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Protein

Zinc finger protein 74

Gene

ZNF74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in RNA metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri248 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • regulation of transcription, DNA-templated Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31624-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 74
Alternative name(s):
Zinc finger protein 520
hZNF7
Gene namesi
Name:ZNF74
Synonyms:ZNF520
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:13144. ZNF74.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7625.
OpenTargetsiENSG00000185252.
PharmGKBiPA37718.

Polymorphism and mutation databases

BioMutaiZNF74.
DMDMi292495055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473831 – 644Zinc finger protein 74Add BLAST644

Proteomic databases

EPDiQ16587.
PaxDbiQ16587.
PeptideAtlasiQ16587.
PRIDEiQ16587.

PTM databases

iPTMnetiQ16587.
PhosphoSitePlusiQ16587.

Expressioni

Tissue specificityi

Highly expressed in the fetal brain.

Gene expression databases

BgeeiENSG00000185252.
CleanExiHS_ZNF74.
ExpressionAtlasiQ16587. baseline and differential.
GenevisibleiQ16587. HS.

Organism-specific databases

HPAiHPA003354.

Interactioni

Protein-protein interaction databases

BioGridi113444. 4 interactors.
IntActiQ16587. 3 interactors.
STRINGi9606.ENSP00000349098.

Structurei

3D structure databases

ProteinModelPortaliQ16587.
SMRiQ16587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 114KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri248 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133913.
HOGENOMiHOG000074097.
HOVERGENiHBG018163.
InParanoidiQ16587.
KOiK09228.
OMAiRCWKAFS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ16587.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q16587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV
60 70 80 90 100
DFTQEEWGQL DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE
110 120 130 140 150
PWSMQREVPR GPCPEWELKA VPSQQQGICK EEPAQEPIME RPLGGAQAWG
160 170 180 190 200
RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP LRCPLFAQQR VPEGGPLLDT
210 220 230 240 250
RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG AGAGEGEFVC
260 270 280 290 300
GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG
310 320 330 340 350
EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH
360 370 380 390 400
LRVHTGEKPY RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH
410 420 430 440 450
SSLTVHEKIH SGDKPFKCSD CEKAFNSRSR LTLHQRTHTG EKPFKCADCG
460 470 480 490 500
KGFSCHAYLL VHRRIHSGEK PFKCNECGKA FSSHAYLIVH RRIHTGEKPF
510 520 530 540 550
DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN HCLIKHQKIH
560 570 580 590 600
SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG
610 620 630 640
SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN
Length:644
Mass (Da):72,207
Last modified:March 23, 2010 - v3
Checksum:i87E5AA122BBC82F1
GO
Isoform 1 (identifier: Q16587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:573
Mass (Da):64,291
Checksum:i446498FAA8BE73E7
GO
Isoform 3 (identifier: Q16587-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-114: Missing.

Show »
Length:612
Mass (Da):68,593
Checksum:iCBF6A98883C7FA99
GO
Isoform 4 (identifier: Q16587-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA

Show »
Length:572
Mass (Da):64,056
Checksum:i7AAF6926643B4E12
GO
Isoform 5 (identifier: Q16587-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
     179-644: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):17,930
Checksum:i99A6F8B0619384A6
GO

Sequence cautioni

The sequence AAF21777 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence AAF21778 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence AAF21779 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence AAF21780 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence CAA50632 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence CAA63379 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171V → A in AAH13395 (PubMed:15489334).Curated1
Sequence conflicti517V → M in CAA63379 (PubMed:8663113).Curated1
Sequence conflicti517V → M in CAA50632 (PubMed:8268910).Curated1
Sequence conflicti517V → M in AAF21777 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21778 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21779 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21780 (Ref. 4) Curated1
Sequence conflicti569S → P in BAH13068 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012993117E → K.2 PublicationsCorresponds to variant rs3747076dbSNPEnsembl.1
Natural variantiVAR_012994623 – 624KL → NF.2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068931 – 82MEIPA…NLLAL → MPSPPFSPRA in isoform 4. CuratedAdd BLAST82
Alternative sequenceiVSP_0068911 – 71Missing in isoform 1. 3 PublicationsAdd BLAST71
Alternative sequenceiVSP_04553012 – 178ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_00689283 – 114Missing in isoform 3. CuratedAdd BLAST32
Alternative sequenceiVSP_045531179 – 644Missing in isoform 5. 1 PublicationAdd BLAST466

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92715 mRNA. Translation: CAA63379.1. Frameshift.
X71623 mRNA. Translation: CAA50632.1. Frameshift.
CR456616 mRNA. Translation: CAG30502.1.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21777.1. Frameshift.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21778.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21779.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21780.1. Frameshift.
AK299569 mRNA. Translation: BAH13068.1.
AC007731 Genomic DNA. No translation available.
BC013395 mRNA. Translation: AAH13395.1.
BC056902 mRNA. No translation available.
X63182 Genomic DNA. Translation: CAC16149.1.
CCDSiCCDS42982.1. [Q16587-1]
CCDS58794.1. [Q16587-5]
PIRiI39311.
RefSeqiNP_001243452.1. NM_001256523.1. [Q16587-5]
NP_001243453.1. NM_001256524.1. [Q16587-1]
NP_001243454.1. NM_001256525.1. [Q16587-2]
NP_003417.2. NM_003426.3. [Q16587-1]
UniGeneiHs.517418.

Genome annotation databases

EnsembliENST00000400451; ENSP00000383301; ENSG00000185252. [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252. [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252. [Q16587-3]
ENST00000611540; ENSP00000483077; ENSG00000185252. [Q16587-1]
GeneIDi7625.
KEGGihsa:7625.
UCSCiuc002zsh.5. human. [Q16587-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92715 mRNA. Translation: CAA63379.1. Frameshift.
X71623 mRNA. Translation: CAA50632.1. Frameshift.
CR456616 mRNA. Translation: CAG30502.1.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21777.1. Frameshift.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21778.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21779.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21780.1. Frameshift.
AK299569 mRNA. Translation: BAH13068.1.
AC007731 Genomic DNA. No translation available.
BC013395 mRNA. Translation: AAH13395.1.
BC056902 mRNA. No translation available.
X63182 Genomic DNA. Translation: CAC16149.1.
CCDSiCCDS42982.1. [Q16587-1]
CCDS58794.1. [Q16587-5]
PIRiI39311.
RefSeqiNP_001243452.1. NM_001256523.1. [Q16587-5]
NP_001243453.1. NM_001256524.1. [Q16587-1]
NP_001243454.1. NM_001256525.1. [Q16587-2]
NP_003417.2. NM_003426.3. [Q16587-1]
UniGeneiHs.517418.

3D structure databases

ProteinModelPortaliQ16587.
SMRiQ16587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113444. 4 interactors.
IntActiQ16587. 3 interactors.
STRINGi9606.ENSP00000349098.

PTM databases

iPTMnetiQ16587.
PhosphoSitePlusiQ16587.

Polymorphism and mutation databases

BioMutaiZNF74.
DMDMi292495055.

Proteomic databases

EPDiQ16587.
PaxDbiQ16587.
PeptideAtlasiQ16587.
PRIDEiQ16587.

Protocols and materials databases

DNASUi7625.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400451; ENSP00000383301; ENSG00000185252. [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252. [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252. [Q16587-3]
ENST00000611540; ENSP00000483077; ENSG00000185252. [Q16587-1]
GeneIDi7625.
KEGGihsa:7625.
UCSCiuc002zsh.5. human. [Q16587-1]

Organism-specific databases

CTDi7625.
DisGeNETi7625.
GeneCardsiZNF74.
HGNCiHGNC:13144. ZNF74.
HPAiHPA003354.
MIMi194548. gene.
neXtProtiNX_Q16587.
OpenTargetsiENSG00000185252.
PharmGKBiPA37718.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133913.
HOGENOMiHOG000074097.
HOVERGENiHBG018163.
InParanoidiQ16587.
KOiK09228.
OMAiRCWKAFS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ16587.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:G66-31624-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF74.
GenomeRNAii7625.
PROiQ16587.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185252.
CleanExiHS_ZNF74.
ExpressionAtlasiQ16587. baseline and differential.
GenevisibleiQ16587. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF74_HUMAN
AccessioniPrimary (citable) accession number: Q16587
Secondary accession number(s): B5MCE3
, B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: November 30, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.