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Q16533 (SNPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
snRNA-activating protein complex subunit 1

Short name=SNAPc subunit 1
Alternative name(s):
Proximal sequence element-binding transcription factor subunit gamma
Short name=PSE-binding factor subunit gamma
Short name=PTF subunit gamma
Small nuclear RNA-activating complex polypeptide 1
snRNA-activating protein complex 43 kDa subunit
Short name=SNAPc 43 kDa subunit
Gene names
Name:SNAPC1
Synonyms:SNAP43
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Ref.5

Subunit structure

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP. Ref.4 Ref.5

Subcellular location

Nucleus.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processgene expression

Traceable author statement. Source: Reactome

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription from RNA polymerase III promoter

Traceable author statement. Source: Reactome

   Cellular_componentnucleoplasm

Traceable author statement. Source: Reactome

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368snRNA-activating protein complex subunit 1
PRO_0000072017

Regions

Region1 – 168168SNAPC3-binding
Region164 – 268105SNAPC4-binding
Compositional bias347 – 3526Poly-Glu

Amino acid modifications

Modified residue2891Phosphoserine Ref.7
Modified residue2901Phosphoserine Ref.6 Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q16533 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 324E89CF8B540C32

FASTA36842,994
        10         20         30         40         50         60 
MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA 

        70         80         90        100        110        120 
LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF 

       130        140        150        160        170        180 
DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM 

       190        200        210        220        230        240 
LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN 

       250        260        270        280        290        300 
DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ 

       310        320        330        340        350        360 
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT 


ASKKRRKH 

« Hide

References

« Hide 'large scale' references
[1]"A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III."
Henry R.W., Sadowski C.L., Kobayashi R., Hernandez N.
Nature 374:653-656(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein."
Yoon J.B., Roeder R.G.
Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Skin.
[4]"A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc."
Ma B., Hernandez N.
J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SNAPC3 AND SNAPC4.
[5]"The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SNAPC3 AND TBP.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z47542 mRNA. Translation: CAA87590.1.
U44754 mRNA. Translation: AAC50358.1.
BC014984 mRNA. Translation: AAH14984.1.
BC019038 mRNA. Translation: AAH19038.1.
CCDSCCDS9755.1.
PIRJC6081.
RefSeqNP_003073.1. NM_003082.3.
UniGeneHs.179312.

3D structure databases

ProteinModelPortalQ16533.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112501. 13 interactions.
DIPDIP-504N.
STRING9606.ENSP00000216294.

PTM databases

PhosphoSiteQ16533.

Polymorphism databases

DMDM8134716.

Proteomic databases

MaxQBQ16533.
PaxDbQ16533.
PRIDEQ16533.

Protocols and materials databases

DNASU6617.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216294; ENSP00000216294; ENSG00000023608.
GeneID6617.
KEGGhsa:6617.
UCSCuc001xft.3. human.

Organism-specific databases

CTD6617.
GeneCardsGC14P062229.
HGNCHGNC:11134. SNAPC1.
MIM600591. gene.
neXtProtNX_Q16533.
PharmGKBPA35982.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307105.
HOGENOMHOG000294209.
HOVERGENHBG058831.
InParanoidQ16533.
KOK15208.
OMASQETERC.
OrthoDBEOG7T7GTM.
PhylomeDBQ16533.
TreeFamTF324445.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.
REACT_71. Gene Expression.

Gene expression databases

BgeeQ16533.
CleanExHS_SNAPC1.
GenevestigatorQ16533.

Family and domain databases

InterProIPR019188. SNAPc_SNAP43.
[Graphical view]
PANTHERPTHR15131. PTHR15131. 1 hit.
PfamPF09808. SNAPc_SNAP43. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSNAPC1.
GenomeRNAi6617.
NextBio25767.
PROQ16533.
SOURCESearch...

Entry information

Entry nameSNPC1_HUMAN
AccessionPrimary (citable) accession number: Q16533
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM