SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q16533

- SNPC1_HUMAN

UniProt

Q16533 - SNPC1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
snRNA-activating protein complex subunit 1
Gene
SNAPC1, SNAP43
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. gene expression Source: Reactome
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription from RNA polymerase III promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 1
Short name:
SNAPc subunit 1
Alternative name(s):
Proximal sequence element-binding transcription factor subunit gamma
Short name:
PSE-binding factor subunit gamma
Short name:
PTF subunit gamma
Small nuclear RNA-activating complex polypeptide 1
snRNA-activating protein complex 43 kDa subunit
Short name:
SNAPc 43 kDa subunit
Gene namesi
Name:SNAPC1
Synonyms:SNAP43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:11134. SNAPC1.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368snRNA-activating protein complex subunit 1
PRO_0000072017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891Phosphoserine1 Publication
Modified residuei290 – 2901Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ16533.
PaxDbiQ16533.
PRIDEiQ16533.

PTM databases

PhosphoSiteiQ16533.

Expressioni

Gene expression databases

BgeeiQ16533.
CleanExiHS_SNAPC1.
GenevestigatoriQ16533.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP.2 Publications

Protein-protein interaction databases

BioGridi112501. 13 interactions.
DIPiDIP-504N.
STRINGi9606.ENSP00000216294.

Structurei

3D structure databases

ProteinModelPortaliQ16533.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 168168SNAPC3-binding
Add
BLAST
Regioni164 – 268105SNAPC4-binding
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi347 – 3526Poly-Glu

Phylogenomic databases

eggNOGiNOG307105.
HOGENOMiHOG000294209.
HOVERGENiHBG058831.
InParanoidiQ16533.
KOiK15208.
OMAiSQETERC.
OrthoDBiEOG7T7GTM.
PhylomeDBiQ16533.
TreeFamiTF324445.

Family and domain databases

InterProiIPR019188. SNAPc_SNAP43.
[Graphical view]
PANTHERiPTHR15131. PTHR15131. 1 hit.
PfamiPF09808. SNAPc_SNAP43. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16533-1 [UniParc]FASTAAdd to Basket

« Hide

MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE    50
KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA 100
LKDWDEVLKF QQDLVNAQHF DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK 150
KIHRAEVTEE FKDPSDRVMK LITSDVLEEM LNVHDHYQNM KHVISVDKSK 200
PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN DGEEKMEGNS 250
QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ 300
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE 350
NESLSGTEFT ASKKRRKH 368
Length:368
Mass (Da):42,994
Last modified:November 1, 1996 - v1
Checksum:i324E89CF8B540C32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47542 mRNA. Translation: CAA87590.1.
U44754 mRNA. Translation: AAC50358.1.
BC014984 mRNA. Translation: AAH14984.1.
BC019038 mRNA. Translation: AAH19038.1.
CCDSiCCDS9755.1.
PIRiJC6081.
RefSeqiNP_003073.1. NM_003082.3.
UniGeneiHs.179312.

Genome annotation databases

EnsembliENST00000216294; ENSP00000216294; ENSG00000023608.
GeneIDi6617.
KEGGihsa:6617.
UCSCiuc001xft.3. human.

Polymorphism databases

DMDMi8134716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47542 mRNA. Translation: CAA87590.1 .
U44754 mRNA. Translation: AAC50358.1 .
BC014984 mRNA. Translation: AAH14984.1 .
BC019038 mRNA. Translation: AAH19038.1 .
CCDSi CCDS9755.1.
PIRi JC6081.
RefSeqi NP_003073.1. NM_003082.3.
UniGenei Hs.179312.

3D structure databases

ProteinModelPortali Q16533.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112501. 13 interactions.
DIPi DIP-504N.
STRINGi 9606.ENSP00000216294.

PTM databases

PhosphoSitei Q16533.

Polymorphism databases

DMDMi 8134716.

Proteomic databases

MaxQBi Q16533.
PaxDbi Q16533.
PRIDEi Q16533.

Protocols and materials databases

DNASUi 6617.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216294 ; ENSP00000216294 ; ENSG00000023608 .
GeneIDi 6617.
KEGGi hsa:6617.
UCSCi uc001xft.3. human.

Organism-specific databases

CTDi 6617.
GeneCardsi GC14P062229.
HGNCi HGNC:11134. SNAPC1.
MIMi 600591. gene.
neXtProti NX_Q16533.
PharmGKBi PA35982.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307105.
HOGENOMi HOG000294209.
HOVERGENi HBG058831.
InParanoidi Q16533.
KOi K15208.
OMAi SQETERC.
OrthoDBi EOG7T7GTM.
PhylomeDBi Q16533.
TreeFami TF324445.

Enzyme and pathway databases

Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

GeneWikii SNAPC1.
GenomeRNAii 6617.
NextBioi 25767.
PROi Q16533.
SOURCEi Search...

Gene expression databases

Bgeei Q16533.
CleanExi HS_SNAPC1.
Genevestigatori Q16533.

Family and domain databases

InterProi IPR019188. SNAPc_SNAP43.
[Graphical view ]
PANTHERi PTHR15131. PTHR15131. 1 hit.
Pfami PF09808. SNAPc_SNAP43. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III."
    Henry R.W., Sadowski C.L., Kobayashi R., Hernandez N.
    Nature 374:653-656(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein."
    Yoon J.B., Roeder R.G.
    Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Skin.
  4. "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc."
    Ma B., Hernandez N.
    J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNAPC3 AND SNAPC4.
  5. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
    Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
    J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SNAPC3 AND TBP.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNPC1_HUMAN
AccessioniPrimary (citable) accession number: Q16533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi