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Protein

Putative apolipoprotein(a)-like protein 2

Gene

LPAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33465-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative apolipoprotein(a)-like protein 2
Short name:
Apo(a)-like protein 2
Short name:
Lp(a)-liker protein 2
Alternative name(s):
Apolipoprotein a-related gene C protein
Short name:
Apo(a)rg-C
Gene namesi
Name:LPAL2
Synonyms:APOARGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21210. LPAL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80350.

Polymorphism and mutation databases

DMDMi74739884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031756622 – 132Putative apolipoprotein(a)-like protein 2Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 105PROSITE-ProRule annotation
Disulfide bondi49 ↔ 88PROSITE-ProRule annotation
Disulfide bondi77 ↔ 100PROSITE-ProRule annotation
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ16609.
PRIDEiQ16609.

Expressioni

Tissue specificityi

Expressed in liver but not in other tissues tested.1 Publication

Gene expression databases

CleanExiHS_LPAL2.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VAC14Q08AM65EBI-10238012,EBI-2107455

Protein-protein interaction databases

IntActiQ16609. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ16609.
SMRiQ16609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 105KringlePROSITE-ProRule annotationAdd BLAST79

Domaini

The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.

Sequence similaritiesi

Contains 1 kringle domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal

Phylogenomic databases

HOVERGENiHBG072100.
InParanoidiQ16609.
PhylomeDBiQ16609.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKEVVLLL LLFLKSAPTE TGPSVQECYH SNGQSYRGTY FTTVTGRTCQ
60 70 80 90 100
AWSSMTPHQH SRTPEKYPND GLISNYCRNP DCSAGPWCYT TDPNVRWEYC
110 120 130
NLTRCSDDEG TVFVPLTVIP VPSLEDSFIQ VA
Length:132
Mass (Da):14,886
Last modified:November 1, 1996 - v1
Checksum:i3794AD30A586DBBA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05110091T → M.Corresponds to variant rs7749199dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19517 mRNA. Translation: AAA85692.1.
U19518 mRNA. Translation: AAA85693.1.
CH471051 Genomic DNA. Translation: EAW47597.1.
CH471051 Genomic DNA. Translation: EAW47598.1.
UniGeneiHs.654503.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19517 mRNA. Translation: AAA85692.1.
U19518 mRNA. Translation: AAA85693.1.
CH471051 Genomic DNA. Translation: EAW47597.1.
CH471051 Genomic DNA. Translation: EAW47598.1.
UniGeneiHs.654503.

3D structure databases

ProteinModelPortaliQ16609.
SMRiQ16609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ16609. 1 interactor.

Polymorphism and mutation databases

DMDMi74739884.

Proteomic databases

PeptideAtlasiQ16609.
PRIDEiQ16609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi80350.
GeneCardsiLPAL2.
HGNCiHGNC:21210. LPAL2.
MIMi611682. gene.
neXtProtiNX_Q16609.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG072100.
InParanoidiQ16609.
PhylomeDBiQ16609.

Enzyme and pathway databases

BioCyciZFISH:G66-33465-MONOMER.

Miscellaneous databases

PROiQ16609.
SOURCEiSearch...

Gene expression databases

CleanExiHS_LPAL2.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPAL2_HUMAN
AccessioniPrimary (citable) accession number: Q16609
Secondary accession number(s): E1P5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.