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Protein

Proprotein convertase subtilisin/kexin type 7

Gene

PCSK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Cofactori

Ca2+By similarity

Enzyme regulationi

Inhibited by zinc and copper.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei187Charge relay systemBy similarity1
Active sitei228Charge relay systemBy similarity1
Active sitei406Charge relay systemBy similarity1

GO - Molecular functioni

  • peptidase activity Source: MGI
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  • peptide hormone processing Source: UniProtKB
  • protein processing Source: MGI

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B27. 2681.
SignaLinkiQ16549.
SIGNORiQ16549.

Protein family/group databases

MEROPSiS08.077.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)
Alternative name(s):
Lymphoma proprotein convertase
Prohormone convertase 7
Proprotein convertase 7
Short name:
PC7
Proprotein convertase 8
Short name:
PC8
Short name:
hPC8
Subtilisin/kexin-like protease PC7
Gene namesi
Name:PCSK7
Synonyms:LPC, PC7, PC8, SPC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000160613.12.
HGNCiHGNC:8748. PCSK7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini142 – 667ExtracellularSequence analysisAdd BLAST526
Transmembranei668 – 688HelicalSequence analysisAdd BLAST21
Topological domaini689 – 785CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9159.
OpenTargetsiENSG00000160613.
PharmGKBiPA33094.

Chemistry databases

ChEMBLiCHEMBL2232.
GuidetoPHARMACOLOGYi2387.

Polymorphism and mutation databases

BioMutaiPCSK7.
DMDMi205830663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37By similarityAdd BLAST37
PropeptideiPRO_000002711438 – 141By similarityAdd BLAST104
ChainiPRO_0000027115142 – 785Proprotein convertase subtilisin/kexin type 7Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Cysteine residues in the cytoplasmic tail are probably palmitoylated.1 Publication
N-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei141 – 142Cleavage; by autolysisBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Lipoprotein, Palmitate, Zymogen

Proteomic databases

EPDiQ16549.
PaxDbiQ16549.
PeptideAtlasiQ16549.
PRIDEiQ16549.

PTM databases

iPTMnetiQ16549.
PhosphoSitePlusiQ16549.
SwissPalmiQ16549.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Gene expression databases

BgeeiENSG00000160613.
CleanExiHS_PCSK7.
ExpressionAtlasiQ16549. baseline and differential.
GenevisibleiQ16549. HS.

Organism-specific databases

HPAiHPA043181.
HPA052957.

Interactioni

Protein-protein interaction databases

BioGridi114604. 1 interactor.
IntActiQ16549. 1 interactor.
MINTiMINT-6630634.
STRINGi9606.ENSP00000325917.

Chemistry databases

BindingDBiQ16549.

Structurei

3D structure databases

ProteinModelPortaliQ16549.
SMRiQ16549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 474Peptidase S8Add BLAST293
Domaini481 – 618P/Homo BPROSITE-ProRule annotationAdd BLAST138

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ16549.
KOiK08673.
OMAiEVLWNVS.
OrthoDBiEOG091G01XU.
PhylomeDBiQ16549.
TreeFamiTF314277.

Family and domain databases

CDDicd04059. Peptidases_S8_Protein_converta. 1 hit.
Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR034182. Kexin/furin.
IPR009020. Peptidase/Inhibitor_I9.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
PfamiView protein in Pfam
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiView protein in PROSITE
PS51829. P_HOMO_B. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG
60 70 80 90 100
GPSWAVHLES LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ
110 120 130 140 150
PAGHRPALEV EAIRQQVEAV LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY
160 170 180 190 200
PQQWHLNNRR SPGRDINVTG VWERNVTGRG VTVVVVDDGV EHTIQDIAPN
210 220 230 240 250
YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP NNSFCAVGVA
260 270 280 290 300
YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP
310 320 330 340 350
HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT
360 370 380 390 400
IGAVDEEGRM PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE
410 420 430 440 450
GHTGTSAAAP LAAGMIALML QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV
460 470 480 490 500
TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT SVPYLASYVS PVLKENKAIP
510 520 530 540 550
QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG SLELKLFCPS
560 570 580 590 600
GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF
610 620 630 640 650
QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL
660 670 680 690 700
KIPEEDGYTI TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR
710 720 730 740 750
SGPCHWPHRS RKAKEEGTEL ESVPLCSSKD PDEVETESRG PPTTSDLLAP
760 770 780
DLLEQGDWSL SQNKSALDCP HQHLDVPHGK EEQIC
Length:785
Mass (Da):86,247
Last modified:July 22, 2008 - v2
Checksum:i4A268754766C32DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52P → A in AAC50417 (PubMed:8615762).Curated1
Sequence conflicti52P → A in AAB03087 (PubMed:8564950).Curated1
Sequence conflicti112A → P in AAC50417 (PubMed:8615762).Curated1
Sequence conflicti112A → P in AAB03087 (PubMed:8564950).Curated1
Sequence conflicti228H → R in BAD96627 (Ref. 5) Curated1
Sequence conflicti353A → T in ACA06037 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044419688L → V. Corresponds to variant dbSNP:rs608620Ensembl.1
Natural variantiVAR_044420689S → N. Corresponds to variant dbSNP:rs45539233Ensembl.1
Natural variantiVAR_044421700R → M. Corresponds to variant dbSNP:rs45574931Ensembl.1
Natural variantiVAR_044422708H → Y. Corresponds to variant dbSNP:rs473131Ensembl.1
Natural variantiVAR_044423711R → Q. Corresponds to variant dbSNP:rs473093Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40623 mRNA. Translation: AAC50417.1.
U33849 mRNA. Translation: AAB03087.1.
BT006870 mRNA. Translation: AAP35516.1.
AK312429 mRNA. Translation: BAG35338.1.
AK222907 mRNA. Translation: BAD96627.1.
EF445005 Genomic DNA. Translation: ACA06036.1.
EF445005 Genomic DNA. Translation: ACA06037.1.
CH471065 Genomic DNA. Translation: EAW67305.1.
BC010696 mRNA. Translation: AAH10696.1.
AF057710 Genomic DNA. Translation: AAD55137.1.
AB231710 mRNA. Translation: BAE46876.1.
CCDSiCCDS8382.1.
PIRiS64706.
RefSeqiNP_004707.2. NM_004716.3.
UniGeneiHs.648612.

Genome annotation databases

EnsembliENST00000320934; ENSP00000325917; ENSG00000160613.
GeneIDi9159.
KEGGihsa:9159.
UCSCiuc001pqr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPCSK7_HUMAN
AccessioniPrimary (citable) accession number: Q16549
Secondary accession number(s): B0YJ60
, Q3C1X1, Q53GM4, Q96FK8, Q9UL57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: September 27, 2017
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families