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Q16552 (IL17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17A

Short name=IL-17
Short name=IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name=CTLA-8
Gene names
Name:IL17A
Synonyms:CTLA8, IL17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

Subunit structure

Homodimer. Ref.8

Subcellular location

Secreted.

Tissue specificity

Restricted to activated memory T-cells.

Post-translational modification

Found both in glycosylated and nonglycosylated forms.

Sequence similarities

Belongs to the IL-17 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Traceable author statement Ref.2. Source: ProtInc

cell death

Traceable author statement PubMed 8390535. Source: ProtInc

cell-cell signaling

Traceable author statement Ref.2. Source: ProtInc

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

fibroblast activation

Inferred from direct assay PubMed 21145111. Source: BHF-UCL

immune response

Traceable author statement Ref.2. Source: ProtInc

inflammatory response

Inferred from electronic annotation. Source: InterPro

positive regulation of cytokine production involved in inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-23 production

Inferred from direct assay PubMed 21145111. Source: BHF-UCL

positive regulation of osteoclast differentiation

Inferred from direct assay PubMed 17888176. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16982811. Source: MGI

protein glycosylation

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Traceable author statement Ref.2. Source: ProtInc

   Molecular_functioncytokine activity

Traceable author statement Ref.2. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.7
Chain24 – 155132Interleukin-17A
PRO_0000015423

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 144 Ref.8
Disulfide bond99 ↔ 146 Ref.8

Secondary structure

...................... 155
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q16552 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2BCAE9CB2F4886D1

FASTA15517,504
        10         20         30         40         50         60 
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 

        70         80         90        100        110        120 
KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 

       130        140        150 
VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA 

« Hide

References

« Hide 'large scale' references
[1]"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines."
Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S.
J. Exp. Med. 183:2593-2603(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human IL-17: a novel cytokine derived from T cells."
Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J.
J. Immunol. 155:5483-5486(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[3]SeattleSNPs variation discovery resource
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
[8]"Structure of IL-17A in complex with a potent, fully human neutralizing antibody."
Gerhardt S., Abbott W.M., Hargreaves D., Pauptit R.A., Davies R.A., Needham M.R., Langham C., Barker W., Aziz A., Snow M.J., Dawson S., Welsh F., Wilkinson T., Vaugan T., Beste G., Bishop S., Popovic B., Rees G. expand/collapse author list , Sleeman M., Tuske S.J., Coales S.J., Hamuro Y., Russell C.
J. Mol. Biol. 394:905-921(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 20-155 IN COMPLEX WITH ANTIBODY, DISULFIDE BONDS, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z58820 mRNA. Translation: CAA91233.1.
U32659 mRNA. Translation: AAC50341.1.
AY460616 Genomic DNA. Translation: AAR23263.1.
AL391221 Genomic DNA. Translation: CAI16678.1.
CH471081 Genomic DNA. Translation: EAX04362.1.
BC066251 mRNA. Translation: AAH66251.1.
BC066252 mRNA. Translation: AAH66252.1.
BC067503 mRNA. Translation: AAH67503.1.
BC067504 mRNA. Translation: AAH67504.1.
BC067505 mRNA. Translation: AAH67505.1.
RefSeqNP_002181.1. NM_002190.2.
UniGeneHs.41724.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VXSX-ray2.63A/B/C/D20-155[»]
4HR9X-ray2.48A/B34-155[»]
4HSAX-ray3.15A/B/D/E34-155[»]
ProteinModelPortalQ16552.
SMRQ16552. Positions 42-150.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109818. 3 interactions.
DIPDIP-6014N.
STRING9606.ENSP00000344192.

PTM databases

PhosphoSiteQ16552.

Polymorphism databases

DMDM2498481.

Proteomic databases

PaxDbQ16552.
PRIDEQ16552.

Protocols and materials databases

DNASU3605.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340057; ENSP00000344192; ENSG00000112115.
GeneID3605.
KEGGhsa:3605.
UCSCuc003pak.1. human.

Organism-specific databases

CTD3605.
GeneCardsGC06P052051.
HGNCHGNC:5981. IL17A.
HPAHPA052258.
MIM603149. gene.
neXtProtNX_Q16552.
PharmGKBPA29794.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42989.
HOGENOMHOG000064520.
HOVERGENHBG006143.
InParanoidQ16552.
KOK05489.
OMAHMNSVPI.
OrthoDBEOG70089V.
PhylomeDBQ16552.
TreeFamTF314701.

Gene expression databases

ArrayExpressQ16552.
BgeeQ16552.
CleanExHS_IL17A.
GenevestigatorQ16552.

Family and domain databases

InterProIPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERPTHR21295. PTHR21295. 1 hit.
PfamPF06083. IL17. 1 hit.
[Graphical view]
PRINTSPR01932. INTRLEUKIN17.
ProtoNetSearch...

Other

EvolutionaryTraceQ16552.
GeneWikiIL17A.
GenomeRNAi3605.
NextBio14089.
PROQ16552.
SOURCESearch...

Entry information

Entry nameIL17_HUMAN
AccessionPrimary (citable) accession number: Q16552
Secondary accession number(s): Q5T2P0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM