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Q16570

- ACKR1_HUMAN

UniProt

Q16570 - ACKR1_HUMAN

Protein

Atypical chemokine receptor 1

Gene

ACKR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 3 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

    GO - Molecular functioni

    1. C-C chemokine binding Source: BHF-UCL
    2. G-protein coupled receptor activity Source: UniProtKB-KW
    3. receptor activity Source: ProtInc
    4. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: InterPro
    2. defense response Source: UniProtKB
    3. inflammatory response Source: Ensembl
    4. regulation of chemokine production Source: Ensembl

    Keywords - Molecular functioni

    Blood group antigen, G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Atypical chemokine receptor 1
    Alternative name(s):
    Duffy antigen/chemokine receptor
    Fy glycoprotein
    Short name:
    GpFy
    Glycoprotein D
    Plasmodium vivax receptor
    CD_antigen: CD234
    Gene namesi
    Name:ACKR1
    Synonyms:DARC, FY, GPD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4035. ACKR1.

    Subcellular locationi

    Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein
    Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome
    4. recycling endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi110700. phenotype.
    611162. phenotype.
    611862. phenotype.
    PharmGKBiPA28451.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Atypical chemokine receptor 1PRO_0000152585Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi16 – 161N-linked (GlcNAc...)1 Publication
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi51 ↔ 2761 Publication
    Disulfide bondi129 ↔ 1951 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ16570.

    PTM databases

    PhosphoSiteiQ16570.

    Expressioni

    Tissue specificityi

    Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.

    Gene expression databases

    ArrayExpressiQ16570.
    BgeeiQ16570.
    CleanExiHS_DARC.
    GenevestigatoriQ16570.

    Organism-specific databases

    HPAiHPA016421.
    HPA017672.

    Interactioni

    Protein-protein interaction databases

    BioGridi108808. 2 interactions.
    DIPiDIP-3783N.

    Structurei

    Secondary structure

    1
    336
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi22 – 287

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4NUUX-ray1.95C16-43[»]
    4NUVX-ray2.60C/D14-43[»]
    ProteinModelPortaliQ16570.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 9511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini117 – 12913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini154 – 16613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini188 – 20720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 24416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28722ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 33628CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 15324Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG28176.
    HOVERGENiHBG051419.
    KOiK06574.
    OMAiHCVATPL.
    OrthoDBiEOG7RFTHW.
    PhylomeDBiQ16570.
    TreeFamiTF105419.

    Family and domain databases

    InterProiIPR005384. Duffy_chemokine_rcpt.
    [Graphical view]
    PANTHERiPTHR14181. PTHR14181. 1 hit.
    PRINTSiPR01559. DUFFYANTIGEN.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q16570-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP    50
    CHSCNLLDDS ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA 100
    QLAVGSALFS IVVPVLAPGL GSTRSSALCS LGYCVWYGSA FAQALLLGCH 150
    ASLGHRLGAG QVPGLTLGLT VGIWGVAALL TLPVTLASGA SGGLCTLIYS 200
    TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG PWMNILWAWF 250
    IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT 300
    PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS 336
    Length:336
    Mass (Da):35,553
    Last modified:June 7, 2005 - v3
    Checksum:iC3F2A3E71D972E2D
    GO
    Isoform 1 (identifier: Q16570-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MGNCLHR → MASSGYVLQ

    Show »
    Length:338
    Mass (Da):35,678
    Checksum:i5AC412B001F07F5B
    GO

    Polymorphismi

    DARC is responsible for the Duffy blood group system (FY) [MIMi:110700]. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and Asp-42 to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by the malarial parasite Plasmodium vivax. This allele is found predominantly in population of African origin [MIMi:611162].
    Genetic variations in DARC define the white blood cell count quantitative trait locus 1 (WBCQ1) [MIMi:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, used to determine evidence of acute infammation or infection. Peripheral WBC is the sum of several cell types including neutrophils and lymphocytes, which are the most common types of WBC, as well as less common cell types such as eosinophils, basophils, and monocytes. Elevated WBC has been associated with risk of coronary heart disease, cancer, and all-cause mortality. White blood cell levels have widespread clinical applications including assessment of patients undergoing chemotherapy and evaluation of infection.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421G → D Antigen Fy(b). 5 Publications
    Corresponds to variant rs12075 [ dbSNP | Ensembl ].
    VAR_003480
    Natural varianti89 – 891R → C Antigen Fy(x). 3 Publications
    Corresponds to variant rs34599082 [ dbSNP | Ensembl ].
    VAR_015068
    Natural varianti100 – 1001A → T.2 Publications
    Corresponds to variant rs13962 [ dbSNP | Ensembl ].
    VAR_015069
    Natural varianti203 – 2031L → Q.
    Corresponds to variant rs3027020 [ dbSNP | Ensembl ].
    VAR_044116
    Natural varianti326 – 3261S → F.2 Publications
    Corresponds to variant rs17851570 [ dbSNP | Ensembl ].
    VAR_044117

