Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q16540 (RM23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L23, mitochondrial

Short name=L23mt
Short name=MRP-L23
Alternative name(s):
L23 mitochondrial-related protein
Ribosomal protein L23-like
Gene names
Name:MRPL23
Synonyms:L23MRP, RPL23L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the ribosomal protein L23P family.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentmitochondrial large ribosomal subunit

Traceable author statement Ref.1. Source: ProtInc

mitochondrion

Inferred from direct assay. Source: HPA

nucleolus

Inferred from direct assay. Source: HPA

   Molecular_functionRNA binding

Traceable author statement Ref.1. Source: ProtInc

nucleotide binding

Inferred from electronic annotation. Source: InterPro

structural constituent of ribosome

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15315339S ribosomal protein L23, mitochondrial
PRO_0000129484

Natural variations

Natural variant111R → Q.
Corresponds to variant rs34134444 [ dbSNP | Ensembl ].
VAR_057197
Natural variant321G → S.
Corresponds to variant rs2240197 [ dbSNP | Ensembl ].
VAR_057198
Natural variant341A → V.
Corresponds to variant rs6512 [ dbSNP | Ensembl ].
VAR_057199
Natural variant811D → N.
Corresponds to variant rs4930142 [ dbSNP | Ensembl ].
VAR_057200
Natural variant1221A → T. Ref.5
Corresponds to variant rs12812 [ dbSNP | Ensembl ].
VAR_057201

Sequences

Sequence LengthMass (Da)Tools
Q16540 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7277C03CA224ED50

FASTA15317,781
        10         20         30         40         50         60 
MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR VDLRNYLEGI 

        70         80         90        100        110        120 
YNVPVAAVRT RVQHGSNKRR DHRNVRIKKP DYKVAYVQLA HGQTFTFPDL FPEKDESPEG 

       130        140        150 
SAADDLYSML EEERQQRQSS DPRRGGVPSW FGL 

« Hide

References

« Hide 'large scale' references
[1]"A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues."
Tsang P., Gilles F., Yuan L., Kuo Y., Lupu F., Samara G., Moosikasuwan J., Goy A., Zelenetz A.D., Selleri L., Tycko B.
Hum. Mol. Genet. 4:1499-1507(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-130, VARIANT THR-122.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49254 mRNA. Translation: CAA89220.1.
U26596 mRNA. Translation: AAC50415.1.
AC051649 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02472.1.
BC027710 mRNA. Translation: AAH27710.1.
AB051340 Genomic DNA. Translation: BAB54930.2.
CCDSCCDS31336.1.
RefSeqNP_066957.3. NM_021134.3.
UniGeneHs.3254.

3D structure databases

ProteinModelPortalQ16540.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112070. 48 interactions.
IntActQ16540. 4 interactions.
STRING9606.ENSP00000370930.

PTM databases

PhosphoSiteQ16540.

Polymorphism databases

DMDM68566020.

Proteomic databases

MaxQBQ16540.
PaxDbQ16540.
PRIDEQ16540.

Protocols and materials databases

DNASU6150.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381519; ENSP00000370930; ENSG00000214026.
ENST00000397298; ENSP00000380466; ENSG00000214026.
GeneID6150.
KEGGhsa:6150.
UCSCuc001lux.3. human.

Organism-specific databases

CTD6150.
GeneCardsGC11P001971.
HGNCHGNC:10322. MRPL23.
HPAHPA050406.
MIM600789. gene.
neXtProtNX_Q16540.
PharmGKBPA30953.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309821.
HOGENOMHOG000231896.
HOVERGENHBG052914.
KOK02892.
OMARVFLPNF.
PhylomeDBQ16540.
TreeFamTF105852.

Gene expression databases

ArrayExpressQ16540.
BgeeQ16540.
CleanExHS_MRPL23.
GenevestigatorQ16540.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamPF00276. Ribosomal_L23. 1 hit.
[Graphical view]
SUPFAMSSF54189. SSF54189. 1 hit.
ProtoNetSearch...

Other

GeneWikiMRPL23.
GenomeRNAi6150.
NextBio23889.
PROQ16540.
SOURCESearch...

Entry information

Entry nameRM23_HUMAN
AccessionPrimary (citable) accession number: Q16540
Secondary accession number(s): A8MT29, Q96Q71
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM