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Q16587

- ZNF74_HUMAN

UniProt

Q16587 - ZNF74_HUMAN

Protein

Zinc finger protein 74

Gene

ZNF74

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    May play a role in RNA metabolism.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri248 – 27023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri416 – 43823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri444 – 46623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri472 – 49423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri500 – 52223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri528 – 55023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri556 – 57823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW
    4. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. multicellular organismal development Source: ProtInc
    2. regulation of transcription, DNA-templated Source: RefGenome
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, RNA-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 74
    Alternative name(s):
    Zinc finger protein 520
    hZNF7
    Gene namesi
    Name:ZNF74
    Synonyms:ZNF520
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:13144. ZNF74.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37718.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 644644Zinc finger protein 74PRO_0000047383Add
    BLAST

    Proteomic databases

    PaxDbiQ16587.
    PRIDEiQ16587.

    PTM databases

    PhosphoSiteiQ16587.

    Expressioni

    Tissue specificityi

    Highly expressed in the fetal brain.

    Gene expression databases

    ArrayExpressiQ16587.
    BgeeiQ16587.
    CleanExiHS_ZNF74.
    GenevestigatoriQ16587.

    Organism-specific databases

    HPAiHPA003354.

    Interactioni

    Protein-protein interaction databases

    BioGridi113444. 5 interactions.
    IntActiQ16587. 1 interaction.
    STRINGi9606.ENSP00000383301.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16587.
    SMRiQ16587. Positions 43-83, 248-578.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 11472KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri248 – 27023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 29823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri360 – 38223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri388 – 41023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri416 – 43823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri444 – 46623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri472 – 49423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri500 – 52223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri528 – 55023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri556 – 57823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG018163.
    InParanoidiQ16587.
    OMAiRCWKAFS.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ16587.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 12 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q16587-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV    50
    DFTQEEWGQL DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE 100
    PWSMQREVPR GPCPEWELKA VPSQQQGICK EEPAQEPIME RPLGGAQAWG 150
    RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP LRCPLFAQQR VPEGGPLLDT 200
    RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG AGAGEGEFVC 250
    GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG 300
    EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH 350
    LRVHTGEKPY RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH 400
    SSLTVHEKIH SGDKPFKCSD CEKAFNSRSR LTLHQRTHTG EKPFKCADCG 450
    KGFSCHAYLL VHRRIHSGEK PFKCNECGKA FSSHAYLIVH RRIHTGEKPF 500
    DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN HCLIKHQKIH 550
    SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG 600
    SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN 644
    Length:644
    Mass (Da):72,207
    Last modified:March 23, 2010 - v3
    Checksum:i87E5AA122BBC82F1
    GO
    Isoform 1 (identifier: Q16587-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-71: Missing.

    Show »
    Length:573
    Mass (Da):64,291
    Checksum:i446498FAA8BE73E7
    GO
    Isoform 3 (identifier: Q16587-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-114: Missing.

    Show »
    Length:612
    Mass (Da):68,593
    Checksum:iCBF6A98883C7FA99
    GO
    Isoform 4 (identifier: Q16587-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA

    Show »
    Length:572
    Mass (Da):64,056
    Checksum:i7AAF6926643B4E12
    GO
    Isoform 5 (identifier: Q16587-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
         179-644: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:178
    Mass (Da):17,930
    Checksum:i99A6F8B0619384A6
    GO

    Sequence cautioni

    The sequence AAF21777.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
    The sequence AAF21778.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
    The sequence AAF21779.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
    The sequence AAF21780.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
    The sequence CAA50632.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
    The sequence CAA63379.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711V → A in AAH13395. (PubMed:15489334)Curated
    Sequence conflicti517 – 5171V → M in CAA63379. (PubMed:8663113)Curated
    Sequence conflicti517 – 5171V → M in CAA50632. (PubMed:8268910)Curated
    Sequence conflicti517 – 5171V → M in AAF21777. 1 PublicationCurated
    Sequence conflicti517 – 5171V → M in AAF21778. 1 PublicationCurated
    Sequence conflicti517 – 5171V → M in AAF21779. 1 PublicationCurated
    Sequence conflicti517 – 5171V → M in AAF21780. 1 PublicationCurated
    Sequence conflicti569 – 5691S → P in BAH13068. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171E → K.2 Publications
    Corresponds to variant rs3747076 [ dbSNP | Ensembl ].
    VAR_012993
    Natural varianti623 – 6242KL → NF.
    VAR_012994

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282MEIPA…NLLAL → MPSPPFSPRA in isoform 4. CuratedVSP_006893Add
    BLAST
    Alternative sequencei1 – 7171Missing in isoform 1. 3 PublicationsVSP_006891Add
    BLAST
    Alternative sequencei12 – 178167ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5. 1 PublicationVSP_045530Add
    BLAST
    Alternative sequencei83 – 11432Missing in isoform 3. CuratedVSP_006892Add
    BLAST
    Alternative sequencei179 – 644466Missing in isoform 5. 1 PublicationVSP_045531Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92715 mRNA. Translation: CAA63379.1. Frameshift.
    X71623 mRNA. Translation: CAA50632.1. Frameshift.
    CR456616 mRNA. Translation: CAG30502.1.
    AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21777.1. Frameshift.
    AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21778.1. Frameshift.
    AF072567, AF072562 Genomic DNA. Translation: AAF21779.1. Frameshift.
    AF072567, AF072562 Genomic DNA. Translation: AAF21780.1. Frameshift.
    AK299569 mRNA. Translation: BAH13068.1.
    AC007731 Genomic DNA. No translation available.
    BC013395 mRNA. Translation: AAH13395.1.
    BC056902 mRNA. No translation available.
    X63182 Genomic DNA. Translation: CAC16149.1.
    CCDSiCCDS42982.1. [Q16587-1]
    CCDS58794.1. [Q16587-5]
    PIRiI39311.
    RefSeqiNP_001243452.1. NM_001256523.1. [Q16587-5]
    NP_001243453.1. NM_001256524.1. [Q16587-1]
    NP_001243454.1. NM_001256525.1. [Q16587-2]
    NP_003417.2. NM_003426.3. [Q16587-1]
    UniGeneiHs.517418.

    Genome annotation databases

    EnsembliENST00000356671; ENSP00000349098; ENSG00000185252. [Q16587-1]
    ENST00000400451; ENSP00000383301; ENSG00000185252. [Q16587-1]
    ENST00000403682; ENSP00000384750; ENSG00000185252. [Q16587-5]
    ENST00000405993; ENSP00000385855; ENSG00000185252. [Q16587-3]
    GeneIDi7625.
    KEGGihsa:7625.
    UCSCiuc002zsg.4. human. [Q16587-1]

    Polymorphism databases

    DMDMi292495055.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92715 mRNA. Translation: CAA63379.1 . Frameshift.
    X71623 mRNA. Translation: CAA50632.1 . Frameshift.
    CR456616 mRNA. Translation: CAG30502.1 .
    AF072567 , AF072557 , AF072562 Genomic DNA. Translation: AAF21777.1 . Frameshift.
    AF072567 , AF072557 , AF072562 Genomic DNA. Translation: AAF21778.1 . Frameshift.
    AF072567 , AF072562 Genomic DNA. Translation: AAF21779.1 . Frameshift.
    AF072567 , AF072562 Genomic DNA. Translation: AAF21780.1 . Frameshift.
    AK299569 mRNA. Translation: BAH13068.1 .
    AC007731 Genomic DNA. No translation available.
    BC013395 mRNA. Translation: AAH13395.1 .
    BC056902 mRNA. No translation available.
    X63182 Genomic DNA. Translation: CAC16149.1 .
    CCDSi CCDS42982.1. [Q16587-1 ]
    CCDS58794.1. [Q16587-5 ]
    PIRi I39311.
    RefSeqi NP_001243452.1. NM_001256523.1. [Q16587-5 ]
    NP_001243453.1. NM_001256524.1. [Q16587-1 ]
    NP_001243454.1. NM_001256525.1. [Q16587-2 ]
    NP_003417.2. NM_003426.3. [Q16587-1 ]
    UniGenei Hs.517418.

    3D structure databases

    ProteinModelPortali Q16587.
    SMRi Q16587. Positions 43-83, 248-578.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113444. 5 interactions.
    IntActi Q16587. 1 interaction.
    STRINGi 9606.ENSP00000383301.

    PTM databases

    PhosphoSitei Q16587.

    Polymorphism databases

    DMDMi 292495055.

    Proteomic databases

    PaxDbi Q16587.
    PRIDEi Q16587.

    Protocols and materials databases

    DNASUi 7625.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356671 ; ENSP00000349098 ; ENSG00000185252 . [Q16587-1 ]
    ENST00000400451 ; ENSP00000383301 ; ENSG00000185252 . [Q16587-1 ]
    ENST00000403682 ; ENSP00000384750 ; ENSG00000185252 . [Q16587-5 ]
    ENST00000405993 ; ENSP00000385855 ; ENSG00000185252 . [Q16587-3 ]
    GeneIDi 7625.
    KEGGi hsa:7625.
    UCSCi uc002zsg.4. human. [Q16587-1 ]

    Organism-specific databases

    CTDi 7625.
    GeneCardsi GC22P020748.
    HGNCi HGNC:13144. ZNF74.
    HPAi HPA003354.
    MIMi 194548. gene.
    neXtProti NX_Q16587.
    PharmGKBi PA37718.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG018163.
    InParanoidi Q16587.
    OMAi RCWKAFS.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q16587.
    TreeFami TF341817.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF74.
    GenomeRNAii 7625.
    NextBioi 29717.
    PROi Q16587.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16587.
    Bgeei Q16587.
    CleanExi HS_ZNF74.
    Genevestigatori Q16587.

    Family and domain databases

    Gene3Di 3.30.160.60. 12 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix."
      Grondin B., Bazinet M., Aubry M.
      J. Biol. Chem. 271:15458-15467(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome."
      Aubry M., Demczuk S., Desmaze C., Aikem M., Aurias M., Julien J.-P., Rouleau G.A.
      Hum. Mol. Genet. 2:1583-1587(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Alternative promoter usage and splicing of ZNF74 gene."
      Aubry M., Cote F.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-117.
      Tissue: Brain.
    6. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
      Tissue: Muscle and Retinoblastoma.
    8. "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)."
      Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.
      Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-583.
    9. "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia."
      Takase K., Ohtsuki T., Migita O., Toru M., Inada T., Yamakawa-Kobayashi K., Arinami T.
      Schizophr. Res. 52:161-165(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LYS-117 AND 623-ASN-PHE-624.

    Entry informationi

    Entry nameiZNF74_HUMAN
    AccessioniPrimary (citable) accession number: Q16587
    Secondary accession number(s): B5MCE3
    , B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3