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Q16587 (ZNF74_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 74
Alternative name(s):
Zinc finger protein 520
hZNF7
Gene names
Name:ZNF74
Synonyms:ZNF520
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length644 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in RNA metabolism.

Subcellular location

Nucleus.

Tissue specificity

Highly expressed in the fetal brain.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAF21777.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

The sequence AAF21778.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

The sequence AAF21779.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

The sequence AAF21780.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

The sequence CAA50632.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

The sequence CAA63379.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: Q16587-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q16587-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
Isoform 3 (identifier: Q16587-3)

The sequence of this isoform differs from the canonical sequence as follows:
     83-114: Missing.
Isoform 4 (identifier: Q16587-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA
Isoform 5 (identifier: Q16587-5)

The sequence of this isoform differs from the canonical sequence as follows:
     12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
     179-644: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 644644Zinc finger protein 74
PRO_0000047383

Regions

Domain43 – 11472KRAB
Zinc finger248 – 27023C2H2-type 1
Zinc finger276 – 29823C2H2-type 2
Zinc finger304 – 32623C2H2-type 3
Zinc finger332 – 35423C2H2-type 4
Zinc finger360 – 38223C2H2-type 5
Zinc finger388 – 41023C2H2-type 6
Zinc finger416 – 43823C2H2-type 7
Zinc finger444 – 46623C2H2-type 8
Zinc finger472 – 49423C2H2-type 9
Zinc finger500 – 52223C2H2-type 10
Zinc finger528 – 55023C2H2-type 11
Zinc finger556 – 57823C2H2-type 12

Natural variations

Alternative sequence1 – 8282MEIPA…NLLAL → MPSPPFSPRA in isoform 4.
VSP_006893
Alternative sequence1 – 7171Missing in isoform 1.
VSP_006891
Alternative sequence12 – 178167ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5.
VSP_045530
Alternative sequence83 – 11432Missing in isoform 3.
VSP_006892
Alternative sequence179 – 644466Missing in isoform 5.
VSP_045531
Natural variant1171E → K. Ref.5 Ref.9
Corresponds to variant rs3747076 [ dbSNP | Ensembl ].
VAR_012993
Natural variant623 – 6242KL → NF.
VAR_012994

Experimental info

Sequence conflict1711V → A in AAH13395. Ref.7
Sequence conflict5171V → M in CAA63379. Ref.1
Sequence conflict5171V → M in CAA50632. Ref.2
Sequence conflict5171V → M in AAF21777. Ref.4
Sequence conflict5171V → M in AAF21778. Ref.4
Sequence conflict5171V → M in AAF21779. Ref.4
Sequence conflict5171V → M in AAF21780. Ref.4
Sequence conflict5691S → P in BAH13068. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified March 23, 2010. Version 3.
Checksum: 87E5AA122BBC82F1

FASTA64472,207
        10         20         30         40         50         60 
MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV DFTQEEWGQL 

        70         80         90        100        110        120 
DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE PWSMQREVPR GPCPEWELKA 

       130        140        150        160        170        180 
VPSQQQGICK EEPAQEPIME RPLGGAQAWG RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP 

       190        200        210        220        230        240 
LRCPLFAQQR VPEGGPLLDT RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG 

       250        260        270        280        290        300 
AGAGEGEFVC GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG 

       310        320        330        340        350        360 
EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH LRVHTGEKPY 

       370        380        390        400        410        420 
RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH SSLTVHEKIH SGDKPFKCSD 

       430        440        450        460        470        480 
CEKAFNSRSR LTLHQRTHTG EKPFKCADCG KGFSCHAYLL VHRRIHSGEK PFKCNECGKA 

       490        500        510        520        530        540 
FSSHAYLIVH RRIHTGEKPF DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN 

       550        560        570        580        590        600 
HCLIKHQKIH SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG 

       610        620        630        640 
SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN 

« Hide

Isoform 1 [UniParc].

Checksum: 446498FAA8BE73E7
Show »

FASTA57364,291
Isoform 3 [UniParc].

Checksum: CBF6A98883C7FA99
Show »

FASTA61268,593
Isoform 4 [UniParc].

Checksum: 7AAF6926643B4E12
Show »

FASTA57264,056
Isoform 5 [UniParc].

Checksum: 99A6F8B0619384A6
Show »

FASTA17817,930

References

« Hide 'large scale' references
[1]"The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix."
Grondin B., Bazinet M., Aubry M.
J. Biol. Chem. 271:15458-15467(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome."
Aubry M., Demczuk S., Desmaze C., Aikem M., Aurias M., Julien J.-P., Rouleau G.A.
Hum. Mol. Genet. 2:1583-1587(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"Alternative promoter usage and splicing of ZNF74 gene."
Aubry M., Cote F.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-117.
Tissue: Brain.
[6]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
Tissue: Muscle and Retinoblastoma.
[8]"Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)."
Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.
Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-583.
[9]"Association of ZNF74 gene genotypes with age-at-onset of schizophrenia."
Takase K., Ohtsuki T., Migita O., Toru M., Inada T., Yamakawa-Kobayashi K., Arinami T.
Schizophr. Res. 52:161-165(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LYS-117 AND 623-ASN-PHE-624.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92715 mRNA. Translation: CAA63379.1. Frameshift.
X71623 mRNA. Translation: CAA50632.1. Frameshift.
CR456616 mRNA. Translation: CAG30502.1.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21777.1. Frameshift.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21778.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21779.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21780.1. Frameshift.
AK299569 mRNA. Translation: BAH13068.1.
AC007731 Genomic DNA. No translation available.
BC013395 mRNA. Translation: AAH13395.1.
BC056902 mRNA. No translation available.
X63182 Genomic DNA. Translation: CAC16149.1.
PIRI39311.
RefSeqNP_001243452.1. NM_001256523.1.
NP_001243453.1. NM_001256524.1.
NP_001243454.1. NM_001256525.1.
NP_003417.2. NM_003426.3.
UniGeneHs.517418.

3D structure databases

ProteinModelPortalQ16587.
SMRQ16587. Positions 43-83, 168-602.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113444. 5 interactions.
IntActQ16587. 1 interaction.
STRING9606.ENSP00000383301.

PTM databases

PhosphoSiteQ16587.

Polymorphism databases

DMDM292495055.

Proteomic databases

PaxDbQ16587.
PRIDEQ16587.

Protocols and materials databases

DNASU7625.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356671; ENSP00000349098; ENSG00000185252. [Q16587-1]
ENST00000400451; ENSP00000383301; ENSG00000185252. [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252. [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252. [Q16587-3]
GeneID7625.
KEGGhsa:7625.
UCSCuc002zsg.4. human. [Q16587-1]

Organism-specific databases

CTD7625.
GeneCardsGC22P020748.
HGNCHGNC:13144. ZNF74.
HPAHPA003354.
MIM194548. gene.
neXtProtNX_Q16587.
PharmGKBPA37718.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
InParanoidQ16587.
OMARCWKAFS.
OrthoDBEOG7KSX7Q.
TreeFamTF341817.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ16587.
BgeeQ16587.
CleanExHS_ZNF74.
GenevestigatorQ16587.

Family and domain databases

Gene3D3.30.160.60. 12 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF74.
GenomeRNAi7625.
NextBio29717.
PROQ16587.
SOURCESearch...

Entry information

Entry nameZNF74_HUMAN
AccessionPrimary (citable) accession number: Q16587
Secondary accession number(s): B5MCE3 expand/collapse secondary AC list , B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: March 19, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM