Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronatin

Gene

NNAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.

GO - Biological processi

  • brain development Source: ProtInc
  • neuron differentiation Source: Ensembl
  • positive regulation of insulin secretion Source: GO_Central
  • protein lipoylation Source: ProtInc
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronatin
Gene namesi
Name:NNAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:7860. NNAT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31665.

Polymorphism and mutation databases

BioMutaiNNAT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181NeuronatinPRO_0000096882Add
BLAST

Proteomic databases

PaxDbiQ16517.
PRIDEiQ16517.
TopDownProteomicsiQ16517-1. [Q16517-1]

Expressioni

Developmental stagei

Abundant in 18-24 week old fetal brain. Postnatally its expression decline and only minimal levels were present in adulthood.

Gene expression databases

BgeeiQ16517.
CleanExiHS_NNAT.
GenevisibleiQ16517. HS.

Interactioni

Protein-protein interaction databases

BioGridi110890. 2 interactions.
IntActiQ16517. 1 interaction.
STRINGi9606.ENSP00000062104.

Structurei

3D structure databases

ProteinModelPortaliQ16517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuronatin family.Curated

Phylogenomic databases

eggNOGiENOG410JDHY. Eukaryota.
ENOG41117T6. LUCA.
GeneTreeiENSGT00390000007412.
HOVERGENiHBG001605.
InParanoidiQ16517.
OMAiMGERRQR.
OrthoDBiEOG79KPJR.
PhylomeDBiQ16517.
TreeFamiTF338710.

Family and domain databases

InterProiIPR024885. Neuronatin.
[Graphical view]
PANTHERiPTHR15285. PTHR15285. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q16517-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS
60 70 80
EVFRYSLQKL AYTVSRTGRQ VLGERRQRAP N
Length:81
Mass (Da):9,237
Last modified:November 1, 1996 - v1
Checksum:i067086C7663E3D20
GO
Isoform Beta (identifier: Q16517-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Show »
Length:54
Mass (Da):6,153
Checksum:i184E7C9642006C87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641V → L in AAV38233 (Ref. 5) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 5127Missing in isoform Beta. 1 PublicationVSP_004331Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25033 mRNA. Translation: AAA93224.1.
U25034 mRNA. Translation: AAA93225.1.
U31767 Genomic DNA. Translation: AAC50627.1.
U31767 Genomic DNA. Translation: AAC50626.1.
AB002392 mRNA. Translation: BAA25016.1.
AK312069 mRNA. Translation: BAG35005.1.
BT019426 mRNA. Translation: AAV38233.1.
AL109614 Genomic DNA. Translation: CAC00476.1.
AL109614 Genomic DNA. Translation: CAC00477.1.
CH471077 Genomic DNA. Translation: EAW76059.1.
CH471077 Genomic DNA. Translation: EAW76060.1.
BC001768 mRNA. Translation: AAH01768.1.
CCDSiCCDS13296.1. [Q16517-1]
CCDS13297.1. [Q16517-2]
PIRiG01783.
RefSeqiNP_005377.1. NM_005386.2. [Q16517-1]
NP_859017.1. NM_181689.1. [Q16517-2]
UniGeneiHs.504703.

Genome annotation databases

EnsembliENST00000062104; ENSP00000062104; ENSG00000053438. [Q16517-1]
ENST00000346199; ENSP00000335497; ENSG00000053438. [Q16517-2]
GeneIDi4826.
KEGGihsa:4826.
UCSCiuc002xhd.4. human. [Q16517-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25033 mRNA. Translation: AAA93224.1.
U25034 mRNA. Translation: AAA93225.1.
U31767 Genomic DNA. Translation: AAC50627.1.
U31767 Genomic DNA. Translation: AAC50626.1.
AB002392 mRNA. Translation: BAA25016.1.
AK312069 mRNA. Translation: BAG35005.1.
BT019426 mRNA. Translation: AAV38233.1.
AL109614 Genomic DNA. Translation: CAC00476.1.
AL109614 Genomic DNA. Translation: CAC00477.1.
CH471077 Genomic DNA. Translation: EAW76059.1.
CH471077 Genomic DNA. Translation: EAW76060.1.
BC001768 mRNA. Translation: AAH01768.1.
CCDSiCCDS13296.1. [Q16517-1]
CCDS13297.1. [Q16517-2]
PIRiG01783.
RefSeqiNP_005377.1. NM_005386.2. [Q16517-1]
NP_859017.1. NM_181689.1. [Q16517-2]
UniGeneiHs.504703.

3D structure databases

ProteinModelPortaliQ16517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110890. 2 interactions.
IntActiQ16517. 1 interaction.
STRINGi9606.ENSP00000062104.

Polymorphism and mutation databases

BioMutaiNNAT.

Proteomic databases

PaxDbiQ16517.
PRIDEiQ16517.
TopDownProteomicsiQ16517-1. [Q16517-1]

Protocols and materials databases

DNASUi4826.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000062104; ENSP00000062104; ENSG00000053438. [Q16517-1]
ENST00000346199; ENSP00000335497; ENSG00000053438. [Q16517-2]
GeneIDi4826.
KEGGihsa:4826.
UCSCiuc002xhd.4. human. [Q16517-1]

Organism-specific databases

CTDi4826.
GeneCardsiNNAT.
HGNCiHGNC:7860. NNAT.
MIMi603106. gene.
neXtProtiNX_Q16517.
PharmGKBiPA31665.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDHY. Eukaryota.
ENOG41117T6. LUCA.
GeneTreeiENSGT00390000007412.
HOVERGENiHBG001605.
InParanoidiQ16517.
OMAiMGERRQR.
OrthoDBiEOG79KPJR.
PhylomeDBiQ16517.
TreeFamiTF338710.

Miscellaneous databases

GenomeRNAii4826.
NextBioi18588.
PROiQ16517.
SOURCEiSearch...

Gene expression databases

BgeeiQ16517.
CleanExiHS_NNAT.
GenevisibleiQ16517. HS.

Family and domain databases

InterProiIPR024885. Neuronatin.
[Graphical view]
PANTHERiPTHR15285. PTHR15285. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel 'proteolipid'."
    Dou D., Joseph R.
    Brain Res. 723:8-22(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
    Tissue: Fetal brain and Placenta.
  2. "Structure and organization of the human neuronatin gene."
    Dou D., Joseph R.
    Genomics 33:292-297(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Tissue: Placenta.
  3. "cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas."
    Usui H., Morii K., Tanaka R., Tamura T., Washiyama K., Ichikawa T., Kumanishi T.
    J. Mol. Neurosci. 9:55-60(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Pituitary adenoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
  6. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Tissue: Eye.

Entry informationi

Entry nameiNNAT_HUMAN
AccessioniPrimary (citable) accession number: Q16517
Secondary accession number(s): B2R558
, E1P5V6, Q16596, Q5U0N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.