Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q165V0

- Q165V0_ROSDO

UniProt

Q165V0 - Q165V0_ROSDO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821NADPUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRDEN375451:GJIZ-2545-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:RD1_2704Imported
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)Imported
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
ProteomesiUP000007029: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi375451.RD1_2704.

Structurei

3D structure databases

ProteinModelPortaliQ165V0.
SMRiQ165V0. Positions 3-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiTRIIWDK.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q165V0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKIKVQNPV VELDGDEMTR IIWDFIKQKL ILPYLDIDLK YYDLGMESRD
60 70 80 90 100
ATDDQITVDA AHAIKEHGVG VKCATITPDE ARVEEFGLKQ MWRSPNGTIR
110 120 130 140 150
NILGGVIFRQ PIICRNVPRL VPGWTKPIVV GRHAYGDQYR ATDFKFPGKG
160 170 180 190 200
KLTLKFVGED GTEIEREVFD APDSGVVMAM YNLDKSIIDF ARASFNYGLT
210 220 230 240 250
LGWPVYLSTK NTILKQYDGR FLELFAQVFE AEFKEKFDAA GIWYEHRLID
260 270 280 290 300
DMVASAMKWS GGYVWACKNY DGDVQSDTVA QGFGSLGLMA SVLMTPDGQV
310 320 330 340 350
VESEAAHGTV TRHYRQHQKG EATSTNSIAS IYAWTGGLKH RAKLDDNDAL
360 370 380 390 400
LNFAETLEKV VVDTVESGFM TKDLALLVGP DQGWLTTQGF LEKISENLNT

ALAG
Length:404
Mass (Da):45,089
Last modified:July 25, 2006 - v1
Checksum:i549FC25A064C89B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG32243.1.
RefSeqiYP_682929.1. NC_008209.1.

Genome annotation databases

EnsemblBacteriaiABG32243; ABG32243; RD1_2704.
GeneIDi4196171.
KEGGirde:RD1_2704.
PATRICi23363413. VBIRosDen86677_2583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA. Translation: ABG32243.1 .
RefSeqi YP_682929.1. NC_008209.1.

3D structure databases

ProteinModelPortali Q165V0.
SMRi Q165V0. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 375451.RD1_2704.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG32243 ; ABG32243 ; RD1_2704 .
GeneIDi 4196171.
KEGGi rde:RD1_2704.
PATRICi 23363413. VBIRosDen86677_2583.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi TRIIWDK.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci RDEN375451:GJIZ-2545-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33942 / OCh 114Imported.

Entry informationi

Entry nameiQ165V0_ROSDO
AccessioniPrimary (citable) accession number: Q165V0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3