Q16589 (CCNG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-G2

Gene names

Name:

CCNG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in growth regulation and in negative regulation of cell cycle progession.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.
Developmental stage	Expression levels increase through the cell cycle to peak in the mid/late-S phase and decrease during G2/M phase.
Induction	Activated by actinomycin-D induced DNA damage.
Sequence similarities	Belongs to the cyclin family. Cyclin G subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Cyclin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle checkpoint Traceable author statement Ref.2. Source: ProtInc cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell cycle Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Cyclin-G2		PRO_0000080469
Natural variations
	Natural variant	4	1	L → V. Ref.4 Corresponds to variant rs4150050 [ dbSNP | Ensembl ].		VAR_014333
	Natural variant	28	1	E → G. Ref.4 Corresponds to variant rs4150051 [ dbSNP | Ensembl ].		VAR_014334

Sequences

	Sequence		Length	Mass (Da)
	Q16589 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D434E0CE92760301	FASTA	344	38,866
	10 20 30 40 50 60 MKDLGAEHLA GHEGVQLLGL LNVYLEQEER FQPREKGLSL IEATPENDNT LCPGLRNAKV 70 80 90 100 110 120 EDLRSLANFF GSCTETFVLA VNILDRFLAL MKVKPKHLSC IGVCSFLLAA RIVEEDCNIP 130 140 150 160 170 180 STHDVIRISQ CKCTASDIKR MEKIISEKLH YELEATTALN FLHLYHTIIL CHTSERKEIL 190 200 210 220 230 240 SLDKLEAQLK ACNCRLIFSK AKPSVLALCL LNLEVETLKS VELLEILLLV KKHSKINDTE 250 260 270 280 290 300 FFYWRELVSK CLAEYSSPEC CKPDLKKLVW IVSRRTAQNL HNSYYSVPEL PTIPEGGCFD 310 320 330 340 ESESEDSCED MSCGEESLSS SPPSDQECTF FFNFKVAQTL CFPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterisation of human cyclin G1 and G2: DNA damage inducible genes." Bates S.A., Rowan S., Vousden K.H. Oncogene 13:1103-1109(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain and Fetal spleen.
[2]	"Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression." Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G., Wahl A.F. J. Biol. Chem. 271:6050-6061(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	NIEHS SNPs program Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-4 AND GLY-28.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U47414 mRNA. Translation: AAC50689.1. L49506 mRNA. Translation: AAC41978.1. BT019503 mRNA. Translation: AAV38310.1. AF549495 Genomic DNA. Translation: AAN40704.1.
IPI	IPI00002976.
RefSeq	NP_004345.1. NM_004354.2.
UniGene	Hs.740456.
3D structure databases
ProteinModelPortal	Q16589.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16589. 1 interaction.
STRING	9606.ENSP00000315743.
PTM databases
PhosphoSite	Q16589.
Polymorphism databases
DMDM	9087132.
Proteomic databases
PaxDb	Q16589.
PRIDE	Q16589.
Protocols and materials databases
DNASU	901.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316355; ENSP00000315743; ENSG00000138764. ENST00000395640; ENSP00000379002; ENSG00000138764. ENST00000502280; ENSP00000424665; ENSG00000138764.
GeneID	901.
KEGG	hsa:901.
UCSC	uc003hkn.4. human.
Organism-specific databases
CTD	901.
GeneCards	GC04P078078.
HGNC	HGNC:1593. CCNG2.
HPA	HPA034684.
MIM	603203. gene.
neXtProt	NX_Q16589.
PharmGKB	PA26158.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5024.
HOGENOM	HOG000059559.
HOVERGEN	HBG050839.
InParanoid	Q16589.
KO	K10146.
OMA	CSRLRNA.
OrthoDB	EOG46WZ8T.
Gene expression databases
ArrayExpress	Q16589.
Bgee	Q16589.
CleanEx	HS_CCNG2.
Genevestigator	Q16589.
GermOnline	ENSG00000138764. Homo sapiens.
Family and domain databases
Gene3D	1.10.472.10. 1 hit.
InterPro	IPR013763. Cyclin-like. IPR006671. Cyclin_N. [Graphical view]
Pfam	PF00134. Cyclin_N. 1 hit. [Graphical view]
SMART	SM00385. CYCLIN. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	CCNG2. human.
GenomeRNAi	901.
NextBio	3724.
SOURCE	Search...

Entry information

Entry name

CCNG2_HUMAN

Accession

Primary (citable) accession number: Q16589

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.