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Q16600 (ZN239_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 239
Alternative name(s):
Zinc finger protein HOK-2
Zinc finger protein MOK-2
Gene names
Name:ZNF239
Synonyms:HOK2, MOK2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 9 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Zinc finger protein 239
PRO_0000047480

Regions

Zinc finger207 – 22923C2H2-type 1
Zinc finger235 – 25723C2H2-type 2
Zinc finger263 – 28523C2H2-type 3
Zinc finger291 – 31323C2H2-type 4
Zinc finger319 – 34123C2H2-type 5
Zinc finger347 – 36923C2H2-type 6
Zinc finger375 – 39723C2H2-type 7
Zinc finger403 – 42523C2H2-type 8
Zinc finger431 – 45323C2H2-type 9

Natural variations

Natural variant1721A → G. Ref.1
Corresponds to variant rs2230660 [ dbSNP | Ensembl ].
VAR_024205
Natural variant2091C → G. Ref.1
Corresponds to variant rs2230661 [ dbSNP | Ensembl ].
VAR_024206
Natural variant2661D → E. Ref.1
Corresponds to variant rs1128865 [ dbSNP | Ensembl ].
VAR_025536

Experimental info

Sequence conflict3401V → D in CAA57637. Ref.1
Sequence conflict3401V → D in CAA57638. Ref.1
Sequence conflict4481I → S in CAA57637. Ref.1
Sequence conflict4481I → S in CAA57638. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q16600 [UniParc].

Last modified July 7, 2009. Version 3.
Checksum: 94753A790CB5F559

FASTA45851,591
        10         20         30         40         50         60 
MASTITGSQD CIVNHRGEVD GEPELDISPC QQWGEASSPI SRNRDSVMTL QSGCFENIES 

        70         80         90        100        110        120 
ETYLPLKVSS QIDTQDSSVK FCKNEPQDHQ ESRRLFVMEE STERKVIKGE SCSENLQVKL 

       130        140        150        160        170        180 
VSDGQELASP LLNGEATCQN GQLKESLDPI DCNCKDIHGW KSQVVSCSQQ RAHTEEKPCD 

       190        200        210        220        230        240 
HNNCGKILNT SPDGHPYEKI HTAEKQYECS QCGKNFSQSS ELLLHQRDHT EEKPYKCEQC 

       250        260        270        280        290        300 
GKGFTRSSSL LIHQAVHTDE KPYKCDKCGK GFTRSSSLLI HHAVHTGEKP YKCDKCGKGF 

       310        320        330        340        350        360 
SQSSKLHIHQ RVHTGEKPYE CEECGMSFSQ RSNLHIHQRV HTGERPYKCG ECGKGFSQSS 

       370        380        390        400        410        420 
NLHIHRCIHT GEKPYQCYEC GKGFSQSSDL RIHLRVHTGE KPYHCGKCGK GFSQSSKLLI 

       430        440        450 
HQRVHTGEKP YECSKCGKGF SQSSNLHIHQ RVHKKDPR 

« Hide

References

« Hide 'large scale' references
[1]"Human and mouse Kruppel-like (MOK2) orthologue genes encode two different zinc finger proteins."
Ernoult-Lange M., Arranz V., le Coniat M., Berger R., Kress M.
J. Mol. Evol. 41:784-794(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS GLY-172; GLY-209 AND GLU-266.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X82125 mRNA. Translation: CAA57637.1.
X82126 Genomic DNA. Translation: CAA57638.1.
AL450326 Genomic DNA. Translation: CAI15021.1.
BC026030 mRNA. Translation: AAH26030.1.
CCDSCCDS41502.1.
RefSeqNP_001092752.1. NM_001099282.1.
NP_001092753.1. NM_001099283.1.
NP_001092754.1. NM_001099284.1.
NP_005665.2. NM_005674.2.
XP_005271885.1. XM_005271828.1.
XP_005271886.1. XM_005271829.1.
XP_005271888.1. XM_005271831.1.
XP_005271889.1. XM_005271832.1.
XP_006718065.1. XM_006718002.1.
XP_006718066.1. XM_006718003.1.
UniGeneHs.25040.

3D structure databases

ProteinModelPortalQ16600.
SMRQ16600. Positions 127-455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113831. 2 interactions.
IntActQ16600. 1 interaction.
MINTMINT-249532.
STRING9606.ENSP00000307774.

PTM databases

PhosphoSiteQ16600.

Polymorphism databases

DMDM251757424.

Proteomic databases

MaxQBQ16600.
PaxDbQ16600.
PRIDEQ16600.

Protocols and materials databases

DNASU8187.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306006; ENSP00000307774; ENSG00000196793.
ENST00000374446; ENSP00000363569; ENSG00000196793.
ENST00000426961; ENSP00000398202; ENSG00000196793.
ENST00000535642; ENSP00000443907; ENSG00000196793.
GeneID8187.
KEGGhsa:8187.
UCSCuc001jaw.4. human.

Organism-specific databases

CTD8187.
GeneCardsGC10M044051.
HGNCHGNC:13031. ZNF239.
HPAHPA046679.
MIM601069. gene.
neXtProtNX_Q16600.
PharmGKBPA37609.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ16600.
OMARVHKKDP.
OrthoDBEOG7KSX7Q.
PhylomeDBQ16600.
TreeFamTF350845.

Gene expression databases

BgeeQ16600.
CleanExHS_ZNF239.
GenevestigatorQ16600.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF239. human.
GeneWikiZNF239.
GenomeRNAi8187.
NextBio30867.
PROQ16600.
SOURCESearch...

Entry information

Entry nameZN239_HUMAN
AccessionPrimary (citable) accession number: Q16600
Secondary accession number(s): Q5T1G9, Q8TAS5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM