Q16552 (IL17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17A
Short name=IL-17
Short name=IL-17A

Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name=CTLA-8

Gene names

Name:	IL17A
Synonyms:	CTLA8, IL17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
Subunit structure	Homodimer. Ref.8
Subcellular location	Secreted.
Tissue specificity	Restricted to activated memory T-cells.
Post-translational modification	Found both in glycosylated and nonglycosylated forms.
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Traceable author statement Ref.2. Source: ProtInc cell-cell signaling Traceable author statement Ref.2. Source: ProtInc cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara fibroblast activation Inferred from direct assay PubMed 21145111. Source: BHF-UCL immune response Traceable author statement Ref.2. Source: ProtInc inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of cytokine production involved in inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of interleukin-23 production Inferred from direct assay PubMed 21145111. Source: BHF-UCL positive regulation of osteoclast differentiation Inferred from direct assay PubMed 17888176. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16982811. Source: MGI protein glycosylation Traceable author statement Ref.2. Source: ProtInc
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular space Traceable author statement Ref.2. Source: ProtInc
Molecular_function	cytokine activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.7

Chain

24 – 155

132

Interleukin-17A

PRO_0000015423

Amino acid modifications

Glycosylation

68

1

N-linked (GlcNAc...) Potential

Disulfide bond

94 ↔ 144

Ref.8

Disulfide bond

99 ↔ 146

Ref.8

Secondary structure

1

.

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.

.

.

.

155

Helix Strand Turn

Details...

Helix

60 – 62

3

Helix

66 – 69

4

Beta strand

70 – 72

3

Beta strand

74 – 80

7

Beta strand

87 – 95

9

Beta strand

97 – 100

4

Beta strand

110 – 121

12

Beta strand

136 – 147

12

Sequences

	Sequence		Length	Mass (Da)
	Q16552 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2BCAE9CB2F4886D1	FASTA	155	17,504
	10 20 30 40 50 60 MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 70 80 90 100 110 120 KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 130 140 150 VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S. J. Exp. Med. 183:2593-2603(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human IL-17: a novel cytokine derived from T cells." Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J. J. Immunol. 155:5483-5486(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[3]	SeattleSNPs variation discovery resource Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
[8]	"Structure of IL-17A in complex with a potent, fully human neutralizing antibody." Gerhardt S., Abbott W.M., Hargreaves D., Pauptit R.A., Davies R.A., Needham M.R., Langham C., Barker W., Aziz A., Snow M.J., Dawson S., Welsh F., Wilkinson T., Vaugan T., Beste G., Bishop S., Popovic B., Rees G. , Sleeman M., Tuske S.J., Coales S.J., Hamuro Y., Russell C. J. Mol. Biol. 394:905-921(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 20-155 IN COMPLEX WITH ANTIBODY, DISULFIDE BONDS, SUBUNIT.
+	Additional computationally mapped references.

Web resources

R&D Systems' cytokine mini-reviews: IL-17

Wikipedia

Interleukin-17 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z58820 mRNA. Translation: CAA91233.1.
U32659 mRNA. Translation: AAC50341.1.
AY460616 Genomic DNA. Translation: AAR23263.1.
AL391221 Genomic DNA. Translation: CAI16678.1.
CH471081 Genomic DNA. Translation: EAX04362.1.
BC066251 mRNA. Translation: AAH66251.1.
BC066252 mRNA. Translation: AAH66252.1.
BC067503 mRNA. Translation: AAH67503.1.
BC067504 mRNA. Translation: AAH67504.1.
BC067505 mRNA. Translation: AAH67505.1.

IPI

IPI00002898.

RefSeq

NP_002181.1. NM_002190.2.

UniGene

Hs.41724.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VXS	X-ray	2.63	A/B/C/D	20-155	[»]

ProteinModelPortal

Q16552.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6014N.

STRING

9606.ENSP00000344192.

PTM databases

PhosphoSite

Q16552.

Polymorphism databases

DMDM

2498481.

Proteomic databases

PaxDb

Q16552.

PRIDE

Q16552.

Protocols and materials databases

DNASU

3605.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000340057; ENSP00000344192; ENSG00000112115.

GeneID

3605.

KEGG

hsa:3605.

UCSC

uc003pak.1. human.

Organism-specific databases

CTD

3605.

GeneCards

GC06P052051.

HGNC

HGNC:5981. IL17A.

HPA

HPA052258.

MIM

603149. gene.

neXtProt

NX_Q16552.

PharmGKB

PA29794.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42989.

HOGENOM

HOG000064520.

HOVERGEN

HBG006143.

InParanoid

Q16552.

KO

K05489.

OMA

HMNSVPI.

OrthoDB

EOG40S0H2.

PhylomeDB

Q16552.

Enzyme and pathway databases

Pathway_Interaction_DB

il23pathway. IL23-mediated signaling events.
il27pathway. IL27-mediated signaling events.

Gene expression databases

ArrayExpress

Q16552.

Bgee

Q16552.

CleanEx

HS_IL17A.

Genevestigator

Q16552.

GermOnline

ENSG00000112115. Homo sapiens.

Family and domain databases

InterPro

IPR010345. Interleukin-17.
IPR020440. Interleukin-17_chordata.
[Graphical view]

PANTHER

PTHR21295. PTHR21295. 1 hit.

Pfam

PF06083. IL17. 1 hit.
[Graphical view]

PRINTS

PR01932. INTRLEUKIN17.

ProtoNet

Search...

Other

EvolutionaryTrace

Q16552.

GenomeRNAi

3605.

NextBio

14089.

SOURCE

Search...

Entry information

Entry name

IL17_HUMAN

Accession

Primary (citable) accession number: Q16552
Secondary accession number(s): Q5T2P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.