ID   IL17_HUMAN              Reviewed;         155 AA.
AC   Q16552; Q5T2P0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-JAN-2012, entry version 105.
DE   RecName: Full=Interleukin-17A;
DE            Short=IL-17;
DE            Short=IL-17A;
DE   AltName: Full=Cytotoxic T-lymphocyte-associated antigen 8;
DE            Short=CTLA-8;
DE   Flags: Precursor;
GN   Name=IL17A; Synonyms=CTLA8, IL17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96281911; PubMed=8676080; DOI=10.1084/jem.183.6.2593;
RA   Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S.,
RA   Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D.,
RA   Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J.,
RA   Lebecque S.;
RT   "T cell interleukin-17 induces stromal cells to produce
RT   proinflammatory and hematopoietic cytokines.";
RL   J. Exp. Med. 183:2593-2603(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=T-cell;
RX   MEDLINE=96094436; PubMed=7499828;
RA   Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M.,
RA   Spriggs M.K., Armitage R.J.;
RT   "Human IL-17: a novel cytokine derived from T cells.";
RL   J. Immunol. 155:5483-5486(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 24-38.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Induces stromal cells to produce proinflammatory and
CC       hematopoietic cytokines. Enhances the surface expression of
CC       ICAM1/intracellular adhesion molecule 1 in fibroblasts.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Restricted to activated memory T-cells.
CC   -!- PTM: Found both in glycosylated and nonglycosylated forms.
CC   -!- SIMILARITY: Belongs to the IL-17 family.
CC   -!- WEB RESOURCE: Name=R&D Systems' cytokine mini-reviews: IL-17;
CC       URL="http://www.rndsystems.com/molecule_detail.aspx?m=1674";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_17";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il17/";
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DR   EMBL; Z58820; CAA91233.1; -; mRNA.
DR   EMBL; U32659; AAC50341.1; -; mRNA.
DR   EMBL; AY460616; AAR23263.1; -; Genomic_DNA.
DR   EMBL; AL391221; CAI16678.1; -; Genomic_DNA.
DR   EMBL; CH471081; EAX04362.1; -; Genomic_DNA.
DR   EMBL; BC066251; AAH66251.1; -; mRNA.
DR   EMBL; BC066252; AAH66252.1; -; mRNA.
DR   EMBL; BC067503; AAH67503.1; -; mRNA.
DR   EMBL; BC067504; AAH67504.1; -; mRNA.
DR   EMBL; BC067505; AAH67505.1; -; mRNA.
DR   IPI; IPI00002898; -.
DR   RefSeq; NP_002181.1; NM_002190.2.
DR   UniGene; Hs.41724; -.
DR   PDB; 2VXS; X-ray; 2.63 A; A/B/C/D=20-155.
DR   PDBsum; 2VXS; -.
DR   ProteinModelPortal; Q16552; -.
DR   SMR; Q16552; 27-152.
DR   DIP; DIP-6014N; -.
DR   STRING; Q16552; -.
DR   DMDM; 2498481; -.
DR   PRIDE; Q16552; -.
DR   Ensembl; ENST00000340057; ENSP00000344192; ENSG00000112115.
DR   GeneID; 3605; -.
DR   KEGG; hsa:3605; -.
DR   UCSC; uc003pak.1; human.
DR   CTD; 3605; -.
DR   GeneCards; GC06P052051; -.
DR   H-InvDB; HIX0032919; -.
DR   HGNC; HGNC:5981; IL17A.
DR   MIM; 603149; gene.
DR   neXtProt; NX_Q16552; -.
DR   PharmGKB; PA29794; -.
DR   eggNOG; prNOG06285; -.
DR   HOGENOM; HBG279620; -.
DR   HOVERGEN; HBG006143; -.
DR   InParanoid; Q16552; -.
DR   OMA; WNLHRNE; -.
DR   OrthoDB; EOG40S0H2; -.
DR   PhylomeDB; Q16552; -.
DR   Pathway_Interaction_DB; il23pathway; IL23-mediated signaling events.
DR   Pathway_Interaction_DB; il27pathway; IL27-mediated signaling events.
DR   NextBio; 14089; -.
DR   ArrayExpress; Q16552; -.
DR   Bgee; Q16552; -.
DR   CleanEx; HS_IL17A; -.
DR   Genevestigator; Q16552; -.
DR   GermOnline; ENSG00000112115; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0005125; F:cytokine activity; TAS:ProtInc.
DR   GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0072537; P:fibroblast activation; IDA:BHF-UCL.
DR   GO; GO:0006955; P:immune response; TAS:ProtInc.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0032747; P:positive regulation of interleukin-23 production; IDA:BHF-UCL.
DR   GO; GO:0045672; P:positive regulation of osteoclast differentiation; IDA:BHF-UCL.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   GO; GO:0006486; P:protein glycosylation; TAS:ProtInc.
DR   InterPro; IPR020440; Interleukin-17_chordata.
DR   InterPro; IPR010345; Interleukin-17_met.
DR   KO; K05489; -.
DR   PANTHER; PTHR21295; IL17; 1.
DR   Pfam; PF06083; IL17; 1.
DR   PRINTS; PR01932; INTRLEUKIN17.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     23
FT   CHAIN        24    155       Interleukin-17A.
FT                                /FTId=PRO_0000015423.
FT   CARBOHYD     68     68       N-linked (GlcNAc...) (Potential).
FT   DISULFID     94    144       By similarity.
FT   DISULFID     99    146       By similarity.
FT   HELIX        60     62
FT   HELIX        66     69
FT   STRAND       70     72
FT   STRAND       74     80
FT   STRAND       87     95
FT   STRAND      110    113
FT   STRAND      116    121
FT   STRAND      136    141
FT   STRAND      145    147
SQ   SEQUENCE   155 AA;  17504 MW;  2BCAE9CB2F4886D1 CRC64;
     MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP
     KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL
     VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA
//