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Protein

Neuronatin

Gene

NNAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.

GO - Biological processi

  • brain development Source: GO_Central
  • neuron differentiation Source: Ensembl
  • positive regulation of insulin secretion Source: GO_Central
  • protein lipoylation Source: ProtInc
  • transport Source: ProtInc

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronatin
Gene namesi
Name:NNAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000053438.8.
HGNCiHGNC:7860. NNAT.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi4826.
OpenTargetsiENSG00000053438.
PharmGKBiPA31665.

Polymorphism and mutation databases

BioMutaiNNAT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968821 – 81NeuronatinAdd BLAST81

Proteomic databases

PaxDbiQ16517.
PeptideAtlasiQ16517.
PRIDEiQ16517.
TopDownProteomicsiQ16517-1. [Q16517-1]

PTM databases

PhosphoSitePlusiQ16517.

Expressioni

Developmental stagei

Abundant in 18-24 week old fetal brain. Postnatally its expression decline and only minimal levels were present in adulthood.

Gene expression databases

BgeeiENSG00000053438.
CleanExiHS_NNAT.
GenevisibleiQ16517. HS.

Interactioni

Protein-protein interaction databases

BioGridi110890. 2 interactors.
IntActiQ16517. 1 interactor.
STRINGi9606.ENSP00000062104.

Structurei

3D structure databases

ProteinModelPortaliQ16517.
SMRiQ16517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuronatin family.Curated

Phylogenomic databases

eggNOGiENOG410JDHY. Eukaryota.
ENOG41117T6. LUCA.
GeneTreeiENSGT00390000007412.
HOVERGENiHBG001605.
InParanoidiQ16517.
OMAiMGERRQR.
OrthoDBiEOG091G1AP2.
PhylomeDBiQ16517.
TreeFamiTF338710.

Family and domain databases

InterProiView protein in InterPro
IPR024885. Neuronatin.
PANTHERiPTHR15285. PTHR15285. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q16517-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS
60 70 80
EVFRYSLQKL AYTVSRTGRQ VLGERRQRAP N
Length:81
Mass (Da):9,237
Last modified:November 1, 1996 - v1
Checksum:i067086C7663E3D20
GO
Isoform Beta (identifier: Q16517-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Show »
Length:54
Mass (Da):6,153
Checksum:i184E7C9642006C87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64V → L in AAV38233 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00433125 – 51Missing in isoform Beta. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25033 mRNA. Translation: AAA93224.1.
U25034 mRNA. Translation: AAA93225.1.
U31767 Genomic DNA. Translation: AAC50627.1.
U31767 Genomic DNA. Translation: AAC50626.1.
AB002392 mRNA. Translation: BAA25016.1.
AK312069 mRNA. Translation: BAG35005.1.
BT019426 mRNA. Translation: AAV38233.1.
AL109614 Genomic DNA. Translation: CAC00476.1.
AL109614 Genomic DNA. Translation: CAC00477.1.
CH471077 Genomic DNA. Translation: EAW76059.1.
CH471077 Genomic DNA. Translation: EAW76060.1.
BC001768 mRNA. Translation: AAH01768.1.
CCDSiCCDS13296.1. [Q16517-1]
CCDS13297.1. [Q16517-2]
PIRiG01783.
RefSeqiNP_001309731.1. NM_001322802.1.
NP_005377.1. NM_005386.3. [Q16517-1]
NP_859017.1. NM_181689.2. [Q16517-2]
UniGeneiHs.504703.

Genome annotation databases

EnsembliENST00000062104; ENSP00000062104; ENSG00000053438. [Q16517-1]
ENST00000346199; ENSP00000335497; ENSG00000053438. [Q16517-2]
GeneIDi4826.
KEGGihsa:4826.
UCSCiuc002xhd.4. human. [Q16517-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNNAT_HUMAN
AccessioniPrimary (citable) accession number: Q16517
Secondary accession number(s): B2R558
, E1P5V6, Q16596, Q5U0N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families