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Protein

Synaptophysin-like protein 1

Gene

SYPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000008282-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 1
Alternative name(s):
Pantophysin
Gene namesi
Name:SYPL1
Synonyms:SYPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11507. SYPL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 116VesicularSequence analysisAdd BLAST62
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 212VesicularSequence analysisAdd BLAST41
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 259CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • integral component of synaptic vesicle membrane Source: GO_Central
  • melanosome Source: UniProtKB-SubCell
  • secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6856.
OpenTargetsiENSG00000008282.
PharmGKBiPA36289.

Polymorphism and mutation databases

BioMutaiSYPL1.
DMDMi48474786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791641 – 259Synaptophysin-like protein 1Add BLAST259
Isoform 2 (identifier: Q16563-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)1 Publication1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ16563.
MaxQBiQ16563.
PaxDbiQ16563.
PeptideAtlasiQ16563.
PRIDEiQ16563.

PTM databases

iPTMnetiQ16563.
PhosphoSitePlusiQ16563.
SwissPalmiQ16563.

Expressioni

Gene expression databases

BgeeiENSG00000008282.
CleanExiHS_SYPL1.
ExpressionAtlasiQ16563. baseline and differential.
GenevisibleiQ16563. HS.

Organism-specific databases

HPAiHPA014141.

Interactioni

Protein-protein interaction databases

BioGridi112722. 5 interactors.
IntActiQ16563. 4 interactors.
MINTiMINT-5004674.
STRINGi9606.ENSP00000011473.

Structurei

3D structure databases

ProteinModelPortaliQ16563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 237MARVELPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9X. Eukaryota.
ENOG4111FYV. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ16563.
OMAiRMSGFQI.
OrthoDBiEOG091G0ZEI.
PhylomeDBiQ16563.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPNIYLVRQ RISRLGQRMS GFQINLNPLK EPLGFIKVLE WIASIFAFAT
60 70 80 90 100
CGGFKGQTEI QVNCPPAVTE NKTVTATFGY PFRLNEASFQ PPPGVNICDV
110 120 130 140 150
NWKDYVLIGD YSSSAQFYVT FAVFVFLYCI AALLLYVGYT SLYLDSRKLP
160 170 180 190 200
MIDFVVTLVA TFLWLVSTSA WAKALTDIKI ATGHNIIDEL PPCKKKAVLC
210 220 230 240 250
YFGSVTSMGS LNVSVIFGFL NMILWGGNAW FVYKETSLHS PSNTSAPHSQ

GGIPPPTGI
Length:259
Mass (Da):28,565
Last modified:November 1, 1996 - v1
Checksum:i20D553779AA82085
GO
Isoform 2 (identifier: Q16563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:241
Mass (Da):26,412
Checksum:i74FECF2A10412BA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 19LGQRM → HLQGR in X61382 (PubMed:1730063).Curated5
Sequence conflicti163 – 165LWL → CGW (PubMed:1730063).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085571 – 18Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72481 mRNA. Translation: AAB31344.1.
X68194 mRNA. Translation: CAA48276.1.
AC005095 Genomic DNA. Translation: AAD50513.1.
CH236947 Genomic DNA. Translation: EAL24402.1.
CH471070 Genomic DNA. Translation: EAW83380.1.
BC016835 mRNA. Translation: AAH16835.3.
BC020938 mRNA. Translation: AAH20938.1.
BC061887 mRNA. Translation: AAH61887.1.
X61382 mRNA. No translation available.
CCDSiCCDS47685.1. [Q16563-2]
CCDS5736.1. [Q16563-1]
PIRiI53171.
S20316.
RefSeqiNP_006745.1. NM_006754.3. [Q16563-1]
NP_874384.1. NM_182715.2. [Q16563-2]
UniGeneiHs.80919.

Genome annotation databases

EnsembliENST00000011473; ENSP00000011473; ENSG00000008282. [Q16563-1]
ENST00000455385; ENSP00000388336; ENSG00000008282. [Q16563-2]
GeneIDi6856.
KEGGihsa:6856.
UCSCiuc003vdo.5. human. [Q16563-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72481 mRNA. Translation: AAB31344.1.
X68194 mRNA. Translation: CAA48276.1.
AC005095 Genomic DNA. Translation: AAD50513.1.
CH236947 Genomic DNA. Translation: EAL24402.1.
CH471070 Genomic DNA. Translation: EAW83380.1.
BC016835 mRNA. Translation: AAH16835.3.
BC020938 mRNA. Translation: AAH20938.1.
BC061887 mRNA. Translation: AAH61887.1.
X61382 mRNA. No translation available.
CCDSiCCDS47685.1. [Q16563-2]
CCDS5736.1. [Q16563-1]
PIRiI53171.
S20316.
RefSeqiNP_006745.1. NM_006754.3. [Q16563-1]
NP_874384.1. NM_182715.2. [Q16563-2]
UniGeneiHs.80919.

3D structure databases

ProteinModelPortaliQ16563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112722. 5 interactors.
IntActiQ16563. 4 interactors.
MINTiMINT-5004674.
STRINGi9606.ENSP00000011473.

PTM databases

iPTMnetiQ16563.
PhosphoSitePlusiQ16563.
SwissPalmiQ16563.

Polymorphism and mutation databases

BioMutaiSYPL1.
DMDMi48474786.

Proteomic databases

EPDiQ16563.
MaxQBiQ16563.
PaxDbiQ16563.
PeptideAtlasiQ16563.
PRIDEiQ16563.

Protocols and materials databases

DNASUi6856.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000011473; ENSP00000011473; ENSG00000008282. [Q16563-1]
ENST00000455385; ENSP00000388336; ENSG00000008282. [Q16563-2]
GeneIDi6856.
KEGGihsa:6856.
UCSCiuc003vdo.5. human. [Q16563-1]

Organism-specific databases

CTDi6856.
DisGeNETi6856.
GeneCardsiSYPL1.
HGNCiHGNC:11507. SYPL1.
HPAiHPA014141.
neXtProtiNX_Q16563.
OpenTargetsiENSG00000008282.
PharmGKBiPA36289.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9X. Eukaryota.
ENOG4111FYV. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ16563.
OMAiRMSGFQI.
OrthoDBiEOG091G0ZEI.
PhylomeDBiQ16563.
TreeFamiTF315804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000008282-MONOMER.

Miscellaneous databases

GeneWikiiSYPL1.
GenomeRNAii6856.
PROiQ16563.

Gene expression databases

BgeeiENSG00000008282.
CleanExiHS_SYPL1.
ExpressionAtlasiQ16563. baseline and differential.
GenevisibleiQ16563. HS.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYPL1_HUMAN
AccessioniPrimary (citable) accession number: Q16563
Secondary accession number(s): A4D0R2, Q96AR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.