Q16552 (IL17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17A
Short name=IL-17
Short name=IL-17A

Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name=CTLA-8

Gene names

Name:	IL17A
Synonyms:	CTLA8, IL17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
Subunit structure	Homodimer.
Subcellular location	Secreted.
Tissue specificity	Restricted to activated memory T-cells.
Post-translational modification	Found both in glycosylated and nonglycosylated forms.
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Traceable author statement. Source: ProtInc cell-cell signaling Traceable author statement. Source: ProtInc fibroblast activation Inferred from direct assay. Source: BHF-UCL immune response Traceable author statement. Source: ProtInc inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of interleukin-23 production Inferred from direct assay. Source: BHF-UCL positive regulation of osteoclast differentiation Inferred from direct assay. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI protein glycosylation Traceable author statement. Source: ProtInc
Cellular component	extracellular space Traceable author statement. Source: ProtInc
Molecular function	cytokine activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.7

Chain

24 – 155

132

Interleukin-17A

PRO_0000015423

Amino acid modifications

Glycosylation

68

1

N-linked (GlcNAc...) Potential

Disulfide bond

94 ↔ 144

By similarity

Disulfide bond

99 ↔ 146

By similarity

Secondary structure

1

.

.

.

.

.

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.

.

.

.

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.

.

.

.

.

.

155

Helix Strand Turn

Details...

Helix

60 – 62

3

Helix

66 – 69

4

Beta strand

70 – 72

3

Beta strand

74 – 80

7

Beta strand

87 – 95

9

Beta strand

110 – 113

4

Beta strand

116 – 121

6

Beta strand

136 – 141

6

Beta strand

145 – 147

3

Sequences

	Sequence		Length	Mass (Da)
	Q16552 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2BCAE9CB2F4886D1	FASTA	155	17,504
	10 20 30 40 50 60 MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 70 80 90 100 110 120 KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 130 140 150 VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S. J. Exp. Med. 183:2593-2603(1996) [PubMed: 8676080] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human IL-17: a novel cytokine derived from T cells." Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J. J. Immunol. 155:5483-5486(1995) [PubMed: 7499828] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[3]	SeattleSNPs variation discovery resource Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
+	Additional computationally mapped references.

Web resources

R&D Systems' cytokine mini-reviews: IL-17

Wikipedia

Interleukin-17 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z58820 mRNA. Translation: CAA91233.1.
U32659 mRNA. Translation: AAC50341.1.
AY460616 Genomic DNA. Translation: AAR23263.1.
AL391221 Genomic DNA. Translation: CAI16678.1.
CH471081 Genomic DNA. Translation: EAX04362.1.
BC066251 mRNA. Translation: AAH66251.1.
BC066252 mRNA. Translation: AAH66252.1.
BC067503 mRNA. Translation: AAH67503.1.
BC067504 mRNA. Translation: AAH67504.1.
BC067505 mRNA. Translation: AAH67505.1.

IPI

IPI00002898.

RefSeq

NP_002181.1. NM_002190.2.

UniGene

Hs.41724.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VXS	X-ray	2.63	A/B/C/D	20-155	[»]

ProteinModelPortal

Q16552.

SMR

Q16552. Positions 27-152.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6014N.

STRING

Q16552.

Polymorphism databases

DMDM

2498481.

Proteomic databases

PRIDE

Q16552.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000340057; ENSP00000344192; ENSG00000112115.

GeneID

3605.

KEGG

hsa:3605.

UCSC

uc003pak.1. human.

Organism-specific databases

CTD

3605.

GeneCards

GC06P052051.

H-InvDB

HIX0032919.

HGNC

HGNC:5981. IL17A.

MIM

603149. gene.

neXtProt

NX_Q16552.

PharmGKB

PA29794.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG06285.

HOGENOM

HBG279620.

HOVERGEN

HBG006143.

InParanoid

Q16552.

OMA

WNLHRNE.

OrthoDB

EOG40S0H2.

PhylomeDB

Q16552.

Enzyme and pathway databases

Pathway_Interaction_DB

il23pathway. IL23-mediated signaling events.
il27pathway. IL27-mediated signaling events.

Gene expression databases

ArrayExpress

Q16552.

Bgee

Q16552.

CleanEx

HS_IL17A.

Genevestigator

Q16552.

GermOnline

ENSG00000112115. Homo sapiens.

Family and domain databases

InterPro

IPR020440. Interleukin-17_chordata.
IPR010345. Interleukin-17_met.
[Graphical view]

KO

K05489.

PANTHER

PTHR21295. IL17. 1 hit.

Pfam

PF06083. IL17. 1 hit.
[Graphical view]

PRINTS

PR01932. INTRLEUKIN17.

ProtoNet

Search...

Other

NextBio

14089.

SOURCE

Search...

Entry information

Entry name

IL17_HUMAN

Accession

Primary (citable) accession number: Q16552
Secondary accession number(s): Q5T2P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.