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Protein

Synaptophysin-like protein 1

Gene

SYPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • synaptic transmission Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 1
Alternative name(s):
Pantophysin
Gene namesi
Name:SYPL1
Synonyms:SYPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11507. SYPL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 11662VesicularSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 15013CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Topological domaini172 – 21241VesicularSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Topological domaini234 – 25926CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • integral component of synaptic vesicle membrane Source: GO_Central
  • melanosome Source: UniProtKB-SubCell
  • secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36289.

Polymorphism and mutation databases

BioMutaiSYPL1.
DMDMi48474786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Synaptophysin-like protein 1PRO_0000179164Add
BLAST
Isoform 2 (identifier: Q16563-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ16563.
MaxQBiQ16563.
PaxDbiQ16563.
PRIDEiQ16563.

PTM databases

iPTMnetiQ16563.
PhosphoSiteiQ16563.
SwissPalmiQ16563.

Expressioni

Gene expression databases

BgeeiQ16563.
CleanExiHS_SYPL1.
ExpressionAtlasiQ16563. baseline and differential.
GenevisibleiQ16563. HS.

Organism-specific databases

HPAiHPA014141.

Interactioni

Protein-protein interaction databases

BioGridi112722. 5 interactions.
IntActiQ16563. 4 interactions.
MINTiMINT-5004674.
STRINGi9606.ENSP00000011473.

Structurei

3D structure databases

ProteinModelPortaliQ16563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 237210MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9X. Eukaryota.
ENOG4111FYV. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ16563.
OMAiRMSGFQI.
OrthoDBiEOG7WT43S.
PhylomeDBiQ16563.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPNIYLVRQ RISRLGQRMS GFQINLNPLK EPLGFIKVLE WIASIFAFAT
60 70 80 90 100
CGGFKGQTEI QVNCPPAVTE NKTVTATFGY PFRLNEASFQ PPPGVNICDV
110 120 130 140 150
NWKDYVLIGD YSSSAQFYVT FAVFVFLYCI AALLLYVGYT SLYLDSRKLP
160 170 180 190 200
MIDFVVTLVA TFLWLVSTSA WAKALTDIKI ATGHNIIDEL PPCKKKAVLC
210 220 230 240 250
YFGSVTSMGS LNVSVIFGFL NMILWGGNAW FVYKETSLHS PSNTSAPHSQ

GGIPPPTGI
Length:259
Mass (Da):28,565
Last modified:November 1, 1996 - v1
Checksum:i20D553779AA82085
GO
Isoform 2 (identifier: Q16563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:241
Mass (Da):26,412
Checksum:i74FECF2A10412BA7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 195LGQRM → HLQGR in X61382 (PubMed:1730063).Curated
Sequence conflicti163 – 1653LWL → CGW (PubMed:1730063).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818Missing in isoform 2. 1 PublicationVSP_008557Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72481 mRNA. Translation: AAB31344.1.
X68194 mRNA. Translation: CAA48276.1.
AC005095 Genomic DNA. Translation: AAD50513.1.
CH236947 Genomic DNA. Translation: EAL24402.1.
CH471070 Genomic DNA. Translation: EAW83380.1.
BC016835 mRNA. Translation: AAH16835.3.
BC020938 mRNA. Translation: AAH20938.1.
BC061887 mRNA. Translation: AAH61887.1.
X61382 mRNA. No translation available.
CCDSiCCDS47685.1. [Q16563-2]
CCDS5736.1. [Q16563-1]
PIRiI53171.
S20316.
RefSeqiNP_006745.1. NM_006754.3. [Q16563-1]
NP_874384.1. NM_182715.2. [Q16563-2]
UniGeneiHs.80919.

Genome annotation databases

EnsembliENST00000011473; ENSP00000011473; ENSG00000008282. [Q16563-1]
ENST00000455385; ENSP00000388336; ENSG00000008282. [Q16563-2]
GeneIDi6856.
KEGGihsa:6856.
UCSCiuc003vdo.5. human. [Q16563-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72481 mRNA. Translation: AAB31344.1.
X68194 mRNA. Translation: CAA48276.1.
AC005095 Genomic DNA. Translation: AAD50513.1.
CH236947 Genomic DNA. Translation: EAL24402.1.
CH471070 Genomic DNA. Translation: EAW83380.1.
BC016835 mRNA. Translation: AAH16835.3.
BC020938 mRNA. Translation: AAH20938.1.
BC061887 mRNA. Translation: AAH61887.1.
X61382 mRNA. No translation available.
CCDSiCCDS47685.1. [Q16563-2]
CCDS5736.1. [Q16563-1]
PIRiI53171.
S20316.
RefSeqiNP_006745.1. NM_006754.3. [Q16563-1]
NP_874384.1. NM_182715.2. [Q16563-2]
UniGeneiHs.80919.

3D structure databases

ProteinModelPortaliQ16563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112722. 5 interactions.
IntActiQ16563. 4 interactions.
MINTiMINT-5004674.
STRINGi9606.ENSP00000011473.

PTM databases

iPTMnetiQ16563.
PhosphoSiteiQ16563.
SwissPalmiQ16563.

Polymorphism and mutation databases

BioMutaiSYPL1.
DMDMi48474786.

Proteomic databases

EPDiQ16563.
MaxQBiQ16563.
PaxDbiQ16563.
PRIDEiQ16563.

Protocols and materials databases

DNASUi6856.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000011473; ENSP00000011473; ENSG00000008282. [Q16563-1]
ENST00000455385; ENSP00000388336; ENSG00000008282. [Q16563-2]
GeneIDi6856.
KEGGihsa:6856.
UCSCiuc003vdo.5. human. [Q16563-1]

Organism-specific databases

CTDi6856.
GeneCardsiSYPL1.
HGNCiHGNC:11507. SYPL1.
HPAiHPA014141.
neXtProtiNX_Q16563.
PharmGKBiPA36289.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9X. Eukaryota.
ENOG4111FYV. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ16563.
OMAiRMSGFQI.
OrthoDBiEOG7WT43S.
PhylomeDBiQ16563.
TreeFamiTF315804.

Miscellaneous databases

GeneWikiiSYPL1.
GenomeRNAii6856.
PROiQ16563.

Gene expression databases

BgeeiQ16563.
CleanExiHS_SYPL1.
ExpressionAtlasiQ16563. baseline and differential.
GenevisibleiQ16563. HS.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human."
    Leube R.E.
    Differentiation 56:163-171(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Keratinocyte.
  2. Isojima S.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Lung.
  7. "Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin."
    Zhong C.Z., Hayzer D.J., Runge M.S.
    Biochim. Biophys. Acta 1129:235-238(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-165 (ISOFORM 1).
    Tissue: Blood.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
    Tissue: Liver.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYPL1_HUMAN
AccessioniPrimary (citable) accession number: Q16563
Secondary accession number(s): A4D0R2, Q96AR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.