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Q16600

- ZN239_HUMAN

UniProt

Q16600 - ZN239_HUMAN

Protein

Zinc finger protein 239

Gene

ZNF239

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. metal ion binding Source: UniProtKB-KW
    3. RNA binding Source: ProtInc
    4. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 239
    Alternative name(s):
    Zinc finger protein HOK-2
    Zinc finger protein MOK-2
    Gene namesi
    Name:ZNF239
    Synonyms:HOK2, MOK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:13031. ZNF239.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37609.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Zinc finger protein 239PRO_0000047480Add
    BLAST

    Proteomic databases

    MaxQBiQ16600.
    PaxDbiQ16600.
    PRIDEiQ16600.

    PTM databases

    PhosphoSiteiQ16600.

    Expressioni

    Gene expression databases

    BgeeiQ16600.
    CleanExiHS_ZNF239.
    GenevestigatoriQ16600.

    Organism-specific databases

    HPAiHPA046679.

    Interactioni

    Protein-protein interaction databases

    BioGridi113831. 2 interactions.
    IntActiQ16600. 1 interaction.
    MINTiMINT-249532.
    STRINGi9606.ENSP00000307774.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16600.
    SMRiQ16600. Positions 127-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ16600.
    OMAiRVHKKDP.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ16600.
    TreeFamiTF350845.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16600-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTITGSQD CIVNHRGEVD GEPELDISPC QQWGEASSPI SRNRDSVMTL    50
    QSGCFENIES ETYLPLKVSS QIDTQDSSVK FCKNEPQDHQ ESRRLFVMEE 100
    STERKVIKGE SCSENLQVKL VSDGQELASP LLNGEATCQN GQLKESLDPI 150
    DCNCKDIHGW KSQVVSCSQQ RAHTEEKPCD HNNCGKILNT SPDGHPYEKI 200
    HTAEKQYECS QCGKNFSQSS ELLLHQRDHT EEKPYKCEQC GKGFTRSSSL 250
    LIHQAVHTDE KPYKCDKCGK GFTRSSSLLI HHAVHTGEKP YKCDKCGKGF 300
    SQSSKLHIHQ RVHTGEKPYE CEECGMSFSQ RSNLHIHQRV HTGERPYKCG 350
    ECGKGFSQSS NLHIHRCIHT GEKPYQCYEC GKGFSQSSDL RIHLRVHTGE 400
    KPYHCGKCGK GFSQSSKLLI HQRVHTGEKP YECSKCGKGF SQSSNLHIHQ 450
    RVHKKDPR 458
    Length:458
    Mass (Da):51,591
    Last modified:July 7, 2009 - v3
    Checksum:i94753A790CB5F559
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401V → D in CAA57637. (PubMed:8587123)Curated
    Sequence conflicti340 – 3401V → D in CAA57638. (PubMed:8587123)Curated
    Sequence conflicti448 – 4481I → S in CAA57637. (PubMed:8587123)Curated
    Sequence conflicti448 – 4481I → S in CAA57638. (PubMed:8587123)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti172 – 1721A → G.1 Publication
    Corresponds to variant rs2230660 [ dbSNP | Ensembl ].
    VAR_024205
    Natural varianti209 – 2091C → G.1 Publication
    Corresponds to variant rs2230661 [ dbSNP | Ensembl ].
    VAR_024206
    Natural varianti266 – 2661D → E.1 Publication
    Corresponds to variant rs1128865 [ dbSNP | Ensembl ].
    VAR_025536

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82125 mRNA. Translation: CAA57637.1.
    X82126 Genomic DNA. Translation: CAA57638.1.
    AL450326 Genomic DNA. Translation: CAI15021.1.
    BC026030 mRNA. Translation: AAH26030.1.
    CCDSiCCDS41502.1.
    RefSeqiNP_001092752.1. NM_001099282.1.
    NP_001092753.1. NM_001099283.1.
    NP_001092754.1. NM_001099284.1.
    NP_005665.2. NM_005674.2.
    XP_005271885.1. XM_005271828.1.
    XP_005271886.1. XM_005271829.1.
    XP_005271888.1. XM_005271831.1.
    XP_005271889.1. XM_005271832.1.
    XP_006718065.1. XM_006718002.1.
    XP_006718066.1. XM_006718003.1.
    UniGeneiHs.25040.

    Genome annotation databases

    EnsembliENST00000306006; ENSP00000307774; ENSG00000196793.
    ENST00000374446; ENSP00000363569; ENSG00000196793.
    ENST00000426961; ENSP00000398202; ENSG00000196793.
    ENST00000535642; ENSP00000443907; ENSG00000196793.
    GeneIDi8187.
    KEGGihsa:8187.
    UCSCiuc001jaw.4. human.

    Polymorphism databases

    DMDMi251757424.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82125 mRNA. Translation: CAA57637.1 .
    X82126 Genomic DNA. Translation: CAA57638.1 .
    AL450326 Genomic DNA. Translation: CAI15021.1 .
    BC026030 mRNA. Translation: AAH26030.1 .
    CCDSi CCDS41502.1.
    RefSeqi NP_001092752.1. NM_001099282.1.
    NP_001092753.1. NM_001099283.1.
    NP_001092754.1. NM_001099284.1.
    NP_005665.2. NM_005674.2.
    XP_005271885.1. XM_005271828.1.
    XP_005271886.1. XM_005271829.1.
    XP_005271888.1. XM_005271831.1.
    XP_005271889.1. XM_005271832.1.
    XP_006718065.1. XM_006718002.1.
    XP_006718066.1. XM_006718003.1.
    UniGenei Hs.25040.

    3D structure databases

    ProteinModelPortali Q16600.
    SMRi Q16600. Positions 127-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113831. 2 interactions.
    IntActi Q16600. 1 interaction.
    MINTi MINT-249532.
    STRINGi 9606.ENSP00000307774.

    PTM databases

    PhosphoSitei Q16600.

    Polymorphism databases

    DMDMi 251757424.

    Proteomic databases

    MaxQBi Q16600.
    PaxDbi Q16600.
    PRIDEi Q16600.

    Protocols and materials databases

    DNASUi 8187.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306006 ; ENSP00000307774 ; ENSG00000196793 .
    ENST00000374446 ; ENSP00000363569 ; ENSG00000196793 .
    ENST00000426961 ; ENSP00000398202 ; ENSG00000196793 .
    ENST00000535642 ; ENSP00000443907 ; ENSG00000196793 .
    GeneIDi 8187.
    KEGGi hsa:8187.
    UCSCi uc001jaw.4. human.

    Organism-specific databases

    CTDi 8187.
    GeneCardsi GC10M044051.
    HGNCi HGNC:13031. ZNF239.
    HPAi HPA046679.
    MIMi 601069. gene.
    neXtProti NX_Q16600.
    PharmGKBi PA37609.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q16600.
    OMAi RVHKKDP.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q16600.
    TreeFami TF350845.

    Miscellaneous databases

    ChiTaRSi ZNF239. human.
    GeneWikii ZNF239.
    GenomeRNAii 8187.
    NextBioi 30867.
    PROi Q16600.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16600.
    CleanExi HS_ZNF239.
    Genevestigatori Q16600.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human and mouse Kruppel-like (MOK2) orthologue genes encode two different zinc finger proteins."
      Ernoult-Lange M., Arranz V., le Coniat M., Berger R., Kress M.
      J. Mol. Evol. 41:784-794(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS GLY-172; GLY-209 AND GLU-266.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiZN239_HUMAN
    AccessioniPrimary (citable) accession number: Q16600
    Secondary accession number(s): Q5T1G9, Q8TAS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3