39S ribosomal protein L23, mitochondrial

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Q16540 (RM23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
39S ribosomal protein L23, mitochondrial
Short name=L23mt
Short name=MRP-L23

Alternative name(s):
L23 mitochondrial-related protein
Ribosomal protein L23-like

Gene names

Name:	MRPL23
Synonyms:	L23MRP, RPL23L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein L23P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Traceable author statement Ref.1. Source: ProtInc
Cellular_component	mitochondrial large ribosomal subunit Traceable author statement Ref.1. Source: ProtInc
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 153

153

39S ribosomal protein L23, mitochondrial

PRO_0000129484

Natural variations

Natural variant

R → Q.
Corresponds to variant rs34134444 [ dbSNP | Ensembl ].

VAR_057197

Natural variant

G → S.
Corresponds to variant rs2240197 [ dbSNP | Ensembl ].

VAR_057198

Natural variant

A → V.
Corresponds to variant rs6512 [ dbSNP | Ensembl ].

VAR_057199

Natural variant

D → N.
Corresponds to variant rs4930142 [ dbSNP | Ensembl ].

VAR_057200

Natural variant

122

A → T. Ref.5
Corresponds to variant rs12812 [ dbSNP | Ensembl ].

VAR_057201

Sequences

Sequence

Length

Mass (Da)

Tools

Q16540 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7277C03CA224ED50
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FASTA

153

17,781

        10         20         30         40         50         60 
MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR VDLRNYLEGI 

        70         80         90        100        110        120 
YNVPVAAVRT RVQHGSNKRR DHRNVRIKKP DYKVAYVQLA HGQTFTFPDL FPEKDESPEG 

       130        140        150 
SAADDLYSML EEERQQRQSS DPRRGGVPSW FGL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues." Tsang P., Gilles F., Yuan L., Kuo Y., Lupu F., Samara G., Moosikasuwan J., Goy A., Zelenetz A.D., Selleri L., Tycko B. Hum. Mol. Genet. 4:1499-1507(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-130, VARIANT THR-122.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49254 mRNA. Translation: CAA89220.1. U26596 mRNA. Translation: AAC50415.1. AC051649 Genomic DNA. No translation available. CH471158 Genomic DNA. Translation: EAX02472.1. BC027710 mRNA. Translation: AAH27710.1. AB051340 Genomic DNA. Translation: BAB54930.2.
IPI	IPI00293476.
RefSeq	NP_066957.3. NM_021134.3.
UniGene	Hs.3254.
3D structure databases
ProteinModelPortal	Q16540.
SMR	Q16540. Positions 35-107.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16540. 4 interactions.
STRING	9606.ENSP00000370930.
PTM databases
PhosphoSite	Q16540.
Polymorphism databases
DMDM	68566020.
Proteomic databases
PaxDb	Q16540.
PRIDE	Q16540.
Protocols and materials databases
DNASU	6150.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381519; ENSP00000370930; ENSG00000214026. ENST00000397298; ENSP00000380466; ENSG00000214026.
GeneID	6150.
KEGG	hsa:6150.
UCSC	uc001lux.3. human.
Organism-specific databases
CTD	6150.
GeneCards	GC11P001961.
HGNC	HGNC:10322. MRPL23.
HPA	HPA050406.
MIM	600789. gene.
neXtProt	NX_Q16540.
PharmGKB	PA30953.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG309821.
HOGENOM	HOG000231896.
HOVERGEN	HBG052914.
KO	K02892.
OMA	RVFLPNF.
OrthoDB	EOG4N5VZ3.
Gene expression databases
ArrayExpress	Q16540.
Bgee	Q16540.
CleanEx	HS_MRPL23.
Genevestigator	Q16540.
GermOnline	ENSG00000205751. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR012678. Ribosomal_L23/L15e_core_dom. IPR013025. Ribosomal_L25/23. [Graphical view]
Pfam	PF00276. Ribosomal_L23. 1 hit. [Graphical view]
SUPFAM	SSF54189. L23_L15e_core. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	6150.
NextBio	23889.
SOURCE	Search...

Entry information

Entry name

RM23_HUMAN

Accession

Primary (citable) accession number: Q16540
Secondary accession number(s): A8MT29, Q96Q71

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.