7.
GenevestigatorQ16617.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEPS01221. PMP22_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4818.
NextBio18566.
PROQ16617.
SOURCESearch...

Entry information

Entry nameNKG7_HUMAN
AccessionPrimary (citable) accession number: Q16617
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM