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Protein

Atypical chemokine receptor 1

Gene

ACKR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

GO - Molecular functioni

  1. C-C chemokine binding Source: BHF-UCL
  2. G-protein coupled receptor activity Source: UniProtKB-KW
  3. receptor activity Source: ProtInc
  4. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. chemokine-mediated signaling pathway Source: InterPro
  2. defense response Source: UniProtKB
  3. inflammatory response Source: Ensembl
  4. regulation of chemokine production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 1
Alternative name(s):
Duffy antigen/chemokine receptor
Fy glycoprotein
Short name:
GpFy
Glycoprotein D
Plasmodium vivax receptor
CD_antigen: CD234
Gene namesi
Name:ACKR1
Synonyms:DARC, FY, GPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4035. ACKR1.

Subcellular locationi

Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein
Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363ExtracellularSequence AnalysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini85 – 9511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini117 – 12913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei130 – 15324Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini154 – 16613CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini188 – 20720ExtracellularSequence AnalysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini229 – 24416CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28722ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 33628CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
  4. recycling endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi110700. phenotype.
611162. phenotype.
611862. phenotype.
PharmGKBiPA28451.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Atypical chemokine receptor 1PRO_0000152585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)1 Publication
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi51 ↔ 2761 Publication
Disulfide bondi129 ↔ 1951 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ16570.

PTM databases

PhosphoSiteiQ16570.

Expressioni

Tissue specificityi

Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.

Gene expression databases

BgeeiQ16570.
CleanExiHS_DARC.
ExpressionAtlasiQ16570. baseline and differential.
GenevestigatoriQ16570.

Organism-specific databases

HPAiHPA016421.
HPA017672.

Interactioni

Protein-protein interaction databases

BioGridi108808. 2 interactions.
DIPiDIP-3783N.

Structurei

Secondary structure

1
336
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 287Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NUUX-ray1.95C16-43[»]
4NUVX-ray2.60C/D14-43[»]
ProteinModelPortaliQ16570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28176.
HOVERGENiHBG051419.
InParanoidiQ16570.
KOiK06574.
OMAiHCVATPL.
OrthoDBiEOG7RFTHW.
PhylomeDBiQ16570.
TreeFamiTF105419.

Family and domain databases

InterProiIPR005384. Duffy_chemokine_rcpt.
[Graphical view]
PANTHERiPTHR14181. PTHR14181. 1 hit.
PRINTSiPR01559. DUFFYANTIGEN.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q16570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP
60 70 80 90 100
CHSCNLLDDS ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA
110 120 130 140 150
QLAVGSALFS IVVPVLAPGL GSTRSSALCS LGYCVWYGSA FAQALLLGCH
160 170 180 190 200
ASLGHRLGAG QVPGLTLGLT VGIWGVAALL TLPVTLASGA SGGLCTLIYS
210 220 230 240 250
TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG PWMNILWAWF
260 270 280 290 300
IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT
310 320 330
PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS
Length:336
Mass (Da):35,553
Last modified:June 6, 2005 - v3
Checksum:iC3F2A3E71D972E2D
GO
Isoform 1 (identifier: Q16570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MGNCLHR → MASSGYVLQ

Show »
Length:338
Mass (Da):35,678
Checksum:i5AC412B001F07F5B
GO

Polymorphismi

DARC is responsible for the Duffy blood group system (FY) [MIMi:110700]. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and Asp-42 to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by the malarial parasite Plasmodium vivax. This allele is found predominantly in population of African origin [MIMi:611162].
Genetic variations in DARC define the white blood cell count quantitative trait locus 1 (WBCQ1) [MIMi:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, used to determine evidence of acute infammation or infection. Peripheral WBC is the sum of several cell types including neutrophils and lymphocytes, which are the most common types of WBC, as well as less common cell types such as eosinophils, basophils, and monocytes. Elevated WBC has been associated with risk of coronary heart disease, cancer, and all-cause mortality. White blood cell levels have widespread clinical applications including assessment of patients undergoing chemotherapy and evaluation of infection.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421G → D Antigen Fy(b). 5 Publications
Corresponds to variant rs12075 [ dbSNP | Ensembl ].
VAR_003480
Natural varianti89 – 891R → C Antigen Fy(x). 3 Publications
Corresponds to variant rs34599082 [ dbSNP | Ensembl ].
VAR_015068
Natural varianti100 – 1001A → T.2 Publications
Corresponds to variant rs13962 [ dbSNP | Ensembl ].
VAR_015069
Natural varianti203 – 2031L → Q.
Corresponds to variant rs3027020 [ dbSNP | Ensembl ].
VAR_044116
Natural varianti326 – 3261S → F.2 Publications
Corresponds to variant rs17851570 [ dbSNP | Ensembl ].
VAR_044117

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77MGNCLHR → MASSGYVLQ in isoform 1. 2 PublicationsVSP_001323

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01839 mRNA. Translation: AAC50055.1.
X85785 Genomic DNA. Translation: CAA59770.1.
S76830 Genomic DNA. Translation: AAB33239.1.
AF055992 Genomic DNA. Translation: AAC72301.1.
AF030521 mRNA. Translation: AAD20435.1.
AM887935 Genomic DNA. Translation: CAP12644.1.
AL035403 Genomic DNA. Translation: CAB56228.1.
BC017817 mRNA. Translation: AAH17817.1.
AF100634 Genomic DNA. Translation: AAF02415.1.
AF100634 Genomic DNA. Translation: AAF02416.1.
CCDSiCCDS1183.1. [Q16570-1]
CCDS44252.1. [Q16570-2]
PIRiI52608.
RefSeqiNP_001116423.1. NM_001122951.2. [Q16570-2]
NP_002027.2. NM_002036.3. [Q16570-1]
UniGeneiHs.153381.

Genome annotation databases

EnsembliENST00000368121; ENSP00000357103; ENSG00000213088. [Q16570-2]
ENST00000368122; ENSP00000357104; ENSG00000213088. [Q16570-1]
ENST00000537147; ENSP00000441985; ENSG00000213088. [Q16570-1]
GeneIDi2532.
KEGGihsa:2532.
UCSCiuc001fto.3. human. [Q16570-1]

Polymorphism databases

DMDMi67476970.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

Duffy antigen entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01839 mRNA. Translation: AAC50055.1.
X85785 Genomic DNA. Translation: CAA59770.1.
S76830 Genomic DNA. Translation: AAB33239.1.
AF055992 Genomic DNA. Translation: AAC72301.1.
AF030521 mRNA. Translation: AAD20435.1.
AM887935 Genomic DNA. Translation: CAP12644.1.
AL035403 Genomic DNA. Translation: CAB56228.1.
BC017817 mRNA. Translation: AAH17817.1.
AF100634 Genomic DNA. Translation: AAF02415.1.
AF100634 Genomic DNA. Translation: AAF02416.1.
CCDSiCCDS1183.1. [Q16570-1]
CCDS44252.1. [Q16570-2]
PIRiI52608.
RefSeqiNP_001116423.1. NM_001122951.2. [Q16570-2]
NP_002027.2. NM_002036.3. [Q16570-1]
UniGeneiHs.153381.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NUUX-ray1.95C16-43[»]
4NUVX-ray2.60C/D14-43[»]
ProteinModelPortaliQ16570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108808. 2 interactions.
DIPiDIP-3783N.

Chemistry

ChEMBLiCHEMBL2321626.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ16570.

Polymorphism databases

DMDMi67476970.

Proteomic databases

PRIDEiQ16570.

Protocols and materials databases

DNASUi2532.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368121; ENSP00000357103; ENSG00000213088. [Q16570-2]
ENST00000368122; ENSP00000357104; ENSG00000213088. [Q16570-1]
ENST00000537147; ENSP00000441985; ENSG00000213088. [Q16570-1]
GeneIDi2532.
KEGGihsa:2532.
UCSCiuc001fto.3. human. [Q16570-1]

Organism-specific databases

CTDi2532.
GeneCardsiGC01P159173.
HGNCiHGNC:4035. ACKR1.
HPAiHPA016421.
HPA017672.
MIMi110700. phenotype.
611162. phenotype.
611862. phenotype.
613665. gene.
neXtProtiNX_Q16570.
PharmGKBiPA28451.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28176.
HOVERGENiHBG051419.
InParanoidiQ16570.
KOiK06574.
OMAiHCVATPL.
OrthoDBiEOG7RFTHW.
PhylomeDBiQ16570.
TreeFamiTF105419.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.

Miscellaneous databases

GeneWikiiDuffy_antigen_system.
GenomeRNAii2532.
NextBioi9987.
PROiQ16570.
SOURCEiSearch...

Gene expression databases

BgeeiQ16570.
CleanExiHS_DARC.
ExpressionAtlasiQ16570. baseline and differential.
GenevestigatoriQ16570.

Family and domain databases

InterProiIPR005384. Duffy_chemokine_rcpt.
[Graphical view]
PANTHERiPTHR14181. PTHR14181. 1 hit.
PRINTSiPR01559. DUFFYANTIGEN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite."
    Chaudhuri A., Polyakova J., Zbrzezna V., Williams K., Gulati S., Pogo A.
    Proc. Natl. Acad. Sci. U.S.A. 90:10793-10797(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, VARIANT ASP-42.
    Tissue: Bone marrow.
  2. "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals."
    Tournamille C., Colin Y., Cartron J.-P., Le van Kim C.
    Nat. Genet. 10:224-228(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-42.
    Tissue: Blood.
  3. "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue."
    Iwamoto S., Omi T., Kajii E., Ikemoto S.
    Blood 85:622-626(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  4. "Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals."
    Tournamille C., Le Van Kim C., Gane P., Le Pennec P.Y., Roubinet F., Babinet J., Cartron J.-P., Colin Y.
    Blood 92:2147-2156(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), VARIANTS ASP-42; CYS-89 AND THR-100.
    Tissue: Blood.
  5. "The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein."
    Olsson M.L., Smythe J.S., Hansson C., Poole J., Mallinson G., Jones J., Avent N.D., Daniels G.
    Br. J. Haematol. 103:1184-1191(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-42; CYS-89 AND THR-100.
  6. "New polymorphisms in DARC."
    Doescher A.
    Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-326.
    Tissue: Peripheral blood.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-326.
    Tissue: Lung.
  9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117 (ISOFORMS 1 AND 2).
  10. "Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites."
    Tournamille C., Filipe A., Wasniowska K., Gane P., Lisowska E., Cartron J.-P., Colin Y., Le Van Kim C.
    Br. J. Haematol. 122:1014-1023(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, GLYCOSYLATION AT ASN-16.
  11. Cited for: POLYMORPHISM, INVOLVEMENT IN RESISTANCE TO MALARIA.
  12. "Chemokine decoy receptors: structure-function and biological properties."
    Bonecchi R., Savino B., Borroni E.M., Mantovani A., Locati M.
    Curr. Top. Microbiol. Immunol. 341:15-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. "Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines."
    Novitzky-Basso I., Rot A.
    Front. Immunol. 3:266-266(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  14. "The biochemistry and biology of the atypical chemokine receptors."
    Graham G.J., Locati M., Mantovani A., Rot A., Thelen M.
    Immunol. Lett. 145:30-38(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  15. Cited for: REVIEW.
  16. "Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism."
    Tournamille C., Le van Kim C., Gane P., Cartron J.-P., Colin Y.
    Hum. Genet. 95:407-410(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASP-42.
    Tissue: Peripheral blood.
  17. "A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype."
    Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S.
    Blood 92:2237-2243(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYS-89.
  18. "Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies."
    Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M., Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V., Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A., Reich D., Harris T.B., Ziv E.
    Am. J. Hum. Genet. 82:81-87(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN WBCQ1.

Entry informationi

Entry nameiACKR1_HUMAN
AccessioniPrimary (citable) accession number: Q16570
Secondary accession number(s): A8YPG5
, O75898, Q16300, Q8WWE3, Q9UJP0, Q9UKZ5, Q9UKZ6, Q9UQE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: June 6, 2005
Last modified: January 6, 2015
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  9. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.