Unreviewed, UniProtKB/TrEMBL Q16525 (Q16525_HUMAN)

Names and origin

Protein names	Submitted name:     C-H-ras-1 gene with novel codon 13 mutation EMBL CAA34461.1 Submitted name:     MDS N-ras oncogene exon 1 MDS = myelodysplastic syndrome EMBL CAA29078.1
Organism	Homo sapiens (Human) EMBL CAA34461.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	37 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Ligand	GTP-binding RuleBase RU003312V0 Spearmint SPM015592 Nucleotide-binding
Gene Ontology (GO)
Biological process	Ras protein signal transduction Inferred from electronic annotation. Source: Compara actin cytoskeleton organization Inferred from electronic annotation. Source: Compara apoptosis Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara endocytosis Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptosis Inferred from electronic annotation. Source: Compara positive regulation of DNA replication Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of Rac protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of nitric-oxide synthase activity Inferred from electronic annotation. Source: Compara protein heterooligomerization Inferred from electronic annotation. Source: Compara regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to mineralocorticoid stimulus Inferred from electronic annotation. Source: Compara striated muscle cell differentiation Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Cellular component	membrane fraction Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular function	GDP binding Inferred from electronic annotation. Source: Compara GMP binding Inferred from electronic annotation. Source: Compara GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro LRR domain binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	37	1	EMBL CAA34461.1

Sequences

	Sequence		Length	Mass (Da)
	Q16525-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BEF4F111D73D686A	FASTA	37	4,136
	10 20 30 MTEYKLVVVG AGRVGKSALT IQLIQNHFVD EYDPTIE

References

[1]	"Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c-H-ras-1 and concurrent amplifications of c-erbB-1 and c-myc." Tadokoro K., Ueda M., Ohshima T., Fujita K., Rikimaru K., Takahashi N., Enomoto S., Tsuchida N. Oncogene 4:499-505(1989) [PubMed: 2654810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Oral carcinoma EMBL CAA34461.1.
[2]	"A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome." Hirai H., Kobayashi Y., Mano H., Hagiwara K., Maru Y., Omine M., Mizoguchi H., Nishida J., Takaku F. Nature 327:430-432(1987) [PubMed: 3295562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Bone-marrow EMBL CAA29078.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X05564 Genomic DNA. Translation: CAA29078.1. X16438 Genomic DNA. Translation: CAA34461.1.
IPI	IPI00791238.
UniGene	Hs.37003 Hs.486502
3D structure databases
HSSP	HSSP built from PDB template 1PLL based on UniProtKB P01112.
SMR	Q16525. Positions 1-37.
ModBase	Search...
Protein-protein interaction databases
STRING	Q16525.
Genome annotation databases
Ensembl	ENST00000256078; ENSP00000256078; ENSG00000133703; Homo sapiens. [Genome view] ENST00000311175; ENSP00000312305; ENSG00000174775; Homo sapiens. [Genome view] ENST00000311189; ENSP00000309845; ENSG00000174775; Homo sapiens. [Genome view] ENST00000311936; ENSP00000308495; ENSG00000133703; Homo sapiens. [Genome view] ENST00000369535; ENSP00000358548; ENSG00000213281; Homo sapiens. [Genome view] ENST00000388730; ENSP00000373382; ENSG00000174775; Homo sapiens. [Genome view] ENST00000395977; ENSP00000379301; ENSG00000133703; Homo sapiens. [Genome view] ENST00000397594; ENSP00000380722; ENSG00000174775; Homo sapiens. [Genome view] ENST00000397596; ENSP00000380723; ENSG00000174775; Homo sapiens. [Genome view] ENST00000406761; ENSP00000385392; ENSG00000133703; Homo sapiens. [Genome view] ENST00000417302; ENSP00000388246; ENSG00000174775; Homo sapiens. [Genome view] ENST00000451590; ENSP00000407586; ENSG00000174775; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:5173. HRAS. HGNC:6407. KRAS. HGNC:7989. NRAS.
Phylogenomic databases
HOVERGEN	Q16525.
Gene expression databases
ArrayExpress	Q16525.
Bgee	Q16525.
Family and domain databases
InterPro	IPR013753. Ras. IPR001806. Ras_GTPase. IPR015592. Ras_Ras_related. IPR020849. Ras_small_GTPase. [Graphical view]
PANTHER	PTHR11708:SF125. Ras_Ras_related. 1 hit.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
PROSITE	PS51421. RAS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q16525_HUMAN

Accession

Primary (citable) accession number: Q16525

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.