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Q16527

- CSRP2_HUMAN

UniProt

Q16527 - CSRP2_HUMAN

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Protein

Cysteine and glycine-rich protein 2

Gene

CSRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 2
Alternative name(s):
Cysteine-rich protein 2
Short name:
CRP2
LIM domain only protein 5
Short name:
LMO-5
Smooth muscle cell LIM protein
Short name:
SmLIM
Gene namesi
Name:CSRP2
Synonyms:LMO5, SMLIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2470. CSRP2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. focal adhesion Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26968.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Cysteine and glycine-rich protein 2PRO_0000075721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121N6-acetyllysineBy similarity
Modified residuei137 – 1371N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ16527.
PaxDbiQ16527.
PRIDEiQ16527.

PTM databases

PhosphoSiteiQ16527.

Expressioni

Tissue specificityi

Highly expressed in the aorta, but not in heart and skeletal muscle.

Gene expression databases

BgeeiQ16527.
CleanExiHS_CSRP2.
ExpressionAtlasiQ16527. baseline and differential.
GenevestigatoriQ16527.

Organism-specific databases

HPAiHPA045617.

Interactioni

Subunit structurei

Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107848. 8 interactions.
IntActiQ16527. 1 interaction.
STRINGi9606.ENSP00000310901.

Structurei

3D structure databases

ProteinModelPortaliQ16527.
SMRiQ16527. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 6152LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini119 – 17052LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi64 – 696Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7816Gly-richAdd
BLAST
Compositional biasi176 – 18712Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG281414.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiQ16527.
KOiK09377.
OrthoDBiEOG7CK39M.
PhylomeDBiQ16527.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16527-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA
60 70 80 90 100
IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP
110 120 130 140 150
TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG
160 170 180 190
KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ
Length:193
Mass (Da):20,954
Last modified:January 23, 2007 - v3
Checksum:i2E4231D6427579E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46006 mRNA. Translation: AAC27344.1.
U57646 mRNA. Translation: AAC51753.1.
U95018 Genomic DNA. Translation: AAC51755.1.
BT019913 mRNA. Translation: AAV38716.1.
BC000992 mRNA. Translation: AAH00992.1.
CCDSiCCDS9015.1.
RefSeqiNP_001287894.1. NM_001300965.1.
NP_001312.1. NM_001321.2.
UniGeneiHs.530904.

Genome annotation databases

EnsembliENST00000311083; ENSP00000310901; ENSG00000175183.
ENST00000546966; ENSP00000450056; ENSG00000175183.
GeneIDi1466.
KEGGihsa:1466.
UCSCiuc001syl.1. human.

Polymorphism databases

DMDMi2497674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46006 mRNA. Translation: AAC27344.1 .
U57646 mRNA. Translation: AAC51753.1 .
U95018 Genomic DNA. Translation: AAC51755.1 .
BT019913 mRNA. Translation: AAV38716.1 .
BC000992 mRNA. Translation: AAH00992.1 .
CCDSi CCDS9015.1.
RefSeqi NP_001287894.1. NM_001300965.1.
NP_001312.1. NM_001321.2.
UniGenei Hs.530904.

3D structure databases

ProteinModelPortali Q16527.
SMRi Q16527. Positions 1-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107848. 8 interactions.
IntActi Q16527. 1 interaction.
STRINGi 9606.ENSP00000310901.

PTM databases

PhosphoSitei Q16527.

Polymorphism databases

DMDMi 2497674.

Proteomic databases

MaxQBi Q16527.
PaxDbi Q16527.
PRIDEi Q16527.

Protocols and materials databases

DNASUi 1466.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311083 ; ENSP00000310901 ; ENSG00000175183 .
ENST00000546966 ; ENSP00000450056 ; ENSG00000175183 .
GeneIDi 1466.
KEGGi hsa:1466.
UCSCi uc001syl.1. human.

Organism-specific databases

CTDi 1466.
GeneCardsi GC12M077185.
HGNCi HGNC:2470. CSRP2.
HPAi HPA045617.
MIMi 601871. gene.
neXtProti NX_Q16527.
PharmGKBi PA26968.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281414.
GeneTreei ENSGT00550000074548.
HOGENOMi HOG000111233.
HOVERGENi HBG051143.
InParanoidi Q16527.
KOi K09377.
OrthoDBi EOG7CK39M.
PhylomeDBi Q16527.
TreeFami TF313758.

Miscellaneous databases

GeneWikii CSRP2.
GenomeRNAii 1466.
NextBioi 6021.
PROi Q16527.
SOURCEi Search...

Gene expression databases

Bgeei Q16527.
CleanExi HS_CSRP2.
ExpressionAtlasi Q16527. baseline and differential.
Genevestigatori Q16527.

Family and domain databases

Gene3Di 2.10.110.10. 2 hits.
InterProi IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00132. LIM. 2 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells."
    Jain M., Fujita K.P., Hsieh C.-M., Endege W.O., Sibinga N.E.S., Yet S.-F., Kashiki S., Lee W.-S., Perrella M.A., Haber E., Lee M.-E.
    J. Biol. Chem. 271:10194-10199(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.
  2. "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2."
    Weiskirchen R., Erdel M., Utermann G., Bister K.
    Genomics 44:83-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein."
    Weiskirchen R., Gressner A.M.
    Biochem. Biophys. Res. Commun. 274:655-663(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CSRP2BP.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSRP2_HUMAN
AccessioniPrimary (citable) accession number: Q16527
Secondary accession number(s): Q93030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3