Reviewed,
UniProtKB/Swiss-Prot Q16543 (CDC37_HUMAN)
Last modified
July 7, 2009.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hsp90 co-chaperone Cdc37 Alternative name(s): Hsp90 chaperone protein kinase-targeting subunit p50Cdc37 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 378 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Ref.1 |
| Subunit structure | Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1. Ref.5 Ref.7 Ref.8 |
| Subcellular location | |
| Post-translational modification | Constitutively sumoylated by UBE2I. Ref.10 |
| Sequence similarities | Belongs to the CDC37 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Molecular function | Chaperone |
| PTM | Phosphoprotein Ubl conjugation |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein targeting Ref.1 Traceable author statement. Source: ProtInc regulation of cyclin-dependent protein kinase activity Ref.1Traceable author statement. Source: ProtInc regulation of interferon-gamma-mediated signaling pathwayInferred from mutant phenotype. Source: MGI regulation of type I interferon-mediated signaling pathwayInferred from mutant phenotype. Source: MGI |
| Molecular function | unfolded protein binding Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| P11500 | 2 | EBI-295634,EBI-640126 | From a different organism. | |
| AKT1 | P31749 | 1 | EBI-295634,EBI-296087 | |
| AKT2 | P31751 | 1 | EBI-295634,EBI-296058 | |
| AKT3 | Q9Y243 | 1 | EBI-295634,EBI-296115 | |
| CDK4 | P11802 | 4 | EBI-295634,EBI-295644 | |
| CDK6 | Q00534 | 1 | EBI-295634,EBI-295663 | |
| EIF2AK1 | P33279 | 1 | EBI-295634,EBI-640100 | From a different organism. |
| HSP82 | P02829 | 1 | EBI-295634,EBI-8659 | From a different organism. |
| NEK6 | Q9HC98 | 1 | EBI-295634,EBI-740364 | |
| SGK1 | O00141 | 1 | EBI-295634,EBI-1042854 | |
| SMYD2 | Q9NRG4 | 1 | EBI-295634,EBI-1055671 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 378 | 378 | Hsp90 co-chaperone Cdc37 | PRO_0000195057 | |||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||
| Modified residue | 298 | 1 | Phosphotyrosine Ref.9 | ||||||||||||||||||||||||||||
| Modified residue | 377 | 1 | Phosphoserine Ref.11 | ||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||
| Natural variant | 360 | 1 | G → E: dbSNP rs280528. Ref.3 | VAR_022220 | |||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||
| Helix | 149 – 164 | 16 | |||||||||||||||||||||||||||||
| Helix | 168 – 176 | 9 | |||||||||||||||||||||||||||||
| Helix | 177 – 181 | 5 | |||||||||||||||||||||||||||||
| Helix | 184 – 199 | 16 | |||||||||||||||||||||||||||||
| Helix | 203 – 226 | 24 | |||||||||||||||||||||||||||||
| Helix | 230 – 232 | 3 | |||||||||||||||||||||||||||||
| Helix | 234 – 242 | 9 | |||||||||||||||||||||||||||||
| Helix | 246 – 284 | 39 | |||||||||||||||||||||||||||||
| Helix | 294 – 300 | 7 | |||||||||||||||||||||||||||||
| Helix | 317 – 321 | 5 | |||||||||||||||||||||||||||||
| Beta strand | 325 – 327 | 3 | |||||||||||||||||||||||||||||
| Helix | 328 – 338 | 11 | |||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4." Stepanova L., Leng X., Parker S.B., Harper J.W. Genes Dev. 10:1491-1502(1996) [PubMed: 8666233] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. |
| [2] | "Physical interaction of mammalian CDC37 with CDK4." Dai K., Kobayashi R., Beach D. J. Biol. Chem. 271:22030-22034(1996) [PubMed: 8703009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | NIEHS SNPs program Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-360. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph and Placenta. |
| [5] | "Interaction between Cdc37 and Cdk4 in human cells." Lamphere L., Fiore F., Xu X., Brizuela L., Keezer S., Sardet C., Draetta G.F., Gyuris J. Oncogene 14:1999-2004(1997) [PubMed: 9150368] [Abstract] Cited for: INTERACTION WITH CDK4 AND CDK6. |
| [6] | "p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules." Hartson S.D., Irwin A.D., Shao J., Scroggins B.T., Volk L., Huang W., Matts R.L. Biochemistry 39:7631-7644(2000) [PubMed: 10858314] [Abstract] Cited for: CHARACTERIZATION. |
| [7] | "Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase." Shao J., Grammatikakis N., Scroggins B.T., Uma S., Huang W., Chen J.-J., Hartson S.D., Matts R.L. J. Biol. Chem. 276:206-214(2001) [PubMed: 11036079] [Abstract] Cited for: INTERACTION WITH EIF2AK1. |
| [8] | "Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor." Rao J., Lee P., Benzeno S., Cardozo C., Albertus J., Robins D.M., Caplan A.J. J. Biol. Chem. 276:5814-5820(2001) [PubMed: 11085988] [Abstract] Cited for: INTERACTION WITH AR. |
| [9] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-298, MASS SPECTROMETRY. |
| [10] | "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation." Jakobs A., Himstedt F., Funk M., Korn B., Gaestel M., Niedenthal R. Nucleic Acids Res. 35:E109-E109(2007) [PubMed: 17709345] [Abstract] Cited for: SUMOYLATION. |
| [11] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377, MASS SPECTROMETRY. |
| [12] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U43077 mRNA. Translation: AAB63979.1. U63131 mRNA. Translation: AAB04798.1. AY864824 Genomic DNA. Translation: AAW34362.1. BC000083 mRNA. Translation: AAH00083.1. BC008793 mRNA. Translation: AAH08793.1. | |||||||||||||||||||||||||
| IPI | IPI00013122. | ||||||||||||||||||||||||
| PIR | G02313. | ||||||||||||||||||||||||
| RefSeq | NP_008996.1. | ||||||||||||||||||||||||
| UniGene | Hs.160958 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| DIP | DIP:27560N. DIP:395N. | ||||||||||||||||||||||||
| IntAct | Q16543. 36 interactions. | ||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||
| PhosphoSite | Q16543. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PeptideAtlas | Q16543. | ||||||||||||||||||||||||
| PRIDE | Q16543. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENSG00000105401. Homo sapiens. [Contig view] | ||||||||||||||||||||||||
| GeneID | 11140. | ||||||||||||||||||||||||
| KEGG | hsa:11140. | ||||||||||||||||||||||||
| UCSC | uc002mof.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| GeneCards | GC19M010362. | ||||||||||||||||||||||||
| H-InvDB | HIX0014745. | ||||||||||||||||||||||||
| HGNC | HGNC:1735. CDC37. | ||||||||||||||||||||||||
| HPA | CAB004214. HPA003928. | ||||||||||||||||||||||||
| MIM | 605065. gene. | ||||||||||||||||||||||||
| PharmGKB | PA142672192. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOGENOM | Q16543. | ||||||||||||||||||||||||
| HOVERGEN | Q16543. | ||||||||||||||||||||||||
| OMA | Q16543. GLWVPNA. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | Q16543. | ||||||||||||||||||||||||
| Bgee | Q16543. | ||||||||||||||||||||||||
| CleanEx | HS_CDC37. | ||||||||||||||||||||||||
| GermOnline | ENSG00000105401. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR004918. Cdc37. IPR013873. Cdc37_C. IPR013874. Cdc37_Hsp90_bd. IPR013855. Cdc37_N. [Graphical view] | ||||||||||||||||||||||||
| PANTHER | PTHR12800. Cdc37. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF08564. CDC37_C. 1 hit. PF08565. CDC37_M. 1 hit. PF03234. CDC37_N. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 42344. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | CDC37_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16543 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


