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Q16559

- TAL2_HUMAN

UniProt

Q16559 - TAL2_HUMAN

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Protein

T-cell acute lymphocytic leukemia protein 2

Gene

TAL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: ProtInc

GO - Biological processi

  1. midbrain development Source: Ensembl
  2. multicellular organism growth Source: Ensembl
  3. post-embryonic development Source: Ensembl
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. thalamus development Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 2
Short name:
TAL-2
Alternative name(s):
Class A basic helix-loop-helix protein 19
Short name:
bHLHa19
Gene namesi
Name:TAL2
Synonyms:BHLHA19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:11557. TAL2.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA36327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108T-cell acute lymphocytic leukemia protein 2PRO_0000127456Add
BLAST

Proteomic databases

PaxDbiQ16559.
PRIDEiQ16559.

PTM databases

PhosphoSiteiQ16559.

Expressioni

Gene expression databases

BgeeiQ16559.
CleanExiHS_TAL2.
GenevestigatoriQ16559.

Organism-specific databases

HPAiHPA030886.

Interactioni

Protein-protein interaction databases

BioGridi112750. 7 interactions.
STRINGi9606.ENSP00000334547.

Structurei

3D structure databases

ProteinModelPortaliQ16559.
SMRiQ16559. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 5453bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG256466.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000129920.
HOVERGENiHBG004515.
InParanoidiQ16559.
KOiK09068.
OMAiHLPGLEN.
OrthoDBiEOG7SN8DF.
PhylomeDBiQ16559.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16559-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY
60 70 80 90 100
INFLVKVLGE QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS

PGPSHHIP
Length:108
Mass (Da):12,291
Last modified:November 1, 1996 - v1
Checksum:iDE9D67D940EF4749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81078 Genomic DNA. Translation: AAA60613.1.
S69377 Genomic DNA. Translation: AAC60629.1.
AL158070 Genomic DNA. Translation: CAC22163.1.
BC069422 mRNA. Translation: AAH69422.1.
BC126373 mRNA. Translation: AAI26374.1.
BC126375 mRNA. Translation: AAI26376.1.
CCDSiCCDS6767.1.
PIRiA41629.
RefSeqiNP_005412.1. NM_005421.2.
UniGeneiHs.247978.

Genome annotation databases

EnsembliENST00000334077; ENSP00000334547; ENSG00000186051.
GeneIDi6887.
KEGGihsa:6887.
UCSCiuc004bct.3. human.

Polymorphism databases

DMDMi7531207.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81078 Genomic DNA. Translation: AAA60613.1 .
S69377 Genomic DNA. Translation: AAC60629.1 .
AL158070 Genomic DNA. Translation: CAC22163.1 .
BC069422 mRNA. Translation: AAH69422.1 .
BC126373 mRNA. Translation: AAI26374.1 .
BC126375 mRNA. Translation: AAI26376.1 .
CCDSi CCDS6767.1.
PIRi A41629.
RefSeqi NP_005412.1. NM_005421.2.
UniGenei Hs.247978.

3D structure databases

ProteinModelPortali Q16559.
SMRi Q16559. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112750. 7 interactions.
STRINGi 9606.ENSP00000334547.

PTM databases

PhosphoSitei Q16559.

Polymorphism databases

DMDMi 7531207.

Proteomic databases

PaxDbi Q16559.
PRIDEi Q16559.

Protocols and materials databases

DNASUi 6887.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334077 ; ENSP00000334547 ; ENSG00000186051 .
GeneIDi 6887.
KEGGi hsa:6887.
UCSCi uc004bct.3. human.

Organism-specific databases

CTDi 6887.
GeneCardsi GC09P108424.
HGNCi HGNC:11557. TAL2.
HPAi HPA030886.
MIMi 186855. gene.
neXtProti NX_Q16559.
PharmGKBi PA36327.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256466.
GeneTreei ENSGT00760000119097.
HOGENOMi HOG000129920.
HOVERGENi HBG004515.
InParanoidi Q16559.
KOi K09068.
OMAi HLPGLEN.
OrthoDBi EOG7SN8DF.
PhylomeDBi Q16559.
TreeFami TF315153.

Miscellaneous databases

GeneWikii TAL2.
GenomeRNAii 6887.
NextBioi 26913.
PROi Q16559.
SOURCEi Search...

Gene expression databases

Bgeei Q16559.
CleanExi HS_TAL2.
Genevestigatori Q16559.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia."
    Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III, Le Beau M.M., Baer R.J.
    Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity."
    Xia Y., Hwang L.Y., Cobb M.H., Baer R.
    Oncogene 9:1437-1446(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTAL2_HUMAN
AccessioniPrimary (citable) accession number: Q16559
Secondary accession number(s): A0AVI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3