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Protein

T-cell acute lymphocytic leukemia protein 2

Gene

TAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 2
Short name:
TAL-2
Alternative name(s):
Class A basic helix-loop-helix protein 19
Short name:
bHLHa19
Gene namesi
Name:TAL2
Synonyms:BHLHA19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11557. TAL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA36327.

Polymorphism and mutation databases

BioMutaiTAL2.
DMDMi7531207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108T-cell acute lymphocytic leukemia protein 2PRO_0000127456Add
BLAST

Proteomic databases

PaxDbiQ16559.
PRIDEiQ16559.

PTM databases

PhosphoSiteiQ16559.

Expressioni

Gene expression databases

BgeeiQ16559.
CleanExiHS_TAL2.
GenevestigatoriQ16559.

Organism-specific databases

HPAiHPA030886.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158843EBI-10237959,EBI-533224

Protein-protein interaction databases

BioGridi112750. 7 interactions.
IntActiQ16559. 1 interaction.
STRINGi9606.ENSP00000334547.

Structurei

3D structure databases

ProteinModelPortaliQ16559.
SMRiQ16559. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 5453bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG256466.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000129920.
HOVERGENiHBG004515.
InParanoidiQ16559.
KOiK09068.
OMAiHLPGLEN.
OrthoDBiEOG7SN8DF.
PhylomeDBiQ16559.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY
60 70 80 90 100
INFLVKVLGE QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS

PGPSHHIP
Length:108
Mass (Da):12,291
Last modified:November 1, 1996 - v1
Checksum:iDE9D67D940EF4749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81078 Genomic DNA. Translation: AAA60613.1.
S69377 Genomic DNA. Translation: AAC60629.1.
AL158070 Genomic DNA. Translation: CAC22163.1.
BC069422 mRNA. Translation: AAH69422.1.
BC126373 mRNA. Translation: AAI26374.1.
BC126375 mRNA. Translation: AAI26376.1.
CCDSiCCDS6767.1.
PIRiA41629.
RefSeqiNP_005412.1. NM_005421.2.
UniGeneiHs.247978.

Genome annotation databases

EnsembliENST00000334077; ENSP00000334547; ENSG00000186051.
GeneIDi6887.
KEGGihsa:6887.
UCSCiuc004bct.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81078 Genomic DNA. Translation: AAA60613.1.
S69377 Genomic DNA. Translation: AAC60629.1.
AL158070 Genomic DNA. Translation: CAC22163.1.
BC069422 mRNA. Translation: AAH69422.1.
BC126373 mRNA. Translation: AAI26374.1.
BC126375 mRNA. Translation: AAI26376.1.
CCDSiCCDS6767.1.
PIRiA41629.
RefSeqiNP_005412.1. NM_005421.2.
UniGeneiHs.247978.

3D structure databases

ProteinModelPortaliQ16559.
SMRiQ16559. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112750. 7 interactions.
IntActiQ16559. 1 interaction.
STRINGi9606.ENSP00000334547.

PTM databases

PhosphoSiteiQ16559.

Polymorphism and mutation databases

BioMutaiTAL2.
DMDMi7531207.

Proteomic databases

PaxDbiQ16559.
PRIDEiQ16559.

Protocols and materials databases

DNASUi6887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334077; ENSP00000334547; ENSG00000186051.
GeneIDi6887.
KEGGihsa:6887.
UCSCiuc004bct.3. human.

Organism-specific databases

CTDi6887.
GeneCardsiGC09P108424.
HGNCiHGNC:11557. TAL2.
HPAiHPA030886.
MIMi186855. gene.
neXtProtiNX_Q16559.
PharmGKBiPA36327.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256466.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000129920.
HOVERGENiHBG004515.
InParanoidiQ16559.
KOiK09068.
OMAiHLPGLEN.
OrthoDBiEOG7SN8DF.
PhylomeDBiQ16559.
TreeFamiTF315153.

Miscellaneous databases

GeneWikiiTAL2.
GenomeRNAii6887.
NextBioi26913.
PROiQ16559.
SOURCEiSearch...

Gene expression databases

BgeeiQ16559.
CleanExiHS_TAL2.
GenevestigatoriQ16559.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia."
    Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III, Le Beau M.M., Baer R.J.
    Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity."
    Xia Y., Hwang L.Y., Cobb M.H., Baer R.
    Oncogene 9:1437-1446(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTAL2_HUMAN
AccessioniPrimary (citable) accession number: Q16559
Secondary accession number(s): A0AVI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.