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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Alpha-D-glucose 1-phosphateUniRule annotation1
Binding sitei171Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei204Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRDEN375451:G1G6J-2661-MONOMER
UniPathwayiUPA00164

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:RD1_2874
OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Taxonomic identifieri375451 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
Proteomesi
  • UP000007029 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002618951 – 419Glucose-1-phosphate adenylyltransferaseAdd BLAST419

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi375451.RD1_2874

Structurei

3D structure databases

ProteinModelPortaliQ165E3
SMRiQ165E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 187Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4 Bacteria
COG0448 LUCA
HOGENOMiHOG000278607
KOiK00975
OMAiHCVLGVR
OrthoDBiPOG091H09L2

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00624 GlgC, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR023049 GlgC_bac
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q165E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNREEQRLAQ QTMAFVLAGG RGSRLYELTD RRAKPAMYFG GKSRIIDFPL
60 70 80 90 100
SNAVNSGIRR IGVATQYKAH SLIRHLQRGW SFFRAERNES LDILPASQQM
110 120 130 140 150
NDENWYKGTA DAVAQNKDII EGYGPKYIII LAGDHIYKQD YAEMIRHHVE
160 170 180 190 200
SGADVTVGCI EVPRMEASGF GVMKVDTEDR ILDFIEKPGD PPAMPGHPDQ
210 220 230 240 250
ALASMGIYVF ETEYLFKIME ECAAVPGYSH DFGGDIIPTI VRGGKAVAHP
260 270 280 290 300
FSRSCVRTVN EEAPYWRDVG TVDAFWQANL DLTDFKPALD LYDTEWPIWT
310 320 330 340 350
YSELTAPAKF IHNEEGRRGS AVSSMVSGGC IISGSSLERC LLFTGVRTHS
360 370 380 390 400
FSQLNGVVSM PYAIINRNAR LTNVVVDRGV VIPQGLVVGE DPALDAQRFR
410
RTDSGVCLIT QPMIDKLDM
Length:419
Mass (Da):46,651
Last modified:July 25, 2006 - v1
Checksum:i7BBF54B1ED466AAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000362 Genomic DNA Translation: ABG32400.1
RefSeqiWP_011569016.1, NZ_FOOO01000002.1

Genome annotation databases

EnsemblBacteriaiABG32400; ABG32400; RD1_2874
KEGGirde:RD1_2874

Similar proteinsi

Entry informationi

Entry nameiGLGC_ROSDO
AccessioniPrimary (citable) accession number: Q165E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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