Q16363 (LAMA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Laminin subunit alpha-4

Alternative name(s):
Laminin-14 subunit alpha
Laminin-8 subunit alpha
Laminin-9 subunit alpha

Gene names

Name:

LAMA4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1823 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subunit structure	Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-4 is a subunit of laminin-8 (laminin-411), laminin-9 (laminin-421) and laminin-14 (laminin-423).
Subcellular location	Secreted › extracellular space › extracellular matrix › basement membrane. Note: Major component.
Tissue specificity	In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.
Domain	The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domain G is globular.
Sequence similarities	Contains 4 laminin EGF-like domains. Contains 5 laminin G-like domains.
Caution	Gene LAMA4 was formerly called LAMA3.
Sequence caution	The sequence BAE06109.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Basement membrane Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Laminin EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell adhesion Inferred from electronic annotation. Source: InterPro regulation of cell migration Inferred from electronic annotation. Source: InterPro regulation of embryonic development Inferred from electronic annotation. Source: InterPro
Cellular component	laminin-1 complex Inferred from electronic annotation. Source: InterPro
Molecular function	extracellular matrix structural constituent Traceable author statement. Source: ProtInc receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q16363-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q16363-2)

The sequence of this isoform differs from the canonical sequence as follows:
     266-272: Missing.

Isoform 3 (identifier: Q16363-3)

The sequence of this isoform differs from the canonical sequence as follows:
     66-120: KCNAGFFHTL...EKCLDGYIGD → VQCPCHCHPA...RKLEIKSFPL
     121-1823: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 1823	1799	Laminin subunit alpha-4		PRO_0000017060
Regions
	Domain	82 – 131	50	Laminin EGF-like 1
	Domain	132 – 186	55	Laminin EGF-like 2
	Domain	187 – 240	54	Laminin EGF-like 3
	Domain	241 – 255	15	Laminin EGF-like 4; truncated
	Domain	833 – 1035	203	Laminin G-like 1
	Domain	1047 – 1227	181	Laminin G-like 2
	Domain	1234 – 1402	169	Laminin G-like 3
	Domain	1469 – 1640	172	Laminin G-like 4
	Domain	1647 – 1820	174	Laminin G-like 5
	Region	256 – 832	577	Domain II and I
	Coiled coil	320 – 403	84	Potential
	Coiled coil	473 – 528	56	Potential
	Coiled coil	581 – 614	34	Potential
	Coiled coil	662 – 724	63	Potential
	Coiled coil	777 – 806	30	Potential
	Motif	724 – 726	3	Cell attachment site Potential
Amino acid modifications
	Modified residue	1593	1	Phosphotyrosine Ref.9
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	215	1	N-linked (GlcNAc...) Potential
	Glycosylation	315	1	N-linked (GlcNAc...) Potential
	Glycosylation	465	1	N-linked (GlcNAc...) Potential
	Glycosylation	531	1	N-linked (GlcNAc...) Potential
	Glycosylation	557	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	578	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	581	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	638	1	N-linked (GlcNAc...) Potential
	Glycosylation	646	1	N-linked (GlcNAc...) Potential
	Glycosylation	742	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	758	1	N-linked (GlcNAc...) Potential
	Glycosylation	761	1	N-linked (GlcNAc...) Potential
	Glycosylation	787	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	810	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	1093	1	N-linked (GlcNAc...) Potential
	Glycosylation	1288	1	N-linked (GlcNAc...) Potential
	Glycosylation	1366	1	N-linked (GlcNAc...) Potential
	Glycosylation	1418	1	N-linked (GlcNAc...) Potential
	Disulfide bond	82 ↔ 91		By similarity
	Disulfide bond	84 ↔ 98		By similarity
	Disulfide bond	101 ↔ 110		By similarity
	Disulfide bond	113 ↔ 129		By similarity
	Disulfide bond	132 ↔ 146		By similarity
	Disulfide bond	134 ↔ 155		By similarity
	Disulfide bond	157 ↔ 166		By similarity
	Disulfide bond	169 ↔ 184		By similarity
	Disulfide bond	187 ↔ 202		By similarity
	Disulfide bond	189 ↔ 209		By similarity
	Disulfide bond	212 ↔ 221		By similarity
	Disulfide bond	224 ↔ 238		By similarity
	Disulfide bond	273		Interchain Probable
	Disulfide bond	276		Interchain Probable
	Disulfide bond	1005 ↔ 1035		By similarity
	Disulfide bond	1201 ↔ 1227		By similarity
	Disulfide bond	1370 ↔ 1402		By similarity
	Disulfide bond	1617 ↔ 1640		By similarity
	Disulfide bond	1792 ↔ 1820		By similarity
Natural variations
	Alternative sequence	66 – 120	55	KCNAG…GYIGD → VQCPCHCHPAGAPAPPRAVP HSSFSLSPPLSSPQCLESFT WARSVRKLEIKSFPL in isoform 3.		VSP_038853
	Alternative sequence	121 – 1823	1703	Missing in isoform 3.		VSP_038854
	Alternative sequence	266 – 272	7	Missing in isoform 2.		VSP_017542
	Natural variant	94	1	G → S. Corresponds to variant rs35349917 [ dbSNP | Ensembl ].		VAR_056140
	Natural variant	154	1	R → W. Corresponds to variant rs11757455 [ dbSNP | Ensembl ].		VAR_056141
	Natural variant	283	1	A → E. Corresponds to variant rs9400522 [ dbSNP | Ensembl ].		VAR_061348
	Natural variant	492	1	L → H. Corresponds to variant rs3752579 [ dbSNP | Ensembl ].		VAR_056142
	Natural variant	498	1	Y → H. Ref.2 Ref.8 Corresponds to variant rs1050348 [ dbSNP | Ensembl ].		VAR_025550
	Natural variant	1117	1	G → S. Ref.1 Ref.2 Ref.8 Corresponds to variant rs2032567 [ dbSNP | Ensembl ].		VAR_025551
	Natural variant	1119	1	P → R. Ref.1 Ref.2 Ref.8 Corresponds to variant rs1050349 [ dbSNP | Ensembl ].		VAR_025552
	Natural variant	1549	1	N → S. Ref.2 Corresponds to variant rs12110554 [ dbSNP | Ensembl ].		VAR_056143
	Natural variant	1815	1	V → I. Corresponds to variant rs3734292 [ dbSNP | Ensembl ].		VAR_056144
Experimental info
	Sequence conflict	143	1	A → P in AAB34635. Ref.1
	Sequence conflict	178	1	L → F in AAB34635. Ref.1
	Sequence conflict	283	1	A → D in AAB34635. Ref.1
	Sequence conflict	283	1	A → D in CAA62596. Ref.2
	Sequence conflict	283	1	A → D in BAE06109. Ref.3
	Sequence conflict	283	1	A → D in CAA54258. Ref.8
	Sequence conflict	1064	1	T → P in AAB34635. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 23, 2010. Version 4. Checksum: 25BFB6120C2A86F1	FASTA	1,823	202,524
	10 20 30 40 50 60 MALSSAWRSV LPLWLLWSAA CSRAASGDDN AFPFDIEGSS AVGRQDPPET SEPRVALGRL 70 80 90 100 110 120 PPAAEKCNAG FFHTLSGECV PCDCNGNSNE CLDGSGYCVH CQRNTTGEHC EKCLDGYIGD 130 140 150 160 170 180 SIRGAPQFCQ PCPCPLPHLA NFAESCYRKN GAVRCICNEN YAGPNCERCA PGYYGNPLLI 190 200 210 220 230 240 GSTCKKCDCS GNSDPNLIFE DCDEVTGQCR NCLRNTTGFK CERCAPGYYG DARIAKNCAV 250 260 270 280 290 300 CNCGGGPCDS VTGECLEEGF EPPTGMDCPT ISCDKCVWDL TDALRLAALS IEEGKSGVLS 310 320 330 340 350 360 VSSGAAAHRH VNEINATIYL LKTKLSEREN QYALRKIQIN NAENTMKSLL SDVEELVEKE 370 380 390 400 410 420 NQASRKGQLV QKESMDTINH ASQLVEQAHD MRDKIQEINN KMLYYGEEHE LSPKEISEKL 430 440 450 460 470 480 VLAQKMLEEI RSRQPFFTQR ELVDEEADEA YELLSQAESW QRLHNETRTL FPVVLEQLDD 490 500 510 520 530 540 YNAKLSDLQE ALDQALNYVR DAEDMNRATA ARQRDHEKQQ ERVREQMEVV NMSLSTSADS 550 560 570 580 590 600 LTTPRLTLSE LDDIIKNASG IYAEIDGAKS ELQVKLSNLS NLSHDLVQEA IDHAQDLQQE 610 620 630 640 650 660 ANELSRKLHS SDMNGLVQKA LDASNVYENI VNYVSEANET AEFALNTTDR IYDAVSGIDT 670 680 690 700 710 720 QIIYHKDESE NLLNQARELQ AKAESSSDEA VADTSRRVGG ALARKSALKT RLSDAVKQLQ 730 740 750 760 770 780 AAERGDAQQR LGQSRLITEE ANRTTMEVQQ ATAPMANNLT NWSQNLQHFD SSAYNTAVNS 790 800 810 820 830 840 ARDAVRNLTE VVPQLLDQLR TVEQKRPASN VSASIQRIRE LIAQTRSVAS KIQVSMMFDG 850 860 870 880 890 900 QSAVEVHSRT SMDDLKAFTS LSLYMKPPVK RPELTETADQ FILYLGSKNA KKEYMGLAIK 910 920 930 940 950 960 NDNLVYVYNL GTKDVEIPLD SKPVSSWPAY FSIVKIERVG KHGKVFLTVP SLSSTAEEKF 970 980 990 1000 1010 1020 IKKGEFSGDD SLLDLDPEDT VFYVGGVPSN FKLPTSLNLP GFVGCLELAT LNNDVISLYN 1030 1040 1050 1060 1070 1080 FKHIYNMDPS TSVPCARDKL AFTQSRAASY FFDGSGYAVV RDITRRGKFG QVTRFDIEVR 1090 1100 1110 1120 1130 1140 TPADNGLILL MVNGSMFFRL EMRNGYLHVF YDFGFSGGPV HLEDTLKKAQ INDAKYHEIS 1150 1160 1170 1180 1190 1200 IIYHNDKKMI LVVDRRHVKS MDNEKMKIPF TDIYIGGAPP EILQSRALRA HLPLDINFRG 1210 1220 1230 1240 1250 1260 CMKGFQFQKK DFNLLEQTET LGVGYGCPED SLISRRAYFN GQSFIASIQK ISFFDGFEGG 1270 1280 1290 1300 1310 1320 FNFRTLQPNG LLFYYASGSD VFSISLDNGT VIMDVKGIKV QSVDKQYNDG LSHFVISSVS 1330 1340 1350 1360 1370 1380 PTRYELIVDK SRVGSKNPTK GKIEQTQASE KKFYFGGSPI SAQYANFTGC ISNAYFTRVD 1390 1400 1410 1420 1430 1440 RDVEVEDFQR YTEKVHTSLY ECPIESSPLF LLHKKGKNLS KPKASQNKKG GKSKDAPSWD 1450 1460 1470 1480 1490 1500 PVALKLPERN TPRNSHCHLS NSPRAIEHAY QYGGTANSRQ EFEHLKGDFG AKSQFSIRLR 1510 1520 1530 1540 1550 1560 TRSSHGMIFY VSDQEENDFM TLFLAHGRLV YMFNVGHKKL KIRSQEKYND GLWHDVIFIR 1570 1580 1590 1600 1610 1620 ERSSGRLVID GLRVLEESLP PTEATWKIKG PIYLGGVAPG KAVKNVQINS IYSFSGCLSN 1630 1640 1650 1660 1670 1680 LQLNGASITS ASQTFSVTPC FEGPMETGTY FSTEGGYVVL DESFNIGLKF EIAFEVRPRS 1690 1700 1710 1720 1730 1740 SSGTLVHGHS VNGEYLNVHM KNGQVIVKVN NGIRDFSTSV TPKQSLCDGR WHRITVIRDS 1750 1760 1770 1780 1790 1800 NVVQLDVDSE VNHVVGPLNP KPIDHREPVF VGGVPESLLT PRLAPSKPFT GCIRHFVIDG 1810 1820 HPVSFSKAAL VSGAVSINSC PAA
	Isoform 2 [UniParc]. Checksum: AEC1A024B5A180ED	FASTA	1,816	201,776
	10 20 30 40 50 60 MALSSAWRSV LPLWLLWSAA CSRAASGDDN AFPFDIEGSS AVGRQDPPET SEPRVALGRL 70 80 90 100 110 120 PPAAEKCNAG FFHTLSGECV PCDCNGNSNE CLDGSGYCVH CQRNTTGEHC EKCLDGYIGD 130 140 150 160 170 180 SIRGAPQFCQ PCPCPLPHLA NFAESCYRKN GAVRCICNEN YAGPNCERCA PGYYGNPLLI 190 200 210 220 230 240 GSTCKKCDCS GNSDPNLIFE DCDEVTGQCR NCLRNTTGFK CERCAPGYYG DARIAKNCAV 250 260 270 280 290 300 CNCGGGPCDS VTGECLEEGF EPPTGCDKCV WDLTDALRLA ALSIEEGKSG VLSVSSGAAA 310 320 330 340 350 360 HRHVNEINAT IYLLKTKLSE RENQYALRKI QINNAENTMK SLLSDVEELV EKENQASRKG 370 380 390 400 410 420 QLVQKESMDT INHASQLVEQ AHDMRDKIQE INNKMLYYGE EHELSPKEIS EKLVLAQKML 430 440 450 460 470 480 EEIRSRQPFF TQRELVDEEA DEAYELLSQA ESWQRLHNET RTLFPVVLEQ LDDYNAKLSD 490 500 510 520 530 540 LQEALDQALN YVRDAEDMNR ATAARQRDHE KQQERVREQM EVVNMSLSTS ADSLTTPRLT 550 560 570 580 590 600 LSELDDIIKN ASGIYAEIDG AKSELQVKLS NLSNLSHDLV QEAIDHAQDL QQEANELSRK 610 620 630 640 650 660 LHSSDMNGLV QKALDASNVY ENIVNYVSEA NETAEFALNT TDRIYDAVSG IDTQIIYHKD 670 680 690 700 710 720 ESENLLNQAR ELQAKAESSS DEAVADTSRR VGGALARKSA LKTRLSDAVK QLQAAERGDA 730 740 750 760 770 780 QQRLGQSRLI TEEANRTTME VQQATAPMAN NLTNWSQNLQ HFDSSAYNTA VNSARDAVRN 790 800 810 820 830 840 LTEVVPQLLD QLRTVEQKRP ASNVSASIQR IRELIAQTRS VASKIQVSMM FDGQSAVEVH 850 860 870 880 890 900 SRTSMDDLKA FTSLSLYMKP PVKRPELTET ADQFILYLGS KNAKKEYMGL AIKNDNLVYV 910 920 930 940 950 960 YNLGTKDVEI PLDSKPVSSW PAYFSIVKIE RVGKHGKVFL TVPSLSSTAE EKFIKKGEFS 970 980 990 1000 1010 1020 GDDSLLDLDP EDTVFYVGGV PSNFKLPTSL NLPGFVGCLE LATLNNDVIS LYNFKHIYNM 1030 1040 1050 1060 1070 1080 DPSTSVPCAR DKLAFTQSRA ASYFFDGSGY AVVRDITRRG KFGQVTRFDI EVRTPADNGL 1090 1100 1110 1120 1130 1140 ILLMVNGSMF FRLEMRNGYL HVFYDFGFSG GPVHLEDTLK KAQINDAKYH EISIIYHNDK 1150 1160 1170 1180 1190 1200 KMILVVDRRH VKSMDNEKMK IPFTDIYIGG APPEILQSRA LRAHLPLDIN FRGCMKGFQF 1210 1220 1230 1240 1250 1260 QKKDFNLLEQ TETLGVGYGC PEDSLISRRA YFNGQSFIAS IQKISFFDGF EGGFNFRTLQ 1270 1280 1290 1300 1310 1320 PNGLLFYYAS GSDVFSISLD NGTVIMDVKG IKVQSVDKQY NDGLSHFVIS SVSPTRYELI 1330 1340 1350 1360 1370 1380 VDKSRVGSKN PTKGKIEQTQ ASEKKFYFGG SPISAQYANF TGCISNAYFT RVDRDVEVED 1390 1400 1410 1420 1430 1440 FQRYTEKVHT SLYECPIESS PLFLLHKKGK NLSKPKASQN KKGGKSKDAP SWDPVALKLP 1450 1460 1470 1480 1490 1500 ERNTPRNSHC HLSNSPRAIE HAYQYGGTAN SRQEFEHLKG DFGAKSQFSI RLRTRSSHGM 1510 1520 1530 1540 1550 1560 IFYVSDQEEN DFMTLFLAHG RLVYMFNVGH KKLKIRSQEK YNDGLWHDVI FIRERSSGRL 1570 1580 1590 1600 1610 1620 VIDGLRVLEE SLPPTEATWK IKGPIYLGGV APGKAVKNVQ INSIYSFSGC LSNLQLNGAS 1630 1640 1650 1660 1670 1680 ITSASQTFSV TPCFEGPMET GTYFSTEGGY VVLDESFNIG LKFEIAFEVR PRSSSGTLVH 1690 1700 1710 1720 1730 1740 GHSVNGEYLN VHMKNGQVIV KVNNGIRDFS TSVTPKQSLC DGRWHRITVI RDSNVVQLDV 1750 1760 1770 1780 1790 1800 DSEVNHVVGP LNPKPIDHRE PVFVGGVPES LLTPRLAPSK PFTGCIRHFV IDGHPVSFSK 1810 AALVSGAVSI NSCPAA
	Isoform 3 [UniParc]. Checksum: 6ABF63CBA663BF3F	FASTA	120	12,819
	10 20 30 40 50 60 MALSSAWRSV LPLWLLWSAA CSRAASGDDN AFPFDIEGSS AVGRQDPPET SEPRVALGRL 70 80 90 100 110 120 PPAAEVQCPC HCHPAGAPAP PRAVPHSSFS LSPPLSSPQC LESFTWARSV RKLEIKSFPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure and expression of a novel human laminin alpha 4 chain." Iivanainen A., Sainio K., Sariola H., Tryggvason K. FEBS Lett. 365:183-188(1995) [PubMed: 7781776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS SER-1117 AND ARG-1119. Tissue: Fetal lung.
[2]	"The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains." Richards A.J., Al-Imara L., Pope F.M. Eur. J. Biochem. 238:813-821(1996) [PubMed: 8706685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS HIS-498; SER-1117; ARG-1119 AND SER-1549.
[3]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Pancreas.
[7]	"The structural organisation of LAMA4, the gene encoding laminin alpha4." Richards A.J., Luccarini C., Pope F.M. Eur. J. Biochem. 248:15-23(1997) [PubMed: 9310354] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24. Tissue: Heart.
[8]	"Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain." Richards A.J., Al-Imara L., Carter N.P., Lloyd J.C., Leversha M.A., Pope F.M. Genomics 22:237-239(1994) [PubMed: 7959779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 236-1823 (ISOFORM 2), VARIANTS HIS-498; SER-1117 AND ARG-1119. Tissue: Heart.
[9]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1593, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-557; ASN-578; ASN-581; ASN-742; ASN-787 AND ASN-810, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S78569 mRNA. Translation: AAB34635.1. X91171 mRNA. Translation: CAA62596.1. X70904 mRNA. Translation: CAA50261.1. AB210027 mRNA. Translation: BAE06109.1. Different initiation. BT006690 mRNA. Translation: AAP35336.1. Z99289, AL590106 Genomic DNA. Translation: CAI42325.1. AL590106 Genomic DNA. Translation: CAI12948.1. AL590106 Genomic DNA. Translation: CAI12949.1. AL590106, Z99289 Genomic DNA. Translation: CAI12950.1. BC004241 mRNA. Translation: AAH04241.1. Y14240 Genomic DNA. Translation: CAA74636.1. X76939 mRNA. Translation: CAA54258.1.
IPI	IPI00024406. IPI00329482. IPI00735310.
PIR	S68960.
RefSeq	NP_001098676.1. NM_001105206.1. NP_001098677.1. NM_001105207.1. NP_001098678.1. NM_001105208.1. NP_001098679.1. NM_001105209.1. NP_002281.2. NM_002290.3.
UniGene	Hs.654572.
3D structure databases
ProteinModelPortal	Q16363.
SMR	Q16363. Positions 33-285, 835-1020, 1235-1389, 1455-1822.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q16363. 15 interactions.
MINT	MINT-1200879.
STRING	Q16363.
PTM databases
PhosphoSite	Q16363.
Polymorphism databases
DMDM	292495093.
Proteomic databases
PRIDE	Q16363.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000230538; ENSP00000230538; ENSG00000112769.
GeneID	3910.
KEGG	hsa:3910.
UCSC	uc003pvt.2. human. uc003pvu.2. human.
Organism-specific databases
CTD	3910.
GeneCards	GC06M112475.
HGNC	HGNC:6484. LAMA4.
HPA	HPA015693.
MIM	600133. gene.
neXtProt	NX_Q16363.
PharmGKB	PA30273.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084051.
HOVERGEN	HBG052299.
InParanoid	Q16363.
OMA	NHVVGPL.
OrthoDB	EOG4QFWCB.
PhylomeDB	Q16363.
Enzyme and pathway databases
Pathway_Interaction_DB	a6b1_a6b4_integrin_pathway. a6b1 and a6b4 Integrin signaling. amb2_neutrophils_pathway. amb2 Integrin signaling. foxm1pathway. FOXM1 transcription factor network.
Gene expression databases
ArrayExpress	Q16363.
Bgee	Q16363.
CleanEx	HS_LAMA4.
Genevestigator	Q16363.
GermOnline	ENSG00000112769. Homo sapiens.
Family and domain databases
InterPro	IPR008985. ConA-like_lec_gl. IPR013320. ConA-like_subgrp. IPR002049. EGF_laminin. IPR001791. Laminin_G. IPR012680. Laminin_G_2. IPR009254. Laminin_I. IPR010307. Laminin_II. [Graphical view]
Gene3D	G3DSA:2.60.120.200. ConA_like_subgrp. 5 hits.
KO	K06241.
Pfam	PF00053. Laminin_EGF. 3 hits. PF02210. Laminin_G_2. 5 hits. PF06008. Laminin_I. 1 hit. PF06009. Laminin_II. 1 hit. [Graphical view]
SMART	SM00180. EGF_Lam. 3 hits. SM00282. LamG. 5 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 5 hits.
PROSITE	PS00022. EGF_1. 1 hit. PS01248. EGF_LAM_1. 3 hits. PS50027. EGF_LAM_2. 3 hits. PS50025. LAM_G_DOMAIN. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	15351.
SOURCE	Search...

Entry information

Entry name

LAMA4_HUMAN

Accession

Primary (citable) accession number: Q16363
Secondary accession number(s): Q14731 , Q14735, Q15335, Q4LE44, Q5SZG8, Q9BTB8, Q9UE18, Q9UJN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	March 23, 2010
Last modified:	January 25, 2012
This is version 123 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.