Q16348 (S15A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 15 member 2

Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2

Gene names

Name:	SLC15A2
Synonyms:	PEPT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	729 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Ontologies

Keywords
Biological process	Peptide transport Protein transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	drug transport Non-traceable author statement PubMed 16738539. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	antibiotic transporter activity Inferred from electronic annotation. Source: Compara dipeptide transporter activity Inferred from electronic annotation. Source: Compara high affinity oligopeptide transporter activity Inferred from electronic annotation. Source: Compara peptide:hydrogen symporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q16348-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q16348-2)

The sequence of this isoform differs from the canonical sequence as follows:
     113-143: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 729	729	Solute carrier family 15 member 2		PRO_0000064308
Regions
	Transmembrane	58 – 78	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	296 – 316	21	Helical; Potential
	Transmembrane	344 – 364	21	Helical; Potential
	Transmembrane	381 – 401	21	Helical; Potential
	Transmembrane	568 – 588	21	Helical; Potential
	Transmembrane	612 – 632	21	Helical; Potential
	Transmembrane	644 – 664	21	Helical; Potential
	Transmembrane	675 – 695	21	Helical; Potential
Amino acid modifications
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	269	1	N-linked (GlcNAc...) Potential
	Glycosylation	373	1	N-linked (GlcNAc...) Potential
	Glycosylation	435	1	N-linked (GlcNAc...) Potential
	Glycosylation	472	1	N-linked (GlcNAc...) Potential
	Glycosylation	528	1	N-linked (GlcNAc...) Potential
	Glycosylation	567	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	113 – 143	31	Missing in isoform 2.		VSP_043084
	Natural variant	57	1	R → H. Corresponds to variant rs1920305 [ dbSNP | Ensembl ].		VAR_047001
	Natural variant	73	1	Y → C. Corresponds to variant rs1143667 [ dbSNP | Ensembl ].		VAR_047002
	Natural variant	350	1	L → F. Corresponds to variant rs2257212 [ dbSNP | Ensembl ].		VAR_047003
	Natural variant	409	1	P → S. Corresponds to variant rs1143671 [ dbSNP | Ensembl ].		VAR_047004
	Natural variant	509	1	R → K. Corresponds to variant rs1143672 [ dbSNP | Ensembl ].		VAR_047005
	Natural variant	609	1	A → G. Corresponds to variant rs1143668 [ dbSNP | Ensembl ].		VAR_047006
	Natural variant	609	1	A → P. Corresponds to variant rs1143673 [ dbSNP | Ensembl ].		VAR_047007
	Natural variant	704	1	M → L. Corresponds to variant rs1920314 [ dbSNP | Ensembl ].		VAR_047008
Experimental info
	Sequence conflict	278 – 279	2	QH → HD in AAB34388. Ref.1
	Sequence conflict	396	1	A → R in AAB34388. Ref.1
	Sequence conflict	609	1	A → R in AAB34388. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 0169DC150BD35BC3	FASTA	729	81,783
	10 20 30 40 50 60 MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY 70 80 90 100 110 120 YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV 130 140 150 160 170 180 YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER 190 200 210 220 230 240 TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK 250 260 270 280 290 300 IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 310 320 330 340 350 360 RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL LVLIFIPLFD 370 380 390 400 410 420 FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQPG PQEVFLQVLN 430 440 450 460 470 480 LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS 490 500 510 520 530 540 VQEKNWYSLV IREDGNSISS MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG 550 560 570 580 590 600 EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 610 620 630 640 650 660 IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV 670 680 690 700 710 720 LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI KLETKKTKL
	Isoform 2 [UniParc]. Checksum: 5FBE321D4F1911D7	FASTA	698	78,527
	10 20 30 40 50 60 MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY 70 80 90 100 110 120 YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKVLSLIGLS 130 140 150 160 170 180 LIALGTGGIK PCVAAFGGDQ FEEKHAEERT RYFSVFYLSI NAGSLISTFI TPMLRGDVQC 190 200 210 220 230 240 FGEDCYALAF GVPGLLMVIA LVVFAMGSKI YNKPPPEGNI VAQVFKCIWF AISNRFKNRS 250 260 270 280 290 300 GDIPKRQHWL DWAAEKYPKQ LIMDVKALTR VLFLYIPLPM FWALLDQQGS RWTLQAIRMN 310 320 330 340 350 360 RNLGFFVLQP DQMQVLNPLL VLIFIPLFDF VIYRLVSKCG INFSSLRKMA VGMILACLAF 370 380 390 400 410 420 AVAAAVEIKI NEMAPAQPGP QEVFLQVLNL ADDEVKVTVV GNENNSLLIE SIKSFQKTPH 430 440 450 460 470 480 YSKLHLKTKS QDFHFHLKYH NLSLYTEHSV QEKNWYSLVI REDGNSISSM MVKDTESRTT 490 500 510 520 530 540 NGMTTVRFVN TLHKDVNISL STDTSLNVGE DYGVSAYRTV QRGEYPAVHC RTEDKNFSLN 550 560 570 580 590 600 LGLLDFGAAY LFVITNNTNQ GLQAWKIEDI PANKMSIAWQ LPQYALVTAG EVMFSVTGLE 610 620 630 640 650 660 FSYSQAPSSM KSVLQAAWLL TIAVGNIIVL VVAQFSGLVQ WAEFILFSCL LLVICLIFSI 670 680 690 MGYYYVPVKT EDMRGPADKH IPHIQGNMIK LETKKTKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney." Liu W., Liang R., Ramamoorthy S., Fei Y.J., Ganapathy M.E., Hediger M.A., Ganapathy V., Leibach F.H. Biochim. Biophys. Acta 1235:461-466(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Trachea.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S78203 mRNA. Translation: AAB34388.1. AK289820 mRNA. Translation: BAF82509.1. AK304189 mRNA. Translation: BAG65069.1. AC072031 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79496.1.
IPI	IPI00328719. IPI00945645.
PIR	I52481.
RefSeq	NP_001139470.1. NM_001145998.1. NP_066568.3. NM_021082.3.
UniGene	Hs.518089.
3D structure databases
ProteinModelPortal	Q16348.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000417085.
PTM databases
PhosphoSite	Q16348.
Polymorphism databases
DMDM	209572672.
Proteomic databases
PaxDb	Q16348.
PRIDE	Q16348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295605; ENSP00000295605; ENSG00000163406. ENST00000489711; ENSP00000417085; ENSG00000163406.
GeneID	6565.
KEGG	hsa:6565.
UCSC	uc003eep.2. human.
Organism-specific databases
CTD	6565.
GeneCards	GC03P121612.
H-InvDB	HIX0024323.
HGNC	HGNC:10921. SLC15A2.
MIM	602339. gene.
neXtProt	NX_Q16348.
PharmGKB	PA35812.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG3104.
HOGENOM	HOG000285186.
HOVERGEN	HBG052962.
InParanoid	Q16348.
KO	K14637.
OMA	QCFGEDC.
OrthoDB	EOG4Z8XW5.
PhylomeDB	Q16348.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
ArrayExpress	Q16348.
Bgee	Q16348.
CleanEx	HS_SLC15A2.
Genevestigator	Q16348.
GermOnline	ENSG00000163406. Homo sapiens.
Family and domain databases
InterPro	IPR016196. MFS_dom_general_subst_transpt. IPR004768. Oligopep_transport. IPR000109. POT_fam. IPR018456. PTR2_symporter_CS. [Graphical view]
PANTHER	PTHR11654. PTHR11654. 1 hit.
Pfam	PF00854. PTR2. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00926. 2A1704. 1 hit.
PROSITE	PS01022. PTR2_1. 1 hit. PS01023. PTR2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q16348.
ChEMBL	CHEMBL1743125.
DrugBank	DB01140. Cefadroxil.
GenomeRNAi	6565.
NextBio	25543.
SOURCE	Search...

Entry information

Entry name

S15A2_HUMAN

Accession

Primary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5, B4E2A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.