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Protein

Cysteine and glycine-rich protein 2

Gene

CSRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 2
Alternative name(s):
Cysteine-rich protein 2
Short name:
CRP2
LIM domain only protein 5
Short name:
LMO-5
Smooth muscle cell LIM protein
Short name:
SmLIM
Gene namesi
Name:CSRP2
Synonyms:LMO5, SMLIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:2470. CSRP2.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. focal adhesion Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26968.

Polymorphism and mutation databases

BioMutaiCSRP2.
DMDMi2497674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Cysteine and glycine-rich protein 2PRO_0000075721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121N6-acetyllysineBy similarity
Modified residuei137 – 1371N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ16527.
PaxDbiQ16527.
PRIDEiQ16527.

PTM databases

PhosphoSiteiQ16527.

Expressioni

Tissue specificityi

Highly expressed in the aorta, but not in heart and skeletal muscle.

Gene expression databases

BgeeiQ16527.
CleanExiHS_CSRP2.
ExpressionAtlasiQ16527. baseline and differential.
GenevestigatoriQ16527.

Organism-specific databases

HPAiHPA045617.

Interactioni

Subunit structurei

Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM27P143733EBI-2959737,EBI-719493

Protein-protein interaction databases

BioGridi107848. 9 interactions.
IntActiQ16527. 3 interactions.
STRINGi9606.ENSP00000310901.

Structurei

3D structure databases

ProteinModelPortaliQ16527.
SMRiQ16527. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 6152LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini119 – 17052LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi64 – 696Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7816Gly-richAdd
BLAST
Compositional biasi176 – 18712Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG281414.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiQ16527.
KOiK09377.
OrthoDBiEOG7CK39M.
PhylomeDBiQ16527.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q16527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA
60 70 80 90 100
IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP
110 120 130 140 150
TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG
160 170 180 190
KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ
Length:193
Mass (Da):20,954
Last modified:January 23, 2007 - v3
Checksum:i2E4231D6427579E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46006 mRNA. Translation: AAC27344.1.
U57646 mRNA. Translation: AAC51753.1.
U95018 Genomic DNA. Translation: AAC51755.1.
BT019913 mRNA. Translation: AAV38716.1.
BC000992 mRNA. Translation: AAH00992.1.
CCDSiCCDS9015.1.
RefSeqiNP_001287894.1. NM_001300965.1.
NP_001312.1. NM_001321.2.
UniGeneiHs.530904.

Genome annotation databases

EnsembliENST00000311083; ENSP00000310901; ENSG00000175183.
ENST00000546966; ENSP00000450056; ENSG00000175183.
GeneIDi1466.
KEGGihsa:1466.
UCSCiuc001syl.1. human.

Polymorphism and mutation databases

BioMutaiCSRP2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46006 mRNA. Translation: AAC27344.1.
U57646 mRNA. Translation: AAC51753.1.
U95018 Genomic DNA. Translation: AAC51755.1.
BT019913 mRNA. Translation: AAV38716.1.
BC000992 mRNA. Translation: AAH00992.1.
CCDSiCCDS9015.1.
RefSeqiNP_001287894.1. NM_001300965.1.
NP_001312.1. NM_001321.2.
UniGeneiHs.530904.

3D structure databases

ProteinModelPortaliQ16527.
SMRiQ16527. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107848. 9 interactions.
IntActiQ16527. 3 interactions.
STRINGi9606.ENSP00000310901.

PTM databases

PhosphoSiteiQ16527.

Polymorphism and mutation databases

BioMutaiCSRP2.
DMDMi2497674.

Proteomic databases

MaxQBiQ16527.
PaxDbiQ16527.
PRIDEiQ16527.

Protocols and materials databases

DNASUi1466.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311083; ENSP00000310901; ENSG00000175183.
ENST00000546966; ENSP00000450056; ENSG00000175183.
GeneIDi1466.
KEGGihsa:1466.
UCSCiuc001syl.1. human.

Organism-specific databases

CTDi1466.
GeneCardsiGC12M077185.
HGNCiHGNC:2470. CSRP2.
HPAiHPA045617.
MIMi601871. gene.
neXtProtiNX_Q16527.
PharmGKBiPA26968.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG281414.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiQ16527.
KOiK09377.
OrthoDBiEOG7CK39M.
PhylomeDBiQ16527.
TreeFamiTF313758.

Miscellaneous databases

GeneWikiiCSRP2.
GenomeRNAii1466.
NextBioi6021.
PROiQ16527.
SOURCEiSearch...

Gene expression databases

BgeeiQ16527.
CleanExiHS_CSRP2.
ExpressionAtlasiQ16527. baseline and differential.
GenevestigatoriQ16527.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells."
    Jain M., Fujita K.P., Hsieh C.-M., Endege W.O., Sibinga N.E.S., Yet S.-F., Kashiki S., Lee W.-S., Perrella M.A., Haber E., Lee M.-E.
    J. Biol. Chem. 271:10194-10199(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.
  2. "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2."
    Weiskirchen R., Erdel M., Utermann G., Bister K.
    Genomics 44:83-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein."
    Weiskirchen R., Gressner A.M.
    Biochem. Biophys. Res. Commun. 274:655-663(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CSRP2BP.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSRP2_HUMAN
AccessioniPrimary (citable) accession number: Q16527
Secondary accession number(s): Q93030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.