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Protein

Zinc finger protein 239

Gene

ZNF239

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
  3. RNA binding Source: ProtInc
  4. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 239
Alternative name(s):
Zinc finger protein HOK-2
Zinc finger protein MOK-2
Gene namesi
Name:ZNF239
Synonyms:HOK2, MOK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13031. ZNF239.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Zinc finger protein 239PRO_0000047480Add
BLAST

Proteomic databases

MaxQBiQ16600.
PaxDbiQ16600.
PRIDEiQ16600.

PTM databases

PhosphoSiteiQ16600.

Expressioni

Gene expression databases

BgeeiQ16600.
CleanExiHS_ZNF239.
GenevestigatoriQ16600.

Organism-specific databases

HPAiHPA046679.

Interactioni

Protein-protein interaction databases

BioGridi113831. 3 interactions.
IntActiQ16600. 1 interaction.
MINTiMINT-249532.
STRINGi9606.ENSP00000307774.

Structurei

3D structure databases

ProteinModelPortaliQ16600.
SMRiQ16600. Positions 139-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri207 – 22923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121920.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ16600.
OMAiRVHKKDP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ16600.
TreeFamiTF350845.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTITGSQD CIVNHRGEVD GEPELDISPC QQWGEASSPI SRNRDSVMTL
60 70 80 90 100
QSGCFENIES ETYLPLKVSS QIDTQDSSVK FCKNEPQDHQ ESRRLFVMEE
110 120 130 140 150
STERKVIKGE SCSENLQVKL VSDGQELASP LLNGEATCQN GQLKESLDPI
160 170 180 190 200
DCNCKDIHGW KSQVVSCSQQ RAHTEEKPCD HNNCGKILNT SPDGHPYEKI
210 220 230 240 250
HTAEKQYECS QCGKNFSQSS ELLLHQRDHT EEKPYKCEQC GKGFTRSSSL
260 270 280 290 300
LIHQAVHTDE KPYKCDKCGK GFTRSSSLLI HHAVHTGEKP YKCDKCGKGF
310 320 330 340 350
SQSSKLHIHQ RVHTGEKPYE CEECGMSFSQ RSNLHIHQRV HTGERPYKCG
360 370 380 390 400
ECGKGFSQSS NLHIHRCIHT GEKPYQCYEC GKGFSQSSDL RIHLRVHTGE
410 420 430 440 450
KPYHCGKCGK GFSQSSKLLI HQRVHTGEKP YECSKCGKGF SQSSNLHIHQ

RVHKKDPR
Length:458
Mass (Da):51,591
Last modified:July 7, 2009 - v3
Checksum:i94753A790CB5F559
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401V → D in CAA57637 (PubMed:8587123).Curated
Sequence conflicti340 – 3401V → D in CAA57638 (PubMed:8587123).Curated
Sequence conflicti448 – 4481I → S in CAA57637 (PubMed:8587123).Curated
Sequence conflicti448 – 4481I → S in CAA57638 (PubMed:8587123).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721A → G.1 Publication
Corresponds to variant rs2230660 [ dbSNP | Ensembl ].
VAR_024205
Natural varianti209 – 2091C → G.1 Publication
Corresponds to variant rs2230661 [ dbSNP | Ensembl ].
VAR_024206
Natural varianti266 – 2661D → E.1 Publication
Corresponds to variant rs1128865 [ dbSNP | Ensembl ].
VAR_025536

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82125 mRNA. Translation: CAA57637.1.
X82126 Genomic DNA. Translation: CAA57638.1.
AL450326 Genomic DNA. Translation: CAI15021.1.
BC026030 mRNA. Translation: AAH26030.1.
CCDSiCCDS41502.1.
RefSeqiNP_001092752.1. NM_001099282.1.
NP_001092753.1. NM_001099283.1.
NP_001092754.1. NM_001099284.1.
NP_005665.2. NM_005674.2.
XP_005271885.1. XM_005271828.1.
XP_005271886.1. XM_005271829.1.
XP_005271888.1. XM_005271831.1.
XP_005271889.1. XM_005271832.1.
XP_006718065.1. XM_006718002.1.
XP_006718066.1. XM_006718003.1.
UniGeneiHs.25040.

Genome annotation databases

EnsembliENST00000306006; ENSP00000307774; ENSG00000196793.
ENST00000374446; ENSP00000363569; ENSG00000196793.
ENST00000426961; ENSP00000398202; ENSG00000196793.
ENST00000535642; ENSP00000443907; ENSG00000196793.
GeneIDi8187.
KEGGihsa:8187.
UCSCiuc001jaw.4. human.

Polymorphism databases

DMDMi251757424.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82125 mRNA. Translation: CAA57637.1.
X82126 Genomic DNA. Translation: CAA57638.1.
AL450326 Genomic DNA. Translation: CAI15021.1.
BC026030 mRNA. Translation: AAH26030.1.
CCDSiCCDS41502.1.
RefSeqiNP_001092752.1. NM_001099282.1.
NP_001092753.1. NM_001099283.1.
NP_001092754.1. NM_001099284.1.
NP_005665.2. NM_005674.2.
XP_005271885.1. XM_005271828.1.
XP_005271886.1. XM_005271829.1.
XP_005271888.1. XM_005271831.1.
XP_005271889.1. XM_005271832.1.
XP_006718065.1. XM_006718002.1.
XP_006718066.1. XM_006718003.1.
UniGeneiHs.25040.

3D structure databases

ProteinModelPortaliQ16600.
SMRiQ16600. Positions 139-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113831. 3 interactions.
IntActiQ16600. 1 interaction.
MINTiMINT-249532.
STRINGi9606.ENSP00000307774.

PTM databases

PhosphoSiteiQ16600.

Polymorphism databases

DMDMi251757424.

Proteomic databases

MaxQBiQ16600.
PaxDbiQ16600.
PRIDEiQ16600.

Protocols and materials databases

DNASUi8187.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306006; ENSP00000307774; ENSG00000196793.
ENST00000374446; ENSP00000363569; ENSG00000196793.
ENST00000426961; ENSP00000398202; ENSG00000196793.
ENST00000535642; ENSP00000443907; ENSG00000196793.
GeneIDi8187.
KEGGihsa:8187.
UCSCiuc001jaw.4. human.

Organism-specific databases

CTDi8187.
GeneCardsiGC10M044051.
HGNCiHGNC:13031. ZNF239.
HPAiHPA046679.
MIMi601069. gene.
neXtProtiNX_Q16600.
PharmGKBiPA37609.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121920.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ16600.
OMAiRVHKKDP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ16600.
TreeFamiTF350845.

Miscellaneous databases

ChiTaRSiZNF239. human.
GeneWikiiZNF239.
GenomeRNAii8187.
NextBioi30867.
PROiQ16600.
SOURCEiSearch...

Gene expression databases

BgeeiQ16600.
CleanExiHS_ZNF239.
GenevestigatoriQ16600.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human and mouse Kruppel-like (MOK2) orthologue genes encode two different zinc finger proteins."
    Ernoult-Lange M., Arranz V., le Coniat M., Berger R., Kress M.
    J. Mol. Evol. 41:784-794(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS GLY-172; GLY-209 AND GLU-266.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN239_HUMAN
AccessioniPrimary (citable) accession number: Q16600
Secondary accession number(s): Q5T1G9, Q8TAS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 7, 2009
Last modified: February 4, 2015
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.