Reviewed, UniProtKB/Swiss-Prot Q16602 (CALRL_HUMAN)

Names and origin

Protein names

Recommended name:
    Calcitonin gene-related peptide type 1 receptor
      Short name=CGRP type 1 receptor
Alternative name(s):
    Calcitonin receptor-like receptor

Gene names

Name:	CALCRL
Synonyms:	CGRPR

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 By similarity. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit structure	Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Predominantly expressed in the lung and heart.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc
Molecular function	calcitonin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.6
	Chain	23 – 461	439	Calcitonin gene-related peptide type 1 receptor		PRO_0000012811
Regions
	Topological domain	23 – 146	124	Extracellular Potential
	Transmembrane	147 – 166	20	1 Potential
	Topological domain	167 – 173	7	Cytoplasmic Potential
	Transmembrane	174 – 193	20	2 Potential
	Topological domain	194 – 213	20	Extracellular Potential
	Transmembrane	214 – 236	23	3 Potential
	Topological domain	237 – 253	17	Cytoplasmic Potential
	Transmembrane	254 – 273	20	4 Potential
	Topological domain	274 – 289	16	Extracellular Potential
	Transmembrane	290 – 313	24	5 Potential
	Topological domain	314 – 336	23	Cytoplasmic Potential
	Transmembrane	337 – 354	18	6 Potential
	Topological domain	355 – 366	12	Extracellular Potential
	Transmembrane	367 – 388	22	7 Potential
	Topological domain	389 – 461	73	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	123	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	8	1	N → Y: dbSNP rs698577. Ref.4		VAR_054822
	Natural variant	16	1	F → L: dbSNP rs13391909.		VAR_049453
	Natural variant	274	1	R → I: dbSNP rs34010553.		VAR_049454
Experimental info
	Sequence conflict	144	1	L → Q in BAF84319. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q16602-1 [UniParc]. Last modified April 14, 2009. Version 2. Checksum: AF98E55E5454767C	FASTA	461	52,929
	10 20 30 40 50 60 MEKKCTLNFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA 70 80 90 100 110 120 EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT 130 140 150 160 170 180 WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL 190 200 210 220 230 240 FFSFVCNSVV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL 250 260 270 280 290 300 IVVAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA 310 320 330 340 350 360 ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI 370 380 390 400 410 420 AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS 430 440 450 460 YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cDNA encoding the calcitonin gene-related peptide type 1 receptor." Aiyar N., Rand K., Elshourbagy N.A., Zeng Z., Adamou J.E., Bergsma D.J., Li Y. J. Biol. Chem. 271:11325-11329(1996) [PubMed: 8626685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"A human orphan calcitonin receptor-like structure." Fluehmann B., Muff R., Hunziker W., Fischer J.A., Born W. Biochem. Biophys. Res. Commun. 206:341-347(1995) [PubMed: 7818539] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-8. Tissue: Placenta and Trachea.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-37.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L76380 mRNA. Translation: AAC41994.1. U17473 mRNA. Translation: AAA62158.1. AY389506 mRNA. Translation: AAQ91332.1. AK291630 mRNA. Translation: BAF84319.1. Different initiation. AK292998 mRNA. Translation: BAF85687.1. AC007319 Genomic DNA. Translation: AAY14806.1. AC074020 Genomic DNA. Translation: AAY14996.1.
IPI	IPI00873582.
PIR	JC2477.
RefSeq	NP_005786.1.
UniGene	Hs.470882
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16602. 2 interactions.
STRING	Q16602.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q16602.
Genome annotation databases
Ensembl	ENST00000392370; ENSP00000376177; ENSG00000064989; Homo sapiens. [Genome view] ENST00000409998; ENSP00000386972; ENSG00000064989; Homo sapiens. [Genome view] ENST00000410068; ENSP00000387190; ENSG00000064989; Homo sapiens. [Genome view]
GeneID	10203.
KEGG	hsa:10203.
UCSC	uc002upv.2. human.
Organism-specific databases
CTD	10203.
GeneCards	GC02M187918.
H-InvDB	HIX0029903.
HGNC	HGNC:16709. CALCRL.
HPA	HPA008070.
MIM	114190. gene.
PharmGKB	PA26033.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06505.
HOGENOM	HBG446561.
HOVERGEN	Q16602.
InParanoid	Q16602.
OMA	SIVTIIH.
OrthoDB	EOG922D43.
PhylomeDB	Q16602.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	Q16602.
Bgee	Q16602.
CleanEx	HS_CALCRL.
Genevestigator	Q16602.
GermOnline	ENSG00000064989. Homo sapiens.
Family and domain databases
InterPro	IPR003287. GCPR_2_calcitonin_rcpt-like. IPR017981. GPCR_2-like. IPR003289. GPCR_2_CGRP1_rcpt. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
PANTHER	PTHR12011:SF67. Calctnin_rcpt. 1 hit.
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR01351. CGRPRECEPTOR. PR01350. CTRFAMILY. PR00249. GPCRSECRETIN.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	38620.
SOURCE	Search...

Entry information

Entry name

CALRL_HUMAN

Accession

Primary (citable) accession number: Q16602
Secondary accession number(s): A8K6G5 , A8KAD3, Q53S02, Q53TS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 14, 2009
Last modified:	January 19, 2010
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.