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Q16552

- IL17_HUMAN

UniProt

Q16552 - IL17_HUMAN

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Protein

Interleukin-17A

Gene

IL17A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

GO - Molecular functioni

  1. cytokine activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. cell-cell signaling Source: ProtInc
  3. cell death Source: ProtInc
  4. cellular response to interleukin-1 Source: Ensembl
  5. fibroblast activation Source: BHF-UCL
  6. immune response Source: ProtInc
  7. inflammatory response Source: InterPro
  8. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
  9. positive regulation of interleukin-23 production Source: BHF-UCL
  10. positive regulation of osteoclast differentiation Source: BHF-UCL
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. protein glycosylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:IL17A
Synonyms:CTLA8, IL17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:5981. IL17A.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 155132Interleukin-17APRO_0000015423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 1441 Publication
Disulfide bondi99 ↔ 1461 Publication

Post-translational modificationi

Found both in glycosylated and nonglycosylated forms.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ16552.
PRIDEiQ16552.

PTM databases

PhosphoSiteiQ16552.

Expressioni

Tissue specificityi

Restricted to activated memory T-cells.

Gene expression databases

BgeeiQ16552.
CleanExiHS_IL17A.
ExpressionAtlasiQ16552. baseline and differential.
GenevestigatoriQ16552.

Organism-specific databases

HPAiHPA052258.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi109818. 9 interactions.
DIPiDIP-6014N.
STRINGi9606.ENSP00000344192.

Structurei

Secondary structure

1
155
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi44 – 485
Helixi60 – 623
Helixi66 – 694
Beta strandi70 – 723
Beta strandi74 – 807
Beta strandi84 – 9512
Beta strandi97 – 1004
Beta strandi104 – 1074
Beta strandi110 – 12617
Beta strandi130 – 14718
Beta strandi151 – 1533

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VXSX-ray2.63A/B/C/D20-155[»]
4HR9X-ray2.48A/B34-155[»]
4HSAX-ray3.15A/B/D/E34-155[»]
ProteinModelPortaliQ16552.
SMRiQ16552. Positions 42-150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16552.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42989.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ16552.
KOiK05489.
OMAiCPHSFRL.
OrthoDBiEOG70089V.
PhylomeDBiQ16552.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16552-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN
60 70 80 90 100
IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI
110 120 130 140 150
NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI

VHHVA
Length:155
Mass (Da):17,504
Last modified:November 1, 1996 - v1
Checksum:i2BCAE9CB2F4886D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z58820 mRNA. Translation: CAA91233.1.
U32659 mRNA. Translation: AAC50341.1.
AY460616 Genomic DNA. Translation: AAR23263.1.
AL391221 Genomic DNA. Translation: CAI16678.1.
CH471081 Genomic DNA. Translation: EAX04362.1.
BC066251 mRNA. Translation: AAH66251.1.
BC066252 mRNA. Translation: AAH66252.1.
BC067503 mRNA. Translation: AAH67503.1.
BC067504 mRNA. Translation: AAH67504.1.
BC067505 mRNA. Translation: AAH67505.1.
CCDSiCCDS4937.1.
RefSeqiNP_002181.1. NM_002190.2.
UniGeneiHs.41724.

Genome annotation databases

EnsembliENST00000340057; ENSP00000344192; ENSG00000112115.
GeneIDi3605.
KEGGihsa:3605.
UCSCiuc003pak.1. human.

Polymorphism databases

DMDMi2498481.

Cross-referencesi

Web resourcesi

R&D Systems' cytokine mini-reviews: IL-17
Wikipedia

Interleukin-17 entry

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z58820 mRNA. Translation: CAA91233.1 .
U32659 mRNA. Translation: AAC50341.1 .
AY460616 Genomic DNA. Translation: AAR23263.1 .
AL391221 Genomic DNA. Translation: CAI16678.1 .
CH471081 Genomic DNA. Translation: EAX04362.1 .
BC066251 mRNA. Translation: AAH66251.1 .
BC066252 mRNA. Translation: AAH66252.1 .
BC067503 mRNA. Translation: AAH67503.1 .
BC067504 mRNA. Translation: AAH67504.1 .
BC067505 mRNA. Translation: AAH67505.1 .
CCDSi CCDS4937.1.
RefSeqi NP_002181.1. NM_002190.2.
UniGenei Hs.41724.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VXS X-ray 2.63 A/B/C/D 20-155 [» ]
4HR9 X-ray 2.48 A/B 34-155 [» ]
4HSA X-ray 3.15 A/B/D/E 34-155 [» ]
ProteinModelPortali Q16552.
SMRi Q16552. Positions 42-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109818. 9 interactions.
DIPi DIP-6014N.
STRINGi 9606.ENSP00000344192.

PTM databases

PhosphoSitei Q16552.

Polymorphism databases

DMDMi 2498481.

Proteomic databases

PaxDbi Q16552.
PRIDEi Q16552.

Protocols and materials databases

DNASUi 3605.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340057 ; ENSP00000344192 ; ENSG00000112115 .
GeneIDi 3605.
KEGGi hsa:3605.
UCSCi uc003pak.1. human.

Organism-specific databases

CTDi 3605.
GeneCardsi GC06P052051.
HGNCi HGNC:5981. IL17A.
HPAi HPA052258.
MIMi 603149. gene.
neXtProti NX_Q16552.
PharmGKBi PA29794.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42989.
GeneTreei ENSGT00730000110824.
HOGENOMi HOG000064520.
HOVERGENi HBG006143.
InParanoidi Q16552.
KOi K05489.
OMAi CPHSFRL.
OrthoDBi EOG70089V.
PhylomeDBi Q16552.
TreeFami TF314701.

Miscellaneous databases

EvolutionaryTracei Q16552.
GeneWikii IL17A.
GenomeRNAii 3605.
NextBioi 14089.
PROi Q16552.
SOURCEi Search...

Gene expression databases

Bgeei Q16552.
CleanExi HS_IL17A.
ExpressionAtlasi Q16552. baseline and differential.
Genevestigatori Q16552.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view ]
PANTHERi PTHR21295. PTHR21295. 1 hit.
Pfami PF06083. IL17. 1 hit.
[Graphical view ]
PRINTSi PR01932. INTRLEUKIN17.
SUPFAMi SSF57501. SSF57501. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human IL-17: a novel cytokine derived from T cells."
    Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J.
    J. Immunol. 155:5483-5486(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.
  3. SeattleSNPs variation discovery resource
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (2.63 ANGSTROMS) OF 20-155 IN COMPLEX WITH ANTIBODY, DISULFIDE BONDS, SUBUNIT.

Entry informationi

Entry nameiIL17_HUMAN
AccessioniPrimary (citable) accession number: Q16552
Secondary accession number(s): Q5T2P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3