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Q16559

- TAL2_HUMAN

UniProt

Q16559 - TAL2_HUMAN

Protein

T-cell acute lymphocytic leukemia protein 2

Gene

TAL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: ProtInc

    GO - Biological processi

    1. midbrain development Source: Ensembl
    2. multicellular organism growth Source: Ensembl
    3. post-embryonic development Source: Ensembl
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. thalamus development Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell acute lymphocytic leukemia protein 2
    Short name:
    TAL-2
    Alternative name(s):
    Class A basic helix-loop-helix protein 19
    Short name:
    bHLHa19
    Gene namesi
    Name:TAL2
    Synonyms:BHLHA19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11557. TAL2.

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA36327.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 108108T-cell acute lymphocytic leukemia protein 2PRO_0000127456Add
    BLAST

    Proteomic databases

    PaxDbiQ16559.
    PRIDEiQ16559.

    PTM databases

    PhosphoSiteiQ16559.

    Expressioni

    Gene expression databases

    BgeeiQ16559.
    CleanExiHS_TAL2.
    GenevestigatoriQ16559.

    Organism-specific databases

    HPAiHPA030886.

    Interactioni

    Protein-protein interaction databases

    BioGridi112750. 7 interactions.
    STRINGi9606.ENSP00000334547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16559.
    SMRiQ16559. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 5453bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG256466.
    HOGENOMiHOG000129920.
    HOVERGENiHBG004515.
    InParanoidiQ16559.
    KOiK09068.
    OMAiHLPGLEN.
    OrthoDBiEOG7SN8DF.
    PhylomeDBiQ16559.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16559-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY    50
    INFLVKVLGE QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS 100
    PGPSHHIP 108
    Length:108
    Mass (Da):12,291
    Last modified:November 1, 1996 - v1
    Checksum:iDE9D67D940EF4749
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81078 Genomic DNA. Translation: AAA60613.1.
    S69377 Genomic DNA. Translation: AAC60629.1.
    AL158070 Genomic DNA. Translation: CAC22163.1.
    BC069422 mRNA. Translation: AAH69422.1.
    BC126373 mRNA. Translation: AAI26374.1.
    BC126375 mRNA. Translation: AAI26376.1.
    CCDSiCCDS6767.1.
    PIRiA41629.
    RefSeqiNP_005412.1. NM_005421.2.
    UniGeneiHs.247978.

    Genome annotation databases

    EnsembliENST00000334077; ENSP00000334547; ENSG00000186051.
    GeneIDi6887.
    KEGGihsa:6887.
    UCSCiuc004bct.3. human.

    Polymorphism databases

    DMDMi7531207.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81078 Genomic DNA. Translation: AAA60613.1 .
    S69377 Genomic DNA. Translation: AAC60629.1 .
    AL158070 Genomic DNA. Translation: CAC22163.1 .
    BC069422 mRNA. Translation: AAH69422.1 .
    BC126373 mRNA. Translation: AAI26374.1 .
    BC126375 mRNA. Translation: AAI26376.1 .
    CCDSi CCDS6767.1.
    PIRi A41629.
    RefSeqi NP_005412.1. NM_005421.2.
    UniGenei Hs.247978.

    3D structure databases

    ProteinModelPortali Q16559.
    SMRi Q16559. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112750. 7 interactions.
    STRINGi 9606.ENSP00000334547.

    PTM databases

    PhosphoSitei Q16559.

    Polymorphism databases

    DMDMi 7531207.

    Proteomic databases

    PaxDbi Q16559.
    PRIDEi Q16559.

    Protocols and materials databases

    DNASUi 6887.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334077 ; ENSP00000334547 ; ENSG00000186051 .
    GeneIDi 6887.
    KEGGi hsa:6887.
    UCSCi uc004bct.3. human.

    Organism-specific databases

    CTDi 6887.
    GeneCardsi GC09P108424.
    HGNCi HGNC:11557. TAL2.
    HPAi HPA030886.
    MIMi 186855. gene.
    neXtProti NX_Q16559.
    PharmGKBi PA36327.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256466.
    HOGENOMi HOG000129920.
    HOVERGENi HBG004515.
    InParanoidi Q16559.
    KOi K09068.
    OMAi HLPGLEN.
    OrthoDBi EOG7SN8DF.
    PhylomeDBi Q16559.
    TreeFami TF315153.

    Miscellaneous databases

    GeneWikii TAL2.
    GenomeRNAii 6887.
    NextBioi 26913.
    PROi Q16559.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16559.
    CleanExi HS_TAL2.
    Genevestigatori Q16559.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia."
      Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III, Le Beau M.M., Baer R.J.
      Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity."
      Xia Y., Hwang L.Y., Cobb M.H., Baer R.
      Oncogene 9:1437-1446(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTAL2_HUMAN
    AccessioniPrimary (citable) accession number: Q16559
    Secondary accession number(s): A0AVI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3