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Protein
Submitted name:

Protein S

Gene

PROS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Protein SImported
Gene namesi
Name:PROS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi100 ↔ 117PROSITE-ProRule annotation
Disulfide bondi119 ↔ 128PROSITE-ProRule annotation
Disulfide bondi135 ↔ 145PROSITE-ProRule annotation
Disulfide bondi613 ↔ 640PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiQ16519
PRIDEiQ16519

Structurei

3D structure databases

ProteinModelPortaliQ16519
SMRiQ16519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 61GlaInterPro annotationAdd BLAST47
Domaini91 – 129EGF-likeInterPro annotationAdd BLAST39
Domaini131 – 174EGF-likeInterPro annotationAdd BLAST44
Domaini175 – 216EGF-likeInterPro annotationAdd BLAST42
Domaini217 – 257EGF-likeInterPro annotationAdd BLAST41
Domaini273 – 449LAM_G_DOMAINInterPro annotationAdd BLAST177
Domaini458 – 640LAM_G_DOMAINInterPro annotationAdd BLAST183

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGF6 Eukaryota
ENOG410ZTGU LUCA
HOVERGENiHBG051702

Family and domain databases

Gene3Di4.10.740.10, 1 hit
InterProiView protein in InterPro
IPR017857 Coagulation_fac-like_Gla_dom
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR033189 PROS1
PANTHERiPTHR24040:SF0 PTHR24040:SF0, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00594 Gla, 1 hit
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
PRINTSiPR00001 GLABLOOD
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM00069 GLA, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
SSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

Sequencei

Sequence statusi: Fragment.

Q16519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSKQQASQVL VRKRRANSLL EETKQGNLER ECIEELCNKE EAREVFENDP
60 70 80 90 100
ETDYFYPKYL VCLRSFQTGL FTAARQSTNA YPDLRSCVNA IPDQCSPLPC
110 120 130 140 150
NEDGYMSCKD GKASFTCTCK PGWQGEKCEF DINECKDPSN INGGCSQICD
160 170 180 190 200
NTPGSYHCSC KNGFVMLSNK KDCKDVDECS LKPSICGTAV CKNILGDFEC
210 220 230 240 250
ECPEGYRYNL KSKSCEDIDE CSENMCAQLC VNYPGGHTCY CDGKKGFKLA
260 270 280 290 300
QDQKSCEVVS VCLPLNLDTK YELLYLAEQF AGVVLYLKFR LPEISRFSAE
310 320 330 340 350
FDFRTYDSEG VILYAESIYH SAWLLIALRG GKIEVQLKNE HTSKITTGGD
360 370 380 390 400
VINNGLWNMV SVEELEHSIS IKIAKEAVMD INKPGPLFKP ENGLLETKVY
410 420 430 440 450
FAGFPRKVES ELIKPINPRL DGCIRSWNLM KQGASGIKEI IQEKQNKHCL
460 470 480 490 500
VTVEKGSYYP GSGIAQFHID YNNVSSAEGW HVNVTLNIRP STGTGVMLAL
510 520 530 540 550
VSGNNTVPFA VSLVDSTSEK SQDILLSVEN TVIYRIQALS LCSDQQSHLE
560 570 580 590 600
FRVNRNNLEL STPLKIETIS HEDLQRQLAV LDKAMKAKVA TYLGGLPDVP
610 620 630 640 650
FSATPVNAFY NGCMEVNING VQLDLDEAIS KHNDIRAHSC PSVWKKTKNS
Length:650
Mass (Da):72,462
Last modified:November 1, 1996 - v1
Checksum:i9A8C044C503BF474
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14338 Transcribed RNA Translation: AAA60181.1
UniGeneiHs.64016

Similar proteinsi

Entry informationi

Entry nameiQ16519_HUMAN
AccessioniPrimary (citable) accession number: Q16519
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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