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Protein
Submitted name:

Protein S

Gene

PROS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein SImported
Gene namesi
Name:PROS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ16519.
PeptideAtlasiQ16519.
PRIDEiQ16519.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000377783.

Structurei

3D structure databases

ProteinModelPortaliQ16519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 6147Gla (gamma-carboxy-glutamate)InterPro annotationAdd
BLAST
Domaini91 – 12939EGF-likeInterPro annotationAdd
BLAST
Domaini131 – 17444EGF-likeInterPro annotationAdd
BLAST
Domaini175 – 21642EGF-likeInterPro annotationAdd
BLAST
Domaini217 – 25741EGF-likeInterPro annotationAdd
BLAST
Domaini273 – 449177LAM_G_DOMAINInterPro annotationAdd
BLAST
Domaini458 – 640183LAM_G_DOMAINInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains Gla (gamma-carboxy-glutamate) domain.SAAS annotation

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGF6. Eukaryota.
ENOG410ZTGU. LUCA.
HOVERGENiHBG051702.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR033189. PROS1.
[Graphical view]
PANTHERiPTHR24040:SF0. PTHR24040:SF0. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q16519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSKQQASQVL VRKRRANSLL EETKQGNLER ECIEELCNKE EAREVFENDP
60 70 80 90 100
ETDYFYPKYL VCLRSFQTGL FTAARQSTNA YPDLRSCVNA IPDQCSPLPC
110 120 130 140 150
NEDGYMSCKD GKASFTCTCK PGWQGEKCEF DINECKDPSN INGGCSQICD
160 170 180 190 200
NTPGSYHCSC KNGFVMLSNK KDCKDVDECS LKPSICGTAV CKNILGDFEC
210 220 230 240 250
ECPEGYRYNL KSKSCEDIDE CSENMCAQLC VNYPGGHTCY CDGKKGFKLA
260 270 280 290 300
QDQKSCEVVS VCLPLNLDTK YELLYLAEQF AGVVLYLKFR LPEISRFSAE
310 320 330 340 350
FDFRTYDSEG VILYAESIYH SAWLLIALRG GKIEVQLKNE HTSKITTGGD
360 370 380 390 400
VINNGLWNMV SVEELEHSIS IKIAKEAVMD INKPGPLFKP ENGLLETKVY
410 420 430 440 450
FAGFPRKVES ELIKPINPRL DGCIRSWNLM KQGASGIKEI IQEKQNKHCL
460 470 480 490 500
VTVEKGSYYP GSGIAQFHID YNNVSSAEGW HVNVTLNIRP STGTGVMLAL
510 520 530 540 550
VSGNNTVPFA VSLVDSTSEK SQDILLSVEN TVIYRIQALS LCSDQQSHLE
560 570 580 590 600
FRVNRNNLEL STPLKIETIS HEDLQRQLAV LDKAMKAKVA TYLGGLPDVP
610 620 630 640 650
FSATPVNAFY NGCMEVNING VQLDLDEAIS KHNDIRAHSC PSVWKKTKNS
Length:650
Mass (Da):72,462
Last modified:November 1, 1996 - v1
Checksum:i9A8C044C503BF474
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14338 Transcribed RNA. Translation: AAA60181.1.
UniGeneiHs.64016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14338 Transcribed RNA. Translation: AAA60181.1.
UniGeneiHs.64016.

3D structure databases

ProteinModelPortaliQ16519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000377783.

Proteomic databases

PaxDbiQ16519.
PeptideAtlasiQ16519.
PRIDEiQ16519.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IGF6. Eukaryota.
ENOG410ZTGU. LUCA.
HOVERGENiHBG051702.

Miscellaneous databases

ChiTaRSiPROS1. human.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR033189. PROS1.
[Graphical view]
PANTHERiPTHR24040:SF0. PTHR24040:SF0. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ16519_HUMAN
AccessioniPrimary (citable) accession number: Q16519
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.