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Protein

Interleukin-17A

Gene

IL17A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).3 Publications

GO - Molecular functioni

  • cytokine activity Source: ProtInc
  • cytokine receptor binding Source: GO_Central

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell death Source: ProtInc
  • cell surface receptor signaling pathway Source: GO_Central
  • cellular response to interleukin-1 Source: Ensembl
  • defense response to fungus Source: Ensembl
  • fibroblast activation Source: BHF-UCL
  • immune response Source: ProtInc
  • inflammatory response Source: GO_Central
  • positive regulation of cytokine production involved in inflammatory response Source: Ensembl
  • positive regulation of interleukin-23 production Source: BHF-UCL
  • positive regulation of interleukin-6 secretion Source: Ensembl
  • positive regulation of osteoclast differentiation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112115-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ16552.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:IL17A
Synonyms:CTLA8, IL17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:5981. IL17A.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3605.
OpenTargetsiENSG00000112115.
PharmGKBiPA29794.

Chemistry databases

ChEMBLiCHEMBL3390822.
DrugBankiDB09029. Secukinumab.

Polymorphism and mutation databases

BioMutaiIL17A.
DMDMi2498481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001542324 – 155Interleukin-17AAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 1441 Publication
Disulfide bondi99 ↔ 1461 Publication

Post-translational modificationi

Found both in glycosylated and nonglycosylated forms.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ16552.
PRIDEiQ16552.

PTM databases

iPTMnetiQ16552.
PhosphoSitePlusiQ16552.

Expressioni

Tissue specificityi

Restricted to activated memory T-cells.

Gene expression databases

BgeeiENSG00000112115.
CleanExiHS_IL17A.
GenevisibleiQ16552. HS.

Organism-specific databases

HPAiHPA052258.

Interactioni

Subunit structurei

Homodimer (PubMed:19835883). Heterodimer with IL17F (PubMed:17355969).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DPH2Q9BQC33EBI-10237926,EBI-10237931

GO - Molecular functioni

  • cytokine activity Source: ProtInc
  • cytokine receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109818. 10 interactors.
DIPiDIP-6014N.
IntActiQ16552. 1 interactor.
STRINGi9606.ENSP00000344192.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 39Combined sources5
Beta strandi44 – 48Combined sources5
Beta strandi50 – 52Combined sources3
Helixi60 – 62Combined sources3
Helixi66 – 69Combined sources4
Beta strandi70 – 72Combined sources3
Beta strandi74 – 80Combined sources7
Beta strandi84 – 95Combined sources12
Beta strandi97 – 100Combined sources4
Beta strandi104 – 107Combined sources4
Beta strandi110 – 125Combined sources16
Beta strandi132 – 147Combined sources16
Beta strandi151 – 153Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VXSX-ray2.63A/B/C/D20-155[»]
4HR9X-ray2.48A/B34-155[»]
4HSAX-ray3.15A/B/D/E34-155[»]
4QHUX-ray2.20C/D24-154[»]
5HHVX-ray2.20A/B34-155[»]
5HHXX-ray3.00A/B20-155[»]
5HI3X-ray2.15A/B24-155[»]
5HI4X-ray1.80A/B24-155[»]
5HI5X-ray1.80A/B24-155[»]
ProteinModelPortaliQ16552.
SMRiQ16552.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16552.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J12P. Eukaryota.
ENOG410YS4N. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ16552.
KOiK05489.
OMAiHMNSVPI.
OrthoDBiEOG091G0RG1.
PhylomeDBiQ16552.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN
60 70 80 90 100
IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI
110 120 130 140 150
NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI

VHHVA
Length:155
Mass (Da):17,504
Last modified:November 1, 1996 - v1
Checksum:i2BCAE9CB2F4886D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z58820 mRNA. Translation: CAA91233.1.
U32659 mRNA. Translation: AAC50341.1.
AY460616 Genomic DNA. Translation: AAR23263.1.
AL391221 Genomic DNA. Translation: CAI16678.1.
CH471081 Genomic DNA. Translation: EAX04362.1.
BC066251 mRNA. Translation: AAH66251.1.
BC066252 mRNA. Translation: AAH66252.1.
BC067503 mRNA. Translation: AAH67503.1.
BC067504 mRNA. Translation: AAH67504.1.
BC067505 mRNA. Translation: AAH67505.1.
CCDSiCCDS4937.1.
RefSeqiNP_002181.1. NM_002190.2.
UniGeneiHs.41724.

Genome annotation databases

EnsembliENST00000340057; ENSP00000344192; ENSG00000112115.
GeneIDi3605.
KEGGihsa:3605.
UCSCiuc003pak.1. human.

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z58820 mRNA. Translation: CAA91233.1.
U32659 mRNA. Translation: AAC50341.1.
AY460616 Genomic DNA. Translation: AAR23263.1.
AL391221 Genomic DNA. Translation: CAI16678.1.
CH471081 Genomic DNA. Translation: EAX04362.1.
BC066251 mRNA. Translation: AAH66251.1.
BC066252 mRNA. Translation: AAH66252.1.
BC067503 mRNA. Translation: AAH67503.1.
BC067504 mRNA. Translation: AAH67504.1.
BC067505 mRNA. Translation: AAH67505.1.
CCDSiCCDS4937.1.
RefSeqiNP_002181.1. NM_002190.2.
UniGeneiHs.41724.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VXSX-ray2.63A/B/C/D20-155[»]
4HR9X-ray2.48A/B34-155[»]
4HSAX-ray3.15A/B/D/E34-155[»]
4QHUX-ray2.20C/D24-154[»]
5HHVX-ray2.20A/B34-155[»]
5HHXX-ray3.00A/B20-155[»]
5HI3X-ray2.15A/B24-155[»]
5HI4X-ray1.80A/B24-155[»]
5HI5X-ray1.80A/B24-155[»]
ProteinModelPortaliQ16552.
SMRiQ16552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109818. 10 interactors.
DIPiDIP-6014N.
IntActiQ16552. 1 interactor.
STRINGi9606.ENSP00000344192.

Chemistry databases

ChEMBLiCHEMBL3390822.
DrugBankiDB09029. Secukinumab.

PTM databases

iPTMnetiQ16552.
PhosphoSitePlusiQ16552.

Polymorphism and mutation databases

BioMutaiIL17A.
DMDMi2498481.

Proteomic databases

PaxDbiQ16552.
PRIDEiQ16552.

Protocols and materials databases

DNASUi3605.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340057; ENSP00000344192; ENSG00000112115.
GeneIDi3605.
KEGGihsa:3605.
UCSCiuc003pak.1. human.

Organism-specific databases

CTDi3605.
DisGeNETi3605.
GeneCardsiIL17A.
HGNCiHGNC:5981. IL17A.
HPAiHPA052258.
MIMi603149. gene.
neXtProtiNX_Q16552.
OpenTargetsiENSG00000112115.
PharmGKBiPA29794.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J12P. Eukaryota.
ENOG410YS4N. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ16552.
KOiK05489.
OMAiHMNSVPI.
OrthoDBiEOG091G0RG1.
PhylomeDBiQ16552.
TreeFamiTF314701.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112115-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ16552.

Miscellaneous databases

EvolutionaryTraceiQ16552.
GeneWikiiIL17A.
GenomeRNAii3605.
PROiQ16552.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112115.
CleanExiHS_IL17A.
GenevisibleiQ16552. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL17_HUMAN
AccessioniPrimary (citable) accession number: Q16552
Secondary accession number(s): Q5T2P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.