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Protein

U11/U12 small nuclear ribonucleoprotein 35 kDa protein

Gene

SNRNP35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • RNA splicing Source: HGNC
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Short name:
U11/U12 snRNP 35 kDa protein
Short name:
U11/U12-35K
Alternative name(s):
Protein HM-1
U1 snRNP-binding protein homolog
Gene namesi
Name:SNRNP35
Synonyms:HM1, U1SNRNPBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30852. SNRNP35.

Subcellular locationi

GO - Cellular componenti

  • commitment complex Source: GO_Central
  • nucleoplasm Source: Reactome
  • nucleus Source: MGI
  • precatalytic spliceosome Source: GO_Central
  • U12-type spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726115.

Polymorphism and mutation databases

DMDMi74754517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246U11/U12 small nuclear ribonucleoprotein 35 kDa proteinPRO_0000307907Add
BLAST

Proteomic databases

EPDiQ16560.
MaxQBiQ16560.
PaxDbiQ16560.
PeptideAtlasiQ16560.
PRIDEiQ16560.

PTM databases

iPTMnetiQ16560.
PhosphoSiteiQ16560.

Expressioni

Tissue specificityi

Expressed in heart, liver, skeletal muscle and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000184209.
CleanExiHS_SNRNP35.
ExpressionAtlasiQ16560. baseline and differential.
GenevisibleiQ16560. HS.

Organism-specific databases

HPAiHPA059145.
HPA067031.

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.1 Publication

Protein-protein interaction databases

BioGridi116250. 17 interactions.
IntActiQ16560. 6 interactions.
MINTiMINT-8247502.
STRINGi9606.ENSP00000403310.

Structurei

3D structure databases

ProteinModelPortaliQ16560.
SMRiQ16560. Positions 47-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12979RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 24491Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0113. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00530000063750.
HOGENOMiHOG000006374.
HOVERGENiHBG104583.
InParanoidiQ16560.
KOiK13155.
OMAiFVEMKSE.
OrthoDBiEOG091G0NV3.
PhylomeDBiQ16560.
TreeFamiTF331614.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDWMPIAKE YDPLKAGSID GTDEDPHDRA VWRAMLARYV PNKGVIGDPL
60 70 80 90 100
LTLFVARLNL QTKEDKLKEV FSRYGDIRRL RLVRDLVTGF SKGYAFIEYK
110 120 130 140 150
EERAVIKAYR DADGLVIDQH EIFVDYELER TLKGWIPRRL GGGLGGKKES
160 170 180 190 200
GQLRFGGRDR PFRKPINLPV VKNDLYREGK RERRERSRSR ERHWDSRTRD
210 220 230 240
RDHDRGREKR WQEREPTRVW PDNDWERERD FRDDRIKGRE KKERGK
Length:246
Mass (Da):29,450
Last modified:November 1, 1996 - v1
Checksum:iE420E6D719D3B0C7
GO
Isoform 2 (identifier: Q16560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKPANM

Show »
Length:251
Mass (Da):29,992
Checksum:iF42379E28EFBD467
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MKPANM in isoform 2. 1 PublicationVSP_028855

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44798 mRNA. Translation: AAA86654.1.
U44799 mRNA. Translation: AAA86655.1.
AK290127 mRNA. Translation: BAF82816.1.
CH471054 Genomic DNA. Translation: EAW98412.1.
BC009622 mRNA. Translation: AAH09622.1.
BC047678 mRNA. Translation: AAH47678.1.
BC054034 mRNA. Translation: AAH54034.1.
BC093671 mRNA. Translation: AAH93671.1.
BC111955 mRNA. Translation: AAI11956.1.
BK005197 mRNA. Translation: DAA05495.1.
CCDSiCCDS45005.1. [Q16560-2]
CCDS9249.1. [Q16560-1]
PIRiG02371.
RefSeqiNP_073208.1. NM_022717.3. [Q16560-1]
NP_851030.1. NM_180699.3. [Q16560-2]
XP_006719267.1. XM_006719204.3. [Q16560-1]
UniGeneiHs.632738.

Genome annotation databases

EnsembliENST00000350887; ENSP00000340774; ENSG00000184209. [Q16560-1]
ENST00000412157; ENSP00000403310; ENSG00000184209. [Q16560-2]
ENST00000526639; ENSP00000432595; ENSG00000184209. [Q16560-1]
GeneIDi11066.
KEGGihsa:11066.
UCSCiuc001ufb.2. human. [Q16560-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44798 mRNA. Translation: AAA86654.1.
U44799 mRNA. Translation: AAA86655.1.
AK290127 mRNA. Translation: BAF82816.1.
CH471054 Genomic DNA. Translation: EAW98412.1.
BC009622 mRNA. Translation: AAH09622.1.
BC047678 mRNA. Translation: AAH47678.1.
BC054034 mRNA. Translation: AAH54034.1.
BC093671 mRNA. Translation: AAH93671.1.
BC111955 mRNA. Translation: AAI11956.1.
BK005197 mRNA. Translation: DAA05495.1.
CCDSiCCDS45005.1. [Q16560-2]
CCDS9249.1. [Q16560-1]
PIRiG02371.
RefSeqiNP_073208.1. NM_022717.3. [Q16560-1]
NP_851030.1. NM_180699.3. [Q16560-2]
XP_006719267.1. XM_006719204.3. [Q16560-1]
UniGeneiHs.632738.

3D structure databases

ProteinModelPortaliQ16560.
SMRiQ16560. Positions 47-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116250. 17 interactions.
IntActiQ16560. 6 interactions.
MINTiMINT-8247502.
STRINGi9606.ENSP00000403310.

PTM databases

iPTMnetiQ16560.
PhosphoSiteiQ16560.

Polymorphism and mutation databases

DMDMi74754517.

Proteomic databases

EPDiQ16560.
MaxQBiQ16560.
PaxDbiQ16560.
PeptideAtlasiQ16560.
PRIDEiQ16560.

Protocols and materials databases

DNASUi11066.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350887; ENSP00000340774; ENSG00000184209. [Q16560-1]
ENST00000412157; ENSP00000403310; ENSG00000184209. [Q16560-2]
ENST00000526639; ENSP00000432595; ENSG00000184209. [Q16560-1]
GeneIDi11066.
KEGGihsa:11066.
UCSCiuc001ufb.2. human. [Q16560-1]

Organism-specific databases

CTDi11066.
GeneCardsiSNRNP35.
HGNCiHGNC:30852. SNRNP35.
HPAiHPA059145.
HPA067031.
neXtProtiNX_Q16560.
PharmGKBiPA164726115.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0113. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00530000063750.
HOGENOMiHOG000006374.
HOVERGENiHBG104583.
InParanoidiQ16560.
KOiK13155.
OMAiFVEMKSE.
OrthoDBiEOG091G0NV3.
PhylomeDBiQ16560.
TreeFamiTF331614.

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

ChiTaRSiSNRNP35. human.
GenomeRNAii11066.
PROiQ16560.

Gene expression databases

BgeeiENSG00000184209.
CleanExiHS_SNRNP35.
ExpressionAtlasiQ16560. baseline and differential.
GenevisibleiQ16560. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiU1SBP_HUMAN
AccessioniPrimary (citable) accession number: Q16560
Secondary accession number(s): A8K262, Q5XKN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.