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Reviewed, UniProtKB/Swiss-Prot Q16552 (IL17_HUMAN)

Last modified November 25, 2008. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Interleukin-17A
      Short name=IL-17A
      Short name=IL-17
Alternative name(s):
    Cytotoxic T-lymphocyte-associated antigen 8
      Short name=CTLA-8
Gene names
Name: IL17A
Synonyms: CTLA8, IL17
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

Restricted to activated memory T-cells.

Post-translational modification

Found both in glycosylated and nonglycosylated forms.

Sequence similarities

Belongs to the IL-17 family.

Ontologies

Keywords

   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Biological processapoptosis Ref.2

Traceable author statement. Source: ProtInc

cell-cell signaling Ref.2

Traceable author statement. Source: ProtInc

immune response Ref.2

Traceable author statement. Source: ProtInc

inflammatory response

Inferred from electronic annotation. Source: InterPro

protein amino acid glycosylation Ref.2

Traceable author statement. Source: ProtInc

   Cellular componentextracellular space Ref.2

Traceable author statement. Source: ProtInc

   Molecular functioncytokine activity Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 155132Interleukin-17A
PRO_0000015423

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 144 By similarity
Disulfide bond99 ↔ 146 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q16552-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2BCAE9CB2F4886D1

FASTA15517,504
        10         20         30         40         50         60 
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 

        70         80         90        100        110        120 
KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 

       130        140        150 
VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA 

« Hide

References

« Hide 'large scale' references
[1]"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines."
Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S.
J. Exp. Med. 183:2593-2603(1996) [PubMed: 8676080] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human IL-17: a novel cytokine derived from T cells."
Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J.
J. Immunol. 155:5483-5486(1995) [PubMed: 7499828] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[3]SeattleSNPs program for genomic applications
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z58820 mRNA. Translation: CAA91233.1.
U32659 mRNA. Translation: AAC50341.1.
AY460616 Genomic DNA. Translation: AAR23263.1.
BC066251 mRNA. Translation: AAH66251.1.
BC066252 mRNA. Translation: AAH66252.1.
BC067503 mRNA. Translation: AAH67503.1.
BC067504 mRNA. Translation: AAH67504.1.
BC067505 mRNA. Translation: AAH67505.1.
RefSeqNP_002181.1.
UniGeneHs.41724

3D structure databases

HSSPHSSP built from PDB template 1JPY based on UniProtKB Q96PD4.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6014N.

Genome annotation databases

EnsemblENSG00000112115. Homo sapiens. [Contig view]
GeneID3605.
KEGGhsa:3605.

Organism-specific databases

H-InvDBHIX0032919.
HGNCHGNC:5981. IL17A.
MIM603149. gene.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ16552.
HOVERGENQ16552.

Gene expression databases

ArrayExpressQ16552.
CleanExHS_IL17A.
GermOnlineENSG00000112115. Homo sapiens.

Family and domain databases

InterProIPR010345. IL17.
[Graphical view]
PANTHERPTHR21295. IL17. 1 hit.
PfamPF06083. IL17. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio14089.
SOURCESearch...

Entry information

Entry nameIL17_HUMAN
AccessionPrimary (citable) accession number: Q16552
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents