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Q16526

- CRY1_HUMAN

UniProt

Q16526 - CRY1_HUMAN

Protein

Cryptochrome-1

Gene

CRY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK:BMAL1 independently of PER proteins and is found at CLOCK:BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK:BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1, ATF4 and MTA1. May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.4 Publications

    Cofactori

    Binds 1 FAD per subunit. Only a minority of the protein molecules contain bound FAD. Contrary to the situation in photolyases, the FAD is bound in a shallow, surface-exposed pocket.
    Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei252 – 2521FAD; via amide nitrogenBy similarity
    Binding sitei289 – 2891FADBy similarity
    Binding sitei355 – 3551FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi387 – 3893FADBy similarity

    GO - Molecular functioni

    1. blue light photoreceptor activity Source: UniProtKB
    2. core promoter binding Source: UniProtKB
    3. DNA binding Source: ProtInc
    4. DNA photolyase activity Source: InterPro
    5. double-stranded DNA binding Source: UniProtKB
    6. nuclear hormone receptor binding Source: UniProtKB
    7. nucleotide binding Source: UniProtKB-KW
    8. phosphatase binding Source: UniProtKB
    9. protein binding Source: UniProtKB
    10. transcription factor binding transcription factor activity Source: BHF-UCL
    11. ubiquitin binding Source: UniProtKB

    GO - Biological processi

    1. blue light signaling pathway Source: UniProtKB
    2. circadian regulation of gene expression Source: UniProtKB
    3. DNA damage induced protein phosphorylation Source: UniProtKB
    4. DNA repair Source: InterPro
    5. entrainment of circadian clock by photoperiod Source: UniProtKB
    6. gluconeogenesis Source: UniProtKB
    7. glucose homeostasis Source: UniProtKB
    8. negative regulation of circadian rhythm Source: UniProtKB
    9. negative regulation of glucocorticoid receptor signaling pathway Source: UniProtKB
    10. negative regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
    11. negative regulation of protein ubiquitination Source: UniProtKB
    12. negative regulation of transcription, DNA-templated Source: UniProtKB
    13. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    14. protein-chromophore linkage Source: UniProtKB-KW
    15. regulation of circadian rhythm Source: UniProtKB
    16. regulation of DNA damage checkpoint Source: UniProtKB
    17. response to glucagon Source: UniProtKB
    18. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Photoreceptor protein, Receptor, Repressor

    Keywords - Biological processi

    Biological rhythms, Sensory transduction, Transcription, Transcription regulation

    Keywords - Ligandi

    Chromophore, FAD, Flavoprotein, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_24941. Circadian Clock.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cryptochrome-1
    Gene namesi
    Name:CRY1
    Synonyms:PHLL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:2384. CRY1.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL/BMAL1.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrion Source: Ensembl
    3. nucleolus Source: HPA
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26904.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Cryptochrome-1PRO_0000261140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei71 – 711Phosphoserine; by AMPKBy similarity
    Cross-linki107 – 107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki159 – 159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei247 – 2471Phosphoserine; by MAPKBy similarity
    Modified residuei280 – 2801Phosphoserine; by AMPKBy similarity
    Cross-linki329 – 329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki485 – 485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei568 – 5681PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-ARNTL/BMAL1-mediated transcriptional activity. Phosphorylation by CSNK1E requires interaction with PER1 or PER2. Phosphorylation at Ser-71 and Ser-280 by AMPK decreases protein stability. Phosphorylation at Ser-568 exhibits a robust circadian rhythm with a peak at CT8, increases protein stability, prevents SCF(FBXL3)-mediated degradation and is antagonized by interaction with PRKDC By similarity.By similarity
    Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY1. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY1 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. Ubiquitination at Lys-11 and Lys-107 are specifically ubiquitinated by the SCF(FBXL21) complex but not by the SCF(FBXL3) complex. Ubiquitination may be inhibit by PER2.1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ16526.
    PaxDbiQ16526.
    PRIDEiQ16526.

    PTM databases

    PhosphoSiteiQ16526.

    Expressioni

    Inductioni

    Expression is regulated by light and circadian rhythms and osicllates diurnally. Peak expression in the suprachiasma nucleus (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL/BMAL1-CLOCK inhibition as part of the autoregulatory feedback loop.

    Gene expression databases

    ArrayExpressiQ16526.
    BgeeiQ16526.
    CleanExiHS_CRY1.
    GenevestigatoriQ16526.

    Organism-specific databases

    HPAiCAB018762.
    HPA047596.

