Q16534 (HLF_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 120.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Hepatic leukemia factor | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Reference proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 295 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Subunit structure | Binds DNA specifically as homodimer or heterodimer with other PAR factors. |
| Subcellular location | Nucleus Probable. |
| Tissue specificity | Highly expressed in liver; lower levels in lung and kidney. |
| Induction | Accumulates according to a robust circadian rhythm By similarity. |
| Involvement in disease | A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3. |
| Sequence similarities | Belongs to the bZIP family. PAR subfamily. Contains 1 bZIP (basic-leucine zipper) domain. |
| Sequence caution | The sequence AAA58445.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Biological rhythms Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Chromosomal rearrangement |
| Disease | Proto-oncogene |
| Ligand | DNA-binding |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | multicellular organismal development Traceable author statement Ref.2. Source: ProtInc rhythmic processInferred from electronic annotation. Source: UniProtKB-KW transcription from RNA polymerase II promoterTraceable author statement PubMed 8639829. Source: ProtInc |
| Cellular_component | nucleus Traceable author statement Ref.2. Source: ProtInc |
| Molecular_function | double-stranded DNA binding Traceable author statement Ref.2. Source: ProtInc sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 295 | 295 | Hepatic leukemia factor | PRO_0000076510 | |||||
Regions | |||||||||
| Domain | 225 – 288 | 64 | bZIP | ||||||
| Region | 227 – 247 | 21 | Basic motif By similarity | ||||||
| Region | 248 – 255 | 8 | Leucine-zipper By similarity | ||||||
| Compositional bias | 158 – 209 | 52 | Pro-rich (proline/acidic region (PAR)) | ||||||
Natural variations | |||||||||
| Natural variant | 253 | 1 | I → F in fusion protein; decreases DNA-binding activity. | VAR_008515 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia." Hunger S.P., Ohyashiki K., Toyama K., Cleary M.L. Genes Dev. 6:1608-1620(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH TCF3. Tissue: Hepatoma. |
| [2] | "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia." Inaba T., Roberts W.M., Shapiro L.H., Jolly K.W., Raimondi S.C., Smith S.D., Look A.T. Science 257:531-534(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH TCF3. Tissue: Hepatoma. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M95585 mRNA. Translation: AAA52675.1. M95586 mRNA. Translation: AAA58445.1. Different initiation. X68985 mRNA. Translation: CAA48777.1. BC036093 mRNA. Translation: AAH36093.1. |
| IPI | IPI00002850. |
| PIR | A44064. |
| RefSeq | NP_002117.1. NM_002126.4. |
| UniGene | Hs.196952. |
3D structure databases | |
| ProteinModelPortal | Q16534. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q16534. 25 interactions. |
| STRING | 9606.ENSP00000226067. |
PTM databases | |
| PhosphoSite | Q16534. |
Polymorphism databases | |
| DMDM | 6919907. |
Proteomic databases | |
| PaxDb | Q16534. |
| PRIDE | Q16534. |
Protocols and materials databases | |
| DNASU | 3131. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000226067; ENSP00000226067; ENSG00000108924. |
| GeneID | 3131. |
| KEGG | hsa:3131. |
| UCSC | uc002iug.1. human. |
Organism-specific databases | |
| CTD | 3131. |
| GeneCards | GC17P053342. |
| HGNC | HGNC:4977. HLF. |
| MIM | 142385. gene. |
| neXtProt | NX_Q16534. |
| Orphanet | 99860. Precursor B-cell acute lymphoblastic leukemia. |
| PharmGKB | PA29311. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG329624. |
| HOGENOM | HOG000234383. |
| HOVERGEN | HBG004983. |
| InParanoid | Q16534. |
| KO | K09057. |
| OMA | PTYGVLK. |
| OrthoDB | EOG4QNMWZ. |
| PhylomeDB | Q16534. |
Gene expression databases | |
| ArrayExpress | Q16534. |
| Bgee | Q16534. |
| CleanEx | HS_HLF. |
| Genevestigator | Q16534. |
| GermOnline | ENSG00000108924. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004827. bZIP. [Graphical view] |
| Pfam | PF07716. bZIP_2. 1 hit. [Graphical view] |
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] |
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 3131. |
| NextBio | 12421. |
| SOURCE | Search... |
Entry information
| Entry name | HLF_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q16534 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
