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Protein

Pregnancy-specific beta-1-glycoprotein 3

Gene

PSG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • defense response Source: UniProtKB
  • female pregnancy Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124467-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 3
Short name:
PS-beta-G-3
Short name:
PSBG-3
Short name:
Pregnancy-specific glycoprotein 3
Alternative name(s):
Carcinoembryonic antigen SG5
Gene namesi
Name:PSG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9520. PSG3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221826.
PharmGKBiPA33865.

Polymorphism and mutation databases

BioMutaiPSG3.
DMDMi108935880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491035 – 428Pregnancy-specific beta-1-glycoprotein 3Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 217Curated
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ16557.
PeptideAtlasiQ16557.
PRIDEiQ16557.
TopDownProteomicsiQ16557.

PTM databases

iPTMnetiQ16557.
PhosphoSitePlusiQ16557.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000221826.
CleanExiHS_PSG3.
ExpressionAtlasiQ16557. baseline and differential.
GenevisibleiQ16557. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111646. 9 interactors.
IntActiQ16557. 4 interactors.
MINTiMINT-1186118.
STRINGi9606.ENSP00000332215.

Structurei

3D structure databases

ProteinModelPortaliQ16557.
SMRiQ16557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ16557.
KOiK06500.
PhylomeDBiQ16557.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSAPPCT QRITWKGLLL TALLLNFWNL PTTAQVTIEA EPTKVSKGKD
60 70 80 90 100
VLLLVHNLPQ NLAGYIWYKG QMKDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTREDAGSY TLHIVKRGDG TRGETGHFTF TLYLETPKPS
160 170 180 190 200
ISSSNLYPRE DMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLQLSKNKR
210 220 230 240 250
TLFLFGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIQDRYGGIR SYPVTLNVLY GPDLPRIYPS FTYYHSGENL
360 370 380 390 400
YLSCFADSNP PAEYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA
410 420
TGMESSKSMT VKVSAPSGTG HLPGLNPL
Length:428
Mass (Da):47,945
Last modified:June 13, 2006 - v2
Checksum:i98750D7CDA426245
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330 – 383Missing (PubMed:2302228).CuratedAdd BLAST54
Sequence conflicti412K → E in AAH05924 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02672223L → S.4 PublicationsCorresponds to variant rs11559136dbSNPEnsembl.1
Natural variantiVAR_01567930L → P.4 PublicationsCorresponds to variant rs12185496dbSNPEnsembl.1
Natural variantiVAR_05940930L → S.Corresponds to variant rs12185496dbSNPEnsembl.1
Natural variantiVAR_026723198N → T.Corresponds to variant rs16976174dbSNPEnsembl.1
Natural variantiVAR_049921199K → N.Corresponds to variant rs17173152dbSNPEnsembl.1
Natural variantiVAR_061323290I → N.Corresponds to variant rs28698193dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34420 mRNA. Translation: AAA52606.1.
M23575 mRNA. Translation: AAA52607.1.
M37399 mRNA. Translation: AAA60958.1.
M93061 mRNA. Translation: AAA60207.1.
S59493 mRNA. Translation: AAC60584.1.
AC004654 Genomic DNA. Translation: AAC15513.1.
AC005337 Genomic DNA. No translation available.
BC005924 mRNA. Translation: AAH05924.2.
AH007624 Genomic DNA. Translation: AAD28498.1.
CCDSiCCDS12611.1.
PIRiI57486.
JS0032.
RefSeqiNP_066296.2. NM_021016.3.
UniGeneiHs.654413.

Genome annotation databases

EnsembliENST00000327495; ENSP00000332215; ENSG00000221826.
ENST00000614582; ENSP00000480223; ENSG00000221826.
GeneIDi5671.
KEGGihsa:5671.
UCSCiuc002oue.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34420 mRNA. Translation: AAA52606.1.
M23575 mRNA. Translation: AAA52607.1.
M37399 mRNA. Translation: AAA60958.1.
M93061 mRNA. Translation: AAA60207.1.
S59493 mRNA. Translation: AAC60584.1.
AC004654 Genomic DNA. Translation: AAC15513.1.
AC005337 Genomic DNA. No translation available.
BC005924 mRNA. Translation: AAH05924.2.
AH007624 Genomic DNA. Translation: AAD28498.1.
CCDSiCCDS12611.1.
PIRiI57486.
JS0032.
RefSeqiNP_066296.2. NM_021016.3.
UniGeneiHs.654413.

3D structure databases

ProteinModelPortaliQ16557.
SMRiQ16557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111646. 9 interactors.
IntActiQ16557. 4 interactors.
MINTiMINT-1186118.
STRINGi9606.ENSP00000332215.

PTM databases

iPTMnetiQ16557.
PhosphoSitePlusiQ16557.

Polymorphism and mutation databases

BioMutaiPSG3.
DMDMi108935880.

Proteomic databases

PaxDbiQ16557.
PeptideAtlasiQ16557.
PRIDEiQ16557.
TopDownProteomicsiQ16557.

Protocols and materials databases

DNASUi5671.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327495; ENSP00000332215; ENSG00000221826.
ENST00000614582; ENSP00000480223; ENSG00000221826.
GeneIDi5671.
KEGGihsa:5671.
UCSCiuc002oue.4. human.

Organism-specific databases

CTDi5671.
GeneCardsiPSG3.
HGNCiHGNC:9520. PSG3.
HPAiHPA046327.
MIMi176392. gene.
neXtProtiNX_Q16557.
OpenTargetsiENSG00000221826.
PharmGKBiPA33865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ16557.
KOiK06500.
PhylomeDBiQ16557.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124467-MONOMER.

Miscellaneous databases

ChiTaRSiPSG3. human.
GeneWikiiPSG3.
GenomeRNAii5671.
PROiQ16557.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221826.
CleanExiHS_PSG3.
ExpressionAtlasiQ16557. baseline and differential.
GenevisibleiQ16557. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG3_HUMAN
AccessioniPrimary (citable) accession number: Q16557
Secondary accession number(s): Q08265
, Q9BRW2, Q9UPL4, Q9UQ77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.