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Protein

Probable G-protein coupled receptor 162

Gene

GPR162

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-32212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 162
Alternative name(s):
Gene-rich cluster gene A protein
Gene namesi
Name:GPR162
Synonyms:GRCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16693. GPR162.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 49CytoplasmicSequence analysisAdd BLAST11
Transmembranei50 – 70Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini71 – 91ExtracellularSequence analysisAdd BLAST21
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 133CytoplasmicSequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 174ExtracellularSequence analysisAdd BLAST20
Transmembranei175 – 195Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini196 – 275CytoplasmicSequence analysisAdd BLAST80
Transmembranei276 – 296Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini297 – 303ExtracellularSequence analysis7
Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini325 – 588CytoplasmicSequence analysisAdd BLAST264

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27239.
OpenTargetsiENSG00000250510.
PharmGKBiPA142671713.

Polymorphism and mutation databases

BioMutaiGPR162.
DMDMi74754516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696471 – 588Probable G-protein coupled receptor 162Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Modified residuei413PhosphoserineBy similarity1
Modified residuei435PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ16538.
PeptideAtlasiQ16538.
PRIDEiQ16538.

PTM databases

PhosphoSitePlusiQ16538.

Expressioni

Gene expression databases

BgeeiENSG00000250510.
CleanExiHS_GPR162.
ExpressionAtlasiQ16538. baseline and differential.
GenevisibleiQ16538. HS.

Organism-specific databases

HPAiHPA055135.

Interactioni

Protein-protein interaction databases

IntActiQ16538. 2 interactors.
STRINGi9606.ENSP00000311528.

Structurei

3D structure databases

ProteinModelPortaliQ16538.
SMRiQ16538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ16538.
KOiK08440.
OMAiGDGRICK.
OrthoDBiEOG091G02R9.
PhylomeDBiQ16538.
TreeFamiTF330832.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022348. GPR162.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01991. GPR153GPR162.
PR01993. GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16538-1) [UniParc]FASTAAdd to basket
Also known as: A-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGGAGAEE ASLRSNALSW LACGLLALLA NAWIILSISA KQQKHKPLEL
60 70 80 90 100
LLCFLAGTHI LMAAVPLTTF AVVQLRRQAS SDYDWNESIC KVFVSTYYTL
110 120 130 140 150
ALATCFTVAS LSYHRMWMVR WPVNYRLSNA KKQALHAVMG IWMVSFILST
160 170 180 190 200
LPSIGWHNNG ERYYARGCQF IVSKIGLGFG VCFSLLLLGG IVMGLVCVAI
210 220 230 240 250
TFYQTLWARP RRARQARRVG GGGGTKAGGP GALGTRPAFE VPAIVVEDAR
260 270 280 290 300
GKRRSSLDGS ESAKTSLQVT NLVSAIVFLY DSLTGVPILV VSFFSLKSDS
310 320 330 340 350
APPWMVLAVL WCSMAQTLLL PSFIWSCERY RADVRTVWEQ CVAIMSEEDG
360 370 380 390 400
DDDGGCDDYA EGRVCKVRFD ANGATGPGSR DPAQVKLLPG RHMLFPPLER
410 420 430 440 450
VHYLQVPLSR RLSHDETNIF STPREPGSFL HKWSSSDDIR VLPAQSRALG
460 470 480 490 500
GPPEYLGQRH RLEDEEDEEE AEGGGLASLR QFLESGVLGS GGGPPRGPGF
510 520 530 540 550
FREEITTFID ETPLPSPTAS PGHSPRRPRP LGLSPRRLSL GSPESRAVGL
560 570 580
PLGLSAGRRC SLTGGEESAR AWGGSWGPGN PIFPQLTL
Length:588
Mass (Da):63,930
Last modified:November 1, 1996 - v1
Checksum:i746BBE0BD83C8566
GO
Isoform 2 (identifier: Q16538-2) [UniParc]FASTAAdd to basket
Also known as: A-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-284: Missing.
     285-289: GVPIL → MLSTG

