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Q16559 (TAL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
T-cell acute lymphocytic leukemia protein 2

Short name=TAL-2
Alternative name(s):
Class A basic helix-loop-helix protein 19
Short name=bHLHa19
Gene names
Name:TAL2
Synonyms:BHLHA19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Involvement in disease

A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 108108T-cell acute lymphocytic leukemia protein 2
PRO_0000127456

Regions

Domain2 – 5453bHLH

Sequences

Sequence LengthMass (Da)Tools
Q16559 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: DE9D67D940EF4749

FASTA10812,291
        10         20         30         40         50         60 
MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY INFLVKVLGE 

        70         80         90        100 
QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS PGPSHHIP 

« Hide

References

« Hide 'large scale' references
[1]"TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia."
Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III, Le Beau M.M., Baer R.J.
Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity."
Xia Y., Hwang L.Y., Cobb M.H., Baer R.
Oncogene 9:1437-1446(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81078 Genomic DNA. Translation: AAA60613.1.
S69377 Genomic DNA. Translation: AAC60629.1.
AL158070 Genomic DNA. Translation: CAC22163.1.
BC069422 mRNA. Translation: AAH69422.1.
BC126373 mRNA. Translation: AAI26374.1.
BC126375 mRNA. Translation: AAI26376.1.
CCDSCCDS6767.1.
PIRA41629.
RefSeqNP_005412.1. NM_005421.2.
UniGeneHs.247978.

3D structure databases

ProteinModelPortalQ16559.
SMRQ16559. Positions 1-61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112750. 7 interactions.
STRING9606.ENSP00000334547.

PTM databases

PhosphoSiteQ16559.

Polymorphism databases

DMDM7531207.

Proteomic databases

PaxDbQ16559.
PRIDEQ16559.

Protocols and materials databases

DNASU6887.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334077; ENSP00000334547; ENSG00000186051.
GeneID6887.
KEGGhsa:6887.
UCSCuc004bct.3. human.

Organism-specific databases

CTD6887.
GeneCardsGC09P108424.
HGNCHGNC:11557. TAL2.
HPAHPA030886.
MIM186855. gene.
neXtProtNX_Q16559.
PharmGKBPA36327.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256466.
HOGENOMHOG000129920.
HOVERGENHBG004515.
InParanoidQ16559.
KOK09068.
OMAHLPGLEN.
OrthoDBEOG7SN8DF.
PhylomeDBQ16559.
TreeFamTF315153.

Gene expression databases

BgeeQ16559.
CleanExHS_TAL2.
GenevestigatorQ16559.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAL2.
GenomeRNAi6887.
NextBio26913.
PROQ16559.
SOURCESearch...

Entry information

Entry nameTAL2_HUMAN
AccessionPrimary (citable) accession number: Q16559
Secondary accession number(s): A0AVI7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM