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Protein

Lymphocyte antigen 6E

Gene

LY6E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.By similarity

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
SignaLinkiQ16553

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6E
Short name:
Ly-6E
Alternative name(s):
Retinoic acid-induced gene E protein
Short name:
RIG-E
Stem cell antigen 2
Short name:
SCA-2
Thymic shared antigen 1
Short name:
TSA-1
Gene namesi
Name:LY6E
Synonyms:9804, RIGE, SCA2, TSA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000160932.10
HGNCiHGNC:6727 LY6E
MIMi601384 gene
neXtProtiNX_Q16553

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4061
OpenTargetsiENSG00000160932
PharmGKBiPA30491

Polymorphism and mutation databases

BioMutaiLY6E
DMDMi10720072

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003613821 – 101Lymphocyte antigen 6EAdd BLAST81
PropeptideiPRO_0000036139102 – 131Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 48By similarity
Disulfide bondi26 ↔ 35By similarity
Disulfide bondi41 ↔ 71By similarity
Disulfide bondi75 ↔ 92By similarity
Disulfide bondi93 ↔ 98By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi101GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ16553
PeptideAtlasiQ16553
PRIDEiQ16553
ProteomicsDBi60911

PTM databases

iPTMnetiQ16553
PhosphoSitePlusiQ16553

Expressioni

Tissue specificityi

Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.

Inductioni

By retinoic acid; in promyelocytic leukemia NB4 and in myeloblast HL-60 cell lines. Activated by IFN-alpha in monocytic cell line U-937 and in peripheral blood monocyte cells.

Gene expression databases

BgeeiENSG00000160932
CleanExiHS_LY6E
ExpressionAtlasiQ16553 baseline and differential
GenevisibleiQ16553 HS

Interactioni

Subunit structurei

Interacts with CHRNA4.By similarity

Protein-protein interaction databases

BioGridi110239, 2 interactors
STRINGi9606.ENSP00000292494

Structurei

3D structure databases

ProteinModelPortaliQ16553
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 101UPAR/Ly6Add BLAST81

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYXK Eukaryota
ENOG4111AYX LUCA
GeneTreeiENSGT00730000111295
HOGENOMiHOG000035114
HOVERGENiHBG001732
InParanoidiQ16553
KOiK06846
OMAiSDNYCVT
OrthoDBiEOG091G0V2A
PhylomeDBiQ16553
TreeFamiTF336080

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT
60 70 80 90 100
VSASAGIGNL VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF
110 120 130
SAADGGLRAS VTLLGAGLLL SLLPALLRFG P
Length:131
Mass (Da):13,507
Last modified:November 1, 1996 - v1
Checksum:i0F6D1157741AFC98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68179 mRNA Translation: CAA92321.1
U42376 mRNA Translation: AAC50519.1
U56145 mRNA Translation: AAC50616.1
U66711 Genomic DNA Translation: AAB07513.1
AK311983 mRNA Translation: BAG34922.1
CH471162 Genomic DNA Translation: EAW82287.1
CH471162 Genomic DNA Translation: EAW82288.1
CH471162 Genomic DNA Translation: EAW82290.1
BC119708 mRNA Translation: AAI19709.1
BC119709 mRNA Translation: AAI19710.1
CCDSiCCDS6394.1
RefSeqiNP_001120685.1, NM_001127213.1
NP_002337.1, NM_002346.2
UniGeneiHs.521903

Genome annotation databases

EnsembliENST00000292494; ENSP00000292494; ENSG00000160932
ENST00000429120; ENSP00000414307; ENSG00000160932
ENST00000520466; ENSP00000428572; ENSG00000160932
ENST00000521003; ENSP00000428169; ENSG00000160932
ENST00000521699; ENSP00000427915; ENSG00000160932
ENST00000522024; ENSP00000428442; ENSG00000160932
ENST00000522971; ENSP00000428159; ENSG00000160932
ENST00000619718; ENSP00000482517; ENSG00000278032
ENST00000631568; ENSP00000488891; ENSG00000278032
ENST00000632424; ENSP00000488421; ENSG00000278032
ENST00000632516; ENSP00000487664; ENSG00000278032
ENST00000632519; ENSP00000488443; ENSG00000278032
ENST00000632812; ENSP00000488556; ENSG00000278032
ENST00000633451; ENSP00000488559; ENSG00000278032
GeneIDi4061
KEGGihsa:4061
UCSCiuc003yxm.3 human

Similar proteinsi

Entry informationi

Entry nameiLY6E_HUMAN
AccessioniPrimary (citable) accession number: Q16553
Secondary accession number(s): B2R4X5, D3DWJ2, Q0VDE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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