Q16348 (S15A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 15 member 2

Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2

Gene names

Name:	SLC15A2
Synonyms:	PEPT2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	729 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Ontologies

Keywords
Biological process	Peptide transport Protein transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	peptide:hydrogen symporter activity Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 729	729	Solute carrier family 15 member 2		PRO_0000064308
Regions
	Transmembrane	58 – 78	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	296 – 316	21	Helical; Potential
	Transmembrane	344 – 364	21	Helical; Potential
	Transmembrane	381 – 401	21	Helical; Potential
	Transmembrane	568 – 588	21	Helical; Potential
	Transmembrane	612 – 632	21	Helical; Potential
	Transmembrane	644 – 664	21	Helical; Potential
	Transmembrane	675 – 695	21	Helical; Potential
Amino acid modifications
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	269	1	N-linked (GlcNAc...) Potential
	Glycosylation	373	1	N-linked (GlcNAc...) Potential
	Glycosylation	435	1	N-linked (GlcNAc...) Potential
	Glycosylation	472	1	N-linked (GlcNAc...) Potential
	Glycosylation	528	1	N-linked (GlcNAc...) Potential
	Glycosylation	567	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	57	1	R → H. Corresponds to variant rs1920305 [ dbSNP | Ensembl ].		VAR_047001
	Natural variant	73	1	Y → C. Corresponds to variant rs1143667 [ dbSNP | Ensembl ].		VAR_047002
	Natural variant	350	1	L → F. Corresponds to variant rs2257212 [ dbSNP | Ensembl ].		VAR_047003
	Natural variant	409	1	P → S. Corresponds to variant rs1143671 [ dbSNP | Ensembl ].		VAR_047004
	Natural variant	509	1	R → K. Corresponds to variant rs1143672 [ dbSNP | Ensembl ].		VAR_047005
	Natural variant	609	1	A → G. Corresponds to variant rs1143668 [ dbSNP | Ensembl ].		VAR_047006
	Natural variant	609	1	A → P. Corresponds to variant rs1143673 [ dbSNP | Ensembl ].		VAR_047007
	Natural variant	704	1	M → L. Corresponds to variant rs1920314 [ dbSNP | Ensembl ].		VAR_047008
Experimental info
	Sequence conflict	278 – 279	2	QH → HD in AAB34388. Ref.1
	Sequence conflict	396	1	A → R in AAB34388. Ref.1
	Sequence conflict	609	1	A → R in AAB34388. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q16348 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 0169DC150BD35BC3	FASTA	729	81,783
	10 20 30 40 50 60 MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY 70 80 90 100 110 120 YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV 130 140 150 160 170 180 YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER 190 200 210 220 230 240 TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK 250 260 270 280 290 300 IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 310 320 330 340 350 360 RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL LVLIFIPLFD 370 380 390 400 410 420 FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQPG PQEVFLQVLN 430 440 450 460 470 480 LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS 490 500 510 520 530 540 VQEKNWYSLV IREDGNSISS MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG 550 560 570 580 590 600 EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 610 620 630 640 650 660 IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV 670 680 690 700 710 720 LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI KLETKKTKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney." Liu W., Liang R., Ramamoorthy S., Fei Y.J., Ganapathy M.E., Hediger M.A., Ganapathy V., Leibach F.H. Biochim. Biophys. Acta 1235:461-466(1995) [PubMed: 7756356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S78203 mRNA. Translation: AAB34388.1. AK289820 mRNA. Translation: BAF82509.1. CH471052 Genomic DNA. Translation: EAW79496.1.
IPI	IPI00328719.
PIR	I52481.
RefSeq	NP_066568.3. NM_021082.3.
UniGene	Hs.518089.
3D structure databases
ProteinModelPortal	Q16348.
ModBase	Search...
Protein-protein interaction databases
STRING	Q16348.
PTM databases
PhosphoSite	Q16348.
Polymorphism databases
DMDM	209572672.
Proteomic databases
PRIDE	Q16348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000489711; ENSP00000417085; ENSG00000163406.
GeneID	6565.
KEGG	hsa:6565.
Organism-specific databases
CTD	6565.
GeneCards	GC03P121612.
H-InvDB	HIX0024323.
HGNC	HGNC:10921. SLC15A2.
MIM	602339. gene.
neXtProt	NX_Q16348.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG447142.
HOVERGEN	HBG052962.
InParanoid	Q16348.
OMA	KCGINFS.
OrthoDB	EOG4Z8XW5.
PhylomeDB	Q16348.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
ArrayExpress	Q16348.
Bgee	Q16348.
CleanEx	HS_SLC15A2.
Genevestigator	Q16348.
GermOnline	ENSG00000163406. Homo sapiens.
Family and domain databases
InterPro	IPR016196. MFS_dom_general_subst_transpt. IPR000109. Oligopeptide_transporter. IPR004768. Pep_H_symport. IPR018456. PTR2_symporter_CS. [Graphical view]
KO	K14637.
Pfam	PF00854. PTR2. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00926. 2A1704. 1 hit.
PROSITE	PS01022. PTR2_1. 1 hit. PS01023. PTR2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB01140. Cefadroxil.
SOURCE	Search...

Entry information

Entry name

S15A2_HUMAN

Accession

Primary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.