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Q16549 (PCSK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proprotein convertase subtilisin/kexin type 7

EC=3.4.21.-
Alternative name(s):
Lymphoma proprotein convertase
Prohormone convertase 7
Proprotein convertase 7
Short name=PC7
Proprotein convertase 8
Short name=PC8
Short name=hPC8
Subtilisin/kexin-like protease PC7
Gene names
Name:PCSK7
Synonyms:LPC, PC7, PC8, SPC7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

Catalytic activity

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Cofactor

Calcium By similarity.

Enzyme regulation

Inhibited by zinc and copper By similarity.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity. Note: Seems to be localized intracellularly to the trans Golgi network By similarity.

Tissue specificity

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Post-translational modification

Cysteine residues in the cytoplasmic tail are probably palmitoylated. Ref.12

N-glycosylated. Ref.12

Sequence similarities

Belongs to the peptidase S8 family.

Contains 1 homo B/P domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 By similarity
Propeptide38 – 141104 By similarity
PRO_0000027114
Chain142 – 785644Proprotein convertase subtilisin/kexin type 7
PRO_0000027115

Regions

Topological domain142 – 667526Extracellular Potential
Transmembrane668 – 68821Helical; Potential
Topological domain689 – 78597Cytoplasmic Potential
Domain482 – 617136Homo B/P
Region142 – 474333Catalytic

Sites

Active site1871Charge relay system By similarity
Active site2281Charge relay system By similarity
Active site4061Charge relay system By similarity
Site141 – 1422Cleavage; by autolysis By similarity

Amino acid modifications

Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation5111N-linked (GlcNAc...) Potential

Natural variations

Natural variant6881L → V.
Corresponds to variant rs608620 [ dbSNP | Ensembl ].
VAR_044419
Natural variant6891S → N.
Corresponds to variant rs45539233 [ dbSNP | Ensembl ].
VAR_044420
Natural variant7001R → M.
Corresponds to variant rs45574931 [ dbSNP | Ensembl ].
VAR_044421
Natural variant7081H → Y.
Corresponds to variant rs473131 [ dbSNP | Ensembl ].
VAR_044422
Natural variant7111R → Q.
Corresponds to variant rs473093 [ dbSNP | Ensembl ].
VAR_044423

Experimental info

Sequence conflict521P → A in AAC50417. Ref.1
Sequence conflict521P → A in AAB03087. Ref.3
Sequence conflict1121A → P in AAC50417. Ref.1
Sequence conflict1121A → P in AAB03087. Ref.3
Sequence conflict2281H → R in BAD96627. Ref.6
Sequence conflict3531A → T in ACA06037. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q16549 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 4A268754766C32DA

FASTA78586,247
        10         20         30         40         50         60 
MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG GPSWAVHLES 

        70         80         90        100        110        120 
LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ PAGHRPALEV EAIRQQVEAV 

       130        140        150        160        170        180 
LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY PQQWHLNNRR SPGRDINVTG VWERNVTGRG 

       190        200        210        220        230        240 
VTVVVVDDGV EHTIQDIAPN YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP 

       250        260        270        280        290        300 
NNSFCAVGVA YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP 

       310        320        330        340        350        360 
HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT IGAVDEEGRM 

       370        380        390        400        410        420 
PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE GHTGTSAAAP LAAGMIALML 

       430        440        450        460        470        480 
QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT 

       490        500        510        520        530        540 
SVPYLASYVS PVLKENKAIP QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG 

       550        560        570        580        590        600 
SLELKLFCPS GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF 

       610        620        630        640        650        660 
QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL KIPEEDGYTI 

       670        680        690        700        710        720 
TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR SGPCHWPHRS RKAKEEGTEL 

       730        740        750        760        770        780 
ESVPLCSSKD PDEVETESRG PPTTSDLLAP DLLEQGDWSL SQNKSALDCP HQHLDVPHGK 