Show »
Length:304
Mass (Da):33,062
Checksum:iD3013B51477F6C28
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049407459R → G.1 PublicationCorresponds to variant rs11612427dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163021 – 284Missing in isoform 2. 2 PublicationsAdd BLAST284
Alternative sequenceiVSP_016303285 – 289GVPIL → MLSTG in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. Translation: AAB51310.1.
U47924 Genomic DNA. Translation: AAB51311.1.
U47925 mRNA. Translation: AAC50463.1.
U47928 mRNA. Translation: AAC50466.1.
BC002353 mRNA. Translation: AAH02353.1.
BC080585 mRNA. Translation: AAH80585.1.
AB209836 mRNA. Translation: BAD93073.1.
CCDSiCCDS44819.1. [Q16538-2]
CCDS8563.1. [Q16538-1]
RefSeqiNP_055264.1. NM_014449.1. [Q16538-2]
NP_062832.1. NM_019858.1. [Q16538-1]
UniGeneiHs.631654.

Genome annotation databases

EnsembliENST00000311268; ENSP00000311528; ENSG00000250510. [Q16538-1]
ENST00000428545; ENSP00000399670; ENSG00000250510. [Q16538-2]
GeneIDi27239.
KEGGihsa:27239.
UCSCiuc001qqw.2. human. [Q16538-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. Translation: AAB51310.1.
U47924 Genomic DNA. Translation: AAB51311.1.
U47925 mRNA. Translation: AAC50463.1.
U47928 mRNA. Translation: AAC50466.1.
BC002353 mRNA. Translation: AAH02353.1.
BC080585 mRNA. Translation: AAH80585.1.
AB209836 mRNA. Translation: BAD93073.1.
CCDSiCCDS44819.1. [Q16538-2]
CCDS8563.1. [Q16538-1]
RefSeqiNP_055264.1. NM_014449.1. [Q16538-2]
NP_062832.1. NM_019858.1. [Q16538-1]
UniGeneiHs.631654.

3D structure databases

ProteinModelPortaliQ16538.
SMRiQ16538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ16538. 2 interactors.
STRINGi9606.ENSP00000311528.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ16538.

Polymorphism and mutation databases

BioMutaiGPR162.
DMDMi74754516.

Proteomic databases

PaxDbiQ16538.
PeptideAtlasiQ16538.
PRIDEiQ16538.

Protocols and materials databases

DNASUi27239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311268; ENSP00000311528; ENSG00000250510. [Q16538-1]
ENST00000428545; ENSP00000399670; ENSG00000250510. [Q16538-2]
GeneIDi27239.
KEGGihsa:27239.
UCSCiuc001qqw.2. human. [Q16538-1]

Organism-specific databases

CTDi27239.
DisGeNETi27239.
GeneCardsiGPR162.
HGNCiHGNC:16693. GPR162.
HPAiHPA055135.
neXtProtiNX_Q16538.
OpenTargetsiENSG00000250510.
PharmGKBiPA142671713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ16538.
KOiK08440.
OMAiGDGRICK.
OrthoDBiEOG091G02R9.
PhylomeDBiQ16538.
TreeFamiTF330832.

Enzyme and pathway databases

BioCyciZFISH:G66-32212-MONOMER.

Miscellaneous databases

ChiTaRSiGPR162. human.
GeneWikiiGPR162.
GenomeRNAii27239.
PROiQ16538.

Gene expression databases

BgeeiENSG00000250510.
CleanExiHS_GPR162.
ExpressionAtlasiQ16538. baseline and differential.
GenevisibleiQ16538. HS.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022348. GPR162.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01991. GPR153GPR162.
PR01993. GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP162_HUMAN
AccessioniPrimary (citable) accession number: Q16538
Secondary accession number(s): Q16664, Q59EH5, Q66K56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.