Reviewed,
UniProtKB/Swiss-Prot Q16576 (RBBP7_HUMAN)
Last modified
November 25, 2008.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone-binding protein RBBP7 Alternative name(s): Retinoblastoma-binding protein 7 Short name=RBBP-7 Retinoblastoma-binding protein p46 Histone acetyltransferase type B subunit 2 Nucleosome-remodeling factor subunit RBAP46 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 425 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. |
| Subunit structure | Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1. |
| Subcellular location | |
| Sequence similarities | Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats. |
Ontologies
Keywords | |
|---|---|
| Biological process | DNA replication Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Repeat WD repeat |
| Molecular function | Chromatin regulator Repressor |
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Ref.1Traceable author statement. Source: ProtInc chromatin modificationInferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Ref.1Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein binding Ref.3 Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 425 | 425 | Histone-binding protein RBBP7 | PRO_0000051195 | |||||
Regions | |||||||||
| Repeat | 121 – 152 | 32 | WD 1 | ||||||
| Repeat | 174 – 205 | 32 | WD 2 | ||||||
| Repeat | 224 – 255 | 32 | WD 3 | ||||||
| Repeat | 270 – 301 | 32 | WD 4 | ||||||
| Repeat | 314 – 345 | 32 | WD 5 | ||||||
| Repeat | 371 – 402 | 32 | WD 6 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 119 | 1 | N6-acetyllysine | ||||||
| Modified residue | 354 | 1 | Phosphoserine | ||||||
| Modified residue | 413 | 1 | Phosphoserine | ||||||
| Modified residue | 416 | 1 | Phosphothreonine | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast." Qian Y.-W., Lee E.Y.-H.P. J. Biol. Chem. 270:25507-25513(1995) [PubMed: 7503932] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RB1. |
| [2] | Nielsen M.S., Rasmussen H.H., Dejgaard K., Celis J.E., Leffers H. Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex." Zhang Y., Iratni R., Erdjument-Bromage H., Tempst P., Reinberg D. Cell 89:357-364(1997) [PubMed: 9150135] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN THE SIN3 HDAC COMPLEX. |
| [4] | "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities." Zhang Y., LeRoy G., Seelig H.-P., Lane W.S., Reinberg D. Cell 95:279-289(1998) [PubMed: 9790534] [Abstract] Cited for: IDENTIFICATION IN THE NURD COMPLEX. |
| [5] | "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase." Verreault A., Kaufman P.D., Kobayashi R., Stillman B. Curr. Biol. 8:96-108(1998) [PubMed: 9427644] [Abstract] Cited for: INTERACTION WITH HAT1 AND HISTONE H4. |
| [6] | "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex." Zhang Y., Sun Z.-W., Iratni R., Erdjument-Bromage H., Tempst P., Hampsey M., Reinberg D. Mol. Cell 1:1021-1031(1998) [PubMed: 9651585] [Abstract] Cited for: IDENTIFICATION IN THE SIN3 HDAC COMPLEX. |
| [7] | "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation." Zhang Y., Ng H.-H., Erdjument-Bromage H., Tempst P., Bird A., Reinberg D. Genes Dev. 13:1924-1935(1999) [PubMed: 10444591] [Abstract] Cited for: IDENTIFICATION IN THE NURD COMPLEX. |
| [8] | "BRCA1 interacts with components of the histone deacetylase complex." Yarden R.I., Brody L.C. Proc. Natl. Acad. Sci. U.S.A. 96:4983-4988(1999) [PubMed: 10220405] [Abstract] Cited for: INTERACTION WITH BRCA1 AND RB1. |
| [9] | "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB." Zhang Q., Vo N., Goodman R.H. Mol. Cell. Biol. 20:4970-4978(2000) [PubMed: 10866654] [Abstract] Cited for: FUNCTION, INTERACTION WITH CREBBP. |
| [10] | "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1." Humphrey G.W., Wang Y., Russanova V.R., Hirai T., Qin J., Nakatani Y., Howard B.H. J. Biol. Chem. 276:6817-6824(2001) [PubMed: 11102443] [Abstract] Cited for: IDENTIFICATION IN THE NURD COMPLEX. |
