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Q16540

- RM23_HUMAN

UniProt

Q16540 - RM23_HUMAN

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Protein
39S ribosomal protein L23, mitochondrial
Gene
MRPL23, L23MRP, RPL23L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. nucleotide binding Source: InterPro
  3. structural constituent of ribosome Source: ProtInc

GO - Biological processi

  1. translation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L23, mitochondrial
Short name:
L23mt
Short name:
MRP-L23
Alternative name(s):
L23 mitochondrial-related protein
Ribosomal protein L23-like
Gene namesi
Name:MRPL23
Synonyms:L23MRP, RPL23L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:10322. MRPL23.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: ProtInc
  2. mitochondrion Source: HPA
  3. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30953.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15315339S ribosomal protein L23, mitochondrial
PRO_0000129484Add
BLAST

Proteomic databases

MaxQBiQ16540.
PaxDbiQ16540.
PRIDEiQ16540.

PTM databases

PhosphoSiteiQ16540.

Expressioni

Gene expression databases

ArrayExpressiQ16540.
BgeeiQ16540.
CleanExiHS_MRPL23.
GenevestigatoriQ16540.

Organism-specific databases

HPAiHPA050406.

Interactioni

Protein-protein interaction databases

BioGridi112070. 48 interactions.
IntActiQ16540. 4 interactions.
STRINGi9606.ENSP00000370930.

Structurei

3D structure databases

ProteinModelPortaliQ16540.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG309821.
HOGENOMiHOG000231896.
HOVERGENiHBG052914.
KOiK02892.
OMAiRVFLPNF.
PhylomeDBiQ16540.
TreeFamiTF105852.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16540-1 [UniParc]FASTAAdd to Basket

« Hide

MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR    50
VDLRNYLEGI YNVPVAAVRT RVQHGSNKRR DHRNVRIKKP DYKVAYVQLA 100
HGQTFTFPDL FPEKDESPEG SAADDLYSML EEERQQRQSS DPRRGGVPSW 150
FGL 153
Length:153
Mass (Da):17,781
Last modified:November 1, 1996 - v1
Checksum:i7277C03CA224ED50
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111R → Q.
Corresponds to variant rs34134444 [ dbSNP | Ensembl ].
VAR_057197
Natural varianti32 – 321G → S.
Corresponds to variant rs2240197 [ dbSNP | Ensembl ].
VAR_057198
Natural varianti34 – 341A → V.
Corresponds to variant rs6512 [ dbSNP | Ensembl ].
VAR_057199
Natural varianti81 – 811D → N.
Corresponds to variant rs4930142 [ dbSNP | Ensembl ].
VAR_057200
Natural varianti122 – 1221A → T.1 Publication
Corresponds to variant rs12812 [ dbSNP | Ensembl ].
VAR_057201

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49254 mRNA. Translation: CAA89220.1.
U26596 mRNA. Translation: AAC50415.1.
AC051649 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02472.1.
BC027710 mRNA. Translation: AAH27710.1.
AB051340 Genomic DNA. Translation: BAB54930.2.
CCDSiCCDS31336.1.
RefSeqiNP_066957.3. NM_021134.3.
UniGeneiHs.3254.

Genome annotation databases

EnsembliENST00000381519; ENSP00000370930; ENSG00000214026.
ENST00000397298; ENSP00000380466; ENSG00000214026.
GeneIDi6150.
KEGGihsa:6150.
UCSCiuc001lux.3. human.

Polymorphism databases

DMDMi68566020.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49254 mRNA. Translation: CAA89220.1 .
U26596 mRNA. Translation: AAC50415.1 .
AC051649 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02472.1 .
BC027710 mRNA. Translation: AAH27710.1 .
AB051340 Genomic DNA. Translation: BAB54930.2 .
CCDSi CCDS31336.1.
RefSeqi NP_066957.3. NM_021134.3.
UniGenei Hs.3254.

3D structure databases

ProteinModelPortali Q16540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112070. 48 interactions.
IntActi Q16540. 4 interactions.
STRINGi 9606.ENSP00000370930.

PTM databases

PhosphoSitei Q16540.

Polymorphism databases

DMDMi 68566020.

Proteomic databases

MaxQBi Q16540.
PaxDbi Q16540.
PRIDEi Q16540.

Protocols and materials databases

DNASUi 6150.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381519 ; ENSP00000370930 ; ENSG00000214026 .
ENST00000397298 ; ENSP00000380466 ; ENSG00000214026 .
GeneIDi 6150.
KEGGi hsa:6150.
UCSCi uc001lux.3. human.

Organism-specific databases

CTDi 6150.
GeneCardsi GC11P001971.
HGNCi HGNC:10322. MRPL23.
HPAi HPA050406.
MIMi 600789. gene.
neXtProti NX_Q16540.
PharmGKBi PA30953.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309821.
HOGENOMi HOG000231896.
HOVERGENi HBG052914.
KOi K02892.
OMAi RVFLPNF.
PhylomeDBi Q16540.
TreeFami TF105852.

Miscellaneous databases

GeneWikii MRPL23.
GenomeRNAii 6150.
NextBioi 23889.
PROi Q16540.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q16540.
Bgeei Q16540.
CleanExi HS_MRPL23.
Genevestigatori Q16540.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR013025. Ribosomal_L25/23.
[Graphical view ]
Pfami PF00276. Ribosomal_L23. 1 hit.
[Graphical view ]
SUPFAMi SSF54189. SSF54189. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues."
    Tsang P., Gilles F., Yuan L., Kuo Y., Lupu F., Samara G., Moosikasuwan J., Goy A., Zelenetz A.D., Selleri L., Tycko B.
    Hum. Mol. Genet. 4:1499-1507(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-130, VARIANT THR-122.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM23_HUMAN
AccessioniPrimary (citable) accession number: Q16540
Secondary accession number(s): A8MT29, Q96Q71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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