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Q16527

- CSRP2_HUMAN

UniProt

Q16527 - CSRP2_HUMAN

Protein

Cysteine and glycine-rich protein 2

Gene

CSRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB
    2. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine and glycine-rich protein 2
    Alternative name(s):
    Cysteine-rich protein 2
    Short name:
    CRP2
    LIM domain only protein 5
    Short name:
    LMO-5
    Smooth muscle cell LIM protein
    Short name:
    SmLIM
    Gene namesi
    Name:CSRP2
    Synonyms:LMO5, SMLIM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:2470. CSRP2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26968.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Cysteine and glycine-rich protein 2PRO_0000075721Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei112 – 1121N6-acetyllysineBy similarity
    Modified residuei137 – 1371N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ16527.
    PaxDbiQ16527.
    PRIDEiQ16527.

    PTM databases

    PhosphoSiteiQ16527.

    Expressioni

    Tissue specificityi

    Highly expressed in the aorta, but not in heart and skeletal muscle.

    Gene expression databases

    ArrayExpressiQ16527.
    BgeeiQ16527.
    CleanExiHS_CSRP2.
    GenevestigatoriQ16527.

    Organism-specific databases

    HPAiHPA045617.

    Interactioni

    Subunit structurei

    Interacts with CSRP2BP. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107848. 8 interactions.
    IntActiQ16527. 1 interaction.
    STRINGi9606.ENSP00000310901.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16527.
    SMRiQ16527. Positions 1-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 6152LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini119 – 17052LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi64 – 696Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi63 – 7816Gly-richAdd
    BLAST
    Compositional biasi176 – 18712Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG281414.
    HOGENOMiHOG000111233.
    HOVERGENiHBG051143.
    InParanoidiQ16527.
    KOiK09377.
    OrthoDBiEOG7CK39M.
    PhylomeDBiQ16527.
    TreeFamiTF313758.

    Family and domain databases

    Gene3Di2.10.110.10. 2 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 2 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16527-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA    50
    IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP 100
    TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG 150
    KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ 193
    Length:193
    Mass (Da):20,954
    Last modified:January 23, 2007 - v3
    Checksum:i2E4231D6427579E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46006 mRNA. Translation: AAC27344.1.
    U57646 mRNA. Translation: AAC51753.1.
    U95018 Genomic DNA. Translation: AAC51755.1.
    BT019913 mRNA. Translation: AAV38716.1.
    BC000992 mRNA. Translation: AAH00992.1.
    CCDSiCCDS9015.1.
    RefSeqiNP_001312.1. NM_001321.1.
    XP_005268735.1. XM_005268678.2.
    UniGeneiHs.530904.

    Genome annotation databases

    EnsembliENST00000311083; ENSP00000310901; ENSG00000175183.
    ENST00000546966; ENSP00000450056; ENSG00000175183.
    GeneIDi1466.
    KEGGihsa:1466.
    UCSCiuc001syl.1. human.

    Polymorphism databases

    DMDMi2497674.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46006 mRNA. Translation: AAC27344.1 .
    U57646 mRNA. Translation: AAC51753.1 .
    U95018 Genomic DNA. Translation: AAC51755.1 .
    BT019913 mRNA. Translation: AAV38716.1 .
    BC000992 mRNA. Translation: AAH00992.1 .
    CCDSi CCDS9015.1.
    RefSeqi NP_001312.1. NM_001321.1.
    XP_005268735.1. XM_005268678.2.
    UniGenei Hs.530904.

    3D structure databases

    ProteinModelPortali Q16527.
    SMRi Q16527. Positions 1-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107848. 8 interactions.
    IntActi Q16527. 1 interaction.
    STRINGi 9606.ENSP00000310901.

    PTM databases

    PhosphoSitei Q16527.

    Polymorphism databases

    DMDMi 2497674.

    Proteomic databases

    MaxQBi Q16527.
    PaxDbi Q16527.
    PRIDEi Q16527.

    Protocols and materials databases

    DNASUi 1466.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311083 ; ENSP00000310901 ; ENSG00000175183 .
    ENST00000546966 ; ENSP00000450056 ; ENSG00000175183 .
    GeneIDi 1466.
    KEGGi hsa:1466.
    UCSCi uc001syl.1. human.

    Organism-specific databases

    CTDi 1466.
    GeneCardsi GC12M077185.
    HGNCi HGNC:2470. CSRP2.
    HPAi HPA045617.
    MIMi 601871. gene.
    neXtProti NX_Q16527.
    PharmGKBi PA26968.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281414.
    HOGENOMi HOG000111233.
    HOVERGENi HBG051143.
    InParanoidi Q16527.
    KOi K09377.
    OrthoDBi EOG7CK39M.
    PhylomeDBi Q16527.
    TreeFami TF313758.

    Miscellaneous databases

    GeneWikii CSRP2.
    GenomeRNAii 1466.
    NextBioi 6021.
    PROi Q16527.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16527.
    Bgeei Q16527.
    CleanExi HS_CSRP2.
    Genevestigatori Q16527.

    Family and domain databases

    Gene3Di 2.10.110.10. 2 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 2 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells."
      Jain M., Fujita K.P., Hsieh C.-M., Endege W.O., Sibinga N.E.S., Yet S.-F., Kashiki S., Lee W.-S., Perrella M.A., Haber E., Lee M.-E.
      J. Biol. Chem. 271:10194-10199(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Aorta.
    2. "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2."
      Weiskirchen R., Erdel M., Utermann G., Bister K.
      Genomics 44:83-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein."
      Weiskirchen R., Gressner A.M.
      Biochem. Biophys. Res. Commun. 274:655-663(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CSRP2BP.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCSRP2_HUMAN
    AccessioniPrimary (citable) accession number: Q16527
    Secondary accession number(s): Q93030
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3