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Protein

Proline-rich protein 4

Gene

PRR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • retina homeostasis Source: UniProtKB
  • visual perception Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 4
Alternative name(s):
Lacrimal proline-rich protein
Nasopharyngeal carcinoma-associated proline-rich protein 4
Gene namesi
Name:PRR4
Synonyms:LPRP, PROL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18020. PRR4.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

MalaCardsiPRR4.
PharmGKBiPA33806.

Polymorphism and mutation databases

BioMutaiPRR4.
DMDMi317373525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 134118Proline-rich protein 4PRO_0000022115Add
BLAST

Proteomic databases

EPDiQ16378.
MaxQBiQ16378.
PaxDbiQ16378.
PeptideAtlasiQ16378.
PRIDEiQ16378.

Expressioni

Tissue specificityi

Abundantly expressed in lacrimal gland where it is found in the acinar cells but not in the intralobular ducts. Also found in the submandibular gland, the parotid and sublingual glands.1 Publication

Gene expression databases

BgeeiQ16378.
CleanExiHS_PRR4.
ExpressionAtlasiQ16378. baseline and differential.
GenevisibleiQ16378. HS.

Organism-specific databases

HPAiHPA042133.

Interactioni

Protein-protein interaction databases

BioGridi116428. 5 interactions.
IntActiQ16378. 2 interactions.
STRINGi9606.ENSP00000228811.

Structurei

3D structure databases

ProteinModelPortaliQ16378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 9554Pro-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IUU4. Eukaryota.
ENOG4110PUN. LUCA.
GeneTreeiENSGT00730000112173.
HOGENOMiHOG000115703.
InParanoidiQ16378.
OMAiPGGHHRY.
OrthoDBiEOG74FF6Z.
PhylomeDBiQ16378.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 1 hit.
[Graphical view]
SMARTiSM01412. Pro-rich. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16378-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLVLLSVVL LALSSAQSTD NDVNYEDFTF TIPDVEDSSQ RPDQGPQRPP
60 70 80 90 100
PEGLLPRPPG DSGNQDDGPQ QRPPKPGGHH RHPPPPPFQN QQRPPRRGHR
110 120 130
QLSLPRFPSV SLQEASSFFQ RDRPARHPQE QPLW
Length:134
Mass (Da):15,097
Last modified:January 11, 2011 - v3
Checksum:i57BB0DCA10938CC8
GO
Isoform 2 (identifier: Q16378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-134: DVEDSSQRPD...ARHPQEQPLW → ACRKHHHSSRGTDQQDIPRSNHSGNLEFSGRK

Note: No experimental confirmation available.Curated
Show »
Length:65
Mass (Da):7,256
Checksum:i6291D846DF039085
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q16378-2)
Sequence conflicti43 – 431R → G in DB198298 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961R → Q.3 Publications
Corresponds to variant rs1063193 [ dbSNP | Ensembl ].
VAR_027926
Natural varianti120 – 1201Q → R.3 Publications
Corresponds to variant rs1047699 [ dbSNP | Ensembl ].
VAR_027927

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 134101DVEDS…EQPLW → ACRKHHHSSRGTDQQDIPRS NHSGNLEFSGRK in isoform 2. 1 PublicationVSP_044635Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79048 mRNA. Translation: AAB35174.1.
AF530472 mRNA. Translation: AAM94338.1.
AK292934 mRNA. Translation: BAF85623.1.
AK292991 mRNA. Translation: BAF85680.1.
DB198298 mRNA. No translation available.
AC006518 Genomic DNA. No translation available.
AC018630 Genomic DNA. No translation available.
AC134349 Genomic DNA. No translation available.
AC217021 Genomic DNA. No translation available.
AC242308 Genomic DNA. No translation available.
BC058035 mRNA. Translation: AAH58035.1.
CCDSiCCDS41756.1. [Q16378-1]
CCDS55804.1. [Q16378-2]
PIRiI54810.
RefSeqiNP_001092008.2. NM_001098538.2. [Q16378-2]
NP_009175.2. NM_007244.2. [Q16378-1]
UniGeneiHs.732031.

Genome annotation databases

EnsembliENST00000228811; ENSP00000228811; ENSG00000111215. [Q16378-1]
ENST00000544994; ENSP00000438046; ENSG00000111215. [Q16378-2]
ENST00000574424; ENSP00000459468; ENSG00000263247. [Q16378-1]
ENST00000576999; ENSP00000461695; ENSG00000263247. [Q16378-2]
ENST00000614435; ENSP00000477689; ENSG00000282269. [Q16378-1]
ENST00000632373; ENSP00000487830; ENSG00000282269. [Q16378-2]
GeneIDi11272.
KEGGihsa:11272.
UCSCiuc001qyz.5. human. [Q16378-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79048 mRNA. Translation: AAB35174.1.
AF530472 mRNA. Translation: AAM94338.1.
AK292934 mRNA. Translation: BAF85623.1.
AK292991 mRNA. Translation: BAF85680.1.
DB198298 mRNA. No translation available.
AC006518 Genomic DNA. No translation available.
AC018630 Genomic DNA. No translation available.
AC134349 Genomic DNA. No translation available.
AC217021 Genomic DNA. No translation available.
AC242308 Genomic DNA. No translation available.
BC058035 mRNA. Translation: AAH58035.1.
CCDSiCCDS41756.1. [Q16378-1]
CCDS55804.1. [Q16378-2]
PIRiI54810.
RefSeqiNP_001092008.2. NM_001098538.2. [Q16378-2]
NP_009175.2. NM_007244.2. [Q16378-1]
UniGeneiHs.732031.

3D structure databases

ProteinModelPortaliQ16378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116428. 5 interactions.
IntActiQ16378. 2 interactions.
STRINGi9606.ENSP00000228811.

Polymorphism and mutation databases

BioMutaiPRR4.
DMDMi317373525.

Proteomic databases

EPDiQ16378.
MaxQBiQ16378.
PaxDbiQ16378.
PeptideAtlasiQ16378.
PRIDEiQ16378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228811; ENSP00000228811; ENSG00000111215. [Q16378-1]
ENST00000544994; ENSP00000438046; ENSG00000111215. [Q16378-2]
ENST00000574424; ENSP00000459468; ENSG00000263247. [Q16378-1]
ENST00000576999; ENSP00000461695; ENSG00000263247. [Q16378-2]
ENST00000614435; ENSP00000477689; ENSG00000282269. [Q16378-1]
ENST00000632373; ENSP00000487830; ENSG00000282269. [Q16378-2]
GeneIDi11272.
KEGGihsa:11272.
UCSCiuc001qyz.5. human. [Q16378-1]

Organism-specific databases

CTDi11272.
GeneCardsiPRR4.
H-InvDBHIX0026352.
HGNCiHGNC:18020. PRR4.
HPAiHPA042133.
MalaCardsiPRR4.
MIMi605359. gene.
neXtProtiNX_Q16378.
PharmGKBiPA33806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUU4. Eukaryota.
ENOG4110PUN. LUCA.
GeneTreeiENSGT00730000112173.
HOGENOMiHOG000115703.
InParanoidiQ16378.
OMAiPGGHHRY.
OrthoDBiEOG74FF6Z.
PhylomeDBiQ16378.

Miscellaneous databases

ChiTaRSiPRR4. human.
GeneWikiiPRR4.
GenomeRNAii11272.
PROiQ16378.
SOURCEiSearch...

Gene expression databases

BgeeiQ16378.
CleanExiHS_PRR4.
ExpressionAtlasiQ16378. baseline and differential.
GenevisibleiQ16378. HS.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 1 hit.
[Graphical view]
SMARTiSM01412. Pro-rich. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A major human lacrimal gland mRNA encodes a new proline-rich protein family member."
    Dickinson D.P., Thiesse M.
    Invest. Ophthalmol. Vis. Sci. 36:2020-2031(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLN-96 AND ARG-120.
    Tissue: Lacrimal gland.
  2. "Isolation of differentially expressed genes in nasopharyngeal carcinoma."
    Zhang B.-C., Li G.-Y.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLN-96 AND ARG-120.
    Tissue: Trachea.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-96 AND ARG-120.
  6. "Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification."
    Azkargorta M., Soria J., Ojeda C., Guzman F., Acera A., Iloro I., Suarez T., Elortza F.
    J. Proteome Res. 14:2649-2658(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 55-134, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Tear.
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 122-134.
    Tissue: Platelet.

Entry informationi

Entry nameiPROL4_HUMAN
AccessioniPrimary (citable) accession number: Q16378
Secondary accession number(s): A8KA69, F5H0D7, Q8NFB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 11, 2011
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.