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Q16549

- PCSK7_HUMAN

UniProt

Q16549 - PCSK7_HUMAN

Protein

Proprotein convertase subtilisin/kexin type 7

Gene

PCSK7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.

    Catalytic activityi

    Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

    Cofactori

    Calcium.By similarity

    Enzyme regulationi

    Inhibited by zinc and copper.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei141 – 1422Cleavage; by autolysisBy similarity
    Active sitei187 – 1871Charge relay systemBy similarity
    Active sitei228 – 2281Charge relay systemBy similarity
    Active sitei406 – 4061Charge relay systemBy similarity

    GO - Molecular functioni

    1. peptidase activity Source: MGI
    2. serine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. peptide hormone processing Source: UniProtKB
    2. protein processing Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    SignaLinkiQ16549.

    Protein family/group databases

    MEROPSiS08.077.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)
    Alternative name(s):
    Lymphoma proprotein convertase
    Prohormone convertase 7
    Proprotein convertase 7
    Short name:
    PC7
    Proprotein convertase 8
    Short name:
    PC8
    Short name:
    hPC8
    Subtilisin/kexin-like protease PC7
    Gene namesi
    Name:PCSK7
    Synonyms:LPC, PC7, PC8, SPC7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8748. PCSK7.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Seems to be localized intracellularly to the trans Golgi network.By similarity

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33094.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737By similarityAdd
    BLAST
    Propeptidei38 – 141104By similarityPRO_0000027114Add
    BLAST
    Chaini142 – 785644Proprotein convertase subtilisin/kexin type 7PRO_0000027115Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Cysteine residues in the cytoplasmic tail are probably palmitoylated.1 Publication
    N-glycosylated.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Lipoprotein, Palmitate, Zymogen

    Proteomic databases

    PaxDbiQ16549.
    PRIDEiQ16549.

    PTM databases

    PhosphoSiteiQ16549.

    Expressioni

    Tissue specificityi

    Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

    Gene expression databases

    ArrayExpressiQ16549.
    BgeeiQ16549.
    CleanExiHS_PCSK7.
    GenevestigatoriQ16549.

    Organism-specific databases

    HPAiHPA043181.
    HPA052957.

    Interactioni

    Protein-protein interaction databases

    BioGridi114604. 1 interaction.
    IntActiQ16549. 1 interaction.
    MINTiMINT-6630634.
    STRINGi9606.ENSP00000325917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16549.
    SMRiQ16549. Positions 147-615.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini142 – 667526ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini689 – 78597CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei668 – 68821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini182 – 474293Peptidase S8Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S8 family.Curated
    Contains 1 peptidase S8 domain.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4935.
    HOGENOMiHOG000192536.
    HOVERGENiHBG008705.
    InParanoidiQ16549.
    KOiK08673.
    OMAiSGPCHWP.
    OrthoDBiEOG73JKV3.
    PhylomeDBiQ16549.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q16549-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG    50
    GPSWAVHLES LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ 100
    PAGHRPALEV EAIRQQVEAV LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY 150
    PQQWHLNNRR SPGRDINVTG VWERNVTGRG VTVVVVDDGV EHTIQDIAPN 200
    YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP NNSFCAVGVA 250
    YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP 300
    HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT 350
    IGAVDEEGRM PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE 400
    GHTGTSAAAP LAAGMIALML QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV 450
    TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT SVPYLASYVS PVLKENKAIP 500
    QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG SLELKLFCPS 550
    GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF 600
    QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL 650
    KIPEEDGYTI TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR 700
    SGPCHWPHRS RKAKEEGTEL ESVPLCSSKD PDEVETESRG PPTTSDLLAP 750
    DLLEQGDWSL SQNKSALDCP HQHLDVPHGK EEQIC 785
    Length:785
    Mass (Da):86,247
    Last modified:July 22, 2008 - v2
    Checksum:i4A268754766C32DA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521P → A in AAC50417. (PubMed:8615762)Curated
    Sequence conflicti52 – 521P → A in AAB03087. (PubMed:8564950)Curated
    Sequence conflicti112 – 1121A → P in AAC50417. (PubMed:8615762)Curated
    Sequence conflicti112 – 1121A → P in AAB03087. (PubMed:8564950)Curated
    Sequence conflicti228 – 2281H → R in BAD96627. 1 PublicationCurated
    Sequence conflicti353 – 3531A → T in ACA06037. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti688 – 6881L → V.
    Corresponds to variant rs608620 [ dbSNP | Ensembl ].
    VAR_044419
    Natural varianti689 – 6891S → N.
    Corresponds to variant rs45539233 [ dbSNP | Ensembl ].
    VAR_044420
    Natural varianti700 – 7001R → M.
    Corresponds to variant rs45574931 [ dbSNP | Ensembl ].
    VAR_044421
    Natural varianti708 – 7081H → Y.
    Corresponds to variant rs473131 [ dbSNP | Ensembl ].
    VAR_044422
    Natural varianti711 – 7111R → Q.
    Corresponds to variant rs473093 [ dbSNP | Ensembl ].
    VAR_044423

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40623 mRNA. Translation: AAC50417.1.
    U33849 mRNA. Translation: AAB03087.1.
    BT006870 mRNA. Translation: AAP35516.1.
    AK312429 mRNA. Translation: BAG35338.1.
    AK222907 mRNA. Translation: BAD96627.1.
    EF445005 Genomic DNA. Translation: ACA06036.1.
    EF445005 Genomic DNA. Translation: ACA06037.1.
    CH471065 Genomic DNA. Translation: EAW67305.1.
    BC010696 mRNA. Translation: AAH10696.1.
    AF057710 Genomic DNA. Translation: AAD55137.1.
    AB231710 mRNA. Translation: BAE46876.1.
    CCDSiCCDS8382.1.
    PIRiS64706.
    RefSeqiNP_004707.2. NM_004716.3.
    UniGeneiHs.648612.

    Genome annotation databases

    EnsembliENST00000320934; ENSP00000325917; ENSG00000160613.
    GeneIDi9159.
    KEGGihsa:9159.
    UCSCiuc001pqr.3. human.

    Polymorphism databases

    DMDMi205830663.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40623 mRNA. Translation: AAC50417.1 .
    U33849 mRNA. Translation: AAB03087.1 .
    BT006870 mRNA. Translation: AAP35516.1 .
    AK312429 mRNA. Translation: BAG35338.1 .
    AK222907 mRNA. Translation: BAD96627.1 .
    EF445005 Genomic DNA. Translation: ACA06036.1 .
    EF445005 Genomic DNA. Translation: ACA06037.1 .
    CH471065 Genomic DNA. Translation: EAW67305.1 .
    BC010696 mRNA. Translation: AAH10696.1 .
    AF057710 Genomic DNA. Translation: AAD55137.1 .
    AB231710 mRNA. Translation: BAE46876.1 .
    CCDSi CCDS8382.1.
    PIRi S64706.
    RefSeqi NP_004707.2. NM_004716.3.
    UniGenei Hs.648612.

    3D structure databases

    ProteinModelPortali Q16549.
    SMRi Q16549. Positions 147-615.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114604. 1 interaction.
    IntActi Q16549. 1 interaction.
    MINTi MINT-6630634.
    STRINGi 9606.ENSP00000325917.

    Chemistry

    BindingDBi Q16549.
    ChEMBLi CHEMBL2232.

    Protein family/group databases

    MEROPSi S08.077.

    PTM databases

    PhosphoSitei Q16549.

    Polymorphism databases

    DMDMi 205830663.

    Proteomic databases

    PaxDbi Q16549.
    PRIDEi Q16549.

    Protocols and materials databases

    DNASUi 9159.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320934 ; ENSP00000325917 ; ENSG00000160613 .
    GeneIDi 9159.
    KEGGi hsa:9159.
    UCSCi uc001pqr.3. human.

    Organism-specific databases

    CTDi 9159.
    GeneCardsi GC11M117109.
    H-InvDB HIX0026164.
    HIX0191666.
    HGNCi HGNC:8748. PCSK7.
    HPAi HPA043181.
    HPA052957.
    MIMi 604872. gene.
    neXtProti NX_Q16549.
    PharmGKBi PA33094.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4935.
    HOGENOMi HOG000192536.
    HOVERGENi HBG008705.
    InParanoidi Q16549.
    KOi K08673.
    OMAi SGPCHWP.
    OrthoDBi EOG73JKV3.
    PhylomeDBi Q16549.
    TreeFami TF314277.

    Enzyme and pathway databases

    SignaLinki Q16549.

    Miscellaneous databases

    ChiTaRSi PCSK7. human.
    GeneWikii PCSK7.
    GenomeRNAii 9159.
    NextBioi 34363.
    PROi Q16549.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16549.
    Bgeei Q16549.
    CleanExi HS_PCSK7.
    Genevestigatori Q16549.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PC8, a new member of the convertase family."
      Bruzzaniti A., Goodge K., Jay P., Taviaux S.A., Lam M.H.C., Berta P., Martin T.J., Moseley J.M., Gillespie M.T.
      Biochem. J. 314:727-731(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung carcinoma.
    2. "A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas."
      Meerabux J., Yaspo M.-L., Roebroek A.J.M., Van de Ven W.J.M., Lister T.A., Young B.D.
      Cancer Res. 56:448-451(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: T-cell lymphoma.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    6. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    9. "Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma."
      Lecointe N., Meerabux J., Ebihara M., Hill A., Young B.D.
      Oncogene 18:2852-2859(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 527-785.
    10. "Identification of novel human genes predicted by combining multiple gene-finders."
      Totoki Y., Yada T., Sakaki Y., Takeda T.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 574-655.
    11. "Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase."
      Van de Loo J.-W.H.P., Creemers J.W.M., Bright N.A., Young B.D., Roebroek A.J.M., Van de Ven W.J.M.
      J. Biol. Chem. 272:27116-27123(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, PALMITOYLATION.

    Entry informationi

    Entry nameiPCSK7_HUMAN
    AccessioniPrimary (citable) accession number: Q16549
    Secondary accession number(s): B0YJ60
    , Q3C1X1, Q53GM4, Q96FK8, Q9UL57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3