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Protein

Solute carrier family 15 member 2

Gene

SLC15A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • drug transport Source: UniProtKB
  • ion transport Source: Reactome
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processPeptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-427975 Proton/oligopeptide cotransporters

Protein family/group databases

TCDBi2.A.17.4.8 the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:SLC15A2
Synonyms:PEPT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163406.10
HGNCiHGNC:10921 SLC15A2
MIMi602339 gene
neXtProtiNX_Q16348

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicCuratedAdd BLAST57
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 83ExtracellularCurated5
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 113CytoplasmicCurated9
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 139ExtracellularCurated5
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 183CytoplasmicCuratedAdd BLAST23
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 217ExtracellularCuratedAdd BLAST13
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 295CytoplasmicCuratedAdd BLAST57
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 343ExtracellularCuratedAdd BLAST27
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 380CytoplasmicCuratedAdd BLAST16
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 611ExtracellularCuratedAdd BLAST210
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
Topological domaini633 – 643CytoplasmicCuratedAdd BLAST11
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 674ExtracellularCurated10
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 729CytoplasmicCuratedAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6565
OpenTargetsiENSG00000163406
PharmGKBiPA35812

Chemistry databases

ChEMBLiCHEMBL1743125
DrugBankiDB00855 Aminolevulinic acid
DB01060 Amoxicillin
DB00415 Ampicillin
DB08795 Azidocillin
DB00542 Benazepril
DB01053 Benzylpenicillin
DB00833 Cefaclor
DB01140 Cefadroxil
DB00456 Cefalotin
DB00535 Cefdinir
DB01413 Cefepime
DB00671 Cefixime
DB00274 Cefmetazole
DB00493 Cefotaxime
DB01333 Cefradine
DB00438 Ceftazidime
DB01415 Ceftibuten
DB01212 Ceftriaxone
DB01112 Cefuroxime
DB00567 Cephalexin
DB00672 Chlorpropamide
DB01340 Cilazapril
DB01147 Cloxacillin
DB01000 Cyclacillin
DB00485 Dicloxacillin
DB00492 Fosinopril
DB01016 Glyburide
DB00447 Loracarbef
DB00691 Moexipril
DB00731 Nateglinide
DB00713 Oxacillin
DB00790 Perindopril
DB00881 Quinapril
DB00178 Ramipril
DB01348 Spirapril
DB01124 Tolbutamide
DB00519 Trandolapril
DB00302 Tranexamic Acid
DB03424 Ubenimex
DB00577 Valaciclovir
DB01610 Valganciclovir
GuidetoPHARMACOLOGYi985

Polymorphism and mutation databases

BioMutaiSLC15A2
DMDMi209572672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643081 – 729Solute carrier family 15 member 2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Glycosylationi435N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi472N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi567N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi587N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ16348
PaxDbiQ16348
PeptideAtlasiQ16348
PRIDEiQ16348
ProteomicsDBi60859
60860 [Q16348-2]

PTM databases

iPTMnetiQ16348
PhosphoSitePlusiQ16348

Expressioni

Tissue specificityi

Expressed in kidney. Not detected in intestine.1 Publication

Gene expression databases

BgeeiENSG00000163406
CleanExiHS_SLC15A2
ExpressionAtlasiQ16348 baseline and differential
GenevisibleiQ16348 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112453, 1 interactor
IntActiQ16348, 27 interactors
STRINGi9606.ENSP00000417085

Chemistry databases

BindingDBiQ16348

Structurei

3D structure databases

ProteinModelPortaliQ16348
SMRiQ16348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00530000062961
HOGENOMiHOG000285186
HOVERGENiHBG052962
InParanoidiQ16348
KOiK14637
OMAiQRGEYPA
OrthoDBiEOG091G0M1S
PhylomeDBiQ16348
TreeFamiTF330897

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004768 Oligopep_transport
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 2 hits
SUPFAMiSSF103473 SSF103473, 2 hits
SSF75217 SSF75217, 1 hit
TIGRFAMsiTIGR00926 2A1704, 1 hit
PROSITEiView protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16348-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVIKSL GALPILGGQV VHTVLSLIGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSVFYLS INAGSLISTF
210 220 230 240 250
ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK IYNKPPPEGN
260 270 280 290 300
IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL
360 370 380 390 400
LVLIFIPLFD FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK
410 420 430 440 450
INEMAPAQPG PQEVFLQVLN LADDEVKVTV VGNENNSLLI ESIKSFQKTP
460 470 480 490 500
HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS VQEKNWYSLV IREDGNSISS
510 520 530 540 550
MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG EDYGVSAYRT
560 570 580 590 600
VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED
610 620 630 640 650
IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTIAVGNIIV LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK
710 720
TEDMRGPADK HIPHIQGNMI KLETKKTKL
Length:729
Mass (Da):81,783
Last modified:October 14, 2008 - v2
Checksum:i0169DC150BD35BC3
GO
Isoform 2 (identifier: Q16348-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-143: Missing.

Note: No experimental confirmation available.
Show »
Length:698
Mass (Da):78,527
Checksum:i5FBE321D4F1911D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278 – 279QH → HD in AAB34388 (PubMed:7756356).Curated2
Sequence conflicti396A → R in AAB34388 (PubMed:7756356).Curated1
Sequence conflicti609A → R in AAB34388 (PubMed:7756356).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04700157R → H. Corresponds to variant dbSNP:rs1920305Ensembl.1
Natural variantiVAR_04700273Y → C. Corresponds to variant dbSNP:rs1143667Ensembl.1
Natural variantiVAR_047003350L → F. Corresponds to variant dbSNP:rs2257212Ensembl.1
Natural variantiVAR_047004409P → S. Corresponds to variant dbSNP:rs1143671Ensembl.1
Natural variantiVAR_047005509R → K. Corresponds to variant dbSNP:rs1143672Ensembl.1
Natural variantiVAR_047006609A → G. Corresponds to variant dbSNP:rs1143668Ensembl.1
Natural variantiVAR_047008704M → L. Corresponds to variant dbSNP:rs1920314Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043084113 – 143Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78203 mRNA Translation: AAB34388.1
AK289820 mRNA Translation: BAF82509.1
AK304189 mRNA Translation: BAG65069.1
AC072031 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79496.1
CCDSiCCDS3007.1 [Q16348-1]
CCDS54631.1 [Q16348-2]
PIRiI52481
RefSeqiNP_001139470.1, NM_001145998.1 [Q16348-2]
NP_066568.3, NM_021082.3 [Q16348-1]
UniGeneiHs.518089

Genome annotation databases

EnsembliENST00000295605; ENSP00000295605; ENSG00000163406 [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406 [Q16348-1]
GeneIDi6565
KEGGihsa:6565
UCSCiuc003eep.3 human [Q16348-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS15A2_HUMAN
AccessioniPrimary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5, B4E2A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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