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Protein

Hsp90 co-chaperone Cdc37

Gene

CDC37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).2 Publications

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • heat shock protein binding Source: UniProtKB
  • kinase binding Source: ParkinsonsUK-UCL
  • protein kinase regulator activity Source: Ensembl
  • protein tyrosine kinase activity Source: Reactome
  • unfolded protein binding Source: ProtInc

GO - Biological processi

  • ERBB2 signaling pathway Source: Reactome
  • mitophagy in response to mitochondrial depolarization Source: Ensembl
  • posttranscriptional regulation of gene expression Source: Ensembl
  • protein folding Source: GO_Central
  • protein stabilization Source: GO_Central
  • protein targeting Source: ProtInc
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  • regulation of interferon-gamma-mediated signaling pathway Source: MGI
  • regulation of type I interferon-mediated signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105401-MONOMER.
ReactomeiR-HSA-1227986. Signaling by ERBB2.
R-HSA-1236382. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.
R-HSA-5637810. Constitutive Signaling by EGFRvIII.
R-HSA-8863795. Downregulation of ERBB2 signaling.
SIGNORiQ16543.

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp90 co-chaperone Cdc37
Alternative name(s):
Hsp90 chaperone protein kinase-targeting subunit
p50Cdc37
Cleaved into the following chain:
Gene namesi
Name:CDC37
Synonyms:CDC37A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1735. CDC37.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: LIFEdb
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • HSP90-CDC37 chaperone complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi11140.
OpenTargetsiENSG00000105401.
PharmGKBiPA402.

Chemistry databases

ChEMBLiCHEMBL1795123.

Polymorphism and mutation databases

BioMutaiCDC37.
DMDMi21542000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950571 – 378Hsp90 co-chaperone Cdc37Add BLAST378
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004231972 – 378Hsp90 co-chaperone Cdc37, N-terminally processedAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processedCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei78N6-acetyllysineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei377PhosphoserineCombined sources1

Post-translational modificationi

Constitutively sumoylated by UBE2I.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ16543.
MaxQBiQ16543.
PaxDbiQ16543.
PeptideAtlasiQ16543.
PRIDEiQ16543.
TopDownProteomicsiQ16543.

PTM databases

iPTMnetiQ16543.
PhosphoSitePlusiQ16543.
SwissPalmiQ16543.

Expressioni

Gene expression databases

BgeeiENSG00000105401.
CleanExiHS_CDC37.
ExpressionAtlasiQ16543. baseline and differential.
GenevisibleiQ16543. HS.

Organism-specific databases

HPAiCAB004214.
HPA003928.

Interactioni

Subunit structurei

Interacts with HSP90AA1 (PubMed:23569206, PubMed:27353360,). Forms a complex with Hsp90/HSP90AB1 and CDK6 (PubMed:9482106). Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1 (PubMed:11036079, PubMed:11085988, PubMed:9150368, PubMed:9482106). Interacts with KSR1 (PubMed:10409742). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360).7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P115003EBI-295634,EBI-640126From a different organism.
AKT1P317492EBI-295634,EBI-296087
AKT3Q9Y2432EBI-295634,EBI-296115
APOEP026493EBI-295634,EBI-1222467
AURKBQ96GD42EBI-295634,EBI-624291
CDK15Q96Q402EBI-295634,EBI-1051975
CDK4P118027EBI-295634,EBI-295644
CDK6Q005343EBI-295634,EBI-295663
CDK9P507503EBI-295634,EBI-1383449
CHUKO151114EBI-295634,EBI-81249
CUL4BQ136202EBI-295634,EBI-456067
EGFRP005339EBI-295634,EBI-297353
EIF2AK1P332793EBI-295634,EBI-640100From a different organism.
ERBB2P046263EBI-295634,EBI-641062
FBXW2Q9UKT82EBI-295634,EBI-914727
FERP165912EBI-295634,EBI-1380661
FKBP4Q027903EBI-295634,EBI-1047444
HSP90AA1P0790014EBI-295634,EBI-296047
HSP90AB1P082387EBI-295634,EBI-352572
IFIT3O148794EBI-295634,EBI-745127
IKBKBO149204EBI-295634,EBI-81266
IKBKEQ141643EBI-295634,EBI-307369
IKBKGQ9Y6K96EBI-295634,EBI-81279
LRRK2Q5S0077EBI-295634,EBI-5323863
MAP3K14Q995582EBI-295634,EBI-358011
MAP3K7O43318-25EBI-295634,EBI-358700
NOS3P294744EBI-295634,EBI-1391623
PPP5CP530414EBI-295634,EBI-716663
PSEN1P497683EBI-295634,EBI-297277
RAF1P040494EBI-295634,EBI-365996
SQSTM1Q135015EBI-295634,EBI-307104
STK11Q158313EBI-295634,EBI-306838
STK38LQ9Y2H12EBI-295634,EBI-991501
ZNF843Q8N4462EBI-295634,EBI-6428016

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • heat shock protein binding Source: UniProtKB
  • kinase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: ProtInc

Protein-protein interaction databases

BioGridi116312. 227 interactors.
DIPiDIP-27560N.
IntActiQ16543. 336 interactors.
MINTiMINT-99762.
STRINGi9606.ENSP00000222005.

Structurei

Secondary structure

1378
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni13 – 15Combined sources3
Helixi27 – 72Combined sources46
Helixi79 – 109Combined sources31
Helixi113 – 116Combined sources4
Helixi149 – 163Combined sources15
Helixi168 – 177Combined sources10
Helixi179 – 181Combined sources3
Helixi184 – 199Combined sources16
Helixi203 – 226Combined sources24
Helixi230 – 241Combined sources12
Helixi247 – 272Combined sources26
Helixi294 – 300Combined sources7
Helixi303 – 310Combined sources8
Helixi317 – 321Combined sources5
Beta strandi325 – 327Combined sources3
Helixi328 – 338Combined sources11
Beta strandi345 – 347Combined sources3
Beta strandi365 – 367Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1US7X-ray2.30B127-378[»]
2K5BNMR-B148-276[»]
2N5XNMR-A288-378[»]
2NCANMR-A1-126[»]
2W0GX-ray1.88A148-276[»]
5FWKelectron microscopy3.90E1-378[»]
5FWLelectron microscopy9.00E1-378[»]
5FWMelectron microscopy8.00E1-378[»]
ProteinModelPortaliQ16543.
SMRiQ16543.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16543.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC37 family.Curated

Phylogenomic databases

eggNOGiKOG2260. Eukaryota.
ENOG410XTCZ. LUCA.
GeneTreeiENSGT00390000013443.
HOGENOMiHOG000018180.
HOVERGENiHBG056343.
InParanoidiQ16543.
KOiK09554.
OrthoDBiEOG091G0HL8.
PhylomeDBiQ16543.
TreeFamiTF101059.

Family and domain databases

InterProiIPR004918. Cdc37.
IPR013873. Cdc37_C.
IPR013874. Cdc37_Hsp90-bd.
IPR013855. Cdc37_N_dom.
[Graphical view]
PANTHERiPTHR12800. PTHR12800. 1 hit.
PfamiPF08564. CDC37_C. 1 hit.
PF08565. CDC37_M. 1 hit.
PF03234. CDC37_N. 1 hit.
[Graphical view]
SMARTiSM01069. CDC37_C. 1 hit.
SM01070. CDC37_M. 1 hit.
SM01071. CDC37_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL
60 70 80 90 100
DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ
110 120 130 140 150
KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT
160 170 180 190 200
FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH LVCEETANYL VIWCIDLEVE
210 220 230 240 250
EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK IKTADRQYME
260 270 280 290 300
GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES
310 320 330 340 350
LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE
360 370
AKEGEEAGPG DPLLEAVPKT GDEKDVSV
Length:378
Mass (Da):44,468
Last modified:November 1, 1996 - v1
Checksum:i55BFEFFF3C2A5442
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022220360G → E.1 PublicationCorresponds to variant rs280528dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43077 mRNA. Translation: AAB63979.1.
U63131 mRNA. Translation: AAB04798.1.
AY864824 Genomic DNA. Translation: AAW34362.1.
BT006796 mRNA. Translation: AAP35442.1.
CH471106 Genomic DNA. Translation: EAW84101.1.
BC000083 mRNA. Translation: AAH00083.1.
BC008793 mRNA. Translation: AAH08793.1.
CCDSiCCDS12237.1.
PIRiG02313.
RefSeqiNP_008996.1. NM_007065.3.
UniGeneiHs.160958.

Genome annotation databases

EnsembliENST00000222005; ENSP00000222005; ENSG00000105401.
GeneIDi11140.
KEGGihsa:11140.
UCSCiuc002mof.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43077 mRNA. Translation: AAB63979.1.
U63131 mRNA. Translation: AAB04798.1.
AY864824 Genomic DNA. Translation: AAW34362.1.
BT006796 mRNA. Translation: AAP35442.1.
CH471106 Genomic DNA. Translation: EAW84101.1.
BC000083 mRNA. Translation: AAH00083.1.
BC008793 mRNA. Translation: AAH08793.1.
CCDSiCCDS12237.1.
PIRiG02313.
RefSeqiNP_008996.1. NM_007065.3.
UniGeneiHs.160958.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1US7X-ray2.30B127-378[»]
2K5BNMR-B148-276[»]
2N5XNMR-A288-378[»]
2NCANMR-A1-126[»]
2W0GX-ray1.88A148-276[»]
5FWKelectron microscopy3.90E1-378[»]
5FWLelectron microscopy9.00E1-378[»]
5FWMelectron microscopy8.00E1-378[»]
ProteinModelPortaliQ16543.
SMRiQ16543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116312. 227 interactors.
DIPiDIP-27560N.
IntActiQ16543. 336 interactors.
MINTiMINT-99762.
STRINGi9606.ENSP00000222005.

Chemistry databases

ChEMBLiCHEMBL1795123.

PTM databases

iPTMnetiQ16543.
PhosphoSitePlusiQ16543.
SwissPalmiQ16543.

Polymorphism and mutation databases

BioMutaiCDC37.
DMDMi21542000.

Proteomic databases

EPDiQ16543.
MaxQBiQ16543.
PaxDbiQ16543.
PeptideAtlasiQ16543.
PRIDEiQ16543.
TopDownProteomicsiQ16543.

Protocols and materials databases

DNASUi11140.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222005; ENSP00000222005; ENSG00000105401.
GeneIDi11140.
KEGGihsa:11140.
UCSCiuc002mof.2. human.

Organism-specific databases

CTDi11140.
DisGeNETi11140.
GeneCardsiCDC37.
HGNCiHGNC:1735. CDC37.
HPAiCAB004214.
HPA003928.
MIMi605065. gene.
neXtProtiNX_Q16543.
OpenTargetsiENSG00000105401.
PharmGKBiPA402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2260. Eukaryota.
ENOG410XTCZ. LUCA.
GeneTreeiENSGT00390000013443.
HOGENOMiHOG000018180.
HOVERGENiHBG056343.
InParanoidiQ16543.
KOiK09554.
OrthoDBiEOG091G0HL8.
PhylomeDBiQ16543.
TreeFamiTF101059.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105401-MONOMER.
ReactomeiR-HSA-1227986. Signaling by ERBB2.
R-HSA-1236382. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.
R-HSA-5637810. Constitutive Signaling by EGFRvIII.
R-HSA-8863795. Downregulation of ERBB2 signaling.
SIGNORiQ16543.

Miscellaneous databases

ChiTaRSiCDC37. human.
EvolutionaryTraceiQ16543.
GeneWikiiCDC37.
GenomeRNAii11140.
PROiQ16543.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105401.
CleanExiHS_CDC37.
ExpressionAtlasiQ16543. baseline and differential.
GenevisibleiQ16543. HS.

Family and domain databases

InterProiIPR004918. Cdc37.
IPR013873. Cdc37_C.
IPR013874. Cdc37_Hsp90-bd.
IPR013855. Cdc37_N_dom.
[Graphical view]
PANTHERiPTHR12800. PTHR12800. 1 hit.
PfamiPF08564. CDC37_C. 1 hit.
PF08565. CDC37_M. 1 hit.
PF03234. CDC37_N. 1 hit.
[Graphical view]
SMARTiSM01069. CDC37_C. 1 hit.
SM01070. CDC37_M. 1 hit.
SM01071. CDC37_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC37_HUMAN
AccessioniPrimary (citable) accession number: Q16543
Secondary accession number(s): Q53YA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.