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Protein

39S ribosomal protein L23, mitochondrial

Gene

MRPL23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L23, mitochondrial
Short name:
L23mt
Short name:
MRP-L23
Alternative name(s):
L23 mitochondrial-related protein
Ribosomal protein L23-like
Gene namesi
Name:MRPL23
Synonyms:L23MRP, RPL23L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10322. MRPL23.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: ProtInc
  • mitochondrion Source: HPA
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30953.

Polymorphism and mutation databases

BioMutaiMRPL23.
DMDMi68566020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15315339S ribosomal protein L23, mitochondrialPRO_0000129484Add
BLAST

Proteomic databases

MaxQBiQ16540.
PaxDbiQ16540.
PRIDEiQ16540.

PTM databases

PhosphoSiteiQ16540.

Expressioni

Gene expression databases

BgeeiQ16540.
CleanExiHS_MRPL23.
ExpressionAtlasiQ16540. baseline and differential.
GenevisibleiQ16540. HS.

Organism-specific databases

HPAiHPA050406.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PNMA1Q8ND903EBI-1046141,EBI-302345

Protein-protein interaction databases

BioGridi112070. 53 interactions.
IntActiQ16540. 5 interactions.
STRINGi9606.ENSP00000370930.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40U1-153[»]
3J9Melectron microscopy3.50U1-153[»]
ProteinModelPortaliQ16540.
SMRiQ16540. Positions 2-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L23P family.Curated

Phylogenomic databases

eggNOGiNOG309821.
GeneTreeiENSGT00390000007739.
HOGENOMiHOG000231896.
HOVERGENiHBG052914.
InParanoidiQ16540.
KOiK02892.
OMAiRGGVTEW.
PhylomeDBiQ16540.
TreeFamiTF105852.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.

Sequencei

Sequence statusi: Complete.

Q16540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR
60 70 80 90 100
VDLRNYLEGI YNVPVAAVRT RVQHGSNKRR DHRNVRIKKP DYKVAYVQLA
110 120 130 140 150
HGQTFTFPDL FPEKDESPEG SAADDLYSML EEERQQRQSS DPRRGGVPSW

FGL
Length:153
Mass (Da):17,781
Last modified:November 1, 1996 - v1
Checksum:i7277C03CA224ED50
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111R → Q.
Corresponds to variant rs34134444 [ dbSNP | Ensembl ].
VAR_057197
Natural varianti32 – 321G → S.
Corresponds to variant rs2240197 [ dbSNP | Ensembl ].
VAR_057198
Natural varianti34 – 341A → V.
Corresponds to variant rs6512 [ dbSNP | Ensembl ].
VAR_057199
Natural varianti81 – 811D → N.
Corresponds to variant rs4930142 [ dbSNP | Ensembl ].
VAR_057200
Natural varianti122 – 1221A → T.1 Publication
Corresponds to variant rs12812 [ dbSNP | Ensembl ].
VAR_057201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49254 mRNA. Translation: CAA89220.1.
U26596 mRNA. Translation: AAC50415.1.
AC051649 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02472.1.
BC027710 mRNA. Translation: AAH27710.1.
AB051340 Genomic DNA. Translation: BAB54930.2.
CCDSiCCDS31336.1.
RefSeqiNP_066957.3. NM_021134.3.
UniGeneiHs.3254.

Genome annotation databases

EnsembliENST00000381519; ENSP00000370930; ENSG00000214026.
ENST00000397298; ENSP00000380466; ENSG00000214026.
GeneIDi6150.
KEGGihsa:6150.
UCSCiuc001lux.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49254 mRNA. Translation: CAA89220.1.
U26596 mRNA. Translation: AAC50415.1.
AC051649 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02472.1.
BC027710 mRNA. Translation: AAH27710.1.
AB051340 Genomic DNA. Translation: BAB54930.2.
CCDSiCCDS31336.1.
RefSeqiNP_066957.3. NM_021134.3.
UniGeneiHs.3254.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40U1-153[»]
3J9Melectron microscopy3.50U1-153[»]
ProteinModelPortaliQ16540.
SMRiQ16540. Positions 2-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112070. 53 interactions.
IntActiQ16540. 5 interactions.
STRINGi9606.ENSP00000370930.

PTM databases

PhosphoSiteiQ16540.

Polymorphism and mutation databases

BioMutaiMRPL23.
DMDMi68566020.

Proteomic databases

MaxQBiQ16540.
PaxDbiQ16540.
PRIDEiQ16540.

Protocols and materials databases

DNASUi6150.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381519; ENSP00000370930; ENSG00000214026.
ENST00000397298; ENSP00000380466; ENSG00000214026.
GeneIDi6150.
KEGGihsa:6150.
UCSCiuc001lux.3. human.

Organism-specific databases

CTDi6150.
GeneCardsiGC11P001972.
HGNCiHGNC:10322. MRPL23.
HPAiHPA050406.
MIMi600789. gene.
neXtProtiNX_Q16540.
PharmGKBiPA30953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG309821.
GeneTreeiENSGT00390000007739.
HOGENOMiHOG000231896.
HOVERGENiHBG052914.
InParanoidiQ16540.
KOiK02892.
OMAiRGGVTEW.
PhylomeDBiQ16540.
TreeFamiTF105852.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL23. human.
GeneWikiiMRPL23.
GenomeRNAii6150.
NextBioi23889.
PROiQ16540.
SOURCEiSearch...

Gene expression databases

BgeeiQ16540.
CleanExiHS_MRPL23.
ExpressionAtlasiQ16540. baseline and differential.
GenevisibleiQ16540. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues."
    Tsang P., Gilles F., Yuan L., Kuo Y., Lupu F., Samara G., Moosikasuwan J., Goy A., Zelenetz A.D., Selleri L., Tycko B.
    Hum. Mol. Genet. 4:1499-1507(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-130, VARIANT THR-122.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM23_HUMAN
AccessioniPrimary (citable) accession number: Q16540
Secondary accession number(s): A8MT29, Q96Q71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.