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Protein

Glutamate receptor ionotropic, kainate 5

Gene

GRIK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-451308 Activation of Ca-permeable Kainate Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 5
Short name:
GluK5
Alternative name(s):
Excitatory amino acid receptor 2
Short name:
EAA2
Glutamate receptor KA-2
Short name:
KA2
Gene namesi
Name:GRIK5
Synonyms:GRIK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105737.9
HGNCiHGNC:4583 GRIK5
MIMi600283 gene
neXtProtiNX_Q16478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 544ExtracellularSequence analysisAdd BLAST530
Transmembranei545 – 565HelicalSequence analysisAdd BLAST21
Topological domaini566 – 622CytoplasmicSequence analysisAdd BLAST57
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 803ExtracellularSequence analysisAdd BLAST160
Transmembranei804 – 824HelicalSequence analysisAdd BLAST21
Topological domaini825 – 980CytoplasmicSequence analysisAdd BLAST156

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2901
OpenTargetsiENSG00000105737
PharmGKBiPA28977

Chemistry databases

ChEMBLiCHEMBL2675
DrugBankiDB00142 L-Glutamic Acid

Polymorphism and mutation databases

BioMutaiGRIK5
DMDMi209572626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000001155215 – 980Glutamate receptor ionotropic, kainate 5Add BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 292By similarity
Disulfide bondi83 ↔ 334By similarity
Disulfide bondi165 ↔ 170By similarity
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ16478
PeptideAtlasiQ16478
PRIDEiQ16478

PTM databases

iPTMnetiQ16478
PhosphoSitePlusiQ16478

Expressioni

Gene expression databases

BgeeiENSG00000105737
CleanExiHS_GRIK2
HS_GRIK5
ExpressionAtlasiQ16478 baseline and differential
GenevisibleiQ16478 HS

Interactioni

Subunit structurei

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109158, 6 interactors
IntActiQ16478, 4 interactors
STRINGi9606.ENSP00000262895

Chemistry databases

BindingDBiQ16478

Structurei

3D structure databases

ProteinModelPortaliQ16478
SMRiQ16478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi860 – 866Poly-Arg7

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISR4 Eukaryota
ENOG410XRUE LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000234371
HOVERGENiHBG051839
InParanoidiQ16478
KOiK05205
OMAiWARHYDQ
OrthoDBiEOG091G02LN
PhylomeDBiQ16478
TreeFamiTF334668

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16478-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAELLLLLI VAFASPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ
60 70 80 90 100
INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP
110 120 130 140 150
ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS
160 170 180 190 200
RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT
210 220 230 240 250
PLLKEIRDDK VSTIIIDANA SISHLILRKA SELGMTSAFY KYILTTMDFP
260 270 280 290 300
ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYLGP
310 320 330 340 350
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL
360 370 380 390 400
RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN
410 420 430 440 450
ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM
460 470 480 490 500
LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF
510 520 530 540 550
TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM
560 570 580 590 600
LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV
610 620 630 640 650
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV
660 670 680 690 700
PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV
710 720 730 740 750
FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI
760 770 780 790 800
GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG
810 820 830 840 850
MENIGGIFIV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR
860 870 880 890 900
HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG
910 920 930 940 950
SAHGGPQRLL DDPGPPSGAR PAAPTPCTHV RVCQECRRIQ ALRASGAGAP
960 970 980
PRGLGVPAEA TSPPRPRPGP AGPRELAEHE
Length:980
Mass (Da):109,265
Last modified:October 14, 2008 - v2
Checksum:i72466FFF64079388
GO
Isoform 2 (identifier: Q16478-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-980: VSVCQEMLQE...AGPRELAEHE → TPALHPAACQ...ATLVTSNFHV

Note: No experimental confirmation available.
Show »
Length:981
Mass (Da):109,658
Checksum:i71DFC5DE362DF1C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436A → G in AAB22591 (PubMed:1321949).Curated1
Sequence conflicti459 – 461RFR → PFP in AAB22591 (PubMed:1321949).Curated3
Sequence conflicti711R → A in AAB22591 (PubMed:1321949).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035585839 – 980VSVCQ…LAEHE → TPALHPAACQCSALGPRTPL KEPSMLLVKVPSTRVQVAFS RTSLRQVCPFLLQHQLSSLY WIQATNVQICCHFSSLKPSP DLTFPPSHRPLSSLLFTALA AVGGLPDASSFFFPPISSCP PLQSGIGPCHSTEATLVTSN FHV in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S40369 mRNA Translation: AAB22591.1
AJ249209 mRNA Translation: CAC80547.1
CH471126 Genomic DNA Translation: EAW57090.1
CCDSiCCDS12595.1 [Q16478-1]
CCDS77305.1 [Q16478-2]
PIRiI57936
RefSeqiNP_001287959.1, NM_001301030.1 [Q16478-2]
NP_002079.3, NM_002088.4 [Q16478-1]
XP_005258878.1, XM_005258821.3 [Q16478-1]
XP_011525165.1, XM_011526863.2 [Q16478-2]
UniGeneiHs.367799

Genome annotation databases

EnsembliENST00000262895; ENSP00000262895; ENSG00000105737 [Q16478-1]
ENST00000301218; ENSP00000301218; ENSG00000105737 [Q16478-2]
ENST00000593562; ENSP00000470251; ENSG00000105737 [Q16478-1]
GeneIDi2901
KEGGihsa:2901
UCSCiuc002osj.3 human [Q16478-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGRIK5_HUMAN
AccessioniPrimary (citable) accession number: Q16478
Secondary accession number(s): Q8WWG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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