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Q165V0 (Q165V0_ROSDO) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q165V0 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 549FC25A064C89B6

FASTA40445,089
        10         20         30         40         50         60 
MTKIKVQNPV VELDGDEMTR IIWDFIKQKL ILPYLDIDLK YYDLGMESRD ATDDQITVDA 

        70         80         90        100        110        120 
AHAIKEHGVG VKCATITPDE ARVEEFGLKQ MWRSPNGTIR NILGGVIFRQ PIICRNVPRL 

       130        140        150        160        170        180 
VPGWTKPIVV GRHAYGDQYR ATDFKFPGKG KLTLKFVGED GTEIEREVFD APDSGVVMAM 

       190        200        210        220        230        240 
YNLDKSIIDF ARASFNYGLT LGWPVYLSTK NTILKQYDGR FLELFAQVFE AEFKEKFDAA 

       250        260        270        280        290        300 
GIWYEHRLID DMVASAMKWS GGYVWACKNY DGDVQSDTVA QGFGSLGLMA SVLMTPDGQV 

       310        320        330        340        350        360 
VESEAAHGTV TRHYRQHQKG EATSTNSIAS IYAWTGGLKH RAKLDDNDAL LNFAETLEKV 

       370        380        390        400 
VVDTVESGFM TKDLALLVGP DQGWLTTQGF LEKISENLNT ALAG 

« Hide

References

[1]"The complete genome sequence of Roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism."
Swingley W.D., Sadekar S., Mastrian S.D., Matthies H.J., Hao J., Ramos H., Acharya C.R., Conrad A.L., Taylor H.L., Dejesa L.C., Shah M.K., O'huallachain M.E., Lince M.T., Blankenship R.E., Beatty J.T., Touchman J.W.
J. Bacteriol. 189:683-690(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33942 / OCh 114.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000362 Genomic DNA. Translation: ABG32243.1.
RefSeqYP_682929.1. NC_008209.1.

3D structure databases

ProteinModelPortalQ165V0.
SMRQ165V0. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING375451.RD1_2704.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG32243; ABG32243; RD1_2704.
GeneID4196171.
KEGGrde:RD1_2704.
PATRIC23363413. VBIRosDen86677_2583.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycRDEN375451:GJIZ-2545-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ165V0_ROSDO
AccessionPrimary (citable) accession number: Q165V0
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)