Reviewed,
UniProtKB/Swiss-Prot Q16548 (B2LA1_HUMAN)
Last modified
January 19, 2010.
Version 97.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Bcl-2-related protein A1 Alternative name(s): Bcl-2-like protein 5 Short name=Bcl2-L-5 Protein BFL-1 Hemopoietic-specific early response protein Protein GRS | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 175 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection By similarity. |
| Subunit structure | Interacts directly with BAK1, BID, BMF and BBC3 By similarity. Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Ref.8 |
| Subcellular location | |
| Tissue specificity | Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. |
| Induction | By phorbol ester and inflammatory cytokines, such as TNF-alpha, or IL-1-beta, but not by growth factors. |
| Sequence similarities | Belongs to the Bcl-2 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | anti-apoptosis Ref.2 Traceable author statement. Source: ProtInc apoptosisInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| BBC3 | Q9BXH1 | 1 | EBI-1003550,EBI-519884 | |
| BCL2L11 | O43521 | 1 | EBI-1003550,EBI-526406 | |
| BID | P55957 | 1 | EBI-1003550,EBI-519672 | |
| NR4A1 | P22736 | 1 | EBI-1003550,EBI-721550 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 175 | 175 | Bcl-2-related protein A1 | PRO_0000143094 | |||||||||||||||||||||
Regions | |||||||||||||||||||||||||
| Motif | 77 – 97 | 21 | BH1 | ||||||||||||||||||||||
| Motif | 132 – 147 | 16 | BH2 | ||||||||||||||||||||||
| Compositional bias | 24 – 33 | 10 | Ala/Pro-rich | ||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||
| Natural variant | 19 | 1 | C → Y: dbSNP rs1138357. Ref.5 | VAR_020342 | |||||||||||||||||||||
| Natural variant | 39 | 1 | N → K: dbSNP rs1138358. Ref.5 | VAR_020343 | |||||||||||||||||||||
| Natural variant | 82 | 1 | G → D: dbSNP rs3826007. Ref.5 | VAR_020344 | |||||||||||||||||||||
| Natural variant | 117 | 1 | E → D: dbSNP rs34080999. | VAR_044059 | |||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||
| Sequence conflict | 72 | 1 | N → T in CAA70566. Ref.3 | ||||||||||||||||||||||
| Sequence conflict | 107 | 1 | Q → H in CAA70566. Ref.3 | ||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||
| Helix | 1 – 20 | 20 | |||||||||||||||||||||||
| Helix | 32 – 51 | 20 | |||||||||||||||||||||||
| Helix | 53 – 56 | 4 | |||||||||||||||||||||||
| Helix | 64 – 79 | 16 | |||||||||||||||||||||||
| Helix | 86 – 106 | 21 | |||||||||||||||||||||||
| Helix | 113 – 115 | 3 | |||||||||||||||||||||||
| Helix | 116 – 136 | 21 | |||||||||||||||||||||||
| Helix | 139 – 142 | 4 | |||||||||||||||||||||||
| Helix | 144 – 148 | 5 | |||||||||||||||||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow." Choi S.S., Park I.-C., Yun J.W., Sung Y.C., Hong S.-I., Shin H.-S. Oncogene 11:1693-1698(1995) [PubMed: 7478596] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | "Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells." Karsan A., Yee E., Kaushansky K., Harlan J.M. Blood 87:3089-3096(1996) [PubMed: 8605321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Umbilical vein. |
| [3] | "GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes." Kenny J.J., Knobloch T.J., Augustus M., Carter K.C., Rosen C.A., Lang J.C. Oncogene 14:997-1001(1997) [PubMed: 9050999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TYR-19; LYS-39 AND ASP-82. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [8] | "Characterization of Bax-sigma, a cell death-inducing isoform of Bax." Schmitt E., Paquet C., Beauchemin M., Dever-Bertrand J., Bertrand R. Biochem. Biophys. Res. Commun. 270:868-879(2000) [PubMed: 10772918] [Abstract] Cited for: INTERACTION WITH BAX. |
| [9] | "Human BCL-2A1 in complex with BIM." Structural genomics consortium (SGC) Submitted (FEB-2008) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 149-608 IN COMPLEX WITH BCL2L11. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U27467 mRNA. Translation: AAC50288.1. U29680 mRNA. Translation: AAC50438.1. Y09397 mRNA. Translation: CAA70566.1. BT007103 mRNA. Translation: AAP35767.1. CR541937 mRNA. Translation: CAG46735.1. CR541962 mRNA. Translation: CAG46760.1. CH471136 Genomic DNA. Translation: EAW99129.1. BC016281 mRNA. Translation: AAH16281.1. | ||||||||||||||||||
| IPI | IPI00002881. | ||||||||||||||||||
| PIR | I39055. | ||||||||||||||||||
| RefSeq | NP_004040.1. | ||||||||||||||||||
| UniGene | Hs.227817 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| IntAct | Q16548. 4 interactions. | ||||||||||||||||||
| STRING | Q16548. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q16548. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000267953; ENSP00000267953; ENSG00000140379; Homo sapiens. [Genome view] | ||||||||||||||||||
| GeneID | 597. | ||||||||||||||||||
| UCSC | uc002bfc.2. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 597. | ||||||||||||||||||
| GeneCards | GC15M078040. | ||||||||||||||||||
| H-InvDB | HIX0012488. | ||||||||||||||||||
| HGNC | HGNC:991. BCL2A1. | ||||||||||||||||||
| HPA | CAB010382. | ||||||||||||||||||
| MIM | 601056. gene. | ||||||||||||||||||
| PharmGKB | PA25303. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | prNOG06809. | ||||||||||||||||||
| HOGENOM | HBG127246. | ||||||||||||||||||
| HOVERGEN | Q16548. | ||||||||||||||||||
| InParanoid | Q16548. | ||||||||||||||||||
| OrthoDB | EOG9WDGX1. | ||||||||||||||||||
| PhylomeDB | Q16548. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| Pathway_Interaction_DB | bcr_5pathway. BCR signaling pathway. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q16548. | ||||||||||||||||||
| Bgee | Q16548. | ||||||||||||||||||
| CleanEx | HS_BCL2A1. | ||||||||||||||||||
| Genevestigator | Q16548. | ||||||||||||||||||
| GermOnline | ENSG00000140379. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR013282. Apop_reg_Bcl2Rel. IPR002475. BCL2_apoptsis. IPR000712. Bcl2_BH. IPR020717. Bcl2_BH1_motif_CS. IPR020726. Bcl2_BH2_motif_CS. [Graphical view] | ||||||||||||||||||
| Pfam | PF00452. Bcl-2. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR01862. BCL2FAMILY. PR01867. BCL2RLATEDA1. | ||||||||||||||||||
| SMART | SM00337. BCL. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 2429. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | B2LA1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16548 Secondary accession number(s): Q6FGZ4, Q6FH19, Q99524 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


