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Protein

Calcium-activated potassium channel subunit beta-1

Gene

KCNMB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

GO - Molecular functioni

  • calcium-activated potassium channel activity Source: ProtInc
  • potassium channel regulator activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145936-MONOMER.
ReactomeiR-HSA-1296052. Ca2+ activated K+ channels.
R-HSA-418457. cGMP effects.

Protein family/group databases

TCDBi8.A.14.1.2. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-1
Alternative name(s):
BK channel subunit beta-1
Short name:
BKbeta
Short name:
BKbeta1
Short name:
Hbeta1
Calcium-activated potassium channel, subfamily M subunit beta-1
Short name:
Calcium-activated potassium channel subunit beta
Charybdotoxin receptor subunit beta-1
K(VCA)beta-1
Maxi K channel subunit beta-1
Slo-beta-1
Short name:
Slo-beta
Gene namesi
Name:KCNMB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6285. KCNMB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 18CytoplasmicSequence analysisAdd BLAST17
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 157ExtracellularSequence analysisAdd BLAST118
Transmembranei158 – 178Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini179 – 191CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3779.
MalaCardsiKCNMB1.
MIMi608622. phenotype.
OpenTargetsiENSG00000145936.
PharmGKBiPA221.

Chemistry databases

ChEMBLiCHEMBL3038495.
DrugBankiDB01110. Miconazole.
DB00721. Procaine.

Polymorphism and mutation databases

DMDMi292495100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001870462 – 191Calcium-activated potassium channel subunit beta-1Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ16558.
PeptideAtlasiQ16558.
PRIDEiQ16558.

PTM databases

PhosphoSitePlusiQ16558.

Expressioni

Tissue specificityi

Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.

Gene expression databases

BgeeiENSG00000145936.
CleanExiHS_KCNMB1.
GenevisibleiQ16558. HS.

Organism-specific databases

HPAiHPA020435.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer.

Protein-protein interaction databases

BioGridi109980. 4 interactors.
IntActiQ16558. 1 interactor.
MINTiMINT-1470084.
STRINGi9606.ENSP00000274629.

Structurei

3D structure databases

ProteinModelPortaliQ16558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWME. Eukaryota.
ENOG41116AX. LUCA.
GeneTreeiENSGT00390000015997.
HOVERGENiHBG052223.
InParanoidiQ16558.
KOiK04937.
OMAiAMLYHTE.
OrthoDBiEOG091G0MVO.
PhylomeDBiQ16558.
TreeFamiTF328589.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]
PRINTSiPR01450. BKCHANNELB.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKKLVMAQK RGETRALCLG VTMVVCAVIT YYILVTTVLP LYQKSVWTQE
60 70 80 90 100
SKCHLIETNI RDQEELKGKK VPQYPCLWVN VSAAGRWAVL YHTEDTRDQN
110 120 130 140 150
QQCSYIPGSV DNYQTARADV EKVRAKFQEQ QVFYCFSAPR GNETSVLFQR
160 170 180 190
LYGPQALLFS LFWPTFLLTG GLLIIAMVKS NQYLSILAAQ K
Length:191
Mass (Da):21,797
Last modified:March 23, 2010 - v5
Checksum:i547432FF194E770D
GO
Isoform 2 (identifier: Q16558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-130: CSYIPGSVDNYQTARADVEKVRAKFQEQ → VLNWRDGDTSLYPCQVCEPVPNCPCPRG
     131-191: Missing.

Note: No experimental confirmation available.
Show »
Length:130
Mass (Da):14,858
Checksum:i2E612865F4130EEE
GO

Polymorphismi

Genetic variation in KCNMB1 can influence the severity of diastolic hypertension (PubMed:15057310).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01932565E → K Has a protective effect against diastolic hypertension. 1 PublicationCorresponds to variant rs11739136dbSNPEnsembl.1
Natural variantiVAR_047009110V → L.Corresponds to variant rs2301149dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009822103 – 130CSYIP…KFQEQ → VLNWRDGDTSLYPCQVCEPV PNCPCPRG in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_009823131 – 191Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25138 mRNA. Translation: AAB02394.1.
U38907 mRNA. Translation: AAA81327.1.
U42600 mRNA. Translation: AAB16827.1.
U42601 Genomic DNA. Translation: AAB16825.1.
U42603, U42602 Genomic DNA. Translation: AAB16826.1.
U61536 mRNA. Translation: AAB61396.1.
U61537 Genomic DNA. Translation: AAB61397.1.
AF026002 mRNA. Translation: AAB88805.1.
AY044441 mRNA. Translation: AAK95827.1.
AY515264 mRNA. Translation: AAS20193.1.
AK313979 mRNA. Translation: BAG36693.1.
CH471062 Genomic DNA. Translation: EAW61474.1.
BC025707 mRNA. Translation: AAH25707.1.
CCDSiCCDS4373.1. [Q16558-1]
PIRiS68842.
RefSeqiNP_004128.1. NM_004137.3. [Q16558-1]
UniGeneiHs.484099.
Hs.744947.

