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Q16478

- GRIK5_HUMAN

UniProt

Q16478 - GRIK5_HUMAN

Protein

Glutamate receptor ionotropic, kainate 5

Gene

GRIK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

    GO - Molecular functioni

    1. extracellular-glutamate-gated ion channel activity Source: RefGenome
    2. kainate selective glutamate receptor activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to glucose stimulus Source: Ensembl
    2. establishment of localization in cell Source: Ensembl
    3. ionotropic glutamate receptor signaling pathway Source: GOC
    4. ion transmembrane transport Source: GOC
    5. positive regulation of neuron apoptotic process Source: Ensembl
    6. protein retention in ER lumen Source: Ensembl
    7. receptor clustering Source: Ensembl
    8. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    9. regulation of synaptic vesicle fusion to presynaptic membrane Source: Ensembl
    10. synaptic transmission Source: Reactome
    11. synaptic transmission, glutamatergic Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_21346. Activation of Ca-permeable Kainate Receptor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, kainate 5
    Short name:
    GluK5
    Alternative name(s):
    Excitatory amino acid receptor 2
    Short name:
    EAA2
    Glutamate receptor KA-2
    Short name:
    KA2
    Gene namesi
    Name:GRIK5
    Synonyms:GRIK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4583. GRIK5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. endoplasmic reticulum Source: Ensembl
    4. kainate selective glutamate receptor complex Source: RefGenome
    5. perikaryon Source: Ensembl
    6. plasma membrane Source: Reactome
    7. postsynaptic density Source: Ensembl
    8. postsynaptic membrane Source: RefGenome
    9. presynaptic membrane Source: RefGenome
    10. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28977.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414Sequence AnalysisAdd
    BLAST
    Chaini15 – 980966Glutamate receptor ionotropic, kainate 5PRO_0000011552Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 292By similarity
    Disulfide bondi83 ↔ 334By similarity
    Disulfide bondi165 ↔ 170By similarity
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ16478.
    PRIDEiQ16478.

    PTM databases

    PhosphoSiteiQ16478.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16478.
    BgeeiQ16478.
    CleanExiHS_GRIK2.
    HS_GRIK5.
    GenevestigatoriQ16478.

    Interactioni

    Subunit structurei

    Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109158. 7 interactions.
    IntActiQ16478. 4 interactions.
    MINTiMINT-1427286.
    STRINGi9606.ENSP00000262895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16478.
    SMRiQ16478. Positions 22-828.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini15 – 544530ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini566 – 62257CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini644 – 803160ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini825 – 980156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei545 – 56521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei623 – 64321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei804 – 82421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi860 – 8667Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG316680.
    HOGENOMiHOG000234371.
    HOVERGENiHBG051839.
    KOiK05205.
    OMAiGLNCNLT.
    OrthoDBiEOG71G9W6.
    PhylomeDBiQ16478.
    TreeFamiTF334668.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16478-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPAELLLLLI VAFASPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ    50
    INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP 100
    ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS 150
    RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT 200
    PLLKEIRDDK VSTIIIDANA SISHLILRKA SELGMTSAFY KYILTTMDFP 250
    ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYLGP 300
    ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL 350
    RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN 400
    ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM 450
    LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF 500
    TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM 550
    LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 600
    GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV 650
    PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV 700
    FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI 750
    GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG 800
    MENIGGIFIV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR 850
    HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 900
    SAHGGPQRLL DDPGPPSGAR PAAPTPCTHV RVCQECRRIQ ALRASGAGAP 950
    PRGLGVPAEA TSPPRPRPGP AGPRELAEHE 980
    Length:980
    Mass (Da):109,265
    Last modified:October 14, 2008 - v2
    Checksum:i72466FFF64079388
    GO
    Isoform 2 (identifier: Q16478-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         839-980: VSVCQEMLQE...AGPRELAEHE → TPALHPAACQ...ATLVTSNFHV

    Note: No experimental confirmation available.

    Show »
    Length:981
    Mass (Da):109,658
    Checksum:i71DFC5DE362DF1C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti436 – 4361A → G in AAB22591. (PubMed:1321949)Curated
    Sequence conflicti459 – 4613RFR → PFP in AAB22591. (PubMed:1321949)Curated
    Sequence conflicti711 – 7111R → A in AAB22591. (PubMed:1321949)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti527 – 5271V → M.
    Corresponds to variant rs2230298 [ dbSNP | Ensembl ].
    VAR_047000

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei839 – 980142VSVCQ…LAEHE → TPALHPAACQCSALGPRTPL KEPSMLLVKVPSTRVQVAFS RTSLRQVCPFLLQHQLSSLY WIQATNVQICCHFSSLKPSP DLTFPPSHRPLSSLLFTALA AVGGLPDASSFFFPPISSCP PLQSGIGPCHSTEATLVTSN FHV in isoform 2. 1 PublicationVSP_035585Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S40369 mRNA. Translation: AAB22591.1.
    AJ249209 mRNA. Translation: CAC80547.1.
    CH471126 Genomic DNA. Translation: EAW57090.1.
    CCDSiCCDS12595.1. [Q16478-1]
    PIRiI57936.
    RefSeqiNP_002079.3. NM_002088.4. [Q16478-1]
    XP_005258878.1. XM_005258821.1. [Q16478-1]
    XP_006723232.1. XM_006723169.1. [Q16478-2]
    UniGeneiHs.367799.

    Genome annotation databases

    EnsembliENST00000262895; ENSP00000262895; ENSG00000105737. [Q16478-1]
    ENST00000301218; ENSP00000301218; ENSG00000105737. [Q16478-2]
    ENST00000593562; ENSP00000470251; ENSG00000105737. [Q16478-1]
    GeneIDi2901.
    KEGGihsa:2901.
    UCSCiuc002osi.2. human. [Q16478-1]

    Polymorphism databases

    DMDMi209572626.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S40369 mRNA. Translation: AAB22591.1 .
    AJ249209 mRNA. Translation: CAC80547.1 .
    CH471126 Genomic DNA. Translation: EAW57090.1 .
    CCDSi CCDS12595.1. [Q16478-1 ]
    PIRi I57936.
    RefSeqi NP_002079.3. NM_002088.4. [Q16478-1 ]
    XP_005258878.1. XM_005258821.1. [Q16478-1 ]
    XP_006723232.1. XM_006723169.1. [Q16478-2 ]
    UniGenei Hs.367799.

    3D structure databases

    ProteinModelPortali Q16478.
    SMRi Q16478. Positions 22-828.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109158. 7 interactions.
    IntActi Q16478. 4 interactions.
    MINTi MINT-1427286.
    STRINGi 9606.ENSP00000262895.

    Chemistry

    BindingDBi Q16478.
    ChEMBLi CHEMBL2675.
    DrugBanki DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 454.

    PTM databases

    PhosphoSitei Q16478.

    Polymorphism databases

    DMDMi 209572626.

    Proteomic databases

    PaxDbi Q16478.
    PRIDEi Q16478.

    Protocols and materials databases

    DNASUi 2901.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262895 ; ENSP00000262895 ; ENSG00000105737 . [Q16478-1 ]
    ENST00000301218 ; ENSP00000301218 ; ENSG00000105737 . [Q16478-2 ]
    ENST00000593562 ; ENSP00000470251 ; ENSG00000105737 . [Q16478-1 ]
    GeneIDi 2901.
    KEGGi hsa:2901.
    UCSCi uc002osi.2. human. [Q16478-1 ]

    Organism-specific databases

    CTDi 2901.
    GeneCardsi GC19M042502.
    H-InvDB HIX0022359.
    HIX0027521.
    HGNCi HGNC:4583. GRIK5.
    MIMi 600283. gene.
    neXtProti NX_Q16478.
    PharmGKBi PA28977.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316680.
    HOGENOMi HOG000234371.
    HOVERGENi HBG051839.
    KOi K05205.
    OMAi GLNCNLT.
    OrthoDBi EOG71G9W6.
    PhylomeDBi Q16478.
    TreeFami TF334668.

    Enzyme and pathway databases

    Reactomei REACT_21346. Activation of Ca-permeable Kainate Receptor.

    Miscellaneous databases

    GeneWikii GRIK5.
    GenomeRNAii 2901.
    NextBioi 11483.
    PROi Q16478.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16478.
    Bgeei Q16478.
    CleanExi HS_GRIK2.
    HS_GRIK5.
    Genevestigatori Q16478.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit."
      Kamboj R.K., Schoepp D.D., Nutt S., Shekter L., Korczak B., True R.A., Zimmerman D.M., Wosnick M.A.
      Mol. Pharmacol. 42:10-15(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    2. "Myeloid progenitor cell growth and apoptosis involves known and cell-specific ionotropic glutamate receptors."
      Langer A., Xu D., Kuehcke K., Fehse B., Abdallah S., Lother H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Erythroleukemia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGRIK5_HUMAN
    AccessioniPrimary (citable) accession number: Q16478
    Secondary accession number(s): Q8WWG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3