EEQIC 

« Hide

References

« Hide 'large scale' references
[1]"PC8, a new member of the convertase family."
Bruzzaniti A., Goodge K., Jay P., Taviaux S.A., Lam M.H.C., Berta P., Martin T.J., Moseley J.M., Gillespie M.T.
Biochem. J. 314:727-731(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung carcinoma.
[2]Erratum
Bruzzaniti A., Goodge K., Jay P., Taviaux S.A., Lam M.H.C., Berta P., Martin T.J., Moseley J.M., Gillespie M.T.
Biochem. J. 316:1007-1007(1996)
[3]"A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas."
Meerabux J., Yaspo M.-L., Roebroek A.J.M., Van de Ven W.J.M., Lister T.A., Young B.D.
Cancer Res. 56:448-451(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell lymphoma.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[7]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[10]"Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma."
Lecointe N., Meerabux J., Ebihara M., Hill A., Young B.D.
Oncogene 18:2852-2859(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 527-785.
[11]"Identification of novel human genes predicted by combining multiple gene-finders."
Totoki Y., Yada T., Sakaki Y., Takeda T.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 574-655.
[12]"Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase."
Van de Loo J.-W.H.P., Creemers J.W.M., Bright N.A., Young B.D., Roebroek A.J.M., Van de Ven W.J.M.
J. Biol. Chem. 272:27116-27123(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION, PALMITOYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40623 mRNA. Translation: AAC50417.1.
U33849 mRNA. Translation: AAB03087.1.
BT006870 mRNA. Translation: AAP35516.1.
AK312429 mRNA. Translation: BAG35338.1.
AK222907 mRNA. Translation: BAD96627.1.
EF445005 Genomic DNA. Translation: ACA06036.1.
EF445005 Genomic DNA. Translation: ACA06037.1.
CH471065 Genomic DNA. Translation: EAW67305.1.
BC010696 mRNA. Translation: AAH10696.1.
AF057710 Genomic DNA. Translation: AAD55137.1.
AB231710 mRNA. Translation: BAE46876.1.
CCDSCCDS8382.1.
PIRS64706.
RefSeqNP_004707.2. NM_004716.3.
UniGeneHs.648612.

3D structure databases

ProteinModelPortalQ16549.
SMRQ16549. Positions 147-615.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114604. 1 interaction.
IntActQ16549. 1 interaction.
MINTMINT-6630634.
STRING9606.ENSP00000325917.

Chemistry

BindingDBQ16549.
ChEMBLCHEMBL2232.

Protein family/group databases

MEROPSS08.077.

PTM databases

PhosphoSiteQ16549.

Polymorphism databases

DMDM205830663.

Proteomic databases

PaxDbQ16549.
PRIDEQ16549.

Protocols and materials databases

DNASU9159.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320934; ENSP00000325917; ENSG00000160613.
GeneID9159.
KEGGhsa:9159.
UCSCuc001pqr.3. human.

Organism-specific databases

CTD9159.
GeneCardsGC11M117109.
H-InvDBHIX0026164.
HIX0191666.
HGNCHGNC:8748. PCSK7.
HPAHPA043181.
HPA052957.
MIM604872. gene.
neXtProtNX_Q16549.
PharmGKBPA33094.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4935.
HOGENOMHOG000192536.
HOVERGENHBG008705.
InParanoidQ16549.
KOK08673.
OMASGPCHWP.
OrthoDBEOG73JKV3.
PhylomeDBQ16549.
TreeFamTF314277.

Enzyme and pathway databases

SignaLinkQ16549.

Gene expression databases

ArrayExpressQ16549.
BgeeQ16549.
CleanExHS_PCSK7.
GenevestigatorQ16549.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERPTHR10795. PTHR10795. 1 hit.
PfamPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSPR00723. SUBTILISIN.
SUPFAMSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPCSK7. human.
GeneWikiPCSK7.
GenomeRNAi9159.
NextBio34363.
PROQ16549.
SOURCESearch...

Entry information

Entry namePCSK7_HUMAN
AccessionPrimary (citable) accession number: Q16549
Secondary accession number(s): B0YJ60 expand/collapse secondary AC list , Q3C1X1, Q53GM4, Q96FK8, Q9UL57
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM