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Q16540

- RM23_HUMAN

UniProt

Q16540 - RM23_HUMAN

Protein

39S ribosomal protein L23, mitochondrial

Gene

MRPL23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: ProtInc
    3. structural constituent of ribosome Source: ProtInc

    GO - Biological processi

    1. translation Source: ProtInc

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L23, mitochondrial
    Short name:
    L23mt
    Short name:
    MRP-L23
    Alternative name(s):
    L23 mitochondrial-related protein
    Ribosomal protein L23-like
    Gene namesi
    Name:MRPL23
    Synonyms:L23MRP, RPL23L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10322. MRPL23.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: ProtInc
    2. mitochondrion Source: HPA
    3. nucleolus Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30953.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15315339S ribosomal protein L23, mitochondrialPRO_0000129484Add
    BLAST

    Proteomic databases

    MaxQBiQ16540.
    PaxDbiQ16540.
    PRIDEiQ16540.

    PTM databases

    PhosphoSiteiQ16540.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16540.
    BgeeiQ16540.
    CleanExiHS_MRPL23.
    GenevestigatoriQ16540.

    Organism-specific databases

    HPAiHPA050406.

    Interactioni

    Protein-protein interaction databases

    BioGridi112070. 48 interactions.
    IntActiQ16540. 4 interactions.
    STRINGi9606.ENSP00000370930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L23P family.Curated

    Phylogenomic databases

    eggNOGiNOG309821.
    HOGENOMiHOG000231896.
    HOVERGENiHBG052914.
    KOiK02892.
    OMAiRVFLPNF.
    PhylomeDBiQ16540.
    TreeFamiTF105852.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    IPR013025. Ribosomal_L25/23.
    [Graphical view]
    PfamiPF00276. Ribosomal_L23. 1 hit.
    [Graphical view]
    SUPFAMiSSF54189. SSF54189. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q16540-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR    50
    VDLRNYLEGI YNVPVAAVRT RVQHGSNKRR DHRNVRIKKP DYKVAYVQLA 100
    HGQTFTFPDL FPEKDESPEG SAADDLYSML EEERQQRQSS DPRRGGVPSW 150
    FGL 153
    Length:153
    Mass (Da):17,781
    Last modified:November 1, 1996 - v1
    Checksum:i7277C03CA224ED50
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111R → Q.
    Corresponds to variant rs34134444 [ dbSNP | Ensembl ].
    VAR_057197
    Natural varianti32 – 321G → S.
    Corresponds to variant rs2240197 [ dbSNP | Ensembl ].
    VAR_057198
    Natural varianti34 – 341A → V.
    Corresponds to variant rs6512 [ dbSNP | Ensembl ].
    VAR_057199
    Natural varianti81 – 811D → N.
    Corresponds to variant rs4930142 [ dbSNP | Ensembl ].
    VAR_057200
    Natural varianti122 – 1221A → T.1 Publication
    Corresponds to variant rs12812 [ dbSNP | Ensembl ].
    VAR_057201

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49254 mRNA. Translation: CAA89220.1.
    U26596 mRNA. Translation: AAC50415.1.
    AC051649 Genomic DNA. No translation available.
    CH471158 Genomic DNA. Translation: EAX02472.1.
    BC027710 mRNA. Translation: AAH27710.1.
    AB051340 Genomic DNA. Translation: BAB54930.2.
    CCDSiCCDS31336.1.
    RefSeqiNP_066957.3. NM_021134.3.
    UniGeneiHs.3254.

    Genome annotation databases

    EnsembliENST00000381519; ENSP00000370930; ENSG00000214026.
    ENST00000397298; ENSP00000380466; ENSG00000214026.
    GeneIDi6150.
    KEGGihsa:6150.
    UCSCiuc001lux.3. human.

    Polymorphism databases

    DMDMi68566020.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49254 mRNA. Translation: CAA89220.1 .
    U26596 mRNA. Translation: AAC50415.1 .
    AC051649 Genomic DNA. No translation available.
    CH471158 Genomic DNA. Translation: EAX02472.1 .
    BC027710 mRNA. Translation: AAH27710.1 .
    AB051340 Genomic DNA. Translation: BAB54930.2 .
    CCDSi CCDS31336.1.
    RefSeqi NP_066957.3. NM_021134.3.
    UniGenei Hs.3254.

    3D structure databases

    ProteinModelPortali Q16540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112070. 48 interactions.
    IntActi Q16540. 4 interactions.
    STRINGi 9606.ENSP00000370930.

    PTM databases

    PhosphoSitei Q16540.

    Polymorphism databases

    DMDMi 68566020.

    Proteomic databases

    MaxQBi Q16540.
    PaxDbi Q16540.
    PRIDEi Q16540.

    Protocols and materials databases

    DNASUi 6150.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381519 ; ENSP00000370930 ; ENSG00000214026 .
    ENST00000397298 ; ENSP00000380466 ; ENSG00000214026 .
    GeneIDi 6150.
    KEGGi hsa:6150.
    UCSCi uc001lux.3. human.

    Organism-specific databases

    CTDi 6150.
    GeneCardsi GC11P001971.
    HGNCi HGNC:10322. MRPL23.
    HPAi HPA050406.
    MIMi 600789. gene.
    neXtProti NX_Q16540.
    PharmGKBi PA30953.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309821.
    HOGENOMi HOG000231896.
    HOVERGENi HBG052914.
    KOi K02892.
    OMAi RVFLPNF.
    PhylomeDBi Q16540.
    TreeFami TF105852.

    Miscellaneous databases

    GeneWikii MRPL23.
    GenomeRNAii 6150.
    NextBioi 23889.
    PROi Q16540.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16540.
    Bgeei Q16540.
    CleanExi HS_MRPL23.
    Genevestigatori Q16540.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    IPR013025. Ribosomal_L25/23.
    [Graphical view ]
    Pfami PF00276. Ribosomal_L23. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54189. SSF54189. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues."
      Tsang P., Gilles F., Yuan L., Kuo Y., Lupu F., Samara G., Moosikasuwan J., Goy A., Zelenetz A.D., Selleri L., Tycko B.
      Hum. Mol. Genet. 4:1499-1507(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-130, VARIANT THR-122.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM23_HUMAN
    AccessioniPrimary (citable) accession number: Q16540
    Secondary accession number(s): A8MT29, Q96Q71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3