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Protein

39S ribosomal protein L23, mitochondrial

Gene

MRPL23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L23, mitochondrial
Short name:
L23mt
Short name:
MRP-L23
Alternative name(s):
L23 mitochondrial-related protein
Mitochondrial large ribosomal subunit protein uL23m1 Publication
Ribosomal protein L23-like
Gene namesi
Name:MRPL23
Synonyms:L23MRP, RPL23L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10322. MRPL23.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi6150.
OpenTargetsiENSG00000214026.
PharmGKBiPA30953.

Polymorphism and mutation databases

BioMutaiMRPL23.
DMDMi68566020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001294841 – 15339S ribosomal protein L23, mitochondrialAdd BLAST153

Proteomic databases

EPDiQ16540.
MaxQBiQ16540.
PaxDbiQ16540.
PeptideAtlasiQ16540.
PRIDEiQ16540.
TopDownProteomicsiQ16540.

PTM databases

iPTMnetiQ16540.
PhosphoSitePlusiQ16540.

Expressioni

Gene expression databases

BgeeiENSG00000214026.
CleanExiHS_MRPL23.
ExpressionAtlasiQ16540. baseline and differential.
GenevisibleiQ16540. HS.

Organism-specific databases

HPAiHPA050406.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PNMA1Q8ND903EBI-1046141,EBI-302345

Protein-protein interaction databases

BioGridi112070. 89 interactors.
IntActiQ16540. 19 interactors.
STRINGi9606.ENSP00000370930.

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 21Combined sources4
Beta strandi27 – 29Combined sources3
Beta strandi39 – 44Combined sources6
Helixi50 – 60Combined sources11
Beta strandi65 – 73Combined sources9
Beta strandi92 – 100Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40U1-153[»]
3J9Melectron microscopy3.50U1-153[»]
ProteinModelPortaliQ16540.
SMRiQ16540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4089. Eukaryota.
ENOG4111IAB. LUCA.
GeneTreeiENSGT00390000007739.
HOGENOMiHOG000231896.
HOVERGENiHBG052914.
InParanoidiQ16540.
KOiK02892.
OMAiEMTKYDV.
PhylomeDBiQ16540.
TreeFamiTF105852.

Family and domain databases

InterProiView protein in InterPro
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR013025. Ribosomal_L25/23.
PfamiView protein in Pfam
PF00276. Ribosomal_L23. 1 hit.
SUPFAMiSSF54189. SSF54189. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR
60 70 80 90 100
VDLRNYLEGI YNVPVAAVRT RVQHGSNKRR DHRNVRIKKP DYKVAYVQLA
110 120 130 140 150
HGQTFTFPDL FPEKDESPEG SAADDLYSML EEERQQRQSS DPRRGGVPSW

FGL
Length:153
Mass (Da):17,781
Last modified:November 1, 1996 - v1
Checksum:i7277C03CA224ED50
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05719711R → Q. Corresponds to variant dbSNP:rs34134444Ensembl.1
Natural variantiVAR_05719832G → S. Corresponds to variant dbSNP:rs2240197Ensembl.1
Natural variantiVAR_05719934A → V. Corresponds to variant dbSNP:rs6512Ensembl.1
Natural variantiVAR_05720081D → N. Corresponds to variant dbSNP:rs4930142Ensembl.1
Natural variantiVAR_057201122A → T1 PublicationCorresponds to variant dbSNP:rs12812Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49254 mRNA. Translation: CAA89220.1.
U26596 mRNA. Translation: AAC50415.1.
AC051649 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02472.1.
BC027710 mRNA. Translation: AAH27710.1.
AB051340 Genomic DNA. Translation: BAB54930.2.
CCDSiCCDS31336.1.
RefSeqiNP_066957.3. NM_021134.3.
UniGeneiHs.3254.

Genome annotation databases

EnsembliENST00000381519; ENSP00000370930; ENSG00000214026.
ENST00000397298; ENSP00000380466; ENSG00000214026.
GeneIDi6150.
KEGGihsa:6150.
UCSCiuc001lux.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM23_HUMAN
AccessioniPrimary (citable) accession number: Q16540
Secondary accession number(s): A8MT29, Q96Q71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families