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Q16581

- C3AR_HUMAN

UniProt

Q16581 - C3AR_HUMAN

Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3AR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (03 Oct 2003)
      Previous versions | rss
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    Functioni

    Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

    GO - Molecular functioni

    1. C3a anaphylatoxin receptor activity Source: ProtInc
    2. complement component C3a receptor activity Source: ProtInc
    3. G-protein coupled receptor activity Source: UniProtKB
    4. phosphatidylinositol phospholipase C activity Source: ProtInc

    GO - Biological processi

    1. blood circulation Source: ProtInc
    2. chemotaxis Source: UniProtKB-KW
    3. complement receptor mediated signaling pathway Source: GOC
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. inflammatory response Source: ProtInc
    6. metabolic process Source: GOC
    7. positive regulation of angiogenesis Source: Ensembl
    8. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    9. positive regulation of macrophage chemotaxis Source: Ensembl
    10. positive regulation of neutrophil chemotaxis Source: Ensembl
    11. positive regulation vascular endothelial growth factor production Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C3a anaphylatoxin chemotactic receptor
    Short name:
    C3AR
    Short name:
    C3a-R
    Gene namesi
    Name:C3AR1
    Synonyms:AZ3B, C3R1, HNFAG09
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:1319. C3AR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25898.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482C3a anaphylatoxin chemotactic receptorPRO_0000069202Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
    Modified residuei174 – 1741Sulfotyrosine1 Publication
    Modified residuei184 – 1841Sulfotyrosine1 Publication
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661O-linked (GalNAc...)1 Publication
    Modified residuei318 – 3181Sulfotyrosine1 Publication

    Post-translational modificationi

    Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.1 Publication
    O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    Proteomic databases

    PaxDbiQ16581.
    PRIDEiQ16581.

    PTM databases

    PhosphoSiteiQ16581.

    Expressioni

    Tissue specificityi

    Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.

    Gene expression databases

    ArrayExpressiQ16581.
    BgeeiQ16581.
    CleanExiHS_C3AR1.
    GenevestigatoriQ16581.

    Organism-specific databases

    HPAiCAB009405.

    Interactioni

    Protein-protein interaction databases

    BioGridi107180. 1 interaction.
    STRINGi9606.ENSP00000302079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16581.
    SMRiQ16581. Positions 24-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 5711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 340180ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 37717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini401 – 41717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini439 – 48244CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4623Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 8023Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei341 – 36020Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei378 – 40023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148047.
    HOGENOMiHOG000261616.
    HOVERGENiHBG002433.
    InParanoidiQ16581.
    KOiK04009.
    OMAiLWVAGLK.
    OrthoDBiEOG7PGDQQ.
    PhylomeDBiQ16581.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR001644. Anaphtx_C3AR1.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF4. PTHR24225:SF4. 1 hit.
    PfamiPF00001. 7tm_1. 2 hits.
    [Graphical view]
    PRINTSiPR01104. ANPHYLATOXNR.
    PR01060. C3ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL    50
    KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS 100
    IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA 150
    FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI 200
    VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT 250
    SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA 300
    SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV 350
    IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS 400
    LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI 450
    QGILEAAFSE ELTRSTHCPS NNVISERNST TV 482
    Length:482
    Mass (Da):53,864
    Last modified:October 3, 2003 - v2
    Checksum:i287E219D98CED203
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511F → C in AAC50657. (PubMed:8702752)Curated
    Sequence conflicti203 – 2031P → R in AAC50374. (PubMed:8605247)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti136 – 1361V → A.1 Publication
    Corresponds to variant rs11567806 [ dbSNP | Ensembl ].
    VAR_019164

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28488 mRNA. Translation: AAC50374.1.
    Z73157 mRNA. Translation: CAA97504.1.
    U62027 mRNA. Translation: AAC50657.1.
    AB065870 Genomic DNA. Translation: BAC06088.1.
    AY268431 Genomic DNA. Translation: AAP23198.1.
    AY455929 Genomic DNA. Translation: AAR13862.1.
    BC020742 mRNA. Translation: AAH20742.1.
    CCDSiCCDS8588.1.
    PIRiS65766.
    RefSeqiNP_004045.1. NM_004054.2.
    UniGeneiHs.591148.

    Genome annotation databases

    EnsembliENST00000307637; ENSP00000302079; ENSG00000171860.
    GeneIDi719.
    KEGGihsa:719.
    UCSCiuc001qtv.1. human.

    Polymorphism databases

    DMDMi37538305.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28488 mRNA. Translation: AAC50374.1 .
    Z73157 mRNA. Translation: CAA97504.1 .
    U62027 mRNA. Translation: AAC50657.1 .
    AB065870 Genomic DNA. Translation: BAC06088.1 .
    AY268431 Genomic DNA. Translation: AAP23198.1 .
    AY455929 Genomic DNA. Translation: AAR13862.1 .
    BC020742 mRNA. Translation: AAH20742.1 .
    CCDSi CCDS8588.1.
    PIRi S65766.
    RefSeqi NP_004045.1. NM_004054.2.
    UniGenei Hs.591148.

    3D structure databases

    ProteinModelPortali Q16581.
    SMRi Q16581. Positions 24-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107180. 1 interaction.
    STRINGi 9606.ENSP00000302079.

    Chemistry

    BindingDBi Q16581.
    ChEMBLi CHEMBL4761.
    GuidetoPHARMACOLOGYi 31.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q16581.

    Polymorphism databases

    DMDMi 37538305.

    Proteomic databases

    PaxDbi Q16581.
    PRIDEi Q16581.

    Protocols and materials databases

    DNASUi 719.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307637 ; ENSP00000302079 ; ENSG00000171860 .
    GeneIDi 719.
    KEGGi hsa:719.
    UCSCi uc001qtv.1. human.

    Organism-specific databases

    CTDi 719.
    GeneCardsi GC12M008210.
    HGNCi HGNC:1319. C3AR1.
    HPAi CAB009405.
    MIMi 605246. gene.
    neXtProti NX_Q16581.
    PharmGKBi PA25898.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148047.
    HOGENOMi HOG000261616.
    HOVERGENi HBG002433.
    InParanoidi Q16581.
    KOi K04009.
    OMAi LWVAGLK.
    OrthoDBi EOG7PGDQQ.
    PhylomeDBi Q16581.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii C3a_receptor.
    GenomeRNAii 719.
    NextBioi 2926.
    PROi Q16581.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16581.
    Bgeei Q16581.
    CleanExi HS_C3AR1.
    Genevestigatori Q16581.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR001644. Anaphtx_C3AR1.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF4. PTHR24225:SF4. 1 hit.
    Pfami PF00001. 7tm_1. 2 hits.
    [Graphical view ]
    PRINTSi PR01104. ANPHYLATOXNR.
    PR01060. C3ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure."
      Roglic A., Prossnitz E.R., Cavanagh S.L., Pan Z., Zou A., Ye R.D.
      Biochim. Biophys. Acta 1305:39-43(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells."
      Crass T., Raffetseder U., Martin U., Grove M., Klos A., Koehl J., Bautsch W.
      Eur. J. Immunol. 26:1944-1950(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Bautsch W.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. SeattleSNPs variation discovery resource
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-136.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    9. "Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin."
      Gao J., Choe H., Bota D., Wright P.L., Gerard C., Gerard N.P.
      J. Biol. Chem. 278:37902-37908(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SULFATION AT TYR-174; TYR-184 AND TYR-318.
    10. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A., Ruetschi U., Larson G., Nilsson J.
      J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiC3AR_HUMAN
    AccessioniPrimary (citable) accession number: Q16581
    Secondary accession number(s): O43771, Q92868
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 3, 2003
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3