Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q16445

- GBRA6_HUMAN

UniProt

Q16445 - GBRA6_HUMAN

Protein

Gamma-aminobutyric acid receptor subunit alpha-6

Gene

GABRA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. benzodiazepine receptor activity Source: ProtInc
    2. chloride channel activity Source: UniProtKB-KW
    3. extracellular ligand-gated ion channel activity Source: InterPro
    4. GABA-A receptor activity Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid signaling pathway Source: InterPro
    2. ion transmembrane transport Source: Reactome
    3. signal transduction Source: ProtInc
    4. synaptic transmission Source: Reactome
    5. transmembrane transport Source: Reactome
    6. transport Source: ProtInc

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_24987. GABA A receptor activation.
    REACT_25387. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-6
    Alternative name(s):
    GABA(A) receptor subunit alpha-6
    Gene namesi
    Name:GABRA6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:4080. GABRA6.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome
    5. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28494.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 453434Gamma-aminobutyric acid receptor subunit alpha-6PRO_0000000447Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi156 ↔ 170By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ16445.
    PRIDEiQ16445.

    PTM databases

    PhosphoSiteiQ16445.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16445.
    BgeeiQ16445.
    CleanExiHS_GABRA6.
    GenevestigatoriQ16445.

    Organism-specific databases

    HPAiCAB022462.
    HPA019188.
    HPA058329.

    Interactioni

    Subunit structurei

    Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.By similarity

    Protein-protein interaction databases

    BioGridi108833. 1 interaction.
    STRINGi9606.ENSP00000274545.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16445.
    SMRiQ16445. Positions 33-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 242223ExtracellularCuratedAdd
    BLAST
    Topological domaini325 – 41995CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei243 – 26422HelicalCuratedAdd
    BLAST
    Transmembranei269 – 29022HelicalCuratedAdd
    BLAST
    Transmembranei301 – 32424HelicalCuratedAdd
    BLAST
    Transmembranei420 – 44122HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    HOGENOMiHOG000231337.
    HOVERGENiHBG051707.
    InParanoidiQ16445.
    KOiK05175.
    OMAiTRAPILQ.
    OrthoDBiEOG7JX342.
    PhylomeDBiQ16445.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005436. GABBAa6_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01619. GABAARALPHA6.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q16445-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSLPWLCI ILWLENALGK LEVEGNFYSE NVSRILDNLL EGYDNRLRPG    50
    FGGAVTEVKT DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFGGPTEI 100
    LSLNNLMVSK IWTPDTFFRN GKKSIAHNMT TPNKLFRIMQ NGTILYTMRL 150
    TINADCPMRL VNFPMDGHAC PLKFGSYAYP KSEIIYTWKK GPLYSVEVPE 200
    ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM GYFMIQIYTP 250
    CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA 300
    TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QTQKAKRKAQ FAAPPTVTIS 350
    KATEPLEAEI VLHPDSKYHL KKRITSLSLP IVSSSEANKV LTRAPILQST 400
    PVTPPPLSPA FGGTSKIDQY SRILFPVAFA GFNLVYWVVY LSKDTMEVSS 450
    SVE 453
    Length:453
    Mass (Da):51,024
    Last modified:February 20, 2007 - v2
    Checksum:i5C9F85845BC8E3B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti408 – 4081S → P in AAB36480. (PubMed:8632757)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti180 – 1801P → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036033
    Natural varianti187 – 1871T → M.
    Corresponds to variant rs3811993 [ dbSNP | Ensembl ].
    VAR_036782
    Natural varianti404 – 4041P → S.
    Corresponds to variant rs34907804 [ dbSNP | Ensembl ].
    VAR_036783

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S81944 mRNA. Translation: AAB36480.1.
    AK289461 mRNA. Translation: BAF82150.1.
    CH471062 Genomic DNA. Translation: EAW61542.1.
    BC096241 mRNA. Translation: AAH96241.1.
    BC096242 mRNA. Translation: AAH96242.1.
    BC099640 mRNA. Translation: AAH99640.1.
    BC099641 mRNA. Translation: AAH99641.1.
    CCDSiCCDS4356.1.
    RefSeqiNP_000802.2. NM_000811.2.
    UniGeneiHs.90791.

    Genome annotation databases

    EnsembliENST00000274545; ENSP00000274545; ENSG00000145863.
    GeneIDi2559.
    KEGGihsa:2559.
    UCSCiuc003lyu.2. human.

    Polymorphism databases

    DMDMi126302548.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Forbidden fruit - Issue 56 of March 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S81944 mRNA. Translation: AAB36480.1 .
    AK289461 mRNA. Translation: BAF82150.1 .
    CH471062 Genomic DNA. Translation: EAW61542.1 .
    BC096241 mRNA. Translation: AAH96241.1 .
    BC096242 mRNA. Translation: AAH96242.1 .
    BC099640 mRNA. Translation: AAH99640.1 .
    BC099641 mRNA. Translation: AAH99641.1 .
    CCDSi CCDS4356.1.
    RefSeqi NP_000802.2. NM_000811.2.
    UniGenei Hs.90791.

    3D structure databases

    ProteinModelPortali Q16445.
    SMRi Q16445. Positions 33-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108833. 1 interaction.
    STRINGi 9606.ENSP00000274545.

    Chemistry

    BindingDBi Q16445.
    ChEMBLi CHEMBL2111370.
    DrugBanki DB00659. Acamprosate.
    DB00404. Alprazolam.
    DB01351. Amobarbital.
    DB00543. Amoxapine.
    DB01352. Aprobarbital.
    DB01558. Bromazepam.
    DB00237. Butabarbital.
    DB00241. Butalbital.
    DB01353. Butethal.
    DB00475. Chlordiazepoxide.
    DB00349. Clobazam.
    DB01068. Clonazepam.
    DB00628. Clorazepate.
    DB01189. Desflurane.
    DB00829. Diazepam.
    DB00228. Enflurane.
    DB01049. Ergoloid mesylate.
    DB01215. Estazolam.
    DB00402. Eszopiclone.
    DB00189. Ethchlorvynol.
    DB00292. Etomidate.
    DB01205. Flumazenil.
    DB01544. Flunitrazepam.
    DB00690. Flurazepam.
    DB01437. Glutethimide.
    DB00801. Halazepam.
    DB01159. Halothane.
    DB01354. Heptabarbital.
    DB01355. Hexobarbital.
    DB00753. Isoflurane.
    DB00186. Lorazepam.
    DB00371. Meprobamate.
    DB01028. Methoxyflurane.
    DB00849. Methylphenobarbital.
    DB01107. Methyprylon.
    DB00683. Midazolam.
    DB01595. Nitrazepam.
    DB00334. Olanzapine.
    DB00842. Oxazepam.
    DB00312. Pentobarbital.
    DB01588. Prazepam.
    DB00794. Primidone.
    DB00818. Propofol.
    DB01589. Quazepam.
    DB00418. Secobarbital.
    DB01236. Sevoflurane.
    DB00306. Talbutal.
    DB00231. Temazepam.
    DB00599. Thiopental.
    DB00273. Topiramate.
    DB00897. Triazolam.
    GuidetoPHARMACOLOGYi 409.

    PTM databases

    PhosphoSitei Q16445.

    Polymorphism databases

    DMDMi 126302548.

    Proteomic databases

    PaxDbi Q16445.
    PRIDEi Q16445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274545 ; ENSP00000274545 ; ENSG00000145863 .
    GeneIDi 2559.
    KEGGi hsa:2559.
    UCSCi uc003lyu.2. human.

    Organism-specific databases

    CTDi 2559.
    GeneCardsi GC05P161045.
    H-InvDB HIX0005382.
    HGNCi HGNC:4080. GABRA6.
    HPAi CAB022462.
    HPA019188.
    HPA058329.
    MIMi 137143. gene.
    neXtProti NX_Q16445.
    PharmGKBi PA28494.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238757.
    HOGENOMi HOG000231337.
    HOVERGENi HBG051707.
    InParanoidi Q16445.
    KOi K05175.
    OMAi TRAPILQ.
    OrthoDBi EOG7JX342.
    PhylomeDBi Q16445.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_24987. GABA A receptor activation.
    REACT_25387. Ligand-gated ion channel transport.

    Miscellaneous databases

    GeneWikii GABRA6.
    GenomeRNAii 2559.
    NextBioi 10107.
    PROi Q16445.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16445.
    Bgeei Q16445.
    CleanExi HS_GABRA6.
    Genevestigatori Q16445.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005436. GABBAa6_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01619. GABAARALPHA6.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors."
      Hadingham K.L., Garrett E.M., Wafford K.A., Bain C., Heavens R.P., Sirinathsinghji D.J., Whiting P.J.
      Mol. Pharmacol. 49:253-259(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cerebellum.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-180.

    Entry informationi

    Entry nameiGBRA6_HUMAN
    AccessioniPrimary (citable) accession number: Q16445
    Secondary accession number(s): A8K096, Q4VAV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3