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Protein

Proprotein convertase subtilisin/kexin type 7

Gene

PCSK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

Catalytic activityi

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Cofactori

Ca2+By similarity

Enzyme regulationi

Inhibited by zinc and copper.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871Charge relay systemBy similarity
Active sitei228 – 2281Charge relay systemBy similarity
Active sitei406 – 4061Charge relay systemBy similarity

GO - Molecular functioni

  • peptidase activity Source: MGI
  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  • peptide hormone processing Source: UniProtKB
  • protein processing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B27. 2681.
SignaLinkiQ16549.
SIGNORiQ16549.

Protein family/group databases

MEROPSiS08.077.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)
Alternative name(s):
Lymphoma proprotein convertase
Prohormone convertase 7
Proprotein convertase 7
Short name:
PC7
Proprotein convertase 8
Short name:
PC8
Short name:
hPC8
Subtilisin/kexin-like protease PC7
Gene namesi
Name:PCSK7
Synonyms:LPC, PC7, PC8, SPC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8748. PCSK7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini142 – 667526ExtracellularSequence analysisAdd
BLAST
Transmembranei668 – 68821HelicalSequence analysisAdd
BLAST
Topological domaini689 – 78597CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33094.

Chemistry

ChEMBLiCHEMBL2232.
GuidetoPHARMACOLOGYi2387.

Polymorphism and mutation databases

BioMutaiPCSK7.
DMDMi205830663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737By similarityAdd
BLAST
Propeptidei38 – 141104By similarityPRO_0000027114Add
BLAST
Chaini142 – 785644Proprotein convertase subtilisin/kexin type 7PRO_0000027115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence analysis
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Cysteine residues in the cytoplasmic tail are probably palmitoylated.1 Publication
N-glycosylated.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei141 – 1422Cleavage; by autolysisBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Lipoprotein, Palmitate, Zymogen

Proteomic databases

EPDiQ16549.
PaxDbiQ16549.
PeptideAtlasiQ16549.
PRIDEiQ16549.

PTM databases

iPTMnetiQ16549.
PhosphoSiteiQ16549.
SwissPalmiQ16549.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Gene expression databases

BgeeiENSG00000160613.
CleanExiHS_PCSK7.
ExpressionAtlasiQ16549. baseline and differential.
GenevisibleiQ16549. HS.

Organism-specific databases

HPAiHPA043181.
HPA052957.

Interactioni

Protein-protein interaction databases

BioGridi114604. 1 interaction.
IntActiQ16549. 1 interaction.
MINTiMINT-6630634.
STRINGi9606.ENSP00000325917.

Chemistry

BindingDBiQ16549.

Structurei

3D structure databases

ProteinModelPortaliQ16549.
SMRiQ16549. Positions 147-615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 474293Peptidase S8Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated
Contains 1 peptidase S8 domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ16549.
KOiK08673.
OMAiHEAVRWH.
OrthoDBiEOG091G01XU.
PhylomeDBiQ16549.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG
60 70 80 90 100
GPSWAVHLES LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ
110 120 130 140 150
PAGHRPALEV EAIRQQVEAV LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY
160 170 180 190 200
PQQWHLNNRR SPGRDINVTG VWERNVTGRG VTVVVVDDGV EHTIQDIAPN
210 220 230 240 250
YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP NNSFCAVGVA
260 270 280 290 300
YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP
310 320 330 340 350
HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT
360 370 380 390 400
IGAVDEEGRM PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE
410 420 430 440 450
GHTGTSAAAP LAAGMIALML QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV
460 470 480 490 500
TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT SVPYLASYVS PVLKENKAIP
510 520 530 540 550
QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG SLELKLFCPS
560 570 580 590 600
GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF
610 620 630 640 650
QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL
660 670 680 690 700
KIPEEDGYTI TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR
710 720 730 740 750
SGPCHWPHRS RKAKEEGTEL ESVPLCSSKD PDEVETESRG PPTTSDLLAP
760 770 780
DLLEQGDWSL SQNKSALDCP HQHLDVPHGK EEQIC
Length:785
Mass (Da):86,247
Last modified:July 22, 2008 - v2
Checksum:i4A268754766C32DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521P → A in AAC50417 (PubMed:8615762).Curated
Sequence conflicti52 – 521P → A in AAB03087 (PubMed:8564950).Curated
Sequence conflicti112 – 1121A → P in AAC50417 (PubMed:8615762).Curated
Sequence conflicti112 – 1121A → P in AAB03087 (PubMed:8564950).Curated
Sequence conflicti228 – 2281H → R in BAD96627 (Ref. 5) Curated
Sequence conflicti353 – 3531A → T in ACA06037 (Ref. 6) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti688 – 6881L → V.
Corresponds to variant rs608620 [ dbSNP | Ensembl ].
VAR_044419
Natural varianti689 – 6891S → N.
Corresponds to variant rs45539233 [ dbSNP | Ensembl ].
VAR_044420
Natural varianti700 – 7001R → M.
Corresponds to variant rs45574931 [ dbSNP | Ensembl ].
VAR_044421
Natural varianti708 – 7081H → Y.
Corresponds to variant rs473131 [ dbSNP | Ensembl ].
VAR_044422
Natural varianti711 – 7111R → Q.
Corresponds to variant rs473093 [ dbSNP | Ensembl ].
VAR_044423

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40623 mRNA. Translation: AAC50417.1.
U33849 mRNA. Translation: AAB03087.1.
BT006870 mRNA. Translation: AAP35516.1.
AK312429 mRNA. Translation: BAG35338.1.
AK222907 mRNA. Translation: BAD96627.1.
EF445005 Genomic DNA. Translation: ACA06036.1.
EF445005 Genomic DNA. Translation: ACA06037.1.
CH471065 Genomic DNA. Translation: EAW67305.1.
BC010696 mRNA. Translation: AAH10696.1.
AF057710 Genomic DNA. Translation: AAD55137.1.
AB231710 mRNA. Translation: BAE46876.1.
CCDSiCCDS8382.1.
PIRiS64706.
RefSeqiNP_004707.2. NM_004716.3.
UniGeneiHs.648612.

Genome annotation databases

EnsembliENST00000320934; ENSP00000325917; ENSG00000160613.
GeneIDi9159.
KEGGihsa:9159.
UCSCiuc001pqr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40623 mRNA. Translation: AAC50417.1.
U33849 mRNA. Translation: AAB03087.1.
BT006870 mRNA. Translation: AAP35516.1.
AK312429 mRNA. Translation: BAG35338.1.
AK222907 mRNA. Translation: BAD96627.1.
EF445005 Genomic DNA. Translation: ACA06036.1.
EF445005 Genomic DNA. Translation: ACA06037.1.
CH471065 Genomic DNA. Translation: EAW67305.1.
BC010696 mRNA. Translation: AAH10696.1.
AF057710 Genomic DNA. Translation: AAD55137.1.
AB231710 mRNA. Translation: BAE46876.1.
CCDSiCCDS8382.1.
PIRiS64706.
RefSeqiNP_004707.2. NM_004716.3.
UniGeneiHs.648612.

3D structure databases

ProteinModelPortaliQ16549.
SMRiQ16549. Positions 147-615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114604. 1 interaction.
IntActiQ16549. 1 interaction.
MINTiMINT-6630634.
STRINGi9606.ENSP00000325917.

Chemistry

BindingDBiQ16549.
ChEMBLiCHEMBL2232.
GuidetoPHARMACOLOGYi2387.

Protein family/group databases

MEROPSiS08.077.

PTM databases

iPTMnetiQ16549.
PhosphoSiteiQ16549.
SwissPalmiQ16549.

Polymorphism and mutation databases

BioMutaiPCSK7.
DMDMi205830663.

Proteomic databases

EPDiQ16549.
PaxDbiQ16549.
PeptideAtlasiQ16549.
PRIDEiQ16549.

Protocols and materials databases

DNASUi9159.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320934; ENSP00000325917; ENSG00000160613.
GeneIDi9159.
KEGGihsa:9159.
UCSCiuc001pqr.4. human.

Organism-specific databases

CTDi9159.
GeneCardsiPCSK7.
H-InvDBHIX0026164.
HIX0191666.
HGNCiHGNC:8748. PCSK7.
HPAiHPA043181.
HPA052957.
MIMi604872. gene.
neXtProtiNX_Q16549.
PharmGKBiPA33094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ16549.
KOiK08673.
OMAiHEAVRWH.
OrthoDBiEOG091G01XU.
PhylomeDBiQ16549.
TreeFamiTF314277.

Enzyme and pathway databases

BRENDAi3.4.21.B27. 2681.
SignaLinkiQ16549.
SIGNORiQ16549.

Miscellaneous databases

ChiTaRSiPCSK7. human.
GeneWikiiPCSK7.
GenomeRNAii9159.
PROiQ16549.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160613.
CleanExiHS_PCSK7.
ExpressionAtlasiQ16549. baseline and differential.
GenevisibleiQ16549. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCSK7_HUMAN
AccessioniPrimary (citable) accession number: Q16549
Secondary accession number(s): B0YJ60
, Q3C1X1, Q53GM4, Q96FK8, Q9UL57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: September 7, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.