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Q16581

- C3AR_HUMAN

UniProt

Q16581 - C3AR_HUMAN

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Protein
C3a anaphylatoxin chemotactic receptor
Gene
C3AR1, AZ3B, C3R1, HNFAG09
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  1. C3a anaphylatoxin receptor activity Source: ProtInc
  2. G-protein coupled receptor activity Source: UniProtKB
  3. complement component C3a receptor activity Source: ProtInc
  4. phosphatidylinositol phospholipase C activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. blood circulation Source: ProtInc
  3. chemotaxis Source: UniProtKB-KW
  4. complement receptor mediated signaling pathway Source: GOC
  5. inflammatory response Source: ProtInc
  6. metabolic process Source: GOC
  7. positive regulation of angiogenesis Source: Ensembl
  8. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  9. positive regulation of macrophage chemotaxis Source: Ensembl
  10. positive regulation of neutrophil chemotaxis Source: Ensembl
  11. positive regulation vascular endothelial growth factor production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3AR1
Synonyms:AZ3B, C3R1, HNFAG09
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:1319. C3AR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4623Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 5711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei58 – 8023Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini81 – 9616Extracellular Reviewed prediction
Add
BLAST
Transmembranei97 – 11822Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini119 – 13921Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini161 – 340180Extracellular Reviewed prediction
Add
BLAST
Transmembranei341 – 36020Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini361 – 37717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei378 – 40023Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini401 – 41717Extracellular Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini439 – 48244Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482C3a anaphylatoxin chemotactic receptor
PRO_0000069202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 172 By similarity
Modified residuei174 – 1741Sulfotyrosine1 Publication
Modified residuei184 – 1841Sulfotyrosine1 Publication
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi266 – 2661O-linked (GalNAc...)1 Publication
Modified residuei318 – 3181Sulfotyrosine1 Publication

Post-translational modificationi

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiQ16581.
PRIDEiQ16581.

PTM databases

PhosphoSiteiQ16581.

Expressioni

Tissue specificityi

Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.

Gene expression databases

ArrayExpressiQ16581.
BgeeiQ16581.
CleanExiHS_C3AR1.
GenevestigatoriQ16581.

Organism-specific databases

HPAiCAB009405.

Interactioni

Protein-protein interaction databases

BioGridi107180. 1 interaction.
STRINGi9606.ENSP00000302079.

Structurei

3D structure databases

ProteinModelPortaliQ16581.
SMRiQ16581. Positions 24-452.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148047.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiQ16581.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG7PGDQQ.
PhylomeDBiQ16581.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF4. PTHR24225:SF4. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16581-1 [UniParc]FASTAAdd to Basket

« Hide

MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL    50
KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS 100
IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA 150
FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI 200
VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT 250
SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA 300
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV 350
IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS 400
LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI 450
QGILEAAFSE ELTRSTHCPS NNVISERNST TV 482
Length:482
Mass (Da):53,864
Last modified:October 3, 2003 - v2
Checksum:i287E219D98CED203
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361V → A.1 Publication
Corresponds to variant rs11567806 [ dbSNP | Ensembl ].
VAR_019164

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511F → C in AAC50657. 1 Publication
Sequence conflicti203 – 2031P → R in AAC50374. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28488 mRNA. Translation: AAC50374.1.
Z73157 mRNA. Translation: CAA97504.1.
U62027 mRNA. Translation: AAC50657.1.
AB065870 Genomic DNA. Translation: BAC06088.1.
AY268431 Genomic DNA. Translation: AAP23198.1.
AY455929 Genomic DNA. Translation: AAR13862.1.
BC020742 mRNA. Translation: AAH20742.1.
CCDSiCCDS8588.1.
PIRiS65766.
RefSeqiNP_004045.1. NM_004054.2.
UniGeneiHs.591148.

Genome annotation databases

EnsembliENST00000307637; ENSP00000302079; ENSG00000171860.
GeneIDi719.
KEGGihsa:719.
UCSCiuc001qtv.1. human.

Polymorphism databases

DMDMi37538305.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28488 mRNA. Translation: AAC50374.1 .
Z73157 mRNA. Translation: CAA97504.1 .
U62027 mRNA. Translation: AAC50657.1 .
AB065870 Genomic DNA. Translation: BAC06088.1 .
AY268431 Genomic DNA. Translation: AAP23198.1 .
AY455929 Genomic DNA. Translation: AAR13862.1 .
BC020742 mRNA. Translation: AAH20742.1 .
CCDSi CCDS8588.1.
PIRi S65766.
RefSeqi NP_004045.1. NM_004054.2.
UniGenei Hs.591148.

3D structure databases

ProteinModelPortali Q16581.
SMRi Q16581. Positions 24-452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107180. 1 interaction.
STRINGi 9606.ENSP00000302079.

Chemistry

BindingDBi Q16581.
ChEMBLi CHEMBL4761.
GuidetoPHARMACOLOGYi 31.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q16581.

Polymorphism databases

DMDMi 37538305.

Proteomic databases

PaxDbi Q16581.
PRIDEi Q16581.

Protocols and materials databases

DNASUi 719.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307637 ; ENSP00000302079 ; ENSG00000171860 .
GeneIDi 719.
KEGGi hsa:719.
UCSCi uc001qtv.1. human.

Organism-specific databases

CTDi 719.
GeneCardsi GC12M008210.
HGNCi HGNC:1319. C3AR1.
HPAi CAB009405.
MIMi 605246. gene.
neXtProti NX_Q16581.
PharmGKBi PA25898.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148047.
HOGENOMi HOG000261616.
HOVERGENi HBG002433.
InParanoidi Q16581.
KOi K04009.
OMAi LWVAGLK.
OrthoDBi EOG7PGDQQ.
PhylomeDBi Q16581.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii C3a_receptor.
GenomeRNAii 719.
NextBioi 2926.
PROi Q16581.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q16581.
Bgeei Q16581.
CleanExi HS_C3AR1.
Genevestigatori Q16581.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF4. PTHR24225:SF4. 1 hit.
Pfami PF00001. 7tm_1. 2 hits.
[Graphical view ]
PRINTSi PR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure."
    Roglic A., Prossnitz E.R., Cavanagh S.L., Pan Z., Zou A., Ye R.D.
    Biochim. Biophys. Acta 1305:39-43(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells."
    Crass T., Raffetseder U., Martin U., Grove M., Klos A., Koehl J., Bautsch W.
    Eur. J. Immunol. 26:1944-1950(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Bautsch W.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. SeattleSNPs variation discovery resource
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-136.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  9. "Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin."
    Gao J., Choe H., Bota D., Wright P.L., Gerard C., Gerard N.P.
    J. Biol. Chem. 278:37902-37908(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SULFATION AT TYR-174; TYR-184 AND TYR-318.
  10. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
    Halim A., Ruetschi U., Larson G., Nilsson J.
    J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiC3AR_HUMAN
AccessioniPrimary (citable) accession number: Q16581
Secondary accession number(s): O43771, Q92868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2003
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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