Q16587 (ZNF74_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 74

Alternative name(s):
Zinc finger protein 520
hZNF7

Gene names

Name:	ZNF74
Synonyms:	ZNF520

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in RNA metabolism.
Subcellular location	Nucleus.
Tissue specificity	Highly expressed in the fetal brain.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAF21777.1 differs from that shown. Reason: Frameshift at positions 164 and 173. The sequence AAF21778.1 differs from that shown. Reason: Frameshift at positions 164 and 173. The sequence AAF21779.1 differs from that shown. Reason: Frameshift at positions 164 and 173. The sequence AAF21780.1 differs from that shown. Reason: Frameshift at positions 164 and 173. The sequence CAA50632.1 differs from that shown. Reason: Frameshift at positions 164 and 173. The sequence CAA63379.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding RNA-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Traceable author statement Ref.8. Source: ProtInc regulation of transcription, DNA-dependent Traceable author statement Ref.8. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	actin cytoskeleton Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q16587-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q16587-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Isoform 3 (identifier: Q16587-3)

The sequence of this isoform differs from the canonical sequence as follows:
     83-114: Missing.

Isoform 4 (identifier: Q16587-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA

Isoform 5 (identifier: Q16587-5)

The sequence of this isoform differs from the canonical sequence as follows:
     12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
     179-644: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 644	644	Zinc finger protein 74		PRO_0000047383
Regions
	Domain	43 – 114	72	KRAB
	Zinc finger	248 – 270	23	C2H2-type 1
	Zinc finger	276 – 298	23	C2H2-type 2
	Zinc finger	304 – 326	23	C2H2-type 3
	Zinc finger	332 – 354	23	C2H2-type 4
	Zinc finger	360 – 382	23	C2H2-type 5
	Zinc finger	388 – 410	23	C2H2-type 6
	Zinc finger	416 – 438	23	C2H2-type 7
	Zinc finger	444 – 466	23	C2H2-type 8
	Zinc finger	472 – 494	23	C2H2-type 9
	Zinc finger	500 – 522	23	C2H2-type 10
	Zinc finger	528 – 550	23	C2H2-type 11
	Zinc finger	556 – 578	23	C2H2-type 12
Natural variations
	Alternative sequence	1 – 82	82	MEIPA…NLLAL → MPSPPFSPRA in isoform 4.		VSP_006893
	Alternative sequence	1 – 71	71	Missing in isoform 1.		VSP_006891
	Alternative sequence	12 – 178	167	ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5.		VSP_045530
	Alternative sequence	83 – 114	32	Missing in isoform 3.		VSP_006892
	Alternative sequence	179 – 644	466	Missing in isoform 5.		VSP_045531
	Natural variant	117	1	E → K. Ref.5 Ref.9 Corresponds to variant rs3747076 [ dbSNP | Ensembl ].		VAR_012993
	Natural variant	623 – 624	2	KL → NF.		VAR_012994
Experimental info
	Sequence conflict	171	1	V → A in AAH13395. Ref.7
	Sequence conflict	517	1	V → M in CAA63379. Ref.1
	Sequence conflict	517	1	V → M in CAA50632. Ref.2
	Sequence conflict	517	1	V → M in AAF21777. Ref.4
	Sequence conflict	517	1	V → M in AAF21778. Ref.4
	Sequence conflict	517	1	V → M in AAF21779. Ref.4
	Sequence conflict	517	1	V → M in AAF21780. Ref.4
	Sequence conflict	569	1	S → P in BAH13068. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified March 23, 2010. Version 3. Checksum: 87E5AA122BBC82F1	FASTA	644	72,207
	10 20 30 40 50 60 MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV DFTQEEWGQL 70 80 90 100 110 120 DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE PWSMQREVPR GPCPEWELKA 130 140 150 160 170 180 VPSQQQGICK EEPAQEPIME RPLGGAQAWG RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP 190 200 210 220 230 240 LRCPLFAQQR VPEGGPLLDT RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG 250 260 270 280 290 300 AGAGEGEFVC GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG 310 320 330 340 350 360 EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH LRVHTGEKPY 370 380 390 400 410 420 RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH SSLTVHEKIH SGDKPFKCSD 430 440 450 460 470 480 CEKAFNSRSR LTLHQRTHTG EKPFKCADCG KGFSCHAYLL VHRRIHSGEK PFKCNECGKA 490 500 510 520 530 540 FSSHAYLIVH RRIHTGEKPF DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN 550 560 570 580 590 600 HCLIKHQKIH SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG 610 620 630 640 SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN
	Isoform 1 [UniParc]. Checksum: 446498FAA8BE73E7	FASTA	573	64,291
	10 20 30 40 50 60 MLENYQNLLA LGPPLHKPDV ISHLERGEEP WSMQREVPRG PCPEWELKAV PSQQQGICKE 70 80 90 100 110 120 EPAQEPIMER PLGGAQAWGR QAGALQRSQA APWAPAPAMV WDVPVEEFPL RCPLFAQQRV 130 140 150 160 170 180 PEGGPLLDTR KNVQATEGRT KAPARLCAGE NASTPSEPEK FPQVRRQRGA GAGEGEFVCG 190 200 210 220 230 240 ECGKAFRQSS SLTLHRRWHS REKAYKCDEC GKAFTWSTNL LEHRRIHTGE KPFFCGECGK 250 260 270 280 290 300 AFSCHSSLNV HQRIHTGERP YKCSACEKAF SCSSLLSMHL RVHTGEKPYR CGECGKAFNQ 310 320 330 340 350 360 RTHLTRHHRI HTGEKPYQCG SCGKAFTCHS SLTVHEKIHS GDKPFKCSDC EKAFNSRSRL 370 380 390 400 410 420 TLHQRTHTGE KPFKCADCGK GFSCHAYLLV HRRIHSGEKP FKCNECGKAF SSHAYLIVHR 430 440 450 460 470 480 RIHTGEKPFD CSQCWKAFSC HSSLIVHQRI HTGEKPYKCS ECGRAFSQNH CLIKHQKIHS 490 500 510 520 530 540 GEKSFKCEKC GEMFNWSSHL TEHQRLHSEG KPLAIQFNKH LLSTYYVPGS LLGAGDAGLR 550 560 570 DVDPIDALDV AKLLCVVPPR AGRNFSLGSK PRN
	Isoform 3 [UniParc]. Checksum: CBF6A98883C7FA99	FASTA	612	68,593
	10 20 30 40 50 60 MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV DFTQEEWGQL 70 80 90 100 110 120 DSPQRALYRD VMLENYQNLL ALEWELKAVP SQQQGICKEE PAQEPIMERP LGGAQAWGRQ 130 140 150 160 170 180 AGALQRSQAA PWAPAPAMVW DVPVEEFPLR CPLFAQQRVP EGGPLLDTRK NVQATEGRTK 190 200 210 220 230 240 APARLCAGEN ASTPSEPEKF PQVRRQRGAG AGEGEFVCGE CGKAFRQSSS LTLHRRWHSR 250 260 270 280 290 300 EKAYKCDECG KAFTWSTNLL EHRRIHTGEK PFFCGECGKA FSCHSSLNVH QRIHTGERPY 310 320 330 340 350 360 KCSACEKAFS CSSLLSMHLR VHTGEKPYRC GECGKAFNQR THLTRHHRIH TGEKPYQCGS 370 380 390 400 410 420 CGKAFTCHSS LTVHEKIHSG DKPFKCSDCE KAFNSRSRLT LHQRTHTGEK PFKCADCGKG 430 440 450 460 470 480 FSCHAYLLVH RRIHSGEKPF KCNECGKAFS SHAYLIVHRR IHTGEKPFDC SQCWKAFSCH 490 500 510 520 530 540 SSLIVHQRIH TGEKPYKCSE CGRAFSQNHC LIKHQKIHSG EKSFKCEKCG EMFNWSSHLT 550 560 570 580 590 600 EHQRLHSEGK PLAIQFNKHL LSTYYVPGSL LGAGDAGLRD VDPIDALDVA KLLCVVPPRA 610 GRNFSLGSKP RN
	Isoform 4 [UniParc]. Checksum: 7AAF6926643B4E12	FASTA	572	64,056
	10 20 30 40 50 60 MPSPPFSPRA GPPLHKPDVI SHLERGEEPW SMQREVPRGP CPEWELKAVP SQQQGICKEE 70 80 90 100 110 120 PAQEPIMERP LGGAQAWGRQ AGALQRSQAA PWAPAPAMVW DVPVEEFPLR CPLFAQQRVP 130 140 150 160 170 180 EGGPLLDTRK NVQATEGRTK APARLCAGEN ASTPSEPEKF PQVRRQRGAG AGEGEFVCGE 190 200 210 220 230 240 CGKAFRQSSS LTLHRRWHSR EKAYKCDECG KAFTWSTNLL EHRRIHTGEK PFFCGECGKA 250 260 270 280 290 300 FSCHSSLNVH QRIHTGERPY KCSACEKAFS CSSLLSMHLR VHTGEKPYRC GECGKAFNQR 310 320 330 340 350 360 THLTRHHRIH TGEKPYQCGS CGKAFTCHSS LTVHEKIHSG DKPFKCSDCE KAFNSRSRLT 370 380 390 400 410 420 LHQRTHTGEK PFKCADCGKG FSCHAYLLVH RRIHSGEKPF KCNECGKAFS SHAYLIVHRR 430 440 450 460 470 480 IHTGEKPFDC SQCWKAFSCH SSLIVHQRIH TGEKPYKCSE CGRAFSQNHC LIKHQKIHSG 490 500 510 520 530 540 EKSFKCEKCG EMFNWSSHLT EHQRLHSEGK PLAIQFNKHL LSTYYVPGSL LGAGDAGLRD 550 560 570 VDPIDALDVA KLLCVVPPRA GRNFSLGSKP RN
	Isoform 5 [UniParc]. Checksum: 99A6F8B0619384A6	FASTA	178	17,930
	10 20 30 40 50 60 MEIPAPEPEK TGIGEFQGCG CGLHPGGVGS TRLPSEGLVP GCDVGELPEP SCPRTSTAQA 70 80 90 100 110 120 RCDLSSGTRR GAMEHAEGSP QRALSRMGAE GGALSTAGHL QRRTGPGAHH GAAPRRGAGV 130 140 150 160 170 GAPGRCSAEE SGCALGARTC HGLGRPCRGI PPQVSPLRPA TRSRGGTLAG HTQERPGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix." Grondin B., Bazinet M., Aubry M. J. Biol. Chem. 271:15458-15467(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome." Aubry M., Demczuk S., Desmaze C., Aikem M., Aurias M., Julien J.-P., Rouleau G.A. Hum. Mol. Genet. 2:1583-1587(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Alternative promoter usage and splicing of ZNF74 gene." Aubry M., Cote F. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-117. Tissue: Brain.
[6]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5). Tissue: Muscle and Retinoblastoma.
[8]	"Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)." Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A. Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-583.
[9]	"Association of ZNF74 gene genotypes with age-at-onset of schizophrenia." Takase K., Ohtsuki T., Migita O., Toru M., Inada T., Yamakawa-Kobayashi K., Arinami T. Schizophr. Res. 52:161-165(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LYS-117 AND 623-ASN-PHE-624.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X92715 mRNA. Translation: CAA63379.1. Frameshift. X71623 mRNA. Translation: CAA50632.1. Frameshift. CR456616 mRNA. Translation: CAG30502.1. AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21777.1. Frameshift. AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21778.1. Frameshift. AF072567, AF072562 Genomic DNA. Translation: AAF21779.1. Frameshift. AF072567, AF072562 Genomic DNA. Translation: AAF21780.1. Frameshift. AK299569 mRNA. Translation: BAH13068.1. AC007731 Genomic DNA. No translation available. BC013395 mRNA. Translation: AAH13395.1. BC056902 mRNA. No translation available. X63182 Genomic DNA. Translation: CAC16149.1.
IPI	IPI00220139. IPI00220140. IPI00480138. IPI00807386. IPI00892733.
PIR	I39311.
RefSeq	NP_001243452.1. NM_001256523.1. NP_001243453.1. NM_001256524.1. NP_001243454.1. NM_001256525.1. NP_003417.2. NM_003426.3.
UniGene	Hs.517418.
3D structure databases
ProteinModelPortal	Q16587.
SMR	Q16587. Positions 43-83, 245-578.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16587. 1 interaction.
STRING	9606.ENSP00000383301.
PTM databases
PhosphoSite	Q16587.
Polymorphism databases
DMDM	292495055.
Proteomic databases
PaxDb	Q16587.
PRIDE	Q16587.
Protocols and materials databases
DNASU	7625.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356671; ENSP00000349098; ENSG00000185252. ENST00000400451; ENSP00000383301; ENSG00000185252. ENST00000403682; ENSP00000384750; ENSG00000185252. ENST00000405993; ENSP00000385855; ENSG00000185252.
GeneID	7625.
KEGG	hsa:7625.
UCSC	uc002zsg.3. human.
Organism-specific databases
CTD	7625.
GeneCards	GC22P020748.
HGNC	HGNC:13144. ZNF74.
HPA	HPA003354.
MIM	194548. gene.
neXtProt	NX_Q16587.
PharmGKB	PA37718.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
InParanoid	Q16587.
OMA	VAKLLCV.
OrthoDB	EOG4GMTWN.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q16587.
Bgee	Q16587.
CleanEx	HS_ZNF74.
Genevestigator	Q16587.
GermOnline	ENSG00000185252. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 12 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 12 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 12 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7625.
NextBio	29717.
SOURCE	Search...

Entry information

Entry name

ZNF74_HUMAN

Accession

Primary (citable) accession number: Q16587
Secondary accession number(s): B5MCE3 , B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 123 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.