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Q16348 (S15A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene names
Name:SLC15A2
Synonyms:PEPT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length729 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q16348-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q16348-2)

The sequence of this isoform differs from the canonical sequence as follows:
     113-143: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 729729Solute carrier family 15 member 2
PRO_0000064308

Regions

Transmembrane58 – 7821Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane296 – 31621Helical; Potential
Transmembrane344 – 36421Helical; Potential
Transmembrane381 – 40121Helical; Potential
Transmembrane568 – 58821Helical; Potential
Transmembrane612 – 63221Helical; Potential
Transmembrane644 – 66421Helical; Potential
Transmembrane675 – 69521Helical; Potential

Amino acid modifications

Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation3731N-linked (GlcNAc...) Potential
Glycosylation4351N-linked (GlcNAc...) Potential
Glycosylation4721N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Glycosylation5671N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence113 – 14331Missing in isoform 2.
VSP_043084
Natural variant571R → H.
Corresponds to variant rs1920305 [ dbSNP | Ensembl ].
VAR_047001
Natural variant731Y → C.
Corresponds to variant rs1143667 [ dbSNP | Ensembl ].
VAR_047002
Natural variant3501L → F.
Corresponds to variant rs2257212 [ dbSNP | Ensembl ].
VAR_047003
Natural variant4091P → S.
Corresponds to variant rs1143671 [ dbSNP | Ensembl ].
VAR_047004
Natural variant5091R → K.
Corresponds to variant rs1143672 [ dbSNP | Ensembl ].
VAR_047005
Natural variant6091A → G.
Corresponds to variant rs1143668 [ dbSNP | Ensembl ].
VAR_047006
Natural variant6091A → P.
Corresponds to variant rs1143673 [ dbSNP | Ensembl ].
VAR_047007
Natural variant7041M → L.
Corresponds to variant rs1920314 [ dbSNP | Ensembl ].
VAR_047008

Experimental info

Sequence conflict278 – 2792QH → HD in AAB34388. Ref.1
Sequence conflict3961A → R in AAB34388. Ref.1
Sequence conflict6091A → R in AAB34388. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 0169DC150BD35BC3

FASTA72981,783
        10         20         30         40         50         60 
MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY 

        70         80         90        100        110        120 
YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV 

       130        140        150        160        170        180 
YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER 

       190        200        210        220        230        240 
TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK 

       250        260        270        280        290        300 
IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT 

       310        320        330        340        350        360 
RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL LVLIFIPLFD 

       370        380        390        400        410        420 
FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQPG PQEVFLQVLN 

       430        440        450        460        470        480 
LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS 

       490        500        510        520        530        540 
VQEKNWYSLV IREDGNSISS MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG 

       550        560        570        580        590        600 
EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED 

       610        620        630        640        650        660 
IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV 

       670        680        690        700        710        720 
LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI 


KLETKKTKL 

« Hide

Isoform 2 [UniParc].

Checksum: 5FBE321D4F1911D7
Show »

FASTA69878,527

References

« Hide 'large scale' references
[1]"Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney."
Liu W., Liang R., Ramamoorthy S., Fei Y.J., Ganapathy M.E., Hediger M.A., Ganapathy V., Leibach F.H.
Biochim. Biophys. Acta 1235:461-466(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Kidney.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Trachea.
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S78203 mRNA. Translation: AAB34388.1.
AK289820 mRNA. Translation: BAF82509.1.
AK304189 mRNA. Translation: BAG65069.1.
AC072031 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79496.1.
CCDSCCDS3007.1. [Q16348-1]
CCDS54631.1. [Q16348-2]
PIRI52481.
RefSeqNP_001139470.1. NM_001145998.1. [Q16348-2]
NP_066568.3. NM_021082.3. [Q16348-1]
UniGeneHs.518089.

3D structure databases

ProteinModelPortalQ16348.
SMRQ16348. Positions 45-400, 603-662.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000417085.

Chemistry

BindingDBQ16348.
ChEMBLCHEMBL1743125.
DrugBankDB01140. Cefadroxil.
GuidetoPHARMACOLOGY985.

Protein family/group databases

TCDB2.A.17.4.8. the proton-dependent oligopeptide transporter (pot) family.

PTM databases

PhosphoSiteQ16348.

Polymorphism databases

DMDM209572672.

Proteomic databases

PaxDbQ16348.
PRIDEQ16348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295605; ENSP00000295605; ENSG00000163406. [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406. [Q16348-1]
GeneID6565.
KEGGhsa:6565.
UCSCuc003eep.2. human. [Q16348-1]
uc011bjn.1. human. [Q16348-2]

Organism-specific databases

CTD6565.
GeneCardsGC03P121612.
H-InvDBHIX0024323.
HGNCHGNC:10921. SLC15A2.
MIM602339. gene.
neXtProtNX_Q16348.
PharmGKBPA35812.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3104.
HOGENOMHOG000285186.
HOVERGENHBG052962.
InParanoidQ16348.
KOK14637.
OMAQCFGEDC.
OrthoDBEOG7M3J0R.
PhylomeDBQ16348.
TreeFamTF330897.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

ArrayExpressQ16348.
BgeeQ16348.
CleanExHS_SLC15A2.
GenevestigatorQ16348.

Family and domain databases

InterProIPR029028. Alpha/beta_knot_MTases.
IPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERPTHR11654. PTHR11654. 1 hit.
PfamPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsTIGR00926. 2A1704. 1 hit.
PROSITEPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC15A2.
GenomeRNAi6565.
NextBio25543.
PROQ16348.
SOURCESearch...

Entry information

Entry nameS15A2_HUMAN
AccessionPrimary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5, B4E2A7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM