Reviewed, UniProtKB/Swiss-Prot Q16520 (BATF_HUMAN)

Names and origin

Protein names

Recommended name:
    Basic leucine zipper transcriptional factor ATF-like
Alternative name(s):
    B-cell activating transcription factor
      Short name=B-ATF
    SF-HT-activated gene 2 protein
      Short name=SFA-2

Gene names

Name:

BATF

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) (consensus: 5'-TGA[CG]TCA-3') and weaker at the cAMP-responsive region (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), but are transcriptionally inert. Ref.6
Subunit structure	Forms heterodimers with JUN, JUNB and JUND. Also interacts with IFI35. Ref.1 Ref.7
Subcellular location	Nucleus.
Tissue specificity	Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. According to Ref.6 also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow. Ref.6 Ref.1 Ref.2
Post-translational modification	Phosphorylated By similarity.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Basic leucine zipper transcriptional factor ATF-like		PRO_0000076595
Regions
	Domain	54 – 75	22	Leucine-zipper
	DNA binding	32 – 50	19	Basic motif

Sequences

	Sequence		Length	Mass (Da)
	Q16520-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7FD633C6F1963DF4	FASTA	125	14,120
	10 20 30 40 50 60 MPHSSDSSDS SFSRSPPPGK QDSSDDVRRV QRREKNRIAA QKSRQRQTQK ADTLHLESED 70 80 90 100 110 120 LEKQNAALRK EIKQLTEELK YFTSVLNSHE PLCSVLAAST PSPPEVVYSA HAFHQPHVSS PRFQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family." Dorsey M.J., Tae H.-J., Sollenberger K.G., Mascarenhas N.T., Johansen L.M., Taparowsky E.J. Oncogene 11:2255-2265(1995) [PubMed: 8570175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH JUN PROTEINS, TISSUE SPECIFICITY.
[2]	"SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes." Hasegawa H., Utsunomiya Y., Kishimoto K., Tange Y., Yasukawa M., Fujita S. Biochem. Biophys. Res. Commun. 222:164-170(1996) [PubMed: 8630063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1." Meyer N.P., Johansen L.M., Tae H.-J., Budde P.P., Williams K.L., Taparowsky E.J. Mamm. Genome 9:849-852(1998) [PubMed: 9745044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Melanoma.
[6]	"B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos." Echlin D.R., Tae H.-J., Mitin N., Taparowsky E.J. Oncogene 19:1752-1763(2000) [PubMed: 10777209] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[7]	"IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors." Wang X., Johansen L.M., Tae H.-J., Taparowsky E.J. Biochem. Biophys. Res. Commun. 229:316-322(1996) [PubMed: 8954125] [Abstract] Cited for: INTERACTION WITH IFI35.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15460 mRNA. Translation: AAC50314.1. D42106 mRNA. Translation: BAA07686.1. AF016898 Genomic DNA. Translation: AAC78243.1. AC007182 Genomic DNA. Translation: AAD51372.1. BC032294 mRNA. Translation: AAH32294.1.
IPI	IPI00007422.
PIR	JC4799.
RefSeq	NP_006390.1.
UniGene	Hs.509964
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16520. 3 interactions.
STRING	Q16520.
PTM databases
PhosphoSite	Q16520.
Proteomic databases
PRIDE	Q16520.
Genome annotation databases
Ensembl	ENST00000286639; ENSP00000286639; ENSG00000156127; Homo sapiens. [Genome view]
GeneID	10538.
KEGG	hsa:10538.
UCSC	uc001xrr.1. human.
Organism-specific databases
CTD	10538.
GeneCards	GC14P075058.
H-InvDB	HIX0011827.
HGNC	HGNC:958. BATF.
MIM	612476. gene.
PharmGKB	PA25268.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q16520.
HOVERGEN	Q16520.
OMA	THAFHQP
OrthoDB	EOG91K1ZG
Gene expression databases
ArrayExpress	Q16520.
Bgee	Q16520.
CleanEx	HS_BATF.
Genevestigator	Q16520.
GermOnline	ENSG00000156127. Homo sapiens.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR000837. Leuzip_Fos. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	39981.
SOURCE	Search...

Entry information

Entry name

BATF_HUMAN

Accession

Primary (citable) accession number: Q16520

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.