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Q16587

- ZNF74_HUMAN

UniProt

Q16587 - ZNF74_HUMAN

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Protein
Zinc finger protein 74
Gene
ZNF74, ZNF520
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in RNA metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri248 – 27023C2H2-type 1
Add
BLAST
Zinc fingeri276 – 29823C2H2-type 2
Add
BLAST
Zinc fingeri304 – 32623C2H2-type 3
Add
BLAST
Zinc fingeri332 – 35423C2H2-type 4
Add
BLAST
Zinc fingeri360 – 38223C2H2-type 5
Add
BLAST
Zinc fingeri388 – 41023C2H2-type 6
Add
BLAST
Zinc fingeri416 – 43823C2H2-type 7
Add
BLAST
Zinc fingeri444 – 46623C2H2-type 8
Add
BLAST
Zinc fingeri472 – 49423C2H2-type 9
Add
BLAST
Zinc fingeri500 – 52223C2H2-type 10
Add
BLAST
Zinc fingeri528 – 55023C2H2-type 11
Add
BLAST
Zinc fingeri556 – 57823C2H2-type 12
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. regulation of transcription, DNA-templated Source: RefGenome
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 74
Alternative name(s):
Zinc finger protein 520
hZNF7
Gene namesi
Name:ZNF74
Synonyms:ZNF520
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:13144. ZNF74.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Zinc finger protein 74
PRO_0000047383Add
BLAST

Proteomic databases

PaxDbiQ16587.
PRIDEiQ16587.

PTM databases

PhosphoSiteiQ16587.

Expressioni

Tissue specificityi

Highly expressed in the fetal brain.

Gene expression databases

ArrayExpressiQ16587.
BgeeiQ16587.
CleanExiHS_ZNF74.
GenevestigatoriQ16587.

Organism-specific databases

HPAiHPA003354.

Interactioni

Protein-protein interaction databases

BioGridi113444. 5 interactions.
IntActiQ16587. 1 interaction.
STRINGi9606.ENSP00000383301.

Structurei

3D structure databases

ProteinModelPortaliQ16587.
SMRiQ16587. Positions 43-83, 248-578.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 11472KRAB
Add
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
InParanoidiQ16587.
OMAiRCWKAFS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ16587.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q16587-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV    50
DFTQEEWGQL DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE 100
PWSMQREVPR GPCPEWELKA VPSQQQGICK EEPAQEPIME RPLGGAQAWG 150
RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP LRCPLFAQQR VPEGGPLLDT 200
RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG AGAGEGEFVC 250
GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG 300
EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH 350
LRVHTGEKPY RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH 400
SSLTVHEKIH SGDKPFKCSD CEKAFNSRSR LTLHQRTHTG EKPFKCADCG 450
KGFSCHAYLL VHRRIHSGEK PFKCNECGKA FSSHAYLIVH RRIHTGEKPF 500
DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN HCLIKHQKIH 550
SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG 600
SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN 644
Length:644
Mass (Da):72,207
Last modified:March 23, 2010 - v3
Checksum:i87E5AA122BBC82F1
GO
Isoform 1 (identifier: Q16587-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:573
Mass (Da):64,291
Checksum:i446498FAA8BE73E7
GO
Isoform 3 (identifier: Q16587-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-114: Missing.

Show »
Length:612
Mass (Da):68,593
Checksum:iCBF6A98883C7FA99
GO
Isoform 4 (identifier: Q16587-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA

Show »
Length:572
Mass (Da):64,056
Checksum:i7AAF6926643B4E12
GO
Isoform 5 (identifier: Q16587-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
     179-644: Missing.

Note: No experimental confirmation available.

Show »
Length:178
Mass (Da):17,930
Checksum:i99A6F8B0619384A6
GO

Sequence cautioni

The sequence AAF21777.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
The sequence AAF21778.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
The sequence AAF21779.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
The sequence AAF21780.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
The sequence CAA50632.1 differs from that shown. Reason: Frameshift at positions 164 and 173.
The sequence CAA63379.1 differs from that shown. Reason: Frameshift at positions 164 and 173.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171E → K.2 Publications
Corresponds to variant rs3747076 [ dbSNP | Ensembl ].
VAR_012993
Natural varianti623 – 6242KL → NF.
VAR_012994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282MEIPA…NLLAL → MPSPPFSPRA in isoform 4.
VSP_006893Add
BLAST
Alternative sequencei1 – 7171Missing in isoform 1.
VSP_006891Add
BLAST
Alternative sequencei12 – 178167ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5.
VSP_045530Add
BLAST
Alternative sequencei83 – 11432Missing in isoform 3.
VSP_006892Add
BLAST
Alternative sequencei179 – 644466Missing in isoform 5.
VSP_045531Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711V → A in AAH13395. 1 Publication
Sequence conflicti517 – 5171V → M in CAA63379. 1 Publication
Sequence conflicti517 – 5171V → M in CAA50632. 1 Publication
Sequence conflicti517 – 5171V → M in AAF21777. 1 Publication
Sequence conflicti517 – 5171V → M in AAF21778. 1 Publication
Sequence conflicti517 – 5171V → M in AAF21779. 1 Publication
Sequence conflicti517 – 5171V → M in AAF21780. 1 Publication
Sequence conflicti569 – 5691S → P in BAH13068. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92715 mRNA. Translation: CAA63379.1. Frameshift.
X71623 mRNA. Translation: CAA50632.1. Frameshift.
CR456616 mRNA. Translation: CAG30502.1.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21777.1. Frameshift.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21778.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21779.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21780.1. Frameshift.
AK299569 mRNA. Translation: BAH13068.1.
AC007731 Genomic DNA. No translation available.
BC013395 mRNA. Translation: AAH13395.1.
BC056902 mRNA. No translation available.
X63182 Genomic DNA. Translation: CAC16149.1.
CCDSiCCDS42982.1. [Q16587-1]
CCDS58794.1. [Q16587-5]
PIRiI39311.
RefSeqiNP_001243452.1. NM_001256523.1. [Q16587-5]
NP_001243453.1. NM_001256524.1. [Q16587-1]
NP_001243454.1. NM_001256525.1. [Q16587-2]
NP_003417.2. NM_003426.3. [Q16587-1]
UniGeneiHs.517418.

Genome annotation databases

EnsembliENST00000356671; ENSP00000349098; ENSG00000185252. [Q16587-1]
ENST00000400451; ENSP00000383301; ENSG00000185252. [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252. [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252. [Q16587-3]
GeneIDi7625.
KEGGihsa:7625.
UCSCiuc002zsg.4. human. [Q16587-1]

Polymorphism databases

DMDMi292495055.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92715 mRNA. Translation: CAA63379.1 . Frameshift.
X71623 mRNA. Translation: CAA50632.1 . Frameshift.
CR456616 mRNA. Translation: CAG30502.1 .
AF072567 , AF072557 , AF072562 Genomic DNA. Translation: AAF21777.1 . Frameshift.
AF072567 , AF072557 , AF072562 Genomic DNA. Translation: AAF21778.1 . Frameshift.
AF072567 , AF072562 Genomic DNA. Translation: AAF21779.1 . Frameshift.
AF072567 , AF072562 Genomic DNA. Translation: AAF21780.1 . Frameshift.
AK299569 mRNA. Translation: BAH13068.1 .
AC007731 Genomic DNA. No translation available.
BC013395 mRNA. Translation: AAH13395.1 .
BC056902 mRNA. No translation available.
X63182 Genomic DNA. Translation: CAC16149.1 .
CCDSi CCDS42982.1. [Q16587-1 ]
CCDS58794.1. [Q16587-5 ]
PIRi I39311.
RefSeqi NP_001243452.1. NM_001256523.1. [Q16587-5 ]
NP_001243453.1. NM_001256524.1. [Q16587-1 ]
NP_001243454.1. NM_001256525.1. [Q16587-2 ]
NP_003417.2. NM_003426.3. [Q16587-1 ]
UniGenei Hs.517418.

3D structure databases

ProteinModelPortali Q16587.
SMRi Q16587. Positions 43-83, 248-578.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113444. 5 interactions.
IntActi Q16587. 1 interaction.
STRINGi 9606.ENSP00000383301.

PTM databases

PhosphoSitei Q16587.

Polymorphism databases

DMDMi 292495055.

Proteomic databases

PaxDbi Q16587.
PRIDEi Q16587.

Protocols and materials databases

DNASUi 7625.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356671 ; ENSP00000349098 ; ENSG00000185252 . [Q16587-1 ]
ENST00000400451 ; ENSP00000383301 ; ENSG00000185252 . [Q16587-1 ]
ENST00000403682 ; ENSP00000384750 ; ENSG00000185252 . [Q16587-5 ]
ENST00000405993 ; ENSP00000385855 ; ENSG00000185252 . [Q16587-3 ]
GeneIDi 7625.
KEGGi hsa:7625.
UCSCi uc002zsg.4. human. [Q16587-1 ]

Organism-specific databases

CTDi 7625.
GeneCardsi GC22P020748.
HGNCi HGNC:13144. ZNF74.
HPAi HPA003354.
MIMi 194548. gene.
neXtProti NX_Q16587.
PharmGKBi PA37718.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG018163.
InParanoidi Q16587.
OMAi RCWKAFS.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q16587.
TreeFami TF341817.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF74.
GenomeRNAii 7625.
NextBioi 29717.
PROi Q16587.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q16587.
Bgeei Q16587.
CleanExi HS_ZNF74.
Genevestigatori Q16587.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix."
    Grondin B., Bazinet M., Aubry M.
    J. Biol. Chem. 271:15458-15467(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome."
    Aubry M., Demczuk S., Desmaze C., Aikem M., Aurias M., Julien J.-P., Rouleau G.A.
    Hum. Mol. Genet. 2:1583-1587(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Alternative promoter usage and splicing of ZNF74 gene."
    Aubry M., Cote F.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-117.
    Tissue: Brain.
  6. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
    Tissue: Muscle and Retinoblastoma.
  8. "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)."
    Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.
    Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-583.
  9. "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia."
    Takase K., Ohtsuki T., Migita O., Toru M., Inada T., Yamakawa-Kobayashi K., Arinami T.
    Schizophr. Res. 52:161-165(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-117 AND 623-ASN-PHE-624.

Entry informationi

Entry nameiZNF74_HUMAN
AccessioniPrimary (citable) accession number: Q16587
Secondary accession number(s): B5MCE3
, B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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