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Q16552

- IL17_HUMAN

UniProt

Q16552 - IL17_HUMAN

Protein

Interleukin-17A

Gene

IL17A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

    GO - Molecular functioni

    1. cytokine activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell-cell signaling Source: ProtInc
    3. cell death Source: ProtInc
    4. cellular response to interleukin-1 Source: Ensembl
    5. fibroblast activation Source: BHF-UCL
    6. immune response Source: ProtInc
    7. inflammatory response Source: InterPro
    8. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
    9. positive regulation of interleukin-23 production Source: BHF-UCL
    10. positive regulation of osteoclast differentiation Source: BHF-UCL
    11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    12. protein glycosylation Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17A
    Short name:
    IL-17
    Short name:
    IL-17A
    Alternative name(s):
    Cytotoxic T-lymphocyte-associated antigen 8
    Short name:
    CTLA-8
    Gene namesi
    Name:IL17A
    Synonyms:CTLA8, IL17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:5981. IL17A.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29794.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 155132Interleukin-17APRO_0000015423Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 1441 Publication
    Disulfide bondi99 ↔ 1461 Publication

    Post-translational modificationi

    Found both in glycosylated and nonglycosylated forms.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ16552.
    PRIDEiQ16552.

    PTM databases

    PhosphoSiteiQ16552.

    Expressioni

    Tissue specificityi

    Restricted to activated memory T-cells.

    Gene expression databases

    ArrayExpressiQ16552.
    BgeeiQ16552.
    CleanExiHS_IL17A.
    GenevestigatoriQ16552.

    Organism-specific databases

    HPAiHPA052258.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi109818. 3 interactions.
    DIPiDIP-6014N.
    STRINGi9606.ENSP00000344192.

    Structurei

    Secondary structure

    1
    155
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi44 – 485
    Helixi60 – 623
    Helixi66 – 694
    Beta strandi70 – 723
    Beta strandi74 – 807
    Beta strandi84 – 9512
    Beta strandi97 – 1004
    Beta strandi104 – 1074
    Beta strandi110 – 12617
    Beta strandi130 – 14718
    Beta strandi151 – 1533

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VXSX-ray2.63A/B/C/D20-155[»]
    4HR9X-ray2.48A/B34-155[»]
    4HSAX-ray3.15A/B/D/E34-155[»]
    ProteinModelPortaliQ16552.
    SMRiQ16552. Positions 42-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ16552.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42989.
    HOGENOMiHOG000064520.
    HOVERGENiHBG006143.
    InParanoidiQ16552.
    KOiK05489.
    OMAiCPHSFRL.
    OrthoDBiEOG70089V.
    PhylomeDBiQ16552.
    TreeFamiTF314701.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view]
    PANTHERiPTHR21295. PTHR21295. 1 hit.
    PfamiPF06083. IL17. 1 hit.
    [Graphical view]
    PRINTSiPR01932. INTRLEUKIN17.
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q16552-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN    50
    IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI 100
    NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI 150
    VHHVA 155
    Length:155
    Mass (Da):17,504
    Last modified:November 1, 1996 - v1
    Checksum:i2BCAE9CB2F4886D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z58820 mRNA. Translation: CAA91233.1.
    U32659 mRNA. Translation: AAC50341.1.
    AY460616 Genomic DNA. Translation: AAR23263.1.
    AL391221 Genomic DNA. Translation: CAI16678.1.
    CH471081 Genomic DNA. Translation: EAX04362.1.
    BC066251 mRNA. Translation: AAH66251.1.
    BC066252 mRNA. Translation: AAH66252.1.
    BC067503 mRNA. Translation: AAH67503.1.
    BC067504 mRNA. Translation: AAH67504.1.
    BC067505 mRNA. Translation: AAH67505.1.
    CCDSiCCDS4937.1.
    RefSeqiNP_002181.1. NM_002190.2.
    UniGeneiHs.41724.

    Genome annotation databases

    EnsembliENST00000340057; ENSP00000344192; ENSG00000112115.
    GeneIDi3605.
    KEGGihsa:3605.
    UCSCiuc003pak.1. human.

    Polymorphism databases

    DMDMi2498481.

    Cross-referencesi

    Web resourcesi

    R&D Systems' cytokine mini-reviews: IL-17
    Wikipedia

    Interleukin-17 entry

    SeattleSNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z58820 mRNA. Translation: CAA91233.1 .
    U32659 mRNA. Translation: AAC50341.1 .
    AY460616 Genomic DNA. Translation: AAR23263.1 .
    AL391221 Genomic DNA. Translation: CAI16678.1 .
    CH471081 Genomic DNA. Translation: EAX04362.1 .
    BC066251 mRNA. Translation: AAH66251.1 .
    BC066252 mRNA. Translation: AAH66252.1 .
    BC067503 mRNA. Translation: AAH67503.1 .
    BC067504 mRNA. Translation: AAH67504.1 .
    BC067505 mRNA. Translation: AAH67505.1 .
    CCDSi CCDS4937.1.
    RefSeqi NP_002181.1. NM_002190.2.
    UniGenei Hs.41724.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VXS X-ray 2.63 A/B/C/D 20-155 [» ]
    4HR9 X-ray 2.48 A/B 34-155 [» ]
    4HSA X-ray 3.15 A/B/D/E 34-155 [» ]
    ProteinModelPortali Q16552.
    SMRi Q16552. Positions 42-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109818. 3 interactions.
    DIPi DIP-6014N.
    STRINGi 9606.ENSP00000344192.

    PTM databases

    PhosphoSitei Q16552.

    Polymorphism databases

    DMDMi 2498481.

    Proteomic databases

    PaxDbi Q16552.
    PRIDEi Q16552.

    Protocols and materials databases

    DNASUi 3605.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340057 ; ENSP00000344192 ; ENSG00000112115 .
    GeneIDi 3605.
    KEGGi hsa:3605.
    UCSCi uc003pak.1. human.

    Organism-specific databases

    CTDi 3605.
    GeneCardsi GC06P052051.
    HGNCi HGNC:5981. IL17A.
    HPAi HPA052258.
    MIMi 603149. gene.
    neXtProti NX_Q16552.
    PharmGKBi PA29794.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42989.
    HOGENOMi HOG000064520.
    HOVERGENi HBG006143.
    InParanoidi Q16552.
    KOi K05489.
    OMAi CPHSFRL.
    OrthoDBi EOG70089V.
    PhylomeDBi Q16552.
    TreeFami TF314701.

    Miscellaneous databases

    EvolutionaryTracei Q16552.
    GeneWikii IL17A.
    GenomeRNAii 3605.
    NextBioi 14089.
    PROi Q16552.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16552.
    Bgeei Q16552.
    CleanExi HS_IL17A.
    Genevestigatori Q16552.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view ]
    PANTHERi PTHR21295. PTHR21295. 1 hit.
    Pfami PF06083. IL17. 1 hit.
    [Graphical view ]
    PRINTSi PR01932. INTRLEUKIN17.
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human IL-17: a novel cytokine derived from T cells."
      Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J.
      J. Immunol. 155:5483-5486(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: T-cell.
    3. SeattleSNPs variation discovery resource
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-38.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 20-155 IN COMPLEX WITH ANTIBODY, DISULFIDE BONDS, SUBUNIT.

    Entry informationi

    Entry nameiIL17_HUMAN
    AccessioniPrimary (citable) accession number: Q16552
    Secondary accession number(s): Q5T2P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3