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Protein

Hepatic leukemia factor

Gene

HLF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • rhythmic process Source: UniProtKB-KW
  • skeletal muscle cell differentiation Source: Ensembl
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108924-MONOMER.
SignaLinkiQ16534.
SIGNORiQ16534.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic leukemia factor
Gene namesi
Name:HLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4977. HLF.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi3131.
MalaCardsiHLF.
OpenTargetsiENSG00000108924.
Orphaneti99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA29311.

Polymorphism and mutation databases

BioMutaiHLF.
DMDMi6919907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765101 – 295Hepatic leukemia factorAdd BLAST295

Proteomic databases

PaxDbiQ16534.
PeptideAtlasiQ16534.
PRIDEiQ16534.

PTM databases

PhosphoSitePlusiQ16534.

Expressioni

Tissue specificityi

Highly expressed in liver; lower levels in lung and kidney.

Inductioni

Accumulates according to a robust circadian rhythm.By similarity

Gene expression databases

BgeeiENSG00000108924.
CleanExiHS_HLF.
ExpressionAtlasiQ16534. baseline and differential.
GenevisibleiQ16534. HS.

Organism-specific databases

HPAiHPA059970.

Interactioni

Subunit structurei

Binds DNA specifically as homodimer or heterodimer with other PAR factors.

Protein-protein interaction databases

BioGridi109376. 4 interactors.
IntActiQ16534. 28 interactors.
STRINGi9606.ENSP00000226067.

Structurei

3D structure databases

ProteinModelPortaliQ16534.
SMRiQ16534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 288bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 247Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni248 – 255Leucine-zipperPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 209Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ16534.
KOiK09057.
OMAiMEKMSRQ.
OrthoDBiEOG091G0EO0.
PhylomeDBiQ16534.
TreeFamiTF315869.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029829. HLF.
[Graphical view]
PANTHERiPTHR11988:SF28. PTHR11988:SF28. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16534-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKMSRPLPL NPTFIPPPYG VLRSLLENPL KLPLHHEDAF SKDKDKEKKL
60 70 80 90 100
DDESNSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS
110 120 130 140 150
PSQHDHSPHP PGLQPASSAA PSVMDLSSRA SAPLHPGIPS PNCMQSPIRP
160 170 180 190 200
GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGQ EMFDPRKRKF
210 220 230 240 250
SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE
260 270 280 290
NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL
Length:295
Mass (Da):33,199
Last modified:November 1, 1996 - v1
Checksum:i80572A727BBB5635
GO
Isoform 2 (identifier: Q16534-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):23,477
Checksum:iCF954DE7F11388D5
GO

Sequence cautioni

The sequence AAA58445 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_008515253I → F in fusion protein; decreases DNA-binding activity. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0538521 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95585 mRNA. Translation: AAA52675.1.
M95586 mRNA. Translation: AAA58445.1. Different initiation.
X68985 mRNA. Translation: CAA48777.1.
AK290043 mRNA. Translation: BAF82732.1.
AK315079 mRNA. Translation: BAG37547.1.
CR541672 mRNA. Translation: CAG46473.1.
AC007638 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94544.1.
BC036093 mRNA. Translation: AAH36093.1.
CCDSiCCDS11585.1. [Q16534-1]
CCDS82164.1. [Q16534-2]
PIRiA44064.
RefSeqiNP_001317304.1. NM_001330375.1.
NP_002117.1. NM_002126.4. [Q16534-1]
UniGeneiHs.196952.

Genome annotation databases

EnsembliENST00000226067; ENSP00000226067; ENSG00000108924. [Q16534-1]
ENST00000430986; ENSP00000402496; ENSG00000108924. [Q16534-2]
ENST00000573945; ENSP00000460296; ENSG00000108924. [Q16534-2]
ENST00000575345; ENSP00000460572; ENSG00000108924. [Q16534-2]
GeneIDi3131.
KEGGihsa:3131.
UCSCiuc002iug.2. human. [Q16534-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95585 mRNA. Translation: AAA52675.1.
M95586 mRNA. Translation: AAA58445.1. Different initiation.
X68985 mRNA. Translation: CAA48777.1.
AK290043 mRNA. Translation: BAF82732.1.
AK315079 mRNA. Translation: BAG37547.1.
CR541672 mRNA. Translation: CAG46473.1.
AC007638 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94544.1.
BC036093 mRNA. Translation: AAH36093.1.
CCDSiCCDS11585.1. [Q16534-1]
CCDS82164.1. [Q16534-2]
PIRiA44064.
RefSeqiNP_001317304.1. NM_001330375.1.
NP_002117.1. NM_002126.4. [Q16534-1]
UniGeneiHs.196952.

3D structure databases

ProteinModelPortaliQ16534.
SMRiQ16534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109376. 4 interactors.
IntActiQ16534. 28 interactors.
STRINGi9606.ENSP00000226067.

PTM databases

PhosphoSitePlusiQ16534.

Polymorphism and mutation databases

BioMutaiHLF.
DMDMi6919907.

Proteomic databases

PaxDbiQ16534.
PeptideAtlasiQ16534.
PRIDEiQ16534.

Protocols and materials databases

DNASUi3131.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226067; ENSP00000226067; ENSG00000108924. [Q16534-1]
ENST00000430986; ENSP00000402496; ENSG00000108924. [Q16534-2]
ENST00000573945; ENSP00000460296; ENSG00000108924. [Q16534-2]
ENST00000575345; ENSP00000460572; ENSG00000108924. [Q16534-2]
GeneIDi3131.
KEGGihsa:3131.
UCSCiuc002iug.2. human. [Q16534-1]

Organism-specific databases

CTDi3131.
DisGeNETi3131.
GeneCardsiHLF.
HGNCiHGNC:4977. HLF.
HPAiHPA059970.
MalaCardsiHLF.
MIMi142385. gene.
neXtProtiNX_Q16534.
OpenTargetsiENSG00000108924.
Orphaneti99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA29311.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ16534.
KOiK09057.
OMAiMEKMSRQ.
OrthoDBiEOG091G0EO0.
PhylomeDBiQ16534.
TreeFamiTF315869.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108924-MONOMER.
SignaLinkiQ16534.
SIGNORiQ16534.

Miscellaneous databases

GeneWikiiHLF_(gene).
GenomeRNAii3131.
PROiQ16534.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108924.
CleanExiHS_HLF.
ExpressionAtlasiQ16534. baseline and differential.
GenevisibleiQ16534. HS.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029829. HLF.
[Graphical view]
PANTHERiPTHR11988:SF28. PTHR11988:SF28. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHLF_HUMAN
AccessioniPrimary (citable) accession number: Q16534
Secondary accession number(s): A8K1X8, Q6FHS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.