| [11] | "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex." Skowyra D., Zeremski M., Neznanov N., Li M., Choi Y., Uesugi M., Hauser C.A., Gu W., Gudkov A.V., Qin J. J. Biol. Chem. 276:8734-8739(2001) [PubMed: 11118440] [Abstract] Cited for: IDENTIFICATION IN THE SIN3 HDAC COMPLEX. |
| [12] | "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein." Kuzmichev A., Nishioka K., Erdjument-Bromage H., Tempst P., Reinberg D. Genes Dev. 16:2893-2905(2002) [PubMed: 12435631] [Abstract] Cited for: IDENTIFICATION IN THE PRC2/EED-EZH2 COMPLEX WITH EED; EZH2; RBBP4 AND SUZ12, METHYLTRANSFERASE ACTIVITY OF THE COMPLEX. |
| [13] | "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)." Kuzmichev A., Zhang Y., Erdjument-Bromage H., Tempst P., Reinberg D. Mol. Cell. Biol. 22:835-848(2002) [PubMed: 11784859] [Abstract] Cited for: IDENTIFICATION IN THE SIN3 HDAC COMPLEX. |
| [14] | "Isolation of human NURF: a regulator of Engrailed gene expression." Barak O., Lazzaro M.A., Lane W.S., Speicher D.W., Picketts D.J., Shiekhattar R. EMBO J. 22:6089-6100(2003) [PubMed: 14609955] [Abstract] Cited for: IDENTIFICATION IN THE NURF COMPLEX, MASS SPECTROMETRY. |
| [15] | "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity." Yao Y.-L., Yang W.-M. J. Biol. Chem. 278:42560-42568(2003) [PubMed: 12920132] [Abstract] Cited for: IDENTIFICATION IN THE MTA1 HDAC COMPLEX. |
| [16] | "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex." Jiang C.-L., Jin S.-G., Pfeifer G.P. J. Biol. Chem. 279:52456-52464(2004) [PubMed: 15456747] [Abstract] Cited for: INTERACTION WITH MBD3L1. |
| [17] | "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-119, MASS SPECTROMETRY. Tissue: Epithelium. |
| [18] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413 AND THR-416, MASS SPECTROMETRY. |
| [19] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U35143 mRNA. Translation: AAC50231.1. X72841 mRNA. Translation: CAA51360.1. | |||||||||||||||||||
| PIR | I39181. | ||||||||||||||||||
| RefSeq | NP_002884.1. | ||||||||||||||||||
| UniGene | Hs.495755 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP:436N. | ||||||||||||||||||
| IntAct | Q16576. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q16576. | ||||||||||||||||||
2-D gel databases | |||||||||||||||||||
| Aarhus/Ghent-2DPAGE | 7442. IEF. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PeptideAtlas | Q16576. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSG00000102054. Homo sapiens. [Contig view] | ||||||||||||||||||
| GeneID | 5931. | ||||||||||||||||||
| KEGG | hsa:5931. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| H-InvDB | HIX0021315. | ||||||||||||||||||
| HGNC | HGNC:9890. RBBP7. | ||||||||||||||||||
| MIM | 602922. gene. | ||||||||||||||||||
| PharmGKB | PA34254. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
| GeneCards | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOVERGEN | Q16576. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q16576. | ||||||||||||||||||
| CleanEx | HS_RBBP7. | ||||||||||||||||||
| GermOnline | ENSG00000102054. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit. | ||||||||||||||||||
| Pfam | PF00400. WD40. 5 hits. [Graphical view] | ||||||||||||||||||
| PRINTS | PR00320. GPROTEINBRPT. | ||||||||||||||||||
| ProDom | PD000018. WD40. 2 hits. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||
| SMART | SM00320. WD40. 6 hits. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 5 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| LinkHub | Q16576. | ||||||||||||||||||
| NextBio | 23110. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | RBBP7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16576 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


