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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3AR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  • complement component C3a receptor activity Source: ProtInc
  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171860-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3AR1
Synonyms:AZ3B, C3R1, HNFAG09
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1319. C3AR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 46Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini47 – 57CytoplasmicSequence analysisAdd BLAST11
Transmembranei58 – 80Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini81 – 96ExtracellularSequence analysisAdd BLAST16
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 340ExtracellularSequence analysisAdd BLAST180
Transmembranei341 – 360Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini361 – 377CytoplasmicSequence analysisAdd BLAST17
Transmembranei378 – 400Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini401 – 417ExtracellularSequence analysisAdd BLAST17
Transmembranei418 – 438Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini439 – 482CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi719.
OpenTargetsiENSG00000171860.
PharmGKBiPA25898.

Chemistry databases

ChEMBLiCHEMBL4761.
GuidetoPHARMACOLOGYi31.

Polymorphism and mutation databases

BioMutaiC3AR1.
DMDMi37538305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692021 – 482C3a anaphylatoxin chemotactic receptorAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Modified residuei174Sulfotyrosine1 Publication1
Modified residuei184Sulfotyrosine1 Publication1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266O-linked (GalNAc...)1 Publication1
Modified residuei318Sulfotyrosine1 Publication1
Modified residuei459PhosphoserineBy similarity1
Modified residuei463PhosphothreonineBy similarity1

Post-translational modificationi

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.1 Publication
O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiQ16581.
PeptideAtlasiQ16581.
PRIDEiQ16581.

PTM databases

iPTMnetiQ16581.
PhosphoSitePlusiQ16581.
UniCarbKBiQ16581.

Expressioni

Tissue specificityi

Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.

Gene expression databases

BgeeiENSG00000171860.
CleanExiHS_C3AR1.
ExpressionAtlasiQ16581. baseline and differential.
GenevisibleiQ16581. HS.

Organism-specific databases

HPAiCAB009405.

Interactioni

Protein-protein interaction databases

BioGridi107180. 92 interactors.
STRINGi9606.ENSP00000302079.

Chemistry databases

BindingDBiQ16581.

Structurei

3D structure databases

ProteinModelPortaliQ16581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiQ16581.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG091G0AEJ.
PhylomeDBiQ16581.
TreeFamiTF330976.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL
60 70 80 90 100
KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS
110 120 130 140 150
IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA
160 170 180 190 200
FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI
210 220 230 240 250
VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT
260 270 280 290 300
SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA
310 320 330 340 350
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV
360 370 380 390 400
IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS
410 420 430 440 450
LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI
460 470 480
QGILEAAFSE ELTRSTHCPS NNVISERNST TV
Length:482
Mass (Da):53,864
Last modified:October 3, 2003 - v2
Checksum:i287E219D98CED203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151F → C in AAC50657 (PubMed:8702752).Curated1
Sequence conflicti203P → R in AAC50374 (PubMed:8605247).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019164136V → A.1 PublicationCorresponds to variant rs11567806dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28488 mRNA. Translation: AAC50374.1.
Z73157 mRNA. Translation: CAA97504.1.
U62027 mRNA. Translation: AAC50657.1.
AB065870 Genomic DNA. Translation: BAC06088.1.
AY268431 Genomic DNA. Translation: AAP23198.1.
AY455929 Genomic DNA. Translation: AAR13862.1.
BC020742 mRNA. Translation: AAH20742.1.
CCDSiCCDS8588.1.
PIRiS65766.
RefSeqiNP_001313404.1. NM_001326475.1.
NP_001313406.1. NM_001326477.1.
NP_004045.1. NM_004054.3.
UniGeneiHs.504656.
Hs.591148.

Genome annotation databases

EnsembliENST00000307637; ENSP00000302079; ENSG00000171860.
GeneIDi719.
KEGGihsa:719.
UCSCiuc001qtv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28488 mRNA. Translation: AAC50374.1.
Z73157 mRNA. Translation: CAA97504.1.
U62027 mRNA. Translation: AAC50657.1.
AB065870 Genomic DNA. Translation: BAC06088.1.
AY268431 Genomic DNA. Translation: AAP23198.1.
AY455929 Genomic DNA. Translation: AAR13862.1.
BC020742 mRNA. Translation: AAH20742.1.
CCDSiCCDS8588.1.
PIRiS65766.
RefSeqiNP_001313404.1. NM_001326475.1.
NP_001313406.1. NM_001326477.1.
NP_004045.1. NM_004054.3.
UniGeneiHs.504656.
Hs.591148.

3D structure databases

ProteinModelPortaliQ16581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107180. 92 interactors.
STRINGi9606.ENSP00000302079.

Chemistry databases

BindingDBiQ16581.
ChEMBLiCHEMBL4761.
GuidetoPHARMACOLOGYi31.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ16581.
PhosphoSitePlusiQ16581.
UniCarbKBiQ16581.

Polymorphism and mutation databases

BioMutaiC3AR1.
DMDMi37538305.

Proteomic databases

PaxDbiQ16581.
PeptideAtlasiQ16581.
PRIDEiQ16581.

Protocols and materials databases

DNASUi719.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307637; ENSP00000302079; ENSG00000171860.
GeneIDi719.
KEGGihsa:719.
UCSCiuc001qtv.2. human.

Organism-specific databases

CTDi719.
DisGeNETi719.
GeneCardsiC3AR1.
HGNCiHGNC:1319. C3AR1.
HPAiCAB009405.
MIMi605246. gene.
neXtProtiNX_Q16581.
OpenTargetsiENSG00000171860.
PharmGKBiPA25898.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiQ16581.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG091G0AEJ.
PhylomeDBiQ16581.
TreeFamiTF330976.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171860-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-977606. Regulation of Complement cascade.

Miscellaneous databases

ChiTaRSiC3AR1. human.
GeneWikiiC3a_receptor.
GenomeRNAii719.
PROiQ16581.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171860.
CleanExiHS_C3AR1.
ExpressionAtlasiQ16581. baseline and differential.
GenevisibleiQ16581. HS.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC3AR_HUMAN
AccessioniPrimary (citable) accession number: Q16581
Secondary accession number(s): O43771, Q92868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2003
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.