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77MGNCLHR → MASSGYVLQ in isoform 1. 2 PublicationsVSP_001323

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01839 mRNA. Translation: AAC50055.1.
    X85785 Genomic DNA. Translation: CAA59770.1.
    S76830 Genomic DNA. Translation: AAB33239.1.
    AF055992 Genomic DNA. Translation: AAC72301.1.
    AF030521 mRNA. Translation: AAD20435.1.
    AM887935 Genomic DNA. Translation: CAP12644.1.
    AL035403 Genomic DNA. Translation: CAB56228.1.
    BC017817 mRNA. Translation: AAH17817.1.
    AF100634 Genomic DNA. Translation: AAF02415.1.
    AF100634 Genomic DNA. Translation: AAF02416.1.
    CCDSiCCDS1183.1. [Q16570-1]
    CCDS44252.1. [Q16570-2]
    PIRiI52608.
    RefSeqiNP_001116423.1. NM_001122951.2. [Q16570-2]
    NP_002027.2. NM_002036.3. [Q16570-1]
    UniGeneiHs.153381.

    Genome annotation databases

    EnsembliENST00000368121; ENSP00000357103; ENSG00000213088. [Q16570-2]
    ENST00000368122; ENSP00000357104; ENSG00000213088. [Q16570-1]
    ENST00000537147; ENSP00000441985; ENSG00000213088. [Q16570-1]
    GeneIDi2532.
    KEGGihsa:2532.
    UCSCiuc001fto.3. human. [Q16570-1]

    Polymorphism databases

    DMDMi67476970.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    Wikipedia

    Duffy antigen entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01839 mRNA. Translation: AAC50055.1 .
    X85785 Genomic DNA. Translation: CAA59770.1 .
    S76830 Genomic DNA. Translation: AAB33239.1 .
    AF055992 Genomic DNA. Translation: AAC72301.1 .
    AF030521 mRNA. Translation: AAD20435.1 .
    AM887935 Genomic DNA. Translation: CAP12644.1 .
    AL035403 Genomic DNA. Translation: CAB56228.1 .
    BC017817 mRNA. Translation: AAH17817.1 .
    AF100634 Genomic DNA. Translation: AAF02415.1 .
    AF100634 Genomic DNA. Translation: AAF02416.1 .
    CCDSi CCDS1183.1. [Q16570-1 ]
    CCDS44252.1. [Q16570-2 ]
    PIRi I52608.
    RefSeqi NP_001116423.1. NM_001122951.2. [Q16570-2 ]
    NP_002027.2. NM_002036.3. [Q16570-1 ]
    UniGenei Hs.153381.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4NUU X-ray 1.95 C 16-43 [» ]
    4NUV X-ray 2.60 C/D 14-43 [» ]
    ProteinModelPortali Q16570.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108808. 2 interactions.
    DIPi DIP-3783N.

    Chemistry

    ChEMBLi CHEMBL2321626.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q16570.

    Polymorphism databases

    DMDMi 67476970.

    Proteomic databases

    PRIDEi Q16570.

