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Q16533

- SNPC1_HUMAN

UniProt

Q16533 - SNPC1_HUMAN

Protein

snRNA-activating protein complex subunit 1

Gene

SNAPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. gene expression Source: Reactome
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription from RNA polymerase III promoter Source: Reactome

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    snRNA-activating protein complex subunit 1
    Short name:
    SNAPc subunit 1
    Alternative name(s):
    Proximal sequence element-binding transcription factor subunit gamma
    Short name:
    PSE-binding factor subunit gamma
    Short name:
    PTF subunit gamma
    Small nuclear RNA-activating complex polypeptide 1
    snRNA-activating protein complex 43 kDa subunit
    Short name:
    SNAPc 43 kDa subunit
    Gene namesi
    Name:SNAPC1
    Synonyms:SNAP43
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:11134. SNAPC1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35982.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368snRNA-activating protein complex subunit 1PRO_0000072017Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei289 – 2891Phosphoserine1 Publication
    Modified residuei290 – 2901Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ16533.
    PaxDbiQ16533.
    PRIDEiQ16533.

    PTM databases

    PhosphoSiteiQ16533.

    Expressioni

    Gene expression databases

    BgeeiQ16533.
    CleanExiHS_SNAPC1.
    GenevestigatoriQ16533.

    Interactioni

    Subunit structurei

    Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP.2 Publications

    Protein-protein interaction databases

    BioGridi112501. 13 interactions.
    DIPiDIP-504N.
    STRINGi9606.ENSP00000216294.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16533.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 168168SNAPC3-bindingAdd
    BLAST
    Regioni164 – 268105SNAPC4-bindingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi347 – 3526Poly-Glu

    Phylogenomic databases

    eggNOGiNOG307105.
    HOGENOMiHOG000294209.
    HOVERGENiHBG058831.
    InParanoidiQ16533.
    KOiK15208.
    OMAiSQETERC.
    OrthoDBiEOG7T7GTM.
    PhylomeDBiQ16533.
    TreeFamiTF324445.

    Family and domain databases

    InterProiIPR019188. SNAPc_SNAP43.
    [Graphical view]
    PANTHERiPTHR15131. PTHR15131. 1 hit.
    PfamiPF09808. SNAPc_SNAP43. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16533-1 [UniParc]FASTAAdd to Basket

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    MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE    50
    KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA 100
    LKDWDEVLKF QQDLVNAQHF DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK 150
    KIHRAEVTEE FKDPSDRVMK LITSDVLEEM LNVHDHYQNM KHVISVDKSK 200
    PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN DGEEKMEGNS 250
    QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ 300
    VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE 350
    NESLSGTEFT ASKKRRKH 368
    Length:368
    Mass (Da):42,994
    Last modified:November 1, 1996 - v1
    Checksum:i324E89CF8B540C32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47542 mRNA. Translation: CAA87590.1.
    U44754 mRNA. Translation: AAC50358.1.
    BC014984 mRNA. Translation: AAH14984.1.
    BC019038 mRNA. Translation: AAH19038.1.
    CCDSiCCDS9755.1.
    PIRiJC6081.
    RefSeqiNP_003073.1. NM_003082.3.
    UniGeneiHs.179312.

    Genome annotation databases

    EnsembliENST00000216294; ENSP00000216294; ENSG00000023608.
    GeneIDi6617.
    KEGGihsa:6617.
    UCSCiuc001xft.3. human.

    Polymorphism databases

    DMDMi8134716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47542 mRNA. Translation: CAA87590.1 .
    U44754 mRNA. Translation: AAC50358.1 .
    BC014984 mRNA. Translation: AAH14984.1 .
    BC019038 mRNA. Translation: AAH19038.1 .
    CCDSi CCDS9755.1.
    PIRi JC6081.
    RefSeqi NP_003073.1. NM_003082.3.
    UniGenei Hs.179312.

    3D structure databases

    ProteinModelPortali Q16533.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112501. 13 interactions.
    DIPi DIP-504N.
    STRINGi 9606.ENSP00000216294.

    PTM databases

    PhosphoSitei Q16533.

    Polymorphism databases

    DMDMi 8134716.

    Proteomic databases

    MaxQBi Q16533.
    PaxDbi Q16533.
    PRIDEi Q16533.

    Protocols and materials databases

    DNASUi 6617.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216294 ; ENSP00000216294 ; ENSG00000023608 .
    GeneIDi 6617.
    KEGGi hsa:6617.
    UCSCi uc001xft.3. human.

    Organism-specific databases

    CTDi 6617.
    GeneCardsi GC14P062229.
    HGNCi HGNC:11134. SNAPC1.
    MIMi 600591. gene.
    neXtProti NX_Q16533.
    PharmGKBi PA35982.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307105.
    HOGENOMi HOG000294209.
    HOVERGENi HBG058831.
    InParanoidi Q16533.
    KOi K15208.
    OMAi SQETERC.
    OrthoDBi EOG7T7GTM.
    PhylomeDBi Q16533.
    TreeFami TF324445.

    Enzyme and pathway databases

    Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Miscellaneous databases

    GeneWikii SNAPC1.
    GenomeRNAii 6617.
    NextBioi 25767.
    PROi Q16533.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q16533.
    CleanExi HS_SNAPC1.
    Genevestigatori Q16533.

    Family and domain databases

    InterProi IPR019188. SNAPc_SNAP43.
    [Graphical view ]
    PANTHERi PTHR15131. PTHR15131. 1 hit.
    Pfami PF09808. SNAPc_SNAP43. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III."
      Henry R.W., Sadowski C.L., Kobayashi R., Hernandez N.
      Nature 374:653-656(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein."
      Yoon J.B., Roeder R.G.
      Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Skin.
    4. "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc."
      Ma B., Hernandez N.
      J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNAPC3 AND SNAPC4.
    5. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
      Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
      J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SNAPC3 AND TBP.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNPC1_HUMAN
    AccessioniPrimary (citable) accession number: Q16533
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3