Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lymphocyte antigen 6E

Gene

LY6E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ16553.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6E
Short name:
Ly-6E
Alternative name(s):
Retinoic acid-induced gene E protein
Short name:
RIG-E
Stem cell antigen 2
Short name:
SCA-2
Thymic shared antigen 1
Short name:
TSA-1
Gene namesi
Name:LY6E
Synonyms:9804, RIGE, SCA2, TSA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6727. LY6E.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30491.

Polymorphism and mutation databases

BioMutaiLY6E.
DMDMi10720072.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 10181Lymphocyte antigen 6EPRO_0000036138Add
BLAST
Propeptidei102 – 13130Removed in mature formSequence analysisPRO_0000036139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 48By similarity
Disulfide bondi26 ↔ 35By similarity
Disulfide bondi41 ↔ 71By similarity
Disulfide bondi75 ↔ 92By similarity
Disulfide bondi93 ↔ 98By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Lipidationi101 – 1011GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ16553.
PeptideAtlasiQ16553.
PRIDEiQ16553.

PTM databases

iPTMnetiQ16553.
PhosphoSiteiQ16553.

Expressioni

Tissue specificityi

Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.

Inductioni

By retinoic acid; in promyelocytic leukemia NB4 and in myeloblast HL-60 cell lines. Activated by IFN-alpha in monocytic cell line U-937 and in peripheral blood monocyte cells.

Gene expression databases

BgeeiQ16553.
CleanExiHS_LY6E.
ExpressionAtlasiQ16553. baseline and differential.
GenevisibleiQ16553. HS.

Organism-specific databases

HPAiHPA027186.

Interactioni

Protein-protein interaction databases

BioGridi110239. 1 interaction.
STRINGi9606.ENSP00000292494.

Structurei

3D structure databases

ProteinModelPortaliQ16553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10181UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYXK. Eukaryota.
ENOG4111AYX. LUCA.
GeneTreeiENSGT00730000111295.
HOGENOMiHOG000035114.
HOVERGENiHBG001732.
InParanoidiQ16553.
KOiK06846.
OMAiSDNYCVT.
PhylomeDBiQ16553.
TreeFamiTF336080.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT
60 70 80 90 100
VSASAGIGNL VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF
110 120 130
SAADGGLRAS VTLLGAGLLL SLLPALLRFG P
Length:131
Mass (Da):13,507
Last modified:November 1, 1996 - v1
Checksum:i0F6D1157741AFC98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68179 mRNA. Translation: CAA92321.1.
U42376 mRNA. Translation: AAC50519.1.
U56145 mRNA. Translation: AAC50616.1.
U66711 Genomic DNA. Translation: AAB07513.1.
AK311983 mRNA. Translation: BAG34922.1.
CH471162 Genomic DNA. Translation: EAW82287.1.
CH471162 Genomic DNA. Translation: EAW82288.1.
CH471162 Genomic DNA. Translation: EAW82290.1.
BC119708 mRNA. Translation: AAI19709.1.
BC119709 mRNA. Translation: AAI19710.1.
CCDSiCCDS6394.1.
RefSeqiNP_001120685.1. NM_001127213.1.
NP_002337.1. NM_002346.2.
UniGeneiHs.521903.

Genome annotation databases

EnsembliENST00000292494; ENSP00000292494; ENSG00000160932.
ENST00000429120; ENSP00000414307; ENSG00000160932.
ENST00000520466; ENSP00000428572; ENSG00000160932.
ENST00000521003; ENSP00000428169; ENSG00000160932.
ENST00000521699; ENSP00000427915; ENSG00000160932.
ENST00000522024; ENSP00000428442; ENSG00000160932.
ENST00000522971; ENSP00000428159; ENSG00000160932.
ENST00000619718; ENSP00000482517; ENSG00000278032.
ENST00000631568; ENSP00000488891; ENSG00000278032.
ENST00000632424; ENSP00000488421; ENSG00000278032.
ENST00000632516; ENSP00000487664; ENSG00000278032.
ENST00000632519; ENSP00000488443; ENSG00000278032.
ENST00000632812; ENSP00000488556; ENSG00000278032.
ENST00000633451; ENSP00000488559; ENSG00000278032.
GeneIDi4061.
KEGGihsa:4061.
UCSCiuc003yxm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68179 mRNA. Translation: CAA92321.1.
U42376 mRNA. Translation: AAC50519.1.
U56145 mRNA. Translation: AAC50616.1.
U66711 Genomic DNA. Translation: AAB07513.1.
AK311983 mRNA. Translation: BAG34922.1.
CH471162 Genomic DNA. Translation: EAW82287.1.
CH471162 Genomic DNA. Translation: EAW82288.1.
CH471162 Genomic DNA. Translation: EAW82290.1.
BC119708 mRNA. Translation: AAI19709.1.
BC119709 mRNA. Translation: AAI19710.1.
CCDSiCCDS6394.1.
RefSeqiNP_001120685.1. NM_001127213.1.
NP_002337.1. NM_002346.2.
UniGeneiHs.521903.

3D structure databases

ProteinModelPortaliQ16553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110239. 1 interaction.
STRINGi9606.ENSP00000292494.

PTM databases

iPTMnetiQ16553.
PhosphoSiteiQ16553.

Polymorphism and mutation databases

BioMutaiLY6E.
DMDMi10720072.

Proteomic databases

PaxDbiQ16553.
PeptideAtlasiQ16553.
PRIDEiQ16553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292494; ENSP00000292494; ENSG00000160932.
ENST00000429120; ENSP00000414307; ENSG00000160932.
ENST00000520466; ENSP00000428572; ENSG00000160932.
ENST00000521003; ENSP00000428169; ENSG00000160932.
ENST00000521699; ENSP00000427915; ENSG00000160932.
ENST00000522024; ENSP00000428442; ENSG00000160932.
ENST00000522971; ENSP00000428159; ENSG00000160932.
ENST00000619718; ENSP00000482517; ENSG00000278032.
ENST00000631568; ENSP00000488891; ENSG00000278032.
ENST00000632424; ENSP00000488421; ENSG00000278032.
ENST00000632516; ENSP00000487664; ENSG00000278032.
ENST00000632519; ENSP00000488443; ENSG00000278032.
ENST00000632812; ENSP00000488556; ENSG00000278032.
ENST00000633451; ENSP00000488559; ENSG00000278032.
GeneIDi4061.
KEGGihsa:4061.
UCSCiuc003yxm.3. human.

Organism-specific databases

CTDi4061.
GeneCardsiLY6E.
HGNCiHGNC:6727. LY6E.
HPAiHPA027186.
MIMi601384. gene.
neXtProtiNX_Q16553.
PharmGKBiPA30491.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYXK. Eukaryota.
ENOG4111AYX. LUCA.
GeneTreeiENSGT00730000111295.
HOGENOMiHOG000035114.
HOVERGENiHBG001732.
InParanoidiQ16553.
KOiK06846.
OMAiSDNYCVT.
PhylomeDBiQ16553.
TreeFamiTF336080.

Enzyme and pathway databases

SignaLinkiQ16553.

Miscellaneous databases

ChiTaRSiLY6E. human.
GeneWikiiLY6E.
GenomeRNAii4061.
PROiQ16553.
SOURCEiSearch...

Gene expression databases

BgeeiQ16553.
CleanExiHS_LY6E.
ExpressionAtlasiQ16553. baseline and differential.
GenevisibleiQ16553. HS.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell."
    Mao M., Yu M., Tong J.-H., Ye J., Zhu J., Huang Q.-H., Fu G., Yu L., Zhao S.-Y., Waxman S., Lanotte M., Wang Z.-Y., Tan J.-Z., Chan S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 93:5910-5914(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Promyelocytic leukemia.
  2. "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2: a new member of the human Ly-6 family."
    Capone M.C., Gorman D.M., Ching E.P., Zlotnik A.
    J. Immunol. 157:969-973(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Mammary gland.
  3. "Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1."
    Shan X., Bourdeau A., Rhoton A., Wells D.E., Cohen E.H., Landgraf B.E., Palfree R.G.E.
    J. Immunol. 160:197-208(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Monocyte.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiLY6E_HUMAN
AccessioniPrimary (citable) accession number: Q16553
Secondary accession number(s): B2R4X5, D3DWJ2, Q0VDE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.