    Interactioni

    Subunit structurei

    Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with FBXL21. Interacts with FBXL3. Interacts with PPP5C (via TPR repeats). Interacts with of the CLOCK-ARNTL/BMAL1 independently of PER2 and DNA. Interacts with HDAC1, HDAC2 and SIN3B. Interacts with nuclear receptors AR, NR1D1, NR3C1/GR, RORA and RORC; the interaction with at least NR3C1/GR is ligand dependent. Interacts with PRKDC. Interacts with the G protein subunit alpha GNAS; the interaction may block GPCR-mediated regulation of cAMP concentrations. Interacts with PRMT5.6 Publications

    Protein-protein interaction databases

    BioGridi107797. 25 interactions.
    IntActiQ16526. 12 interactions.
    MINTiMINT-1437226.
    STRINGi9606.ENSP00000008527.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16526.
    SMRiQ16526. Positions 3-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 132130Photolyase/cryptochrome alpha/betaAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni371 – 470100Required for inhibition of CLOCK-ARNTL/BMAL1-mediated transcriptionBy similarityAdd
    BLAST
    Regioni471 – 49323Interaction with TIMELESSBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA photolyase class-1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0415.
    HOGENOMiHOG000245622.
    HOVERGENiHBG053470.
    InParanoidiQ16526.
    KOiK02295.
    OMAiFDTDGLP.
    OrthoDBiEOG7QG43M.
    PhylomeDBiQ16526.
    TreeFamiTF323191.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    InterProiIPR006050. DNA_photolyase_N.
    IPR005101. Photolyase_FAD-bd/Cryptochr_C.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00875. DNA_photolyase. 1 hit.
    PF03441. FAD_binding_7. 1 hit.
    [Graphical view]
    SUPFAMiSSF48173. SSF48173. 1 hit.
    SSF52425. SSF52425. 1 hit.
    PROSITEiPS51645. PHR_CRY_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q16526-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVNAVHWFR KGLRLHDNPA LKECIQGADT IRCVYILDPW FAGSSNVGIN    50
    RWRFLLQCLE DLDANLRKLN SRLFVIRGQP ADVFPRLFKE WNITKLSIEY 100
    DSEPFGKERD AAIKKLATEA GVEVIVRISH TLYDLDKIIE LNGGQPPLTY 150
    KRFQTLISKM EPLEIPVETI TSEVIEKCTT PLSDDHDEKY GVPSLEELGF 200
    DTDGLSSAVW PGGETEALTR LERHLERKAW VANFERPRMN ANSLLASPTG 250
    LSPYLRFGCL SCRLFYFKLT DLYKKVKKNS SPPLSLYGQL LWREFFYTAA 300
    TNNPRFDKME GNPICVQIPW DKNPEALAKW AEGRTGFPWI DAIMTQLRQE 350
    GWIHHLARHA VACFLTRGDL WISWEEGMKV FEELLLDADW SINAGSWMWL 400
    SCSSFFQQFF HCYCPVGFGR RTDPNGDYIR RYLPVLRGFP AKYIYDPWNA 450
    PEGIQKVAKC LIGVNYPKPM VNHAEASRLN IERMKQIYQQ LSRYRGLGLL 500
    ASVPSNPNGN GGFMGYSAEN IPGCSSSGSC SQGSGILHYA HGDSQQTHLL 550
    KQGRSSMGTG LSGGKRPSQE EDTQSIGPKV QRQSTN 586
    Length:586
    Mass (Da):66,395
    Last modified:November 1, 1996 - v1
    Checksum:i96A5B09A6364D3B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84657 mRNA. Translation: BAA12710.1.
    D83702 mRNA. Translation: BAA12068.1.
    BC030519 mRNA. Translation: AAH30519.1.
    CCDSiCCDS9112.1.
    RefSeqiNP_004066.1. NM_004075.4.
    UniGeneiHs.151573.

    Genome annotation databases

    EnsembliENST00000008527; ENSP00000008527; ENSG00000008405.
    GeneIDi1407.
    KEGGihsa:1407.
    UCSCiuc001tmi.4. human.

    Polymorphism databases

    DMDMi74735764.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Cryptochrome entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84657 mRNA. Translation: BAA12710.1 .
    D83702 mRNA. Translation: BAA12068.1 .
    BC030519 mRNA. Translation: AAH30519.1 .
    CCDSi CCDS9112.1.
    RefSeqi NP_004066.1. NM_004075.4.
    UniGenei Hs.151573.

    3D structure databases

    ProteinModelPortali Q16526.
    SMRi Q16526. Positions 3-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107797. 25 interactions.
    IntActi Q16526. 12 interactions.
    MINTi MINT-1437226.
    STRINGi 9606.ENSP00000008527.

