Reviewed, UniProtKB/Swiss-Prot Q16552 (IL17_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-17A
      Short name=IL-17A
      Short name=IL-17
Alternative name(s):
    Cytotoxic T-lymphocyte-associated antigen 8
      Short name=CTLA-8

Gene names

Name:	IL17A
Synonyms:	CTLA8, IL17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
Subunit structure	Homodimer.
Subcellular location	Secreted.
Tissue specificity	Restricted to activated memory T-cells.
Post-translational modification	Found both in glycosylated and nonglycosylated forms.
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Ref.2 Traceable author statement. Source: ProtInc cell-cell signaling Ref.2 Traceable author statement. Source: ProtInc immune response Ref.2 Traceable author statement. Source: ProtInc inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI protein amino acid glycosylation Ref.2 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Ref.2 Traceable author statement. Source: ProtInc
Molecular function	cytokine activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.5
	Chain	24 – 155	132	Interleukin-17A		PRO_0000015423
Amino acid modifications
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Disulfide bond	94 ↔ 144		By similarity
	Disulfide bond	99 ↔ 146		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q16552-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2BCAE9CB2F4886D1	FASTA	155	17,504
	10 20 30 40 50 60 MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 70 80 90 100 110 120 KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 130 140 150 VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S. J. Exp. Med. 183:2593-2603(1996) [PubMed: 8676080] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human IL-17: a novel cytokine derived from T cells." Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J. J. Immunol. 155:5483-5486(1995) [PubMed: 7499828] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[3]	SeattleSNPs variation discovery resource Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
+	Additional computationally mapped references.

Web resources

R&D Systems' cytokine mini-reviews: IL-17

Wikipedia

Interleukin-17 entry

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z58820 mRNA. Translation: CAA91233.1. U32659 mRNA. Translation: AAC50341.1. AY460616 Genomic DNA. Translation: AAR23263.1. BC066251 mRNA. Translation: AAH66251.1. BC066252 mRNA. Translation: AAH66252.1. BC067503 mRNA. Translation: AAH67503.1. BC067504 mRNA. Translation: AAH67504.1. BC067505 mRNA. Translation: AAH67505.1.
IPI	IPI00002898.
RefSeq	NP_002181.1.
UniGene	Hs.41724
3D structure databases
HSSP	HSSP built from PDB template 1JPY based on UniProtKB Q96PD4.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:6014N.
Proteomic databases
PRIDE	Q16552.
Genome annotation databases
Ensembl	ENSG00000112115. Homo sapiens. [Contig view]
GeneID	3605.
KEGG	hsa:3605.
Organism-specific databases
GeneCards	GC06P052160.
H-InvDB	HIX0032919.
HGNC	HGNC:5981. IL17A.
MIM	603149. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q16552.
HOVERGEN	Q16552.
OMA	Q16552. WNLHRNE.
Enzyme and pathway databases
Pathway_Interaction_DB	il23pathway. IL23-mediated signaling events. il27pathway. IL27-mediated signaling events.
Gene expression databases
ArrayExpress	Q16552.
Bgee	Q16552.
CleanEx	HS_IL17A.
GermOnline	ENSG00000112115. Homo sapiens.
Family and domain databases
InterPro	IPR010345. IL17. [Graphical view]
PANTHER	PTHR21295. IL17. 1 hit.
Pfam	PF06083. IL17. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14089.
SOURCE	Search...

Entry information

Entry name

IL17_HUMAN

Accession

Primary (citable) accession number: Q16552

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 5, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)