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Q16348

- S15A2_HUMAN

UniProt

Q16348 - S15A2_HUMAN

Protein

Solute carrier family 15 member 2

Gene

SLC15A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

    GO - Molecular functioni

    1. antibiotic transporter activity Source: Ensembl
    2. dipeptide transporter activity Source: Ensembl
    3. high-affinity oligopeptide transporter activity Source: Ensembl
    4. peptide:proton symporter activity Source: ProtInc
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. drug transport Source: UniProtKB
    2. ion transport Source: Reactome
    3. protein transport Source: UniProtKB-KW
    4. proton transport Source: GOC
    5. transmembrane transport Source: Reactome
    6. transport Source: ProtInc

    Keywords - Biological processi

    Peptide transport, Protein transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

    Protein family/group databases

    TCDBi2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 2
    Alternative name(s):
    Kidney H(+)/peptide cotransporter
    Oligopeptide transporter, kidney isoform
    Peptide transporter 2
    Gene namesi
    Name:SLC15A2
    Synonyms:PEPT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:10921. SLC15A2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35812.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Solute carrier family 15 member 2PRO_0000064308Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ16348.
    PRIDEiQ16348.

    PTM databases

    PhosphoSiteiQ16348.

    Expressioni

    Gene expression databases

    ArrayExpressiQ16348.
    BgeeiQ16348.
    CleanExiHS_SLC15A2.
    GenevestigatoriQ16348.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000417085.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16348.
    SMRiQ16348. Positions 45-400, 603-662.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei568 – 58821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei612 – 63221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei675 – 69521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3104.
    HOGENOMiHOG000285186.
    HOVERGENiHBG052962.
    InParanoidiQ16348.
    KOiK14637.
    OMAiQCFGEDC.
    OrthoDBiEOG7M3J0R.
    PhylomeDBiQ16348.
    TreeFamiTF330897.

    Family and domain databases

    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004768. Oligopep_transport.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11654. PTHR11654. 1 hit.
    PfamiPF00854. PTR2. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    SSF75217. SSF75217. 1 hit.
    TIGRFAMsiTIGR00926. 2A1704. 1 hit.
    PROSITEiPS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q16348-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV    50
    VNEFCERFSY YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG 100
    AAIADSWLGK FKTIIYLSLV YVLGHVIKSL GALPILGGQV VHTVLSLIGL 150
    SLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSVFYLS INAGSLISTF 200
    ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK IYNKPPPEGN 250
    IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 300
    RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL 350
    LVLIFIPLFD FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK 400
    INEMAPAQPG PQEVFLQVLN LADDEVKVTV VGNENNSLLI ESIKSFQKTP 450
    HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS VQEKNWYSLV IREDGNSISS 500
    MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG EDYGVSAYRT 550
    VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 600
    IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL 650
    LTIAVGNIIV LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK 700
    TEDMRGPADK HIPHIQGNMI KLETKKTKL 729
    Length:729
    Mass (Da):81,783
    Last modified:October 14, 2008 - v2
    Checksum:i0169DC150BD35BC3
    GO
    Isoform 2 (identifier: Q16348-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         113-143: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:698
    Mass (Da):78,527
    Checksum:i5FBE321D4F1911D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti278 – 2792QH → HD in AAB34388. (PubMed:7756356)Curated
    Sequence conflicti396 – 3961A → R in AAB34388. (PubMed:7756356)Curated
    Sequence conflicti609 – 6091A → R in AAB34388. (PubMed:7756356)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571R → H.
    Corresponds to variant rs1920305 [ dbSNP | Ensembl ].
    VAR_047001
    Natural varianti73 – 731Y → C.
    Corresponds to variant rs1143667 [ dbSNP | Ensembl ].
    VAR_047002
    Natural varianti350 – 3501L → F.
    Corresponds to variant rs2257212 [ dbSNP | Ensembl ].
    VAR_047003
    Natural varianti409 – 4091P → S.
    Corresponds to variant rs1143671 [ dbSNP | Ensembl ].
    VAR_047004
    Natural varianti509 – 5091R → K.
    Corresponds to variant rs1143672 [ dbSNP | Ensembl ].
    VAR_047005
    Natural varianti609 – 6091A → G.
    Corresponds to variant rs1143668 [ dbSNP | Ensembl ].
    VAR_047006
    Natural varianti609 – 6091A → P.
    Corresponds to variant rs1143673 [ dbSNP | Ensembl ].
    VAR_047007
    Natural varianti704 – 7041M → L.
    Corresponds to variant rs1920314 [ dbSNP | Ensembl ].
    VAR_047008

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei113 – 14331Missing in isoform 2. 1 PublicationVSP_043084Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78203 mRNA. Translation: AAB34388.1.
    AK289820 mRNA. Translation: BAF82509.1.
    AK304189 mRNA. Translation: BAG65069.1.
    AC072031 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79496.1.
    CCDSiCCDS3007.1. [Q16348-1]
    CCDS54631.1. [Q16348-2]
    PIRiI52481.
    RefSeqiNP_001139470.1. NM_001145998.1. [Q16348-2]
    NP_066568.3. NM_021082.3. [Q16348-1]
    UniGeneiHs.518089.

    Genome annotation databases

    EnsembliENST00000295605; ENSP00000295605; ENSG00000163406. [Q16348-2]
    ENST00000489711; ENSP00000417085; ENSG00000163406. [Q16348-1]
    GeneIDi6565.
    KEGGihsa:6565.
    UCSCiuc003eep.2. human. [Q16348-1]
    uc011bjn.1. human. [Q16348-2]

    Polymorphism databases

    DMDMi209572672.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78203 mRNA. Translation: AAB34388.1 .
    AK289820 mRNA. Translation: BAF82509.1 .
    AK304189 mRNA. Translation: BAG65069.1 .
    AC072031 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79496.1 .
    CCDSi CCDS3007.1. [Q16348-1 ]
    CCDS54631.1. [Q16348-2 ]
    PIRi I52481.
    RefSeqi NP_001139470.1. NM_001145998.1. [Q16348-2 ]
    NP_066568.3. NM_021082.3. [Q16348-1 ]
    UniGenei Hs.518089.

    3D structure databases

    ProteinModelPortali Q16348.
    SMRi Q16348. Positions 45-400, 603-662.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000417085.

    Chemistry

    BindingDBi Q16348.
    ChEMBLi CHEMBL1743125.
    DrugBanki DB01140. Cefadroxil.
    GuidetoPHARMACOLOGYi 985.

    Protein family/group databases

    TCDBi 2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

    PTM databases

    PhosphoSitei Q16348.

    Polymorphism databases

    DMDMi 209572672.

    Proteomic databases

    PaxDbi Q16348.
    PRIDEi Q16348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295605 ; ENSP00000295605 ; ENSG00000163406 . [Q16348-2 ]
    ENST00000489711 ; ENSP00000417085 ; ENSG00000163406 . [Q16348-1 ]
    GeneIDi 6565.
    KEGGi hsa:6565.
    UCSCi uc003eep.2. human. [Q16348-1 ]
    uc011bjn.1. human. [Q16348-2 ]

    Organism-specific databases

    CTDi 6565.
    GeneCardsi GC03P121612.
    H-InvDB HIX0024323.
    HGNCi HGNC:10921. SLC15A2.
    MIMi 602339. gene.
    neXtProti NX_Q16348.
    PharmGKBi PA35812.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3104.
    HOGENOMi HOG000285186.
    HOVERGENi HBG052962.
    InParanoidi Q16348.
    KOi K14637.
    OMAi QCFGEDC.
    OrthoDBi EOG7M3J0R.
    PhylomeDBi Q16348.
    TreeFami TF330897.

    Enzyme and pathway databases

    Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

    Miscellaneous databases

    GeneWikii SLC15A2.
    GenomeRNAii 6565.
    NextBioi 25543.
    PROi Q16348.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16348.
    Bgeei Q16348.
    CleanExi HS_SLC15A2.
    Genevestigatori Q16348.

    Family and domain databases

    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004768. Oligopep_transport.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11654. PTHR11654. 1 hit.
    Pfami PF00854. PTR2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    SSF75217. SSF75217. 1 hit.
    TIGRFAMsi TIGR00926. 2A1704. 1 hit.
    PROSITEi PS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney."
      Liu W., Liang R., Ramamoorthy S., Fei Y.J., Ganapathy M.E., Hediger M.A., Ganapathy V., Leibach F.H.
      Biochim. Biophys. Acta 1235:461-466(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Trachea.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiS15A2_HUMAN
    AccessioniPrimary (citable) accession number: Q16348
    Secondary accession number(s): A8K1A5, B4E2A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3