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Protein

Protein NKG7

Gene

NKG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105374-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NKG7
Alternative name(s):
G-CSF-induced gene 1 protein
Short name:
GIG-1 protein
Granule membrane protein of 17 kDa
Short name:
GMP-17
Natural killer cell protein 7
p15-TIA-1
Gene namesi
Name:NKG7
Synonyms:GIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7830. NKG7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4818.
OpenTargetsiENSG00000105374.
PharmGKBiPA31639.

Polymorphism and mutation databases

BioMutaiNKG7.
DMDMi3914144.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646671 – 165Protein NKG7Add BLAST165

Proteomic databases

PaxDbiQ16617.
PRIDEiQ16617.

PTM databases

PhosphoSitePlusiQ16617.

Expressioni

Tissue specificityi

Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

Inductioni

By CSF3/G-CSF.

Gene expression databases

BgeeiENSG00000105374.
CleanExiHS_NKG7.
ExpressionAtlasiQ16617. baseline and differential.
GenevisibleiQ16617. HS.

Organism-specific databases

HPAiHPA071454.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-3919611,EBI-741181
MSR1P217573EBI-3919611,EBI-1776976

Protein-protein interaction databases

BioGridi110883. 4 interactors.
IntActiQ16617. 5 interactors.
STRINGi9606.ENSP00000221978.

Structurei

3D structure databases

ProteinModelPortaliQ16617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0HZ. Eukaryota.
ENOG41113EP. LUCA.
GeneTreeiENSGT00510000049212.
HOGENOMiHOG000113791.
HOVERGENiHBG000485.
InParanoidiQ16617.
OMAiIQTFFSW.
OrthoDBiEOG091G0UXL.
PhylomeDBiQ16617.
TreeFamiTF330587.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01221. PMP22_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI
60 70 80 90 100
ISGYIHVTQT FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA
110 120 130 140 150
AAISMVVAMA VYTSERWDQP PHPQIQTFFS WSFYLGWVSA ILLLCTGALS
160
LGAHCGGPRP GYETL
Length:165
Mass (Da):17,665
Last modified:November 1, 1996 - v1
Checksum:iCEE2901B6DC42A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09608 mRNA. Translation: AAA18209.1.
S69115 mRNA. Translation: AAB30078.1.
AF305941 Genomic DNA. Translation: AAG32329.1.
BC015759 mRNA. Translation: AAH15759.1.
CCDSiCCDS12830.1.
PIRiJC2081.
RefSeqiNP_005592.1. NM_005601.3.
UniGeneiHs.10306.

Genome annotation databases

EnsembliENST00000221978; ENSP00000221978; ENSG00000105374.
GeneIDi4818.
KEGGihsa:4818.
UCSCiuc002pwj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09608 mRNA. Translation: AAA18209.1.
S69115 mRNA. Translation: AAB30078.1.
AF305941 Genomic DNA. Translation: AAG32329.1.
BC015759 mRNA. Translation: AAH15759.1.
CCDSiCCDS12830.1.
PIRiJC2081.
RefSeqiNP_005592.1. NM_005601.3.
UniGeneiHs.10306.

3D structure databases

ProteinModelPortaliQ16617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110883. 4 interactors.
IntActiQ16617. 5 interactors.
STRINGi9606.ENSP00000221978.

PTM databases

PhosphoSitePlusiQ16617.

Polymorphism and mutation databases

BioMutaiNKG7.
DMDMi3914144.

Proteomic databases

PaxDbiQ16617.
PRIDEiQ16617.

Protocols and materials databases

DNASUi4818.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221978; ENSP00000221978; ENSG00000105374.
GeneIDi4818.
KEGGihsa:4818.
UCSCiuc002pwj.4. human.

Organism-specific databases

CTDi4818.
DisGeNETi4818.
GeneCardsiNKG7.
HGNCiHGNC:7830. NKG7.
HPAiHPA071454.
MIMi606008. gene.
neXtProtiNX_Q16617.
OpenTargetsiENSG00000105374.
PharmGKBiPA31639.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0HZ. Eukaryota.
ENOG41113EP. LUCA.
GeneTreeiENSGT00510000049212.
HOGENOMiHOG000113791.
HOVERGENiHBG000485.
InParanoidiQ16617.
OMAiIQTFFSW.
OrthoDBiEOG091G0UXL.
PhylomeDBiQ16617.
TreeFamiTF330587.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105374-MONOMER.

Miscellaneous databases

GenomeRNAii4818.
PROiQ16617.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105374.
CleanExiHS_NKG7.
ExpressionAtlasiQ16617. baseline and differential.
GenevisibleiQ16617. HS.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01221. PMP22_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNKG7_HUMAN
AccessioniPrimary (citable) accession number: Q16617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.