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Q164G2

- PDXA_ROSDO

UniProt

Q164G2 - PDXA_ROSDO

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei132 – 1321SubstrateUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Metal bindingi163 – 1631Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi208 – 2081Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi263 – 2631Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei271 – 2711SubstrateUniRule annotation
    Binding sitei280 – 2801SubstrateUniRule annotation
    Binding sitei289 – 2891SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-2938-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:RD1_3123
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3263264-hydroxythreonine-4-phosphate dehydrogenasePRO_1000051512Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi375451.RD1_3123.

    Structurei

    3D structure databases

    ProteinModelPortaliQ164G2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221592.
    KOiK00097.
    OMAiAIGTEDE.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q164G2-1 [UniParc]FASTAAdd to Basket

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    MSPATAPVLI SCGEPAGIGP EIAVAAWDAL QGTIPLAWVG DPRHLPASTT    50
    FTAITHPRAV ADVPTGSLPV LVHDFAAPST PGHPDPANAQ GVIDVIAACV 100
    AWVQEGAAAA LCTAPIHKKA LIDGADFKHP GHTEYLQALA GGRSRAVMML 150
    ASDALRVVPT TIHIALEDVP RVLTPALLRE TITITHAALQ RQFGIQAPRI 200
    VVAGLNPHAG EGGAMGLEEQ DWIADVISAL AASGMNLRGP LPADTMFHAR 250
    AREGYDAAIA MYHDQALIPI KTLDFDRGVN VTLGLPFIRT SPDHGTAFDI 300
    AGKGIANPTS MIEAIKLAAH MAARHV 326
    Length:326
    Mass (Da):33,952
    Last modified:July 25, 2006 - v1
    Checksum:i118B06B5980A5AE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG32631.1.
    RefSeqiWP_011569247.1. NC_008209.1.
    YP_683317.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG32631; ABG32631; RD1_3123.
    GeneIDi4198668.
    KEGGirde:RD1_3123.
    PATRICi23364221. VBIRosDen86677_2982.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG32631.1 .
    RefSeqi WP_011569247.1. NC_008209.1.
    YP_683317.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q164G2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_3123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG32631 ; ABG32631 ; RD1_3123 .
    GeneIDi 4198668.
    KEGGi rde:RD1_3123.
    PATRICi 23364221. VBIRosDen86677_2982.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221592.
    KOi K00097.
    OMAi AIGTEDE.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci RDEN375451:GJIZ-2938-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiPDXA_ROSDO
    AccessioniPrimary (citable) accession number: Q164G2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3