ID   IL17_HUMAN              Reviewed;         155 AA.
AC   Q16552;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   07-JUL-2009, entry version 81.
DE   RecName: Full=Interleukin-17A;
DE            Short=IL-17A;
DE            Short=IL-17;
DE   AltName: Full=Cytotoxic T-lymphocyte-associated antigen 8;
DE            Short=CTLA-8;
DE   Flags: Precursor;
GN   Name=IL17A; Synonyms=CTLA8, IL17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96281911; PubMed=8676080; DOI=10.1084/jem.183.6.2593;
RA   Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S.,
RA   Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D.,
RA   Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J.,
RA   Lebecque S.;
RT   "T cell interleukin-17 induces stromal cells to produce
RT   proinflammatory and hematopoietic cytokines.";
RL   J. Exp. Med. 183:2593-2603(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=T-cell;
RX   MEDLINE=96094436; PubMed=7499828;
RA   Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M.,
RA   Spriggs M.K., Armitage R.J.;
RT   "Human IL-17: a novel cytokine derived from T cells.";
RL   J. Immunol. 155:5483-5486(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 24-38.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Induces stromal cells to produce proinflammatory and
CC       hematopoietic cytokines. Enhances the surface expression of the
CC       intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Restricted to activated memory T-cells.
CC   -!- PTM: Found both in glycosylated and nonglycosylated forms.
CC   -!- SIMILARITY: Belongs to the IL-17 family.
CC   -!- WEB RESOURCE: Name=R&D Systems' cytokine mini-reviews: IL-17;
CC       URL="http://www.rndsystems.com/molecule_detail.aspx?m=1674";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_17";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il17/";
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DR   EMBL; Z58820; CAA91233.1; -; mRNA.
DR   EMBL; U32659; AAC50341.1; -; mRNA.
DR   EMBL; AY460616; AAR23263.1; -; Genomic_DNA.
DR   EMBL; BC066251; AAH66251.1; -; mRNA.
DR   EMBL; BC066252; AAH66252.1; -; mRNA.
DR   EMBL; BC067503; AAH67503.1; -; mRNA.
DR   EMBL; BC067504; AAH67504.1; -; mRNA.
DR   EMBL; BC067505; AAH67505.1; -; mRNA.
DR   IPI; IPI00002898; -.
DR   RefSeq; NP_002181.1; -.
DR   UniGene; Hs.41724; -.
DR   HSSP; Q96PD4; 1JPY.
DR   DIP; DIP:6014N; -.
DR   PRIDE; Q16552; -.
DR   Ensembl; ENSG00000112115; Homo sapiens.
DR   GeneID; 3605; -.
DR   KEGG; hsa:3605; -.
DR   UCSC; uc003pak.1; human.
DR   GeneCards; GC06P052160; -.
DR   H-InvDB; HIX0032919; -.
DR   HGNC; HGNC:5981; IL17A.
DR   MIM; 603149; gene.
DR   HOGENOM; Q16552; -.
DR   HOVERGEN; Q16552; -.
DR   OMA; Q16552; WNLHRNE.
DR   Pathway_Interaction_DB; il23pathway; IL23-mediated signaling events.
DR   Pathway_Interaction_DB; il27pathway; IL27-mediated signaling events.
DR   NextBio; 14089; -.
DR   ArrayExpress; Q16552; -.
DR   Bgee; Q16552; -.
DR   CleanEx; HS_IL17A; -.
DR   GermOnline; ENSG00000112115; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0005125; F:cytokine activity; TAS:ProtInc.
DR   GO; GO:0006915; P:apoptosis; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0006955; P:immune response; TAS:ProtInc.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription from R...; IDA:MGI.
DR   GO; GO:0006486; P:protein amino acid glycosylation; TAS:ProtInc.
DR   InterPro; IPR010345; IL17.
DR   PANTHER; PTHR21295; IL17; 1.
DR   Pfam; PF06083; IL17; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL        1     23
FT   CHAIN        24    155       Interleukin-17A.
FT                                /FTId=PRO_0000015423.
FT   CARBOHYD     68     68       N-linked (GlcNAc...) (Potential).
FT   DISULFID     94    144       By similarity.
FT   DISULFID     99    146       By similarity.
SQ   SEQUENCE   155 AA;  17504 MW;  2BCAE9CB2F4886D1 CRC64;
     MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP
     KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL
     VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA
//