    Protocols and materials databases

    DNASUi 2532.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368121 ; ENSP00000357103 ; ENSG00000213088 . [Q16570-2 ]
    ENST00000368122 ; ENSP00000357104 ; ENSG00000213088 . [Q16570-1 ]
    ENST00000537147 ; ENSP00000441985 ; ENSG00000213088 . [Q16570-1 ]
    GeneIDi 2532.
    KEGGi hsa:2532.
    UCSCi uc001fto.3. human. [Q16570-1 ]

    Organism-specific databases

    CTDi 2532.
    GeneCardsi GC01P159173.
    HGNCi HGNC:4035. ACKR1.
    HPAi HPA016421.
    HPA017672.
    MIMi 110700. phenotype.
    611162. phenotype.
    611862. phenotype.
    613665. gene.
    neXtProti NX_Q16570.
    PharmGKBi PA28451.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28176.
    HOVERGENi HBG051419.
    KOi K06574.
    OMAi HCVATPL.
    OrthoDBi EOG7RFTHW.
    PhylomeDBi Q16570.
    TreeFami TF105419.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.

    Miscellaneous databases

    ChiTaRSi DARC. human.
    GeneWikii Duffy_antigen_system.
    GenomeRNAii 2532.
    NextBioi 9987.
    PROi Q16570.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16570.
    Bgeei Q16570.
    CleanExi HS_DARC.
    Genevestigatori Q16570.

    Family and domain databases

    InterProi IPR005384. Duffy_chemokine_rcpt.
    [Graphical view ]
    PANTHERi PTHR14181. PTHR14181. 1 hit.
    PRINTSi PR01559. DUFFYANTIGEN.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite."
      Chaudhuri A., Polyakova J., Zbrzezna V., Williams K., Gulati S., Pogo A.
      Proc. Natl. Acad. Sci. U.S.A. 90:10793-10797(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, VARIANT ASP-42.
      Tissue: Bone marrow.
    2. "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals."
      Tournamille C., Colin Y., Cartron J.-P., Le van Kim C.
      Nat. Genet. 10:224-228(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-42.
      Tissue: Blood.
    3. "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue."
      Iwamoto S., Omi T., Kajii E., Ikemoto S.
      Blood 85:622-626(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    4. "Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals."
      Tournamille C., Le Van Kim C., Gane P., Le Pennec P.Y., Roubinet F., Babinet J., Cartron J.-P., Colin Y.
      Blood 92:2147-2156(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), VARIANTS ASP-42; CYS-89 AND THR-100.
      Tissue: Blood.
    5. "The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein."
      Olsson M.L., Smythe J.S., Hansson C., Poole J., Mallinson G., Jones J., Avent N.D., Daniels G.
      Br. J. Haematol. 103:1184-1191(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-42; CYS-89 AND THR-100.
    6. "New polymorphisms in DARC."
      Doescher A.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-326.
      Tissue: Peripheral blood.
    7. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-326.
      Tissue: Lung.
    9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117 (ISOFORMS 1 AND 2).
    10. "Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites."
      Tournamille C., Filipe A., Wasniowska K., Gane P., Lisowska E., Cartron J.-P., Colin Y., Le Van Kim C.
      Br. J. Haematol. 122:1014-1023(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, GLYCOSYLATION AT ASN-16.
    11. Cited for: POLYMORPHISM, INVOLVEMENT IN RESISTANCE TO MALARIA.
    12. "Chemokine decoy receptors: structure-function and biological properties."
      Bonecchi R., Savino B., Borroni E.M., Mantovani A., Locati M.
      Curr. Top. Microbiol. Immunol. 341:15-36(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    13. "Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines."
      Novitzky-Basso I., Rot A.
      Front. Immunol. 3:266-266(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    14. "The biochemistry and biology of the atypical chemokine receptors."
      Graham G.J., Locati M., Mantovani A., Rot A., Thelen M.
      Immunol. Lett. 145:30-38(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    15. Cited for: REVIEW.
    16. "Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism."
      Tournamille C., Le van Kim C., Gane P., Cartron J.-P., Colin Y.
      Hum. Genet. 95:407-410(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASP-42.
      Tissue: Peripheral blood.
    17. "A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype."
      Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S.
      Blood 92:2237-2243(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-89.
    18. "Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies."
      Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M., Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V., Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A., Reich D., Harris T.B., Ziv E.
      Am. J. Hum. Genet. 82:81-87(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN WBCQ1.

    Entry informationi

    Entry nameiACKR1_HUMAN
    AccessioniPrimary (citable) accession number: Q16570
    Secondary accession number(s): A8YPG5
    , O75898, Q16300, Q8WWE3, Q9UJP0, Q9UKZ5, Q9UKZ6, Q9UQE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 139 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    3. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    4. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    6. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    7. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    8. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    9. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3