Genome annotation databases

EnsembliENST00000274629; ENSP00000274629; ENSG00000145936. [Q16558-1]
ENST00000521859; ENSP00000427940; ENSG00000145936. [Q16558-2]
GeneIDi3779.
KEGGihsa:3779.
UCSCiuc003maq.3. human. [Q16558-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25138 mRNA. Translation: AAB02394.1.
U38907 mRNA. Translation: AAA81327.1.
U42600 mRNA. Translation: AAB16827.1.
U42601 Genomic DNA. Translation: AAB16825.1.
U42603, U42602 Genomic DNA. Translation: AAB16826.1.
U61536 mRNA. Translation: AAB61396.1.
U61537 Genomic DNA. Translation: AAB61397.1.
AF026002 mRNA. Translation: AAB88805.1.
AY044441 mRNA. Translation: AAK95827.1.
AY515264 mRNA. Translation: AAS20193.1.
AK313979 mRNA. Translation: BAG36693.1.
CH471062 Genomic DNA. Translation: EAW61474.1.
BC025707 mRNA. Translation: AAH25707.1.
CCDSiCCDS4373.1. [Q16558-1]
PIRiS68842.
RefSeqiNP_004128.1. NM_004137.3. [Q16558-1]
UniGeneiHs.484099.
Hs.744947.

3D structure databases

ProteinModelPortaliQ16558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109980. 4 interactors.
IntActiQ16558. 1 interactor.
MINTiMINT-1470084.
STRINGi9606.ENSP00000274629.

Chemistry databases

ChEMBLiCHEMBL3038495.
DrugBankiDB01110. Miconazole.
DB00721. Procaine.

Protein family/group databases

TCDBi8.A.14.1.2. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family.

PTM databases

PhosphoSitePlusiQ16558.

Polymorphism and mutation databases

DMDMi292495100.

Proteomic databases

PaxDbiQ16558.
PeptideAtlasiQ16558.
PRIDEiQ16558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274629; ENSP00000274629; ENSG00000145936. [Q16558-1]
ENST00000521859; ENSP00000427940; ENSG00000145936. [Q16558-2]
GeneIDi3779.
KEGGihsa:3779.
UCSCiuc003maq.3. human. [Q16558-1]

Organism-specific databases

CTDi3779.
DisGeNETi3779.
GeneCardsiKCNMB1.
HGNCiHGNC:6285. KCNMB1.
HPAiHPA020435.
MalaCardsiKCNMB1.
MIMi603951. gene.
608622. phenotype.
neXtProtiNX_Q16558.
OpenTargetsiENSG00000145936.
PharmGKBiPA221.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWME. Eukaryota.
ENOG41116AX. LUCA.
GeneTreeiENSGT00390000015997.
HOVERGENiHBG052223.
InParanoidiQ16558.
KOiK04937.
OMAiAMLYHTE.
OrthoDBiEOG091G0MVO.
PhylomeDBiQ16558.
TreeFamiTF328589.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145936-MONOMER.
ReactomeiR-HSA-1296052. Ca2+ activated K+ channels.
R-HSA-418457. cGMP effects.

Miscellaneous databases

GeneWikiiKCNMB1.
GenomeRNAii3779.
PROiQ16558.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145936.
CleanExiHS_KCNMB1.
GenevisibleiQ16558. HS.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]
PRINTSiPR01450. BKCHANNELB.
ProtoNetiSearch...

Entry informationi

Entry nameiKCMB1_HUMAN
AccessioniPrimary (citable) accession number: Q16558
Secondary accession number(s): O00707
, O00708, P78475, Q53YR0, Q8TAX3, Q93005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 141 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.