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Protein

Protein NKG7

Gene

NKG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NKG7
Alternative name(s):
G-CSF-induced gene 1 protein
Short name:
GIG-1 protein
Granule membrane protein of 17 kDa
Short name:
GMP-17
Natural killer cell protein 7
p15-TIA-1
Gene namesi
Name:NKG7
Synonyms:GIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105374.9
HGNCiHGNC:7830 NKG7
MIMi606008 gene
neXtProtiNX_Q16617

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4818
OpenTargetsiENSG00000105374
PharmGKBiPA31639

Polymorphism and mutation databases

BioMutaiNKG7
DMDMi3914144

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646671 – 165Protein NKG7Add BLAST165

Proteomic databases

PaxDbiQ16617
PeptideAtlasiQ16617
PRIDEiQ16617

PTM databases

PhosphoSitePlusiQ16617

Expressioni

Tissue specificityi

Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

Inductioni

By CSF3/G-CSF.

Gene expression databases

BgeeiENSG00000105374
CleanExiHS_NKG7
ExpressionAtlasiQ16617 baseline and differential
GenevisibleiQ16617 HS

Organism-specific databases

HPAiHPA071454

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1108835 interactors.
IntActiQ16617 14 interactors.
STRINGi9606.ENSP00000221978

Structurei

3D structure databases

ProteinModelPortaliQ16617
SMRiQ16617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0HZ Eukaryota
ENOG41113EP LUCA
GeneTreeiENSGT00510000049212
HOGENOMiHOG000113791
HOVERGENiHBG000485
InParanoidiQ16617
OMAiIQTFFSW
OrthoDBiEOG091G0UXL
PhylomeDBiQ16617
TreeFamiTF330587

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q16617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI
60 70 80 90 100
ISGYIHVTQT FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA
110 120 130 140 150
AAISMVVAMA VYTSERWDQP PHPQIQTFFS WSFYLGWVSA ILLLCTGALS
160
LGAHCGGPRP GYETL
Length:165
Mass (Da):17,665
Last modified:November 1, 1996 - v1
Checksum:iCEE2901B6DC42A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09608 mRNA Translation: AAA18209.1
S69115 mRNA Translation: AAB30078.1
AF305941 Genomic DNA Translation: AAG32329.1
BC015759 mRNA Translation: AAH15759.1
CCDSiCCDS12830.1
PIRiJC2081
RefSeqiNP_005592.1, NM_005601.3
UniGeneiHs.10306

Genome annotation databases

EnsembliENST00000221978; ENSP00000221978; ENSG00000105374
GeneIDi4818
KEGGihsa:4818
UCSCiuc002pwj.4 human

Similar proteinsi

Entry informationi

Entry nameiNKG7_HUMAN
AccessioniPrimary (citable) accession number: Q16617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome