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Q16587

- ZNF74_HUMAN

UniProt

Q16587 - ZNF74_HUMAN

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Protein

Zinc finger protein 74

Gene

ZNF74

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in RNA metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri248 – 27023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. regulation of transcription, DNA-templated Source: RefGenome
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 74
Alternative name(s):
Zinc finger protein 520
hZNF7
Gene namesi
Name:ZNF74
Synonyms:ZNF520
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:13144. ZNF74.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Zinc finger protein 74PRO_0000047383Add
BLAST

Proteomic databases

PaxDbiQ16587.
PRIDEiQ16587.

PTM databases

PhosphoSiteiQ16587.

Expressioni

Tissue specificityi

Highly expressed in the fetal brain.

Gene expression databases

BgeeiQ16587.
CleanExiHS_ZNF74.
ExpressionAtlasiQ16587. baseline and differential.
GenevestigatoriQ16587.

Organism-specific databases

HPAiHPA003354.

Interactioni

Protein-protein interaction databases

BioGridi113444. 5 interactions.
IntActiQ16587. 1 interaction.
STRINGi9606.ENSP00000383301.

Structurei

3D structure databases

ProteinModelPortaliQ16587.
SMRiQ16587. Positions 43-83, 248-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 11472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri248 – 27023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120488.
HOVERGENiHBG018163.
InParanoidiQ16587.
OMAiRCWKAFS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ16587.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q16587-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV
60 70 80 90 100
DFTQEEWGQL DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE
110 120 130 140 150
PWSMQREVPR GPCPEWELKA VPSQQQGICK EEPAQEPIME RPLGGAQAWG
160 170 180 190 200
RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP LRCPLFAQQR VPEGGPLLDT
210 220 230 240 250
RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG AGAGEGEFVC
260 270 280 290 300
GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG
310 320 330 340 350
EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH
360 370 380 390 400
LRVHTGEKPY RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH
410 420 430 440 450
SSLTVHEKIH SGDKPFKCSD CEKAFNSRSR LTLHQRTHTG EKPFKCADCG
460 470 480 490 500
KGFSCHAYLL VHRRIHSGEK PFKCNECGKA FSSHAYLIVH RRIHTGEKPF
510 520 530 540 550
DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN HCLIKHQKIH
560 570 580 590 600
SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG
610 620 630 640
SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN
Length:644
Mass (Da):72,207
Last modified:March 23, 2010 - v3
Checksum:i87E5AA122BBC82F1
GO
Isoform 1 (identifier: Q16587-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:573
Mass (Da):64,291
Checksum:i446498FAA8BE73E7
GO
Isoform 3 (identifier: Q16587-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-114: Missing.

Show »
Length:612
Mass (Da):68,593
Checksum:iCBF6A98883C7FA99
GO
Isoform 4 (identifier: Q16587-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA

Show »
Length:572
Mass (Da):64,056
Checksum:i7AAF6926643B4E12
GO
Isoform 5 (identifier: Q16587-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
     179-644: Missing.

Note: No experimental confirmation available.

Show »
Length:178
Mass (Da):17,930
Checksum:i99A6F8B0619384A6
GO

Sequence cautioni

The sequence AAF21777.1 differs from that shown. Reason: Frameshift at positions 164 and 173. Curated
The sequence AAF21778.1 differs from that shown. Reason: Frameshift at positions 164 and 173. Curated
The sequence AAF21779.1 differs from that shown. Reason: Frameshift at positions 164 and 173. Curated
The sequence AAF21780.1 differs from that shown. Reason: Frameshift at positions 164 and 173. Curated
The sequence CAA50632.1 differs from that shown. Reason: Frameshift at positions 164 and 173. Curated
The sequence CAA63379.1 differs from that shown. Reason: Frameshift at positions 164 and 173. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711V → A in AAH13395. (PubMed:15489334)Curated
Sequence conflicti517 – 5171V → M in CAA63379. (PubMed:8663113)Curated
Sequence conflicti517 – 5171V → M in CAA50632. (PubMed:8268910)Curated
Sequence conflicti517 – 5171V → M in AAF21777. 1 PublicationCurated
Sequence conflicti517 – 5171V → M in AAF21778. 1 PublicationCurated
Sequence conflicti517 – 5171V → M in AAF21779. 1 PublicationCurated
Sequence conflicti517 – 5171V → M in AAF21780. 1 PublicationCurated
Sequence conflicti569 – 5691S → P in BAH13068. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171E → K.2 Publications
Corresponds to variant rs3747076 [ dbSNP | Ensembl ].
VAR_012993
Natural varianti623 – 6242KL → NF.
VAR_012994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282MEIPA…NLLAL → MPSPPFSPRA in isoform 4. CuratedVSP_006893Add
BLAST
Alternative sequencei1 – 7171Missing in isoform 1. 3 PublicationsVSP_006891Add
BLAST
Alternative sequencei12 – 178167ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5. 1 PublicationVSP_045530Add
BLAST
Alternative sequencei83 – 11432Missing in isoform 3. CuratedVSP_006892Add
BLAST
Alternative sequencei179 – 644466Missing in isoform 5. 1 PublicationVSP_045531Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92715 mRNA. Translation: CAA63379.1. Frameshift.
X71623 mRNA. Translation: CAA50632.1. Frameshift.
CR456616 mRNA. Translation: CAG30502.1.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21777.1. Frameshift.
AF072567, AF072557, AF072562 Genomic DNA. Translation: AAF21778.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21779.1. Frameshift.
AF072567, AF072562 Genomic DNA. Translation: AAF21780.1. Frameshift.
AK299569 mRNA. Translation: BAH13068.1.
AC007731 Genomic DNA. No translation available.
BC013395 mRNA. Translation: AAH13395.1.
BC056902 mRNA. No translation available.
X63182 Genomic DNA. Translation: CAC16149.1.
CCDSiCCDS42982.1. [Q16587-1]
CCDS58794.1. [Q16587-5]
PIRiI39311.
RefSeqiNP_001243452.1. NM_001256523.1. [Q16587-5]
NP_001243453.1. NM_001256524.1. [Q16587-1]
NP_001243454.1. NM_001256525.1. [Q16587-2]
NP_003417.2. NM_003426.3. [Q16587-1]
UniGeneiHs.517418.

Genome annotation databases

EnsembliENST00000400451; ENSP00000383301; ENSG00000185252. [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252. [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252. [Q16587-3]
ENST00000611540; ENSP00000483077; ENSG00000185252. [Q16587-1]
GeneIDi7625.
KEGGihsa:7625.
UCSCiuc002zsg.4. human. [Q16587-1]

Polymorphism databases

DMDMi292495055.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92715 mRNA. Translation: CAA63379.1 . Frameshift.
X71623 mRNA. Translation: CAA50632.1 . Frameshift.
CR456616 mRNA. Translation: CAG30502.1 .
AF072567 , AF072557 , AF072562 Genomic DNA. Translation: AAF21777.1 . Frameshift.
AF072567 , AF072557 , AF072562 Genomic DNA. Translation: AAF21778.1 . Frameshift.
AF072567 , AF072562 Genomic DNA. Translation: AAF21779.1 . Frameshift.
AF072567 , AF072562 Genomic DNA. Translation: AAF21780.1 . Frameshift.
AK299569 mRNA. Translation: BAH13068.1 .
AC007731 Genomic DNA. No translation available.
BC013395 mRNA. Translation: AAH13395.1 .
BC056902 mRNA. No translation available.
X63182 Genomic DNA. Translation: CAC16149.1 .
CCDSi CCDS42982.1. [Q16587-1 ]
CCDS58794.1. [Q16587-5 ]
PIRi I39311.
RefSeqi NP_001243452.1. NM_001256523.1. [Q16587-5 ]
NP_001243453.1. NM_001256524.1. [Q16587-1 ]
NP_001243454.1. NM_001256525.1. [Q16587-2 ]
NP_003417.2. NM_003426.3. [Q16587-1 ]
UniGenei Hs.517418.

3D structure databases

ProteinModelPortali Q16587.
SMRi Q16587. Positions 43-83, 248-578.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113444. 5 interactions.
IntActi Q16587. 1 interaction.
STRINGi 9606.ENSP00000383301.

PTM databases

PhosphoSitei Q16587.

Polymorphism databases

DMDMi 292495055.

Proteomic databases

PaxDbi Q16587.
PRIDEi Q16587.

Protocols and materials databases

DNASUi 7625.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400451 ; ENSP00000383301 ; ENSG00000185252 . [Q16587-1 ]
ENST00000403682 ; ENSP00000384750 ; ENSG00000185252 . [Q16587-5 ]
ENST00000405993 ; ENSP00000385855 ; ENSG00000185252 . [Q16587-3 ]
ENST00000611540 ; ENSP00000483077 ; ENSG00000185252 . [Q16587-1 ]
GeneIDi 7625.
KEGGi hsa:7625.
UCSCi uc002zsg.4. human. [Q16587-1 ]

Organism-specific databases

CTDi 7625.
GeneCardsi GC22P020748.
HGNCi HGNC:13144. ZNF74.
HPAi HPA003354.
MIMi 194548. gene.
neXtProti NX_Q16587.
PharmGKBi PA37718.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120488.
HOVERGENi HBG018163.
InParanoidi Q16587.
OMAi RCWKAFS.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q16587.
TreeFami TF341817.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF74.
GenomeRNAii 7625.
NextBioi 29717.
PROi Q16587.
SOURCEi Search...

Gene expression databases

Bgeei Q16587.
CleanExi HS_ZNF74.
ExpressionAtlasi Q16587. baseline and differential.
Genevestigatori Q16587.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix."
    Grondin B., Bazinet M., Aubry M.
    J. Biol. Chem. 271:15458-15467(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome."
    Aubry M., Demczuk S., Desmaze C., Aikem M., Aurias M., Julien J.-P., Rouleau G.A.
    Hum. Mol. Genet. 2:1583-1587(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Alternative promoter usage and splicing of ZNF74 gene."
    Aubry M., Cote F.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-117.
    Tissue: Brain.
  6. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
    Tissue: Muscle and Retinoblastoma.
  8. "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)."
    Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.
    Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-583.
  9. "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia."
    Takase K., Ohtsuki T., Migita O., Toru M., Inada T., Yamakawa-Kobayashi K., Arinami T.
    Schizophr. Res. 52:161-165(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-117 AND 623-ASN-PHE-624.

Entry informationi

Entry nameiZNF74_HUMAN
AccessioniPrimary (citable) accession number: Q16587
Secondary accession number(s): B5MCE3
, B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3