    PTM databases

    PhosphoSitei Q16526.

    Polymorphism databases

    DMDMi 74735764.

    Proteomic databases

    MaxQBi Q16526.
    PaxDbi Q16526.
    PRIDEi Q16526.

    Protocols and materials databases

    DNASUi 1407.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000008527 ; ENSP00000008527 ; ENSG00000008405 .
    GeneIDi 1407.
    KEGGi hsa:1407.
    UCSCi uc001tmi.4. human.

    Organism-specific databases

    CTDi 1407.
    GeneCardsi GC12M107385.
    HGNCi HGNC:2384. CRY1.
    HPAi CAB018762.
    HPA047596.
    MIMi 601933. gene.
    neXtProti NX_Q16526.
    PharmGKBi PA26904.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0415.
    HOGENOMi HOG000245622.
    HOVERGENi HBG053470.
    InParanoidi Q16526.
    KOi K02295.
    OMAi FDTDGLP.
    OrthoDBi EOG7QG43M.
    PhylomeDBi Q16526.
    TreeFami TF323191.

    Enzyme and pathway databases

    Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_24941. Circadian Clock.

    Miscellaneous databases

    ChiTaRSi CRY1. human.
    GenomeRNAii 1407.
    NextBioi 5753.
    PROi Q16526.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16526.
    Bgeei Q16526.
    CleanExi HS_CRY1.
    Genevestigatori Q16526.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    InterProi IPR006050. DNA_photolyase_N.
    IPR005101. Photolyase_FAD-bd/Cryptochr_C.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00875. DNA_photolyase. 1 hit.
    PF03441. FAD_binding_7. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48173. SSF48173. 1 hit.
    SSF52425. SSF52425. 1 hit.
    PROSITEi PS51645. PHR_CRY_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins."
      Hsu D.S., Zhao X., Zhao S., Kazantsev A., Wang R.-P., Todo T., Wei Y.-F., Sancar A.
      Biochemistry 35:13871-13877(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Fibroblast.
    2. "Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors."
      van der Spek P.J., Kobayashi K., Bootsma D., Takao M., Eker A.P.M., Yasui A.
      Genomics 37:177-182(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Testis.
    3. "Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family."
      Todo T., Ryo H., Yamamoto K., Toh H., Inui T., Ayaki H., Nomura T., Ikenaga M.
      Science 272:109-112(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Light-independent role of CRY1 and CRY2 in the mammalian circadian clock."
      Griffin E.A. Jr., Staknis D., Weitz C.J.
      Science 286:768-771(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: FUNCTION.
    7. "Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5."
      Partch C.L., Shields K.F., Thompson C.L., Selby C.P., Sancar A.
      Proc. Natl. Acad. Sci. U.S.A. 103:10467-10472(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPP5C.
    8. "SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins."
      Busino L., Bassermann F., Maiolica A., Lee C., Nolan P.M., Godinho S.I., Draetta G.F., Pagano M.
      Science 316:900-904(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, UBIQUITINATION BY FBXL3, INTERACTION WITH FBXL3.
    9. "Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis."
      Zhang E.E., Liu Y., Dentin R., Pongsawakul P.Y., Liu A.C., Hirota T., Nusinow D.A., Sun X., Landais S., Kodama Y., Brenner D.A., Montminy M., Kay S.A.
      Nat. Med. 16:1152-1156(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GNAS.
    10. "Biochemical analysis of the canonical model for the mammalian circadian clock."
      Ye R., Selby C.P., Ozturk N., Annayev Y., Sancar A.
      J. Biol. Chem. 286:25891-25902(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PER2.
    11. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
      Lamia K.A., Papp S.J., Yu R.T., Barish G.D., Uhlenhaut N.H., Jonker J.W., Downes M., Evans R.M.
      Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS NR3C1 REPRESSOR, INTERACTION WITH AR; NR1D1; NR3C1; RORA AND RORC.
    12. "Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene."
      Na J., Lee K., Kim H.G., Shin J.Y., Na W., Jeong H., Lee J.W., Cho S., Kim W.S., Ju B.G.
      PLoS ONE 7:E48152-E48152(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PRMT5.
    13. "Metabolism and the circadian clock converge."
      Eckel-Mahan K., Sassone-Corsi P.
      Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    14. "Molecular architecture of the mammalian circadian clock."
      Partch C.L., Green C.B., Takahashi J.S.
      Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCRY1_HUMAN
    AccessioniPrimary (citable) accession number: Q16526
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3