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Q16527 (CSRP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine and glycine-rich protein 2
Alternative name(s):
Cysteine-rich protein 2
Short name=CRP2
LIM domain only protein 5
Short name=LMO-5
Smooth muscle cell LIM protein
Short name=SmLIM
Gene names
Name:CSRP2
Synonyms:LMO5, SMLIM
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Subunit structure

Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 By similarity. Ref.5

Subcellular location

Nucleus By similarity.

Tissue specificity

Highly expressed in the aorta, but not in heart and skeletal muscle.

Sequence similarities

Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentNucleus
   DomainLIM domain
Repeat
   LigandMetal-binding
Zinc
   Molecular functionDevelopmental protein
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Non-traceable author statement Ref.1. Source: UniProtKB

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Cysteine and glycine-rich protein 2
PRO_0000075721

Regions

Domain10 – 6152LIM zinc-binding 1
Domain119 – 17052LIM zinc-binding 2
Motif64 – 696Nuclear localization signal Potential
Compositional bias63 – 7816Gly-rich
Compositional bias176 – 18712Gly-rich

Amino acid modifications

Modified residue1121N6-acetyllysine By similarity
Modified residue1371N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q16527 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 2E4231D6427579E7

FASTA19320,954
        10         20         30         40         50         60 
MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA IHDEEIYCKS 

        70         80         90        100        110        120 
CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP TTNPNTSKFA QKYGGAEKCS 

       130        140        150        160        170        180 
RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG KSLESTTLTE KEGEIYCKGC YAKNFGPKGF 

       190 
GYGQGAGALV HAQ 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells."
Jain M., Fujita K.P., Hsieh C.-M., Endege W.O., Sibinga N.E.S., Yet S.-F., Kashiki S., Lee W.-S., Perrella M.A., Haber E., Lee M.-E.
J. Biol. Chem. 271:10194-10199(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Aorta.
[2]"Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2."
Weiskirchen R., Erdel M., Utermann G., Bister K.
Genomics 44:83-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]"The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein."
Weiskirchen R., Gressner A.M.
Biochem. Biophys. Res. Commun. 274:655-663(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CSRP2BP.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U46006 mRNA. Translation: AAC27344.1.
U57646 mRNA. Translation: AAC51753.1.
U95018 Genomic DNA. Translation: AAC51755.1.
BT019913 mRNA. Translation: AAV38716.1.
BC000992 mRNA. Translation: AAH00992.1.
CCDSCCDS9015.1.
RefSeqNP_001312.1. NM_001321.1.
XP_005268735.1. XM_005268678.2.
UniGeneHs.530904.

3D structure databases

ProteinModelPortalQ16527.
SMRQ16527. Positions 1-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107848. 8 interactions.
IntActQ16527. 1 interaction.
STRING9606.ENSP00000310901.

PTM databases

PhosphoSiteQ16527.

Polymorphism databases

DMDM2497674.

Proteomic databases

MaxQBQ16527.
PaxDbQ16527.
PRIDEQ16527.

Protocols and materials databases

DNASU1466.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311083; ENSP00000310901; ENSG00000175183.
ENST00000546966; ENSP00000450056; ENSG00000175183.
GeneID1466.
KEGGhsa:1466.
UCSCuc001syl.1. human.

Organism-specific databases

CTD1466.
GeneCardsGC12M077185.
HGNCHGNC:2470. CSRP2.
HPAHPA045617.
MIM601871. gene.
neXtProtNX_Q16527.
PharmGKBPA26968.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281414.
HOGENOMHOG000111233.
HOVERGENHBG051143.
InParanoidQ16527.
KOK09377.
OrthoDBEOG7CK39M.
PhylomeDBQ16527.
TreeFamTF313758.

Gene expression databases

ArrayExpressQ16527.
BgeeQ16527.
CleanExHS_CSRP2.
GenevestigatorQ16527.

Family and domain databases

Gene3D2.10.110.10. 2 hits.
InterProIPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00132. LIM. 2 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCSRP2.
GenomeRNAi1466.
NextBio6021.
PROQ16527.
SOURCESearch...

Entry information

Entry nameCSRP2_HUMAN
AccessionPrimary (citable) accession number: Q16527
Secondary accession number(s): Q93030
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM