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Q16348

- S15A2_HUMAN

UniProt

Q16348 - S15A2_HUMAN

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Protein
Solute carrier family 15 member 2
Gene
SLC15A2, PEPT2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

GO - Molecular functioni

  1. antibiotic transporter activity Source: Ensembl
  2. dipeptide transporter activity Source: Ensembl
  3. high affinity oligopeptide transporter activity Source: Ensembl
  4. peptide:proton symporter activity Source: ProtInc
  5. protein binding Source: UniProtKB

GO - Biological processi

  1. drug transport Source: UniProtKB
  2. ion transport Source: Reactome
  3. protein transport Source: UniProtKB-KW
  4. proton transport Source: GOC
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

Protein family/group databases

TCDBi2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:SLC15A2
Synonyms:PEPT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10921. SLC15A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei115 – 13521Helical; Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Transmembranei296 – 31621Helical; Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Reviewed prediction
Add
BLAST
Transmembranei568 – 58821Helical; Reviewed prediction
Add
BLAST
Transmembranei612 – 63221Helical; Reviewed prediction
Add
BLAST
Transmembranei644 – 66421Helical; Reviewed prediction
Add
BLAST
Transmembranei675 – 69521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Solute carrier family 15 member 2
PRO_0000064308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi528 – 5281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi567 – 5671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ16348.
PRIDEiQ16348.

PTM databases

PhosphoSiteiQ16348.

Expressioni

Gene expression databases

ArrayExpressiQ16348.
BgeeiQ16348.
CleanExiHS_SLC15A2.
GenevestigatoriQ16348.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417085.

Structurei

3D structure databases

ProteinModelPortaliQ16348.
SMRiQ16348. Positions 45-400, 603-662.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ16348.
KOiK14637.
OMAiQCFGEDC.
OrthoDBiEOG7M3J0R.
PhylomeDBiQ16348.
TreeFamiTF330897.

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q16348-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV    50
VNEFCERFSY YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG 100
AAIADSWLGK FKTIIYLSLV YVLGHVIKSL GALPILGGQV VHTVLSLIGL 150
SLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSVFYLS INAGSLISTF 200
ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK IYNKPPPEGN 250
IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 300
RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL 350
LVLIFIPLFD FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK 400
INEMAPAQPG PQEVFLQVLN LADDEVKVTV VGNENNSLLI ESIKSFQKTP 450
HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS VQEKNWYSLV IREDGNSISS 500
MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG EDYGVSAYRT 550
VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 600
IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL 650
LTIAVGNIIV LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK 700
TEDMRGPADK HIPHIQGNMI KLETKKTKL 729
Length:729
Mass (Da):81,783
Last modified:October 14, 2008 - v2
Checksum:i0169DC150BD35BC3
GO
Isoform 2 (identifier: Q16348-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-143: Missing.

Note: No experimental confirmation available.

Show »
Length:698
Mass (Da):78,527
Checksum:i5FBE321D4F1911D7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571R → H.
Corresponds to variant rs1920305 [ dbSNP | Ensembl ].
VAR_047001
Natural varianti73 – 731Y → C.
Corresponds to variant rs1143667 [ dbSNP | Ensembl ].
VAR_047002
Natural varianti350 – 3501L → F.
Corresponds to variant rs2257212 [ dbSNP | Ensembl ].
VAR_047003
Natural varianti409 – 4091P → S.
Corresponds to variant rs1143671 [ dbSNP | Ensembl ].
VAR_047004
Natural varianti509 – 5091R → K.
Corresponds to variant rs1143672 [ dbSNP | Ensembl ].
VAR_047005
Natural varianti609 – 6091A → G.
Corresponds to variant rs1143668 [ dbSNP | Ensembl ].
VAR_047006
Natural varianti609 – 6091A → P.
Corresponds to variant rs1143673 [ dbSNP | Ensembl ].
VAR_047007
Natural varianti704 – 7041M → L.
Corresponds to variant rs1920314 [ dbSNP | Ensembl ].
VAR_047008

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 14331Missing in isoform 2.
VSP_043084Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2792QH → HD in AAB34388. 1 Publication
Sequence conflicti396 – 3961A → R in AAB34388. 1 Publication
Sequence conflicti609 – 6091A → R in AAB34388. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78203 mRNA. Translation: AAB34388.1.
AK289820 mRNA. Translation: BAF82509.1.
AK304189 mRNA. Translation: BAG65069.1.
AC072031 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79496.1.
CCDSiCCDS3007.1. [Q16348-1]
CCDS54631.1. [Q16348-2]
PIRiI52481.
RefSeqiNP_001139470.1. NM_001145998.1. [Q16348-2]
NP_066568.3. NM_021082.3. [Q16348-1]
UniGeneiHs.518089.

Genome annotation databases

EnsembliENST00000295605; ENSP00000295605; ENSG00000163406. [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406. [Q16348-1]
GeneIDi6565.
KEGGihsa:6565.
UCSCiuc003eep.2. human. [Q16348-1]
uc011bjn.1. human. [Q16348-2]

Polymorphism databases

DMDMi209572672.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78203 mRNA. Translation: AAB34388.1 .
AK289820 mRNA. Translation: BAF82509.1 .
AK304189 mRNA. Translation: BAG65069.1 .
AC072031 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79496.1 .
CCDSi CCDS3007.1. [Q16348-1 ]
CCDS54631.1. [Q16348-2 ]
PIRi I52481.
RefSeqi NP_001139470.1. NM_001145998.1. [Q16348-2 ]
NP_066568.3. NM_021082.3. [Q16348-1 ]
UniGenei Hs.518089.

3D structure databases

ProteinModelPortali Q16348.
SMRi Q16348. Positions 45-400, 603-662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000417085.

Chemistry

BindingDBi Q16348.
ChEMBLi CHEMBL1743125.
DrugBanki DB01140. Cefadroxil.
GuidetoPHARMACOLOGYi 985.

Protein family/group databases

TCDBi 2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitei Q16348.

Polymorphism databases

DMDMi 209572672.

Proteomic databases

PaxDbi Q16348.
PRIDEi Q16348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295605 ; ENSP00000295605 ; ENSG00000163406 . [Q16348-2 ]
ENST00000489711 ; ENSP00000417085 ; ENSG00000163406 . [Q16348-1 ]
GeneIDi 6565.
KEGGi hsa:6565.
UCSCi uc003eep.2. human. [Q16348-1 ]
uc011bjn.1. human. [Q16348-2 ]

Organism-specific databases

CTDi 6565.
GeneCardsi GC03P121612.
H-InvDB HIX0024323.
HGNCi HGNC:10921. SLC15A2.
MIMi 602339. gene.
neXtProti NX_Q16348.
PharmGKBi PA35812.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3104.
HOGENOMi HOG000285186.
HOVERGENi HBG052962.
InParanoidi Q16348.
KOi K14637.
OMAi QCFGEDC.
OrthoDBi EOG7M3J0R.
PhylomeDBi Q16348.
TreeFami TF330897.

Enzyme and pathway databases

Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

Miscellaneous databases

GeneWikii SLC15A2.
GenomeRNAii 6565.
NextBioi 25543.
PROi Q16348.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q16348.
Bgeei Q16348.
CleanExi HS_SLC15A2.
Genevestigatori Q16348.

Family and domain databases

InterProi IPR029028. Alpha/beta_knot_MTases.
IPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsi TIGR00926. 2A1704. 1 hit.
PROSITEi PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney."
    Liu W., Liang R., Ramamoorthy S., Fei Y.J., Ganapathy M.E., Hediger M.A., Ganapathy V., Leibach F.H.
    Biochim. Biophys. Acta 1235:461-466(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Trachea.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiS15A2_HUMAN
AccessioniPrimary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5, B4E2A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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