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Q16348

- S15A2_HUMAN

UniProt

Q16348 - S15A2_HUMAN

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Protein

Solute carrier family 15 member 2

Gene

SLC15A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

GO - Molecular functioni

  1. antibiotic transporter activity Source: Ensembl
  2. dipeptide transporter activity Source: Ensembl
  3. high-affinity oligopeptide transporter activity Source: Ensembl
  4. peptide:proton symporter activity Source: ProtInc

GO - Biological processi

  1. drug transport Source: UniProtKB
  2. ion transport Source: Reactome
  3. protein transport Source: UniProtKB-KW
  4. proton transport Source: GOC
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

Protein family/group databases

TCDBi2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:SLC15A2
Synonyms:PEPT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10921. SLC15A2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Solute carrier family 15 member 2PRO_0000064308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ16348.
PRIDEiQ16348.

PTM databases

PhosphoSiteiQ16348.

Expressioni

Gene expression databases

BgeeiQ16348.
CleanExiHS_SLC15A2.
ExpressionAtlasiQ16348. baseline and differential.
GenevestigatoriQ16348.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417085.

Structurei

3D structure databases

ProteinModelPortaliQ16348.
SMRiQ16348. Positions 43-395, 603-662.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence AnalysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence AnalysisAdd
BLAST
Transmembranei644 – 66421HelicalSequence AnalysisAdd
BLAST
Transmembranei675 – 69521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ16348.
KOiK14637.
OMAiQCFGEDC.
OrthoDBiEOG7M3J0R.
PhylomeDBiQ16348.
TreeFamiTF330897.

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q16348-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVIKSL GALPILGGQV VHTVLSLIGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSVFYLS INAGSLISTF
210 220 230 240 250
ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK IYNKPPPEGN
260 270 280 290 300
IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL
360 370 380 390 400
LVLIFIPLFD FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK
410 420 430 440 450
INEMAPAQPG PQEVFLQVLN LADDEVKVTV VGNENNSLLI ESIKSFQKTP
460 470 480 490 500
HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS VQEKNWYSLV IREDGNSISS
510 520 530 540 550
MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG EDYGVSAYRT
560 570 580 590 600
VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED
610 620 630 640 650
IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTIAVGNIIV LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK
710 720
TEDMRGPADK HIPHIQGNMI KLETKKTKL
Length:729
Mass (Da):81,783
Last modified:October 14, 2008 - v2
Checksum:i0169DC150BD35BC3
GO
Isoform 2 (identifier: Q16348-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-143: Missing.

Note: No experimental confirmation available.

Show »
Length:698
Mass (Da):78,527
Checksum:i5FBE321D4F1911D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2792QH → HD in AAB34388. (PubMed:7756356)Curated
Sequence conflicti396 – 3961A → R in AAB34388. (PubMed:7756356)Curated
Sequence conflicti609 – 6091A → R in AAB34388. (PubMed:7756356)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571R → H.
Corresponds to variant rs1920305 [ dbSNP | Ensembl ].
VAR_047001
Natural varianti73 – 731Y → C.
Corresponds to variant rs1143667 [ dbSNP | Ensembl ].
VAR_047002
Natural varianti350 – 3501L → F.
Corresponds to variant rs2257212 [ dbSNP | Ensembl ].
VAR_047003
Natural varianti409 – 4091P → S.
Corresponds to variant rs1143671 [ dbSNP | Ensembl ].
VAR_047004
Natural varianti509 – 5091R → K.
Corresponds to variant rs1143672 [ dbSNP | Ensembl ].
VAR_047005
Natural varianti609 – 6091A → G.
Corresponds to variant rs1143668 [ dbSNP | Ensembl ].
VAR_047006
Natural varianti609 – 6091A → P.
Corresponds to variant rs1143673 [ dbSNP | Ensembl ].
VAR_047007
Natural varianti704 – 7041M → L.
Corresponds to variant rs1920314 [ dbSNP | Ensembl ].
VAR_047008

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 14331Missing in isoform 2. 1 PublicationVSP_043084Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78203 mRNA. Translation: AAB34388.1.
AK289820 mRNA. Translation: BAF82509.1.
AK304189 mRNA. Translation: BAG65069.1.
AC072031 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79496.1.
CCDSiCCDS3007.1. [Q16348-1]
CCDS54631.1. [Q16348-2]
PIRiI52481.
RefSeqiNP_001139470.1. NM_001145998.1. [Q16348-2]
NP_066568.3. NM_021082.3. [Q16348-1]
UniGeneiHs.518089.

Genome annotation databases

EnsembliENST00000295605; ENSP00000295605; ENSG00000163406. [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406. [Q16348-1]
GeneIDi6565.
KEGGihsa:6565.
UCSCiuc003eep.2. human. [Q16348-1]
uc011bjn.1. human. [Q16348-2]

Polymorphism databases

DMDMi209572672.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78203 mRNA. Translation: AAB34388.1 .
AK289820 mRNA. Translation: BAF82509.1 .
AK304189 mRNA. Translation: BAG65069.1 .
AC072031 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79496.1 .
CCDSi CCDS3007.1. [Q16348-1 ]
CCDS54631.1. [Q16348-2 ]
PIRi I52481.
RefSeqi NP_001139470.1. NM_001145998.1. [Q16348-2 ]
NP_066568.3. NM_021082.3. [Q16348-1 ]
UniGenei Hs.518089.

3D structure databases

ProteinModelPortali Q16348.
SMRi Q16348. Positions 43-395, 603-662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000417085.

Chemistry

BindingDBi Q16348.
ChEMBLi CHEMBL1743125.
DrugBanki DB00855. Aminolevulinic acid.
DB01060. Amoxicillin.
DB00415. Ampicillin.
DB08795. Azidocillin.
DB00542. Benazepril.
DB01053. Benzylpenicillin.
DB00833. Cefaclor.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00535. Cefdinir.
DB01413. Cefepime.
DB00671. Cefixime.
DB00274. Cefmetazole.
DB00493. Cefotaxime.
DB01333. Cefradine.
DB00438. Ceftazidime.
DB01415. Ceftibuten.
DB01212. Ceftriaxone.
DB01112. Cefuroxime.
DB00567. Cephalexin.
DB00672. Chlorpropamide.
DB01340. Cilazapril.
DB01147. Cloxacillin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00492. Fosinopril.
DB01016. Glyburide.
DB00691. Moexipril.
DB00731. Nateglinide.
DB00713. Oxacillin.
DB00790. Perindopril.
DB00881. Quinapril.
DB00178. Ramipril.
DB01348. Spirapril.
DB01124. Tolbutamide.
DB00519. Trandolapril.
DB00302. Tranexamic Acid.
DB00577. Valaciclovir.
DB01610. Valganciclovir.
GuidetoPHARMACOLOGYi 985.

Protein family/group databases

TCDBi 2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitei Q16348.

Polymorphism databases

DMDMi 209572672.

Proteomic databases

PaxDbi Q16348.
PRIDEi Q16348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295605 ; ENSP00000295605 ; ENSG00000163406 . [Q16348-2 ]
ENST00000489711 ; ENSP00000417085 ; ENSG00000163406 . [Q16348-1 ]
GeneIDi 6565.
KEGGi hsa:6565.
UCSCi uc003eep.2. human. [Q16348-1 ]
uc011bjn.1. human. [Q16348-2 ]

Organism-specific databases

CTDi 6565.
GeneCardsi GC03P121612.
H-InvDB HIX0024323.
HGNCi HGNC:10921. SLC15A2.
MIMi 602339. gene.
neXtProti NX_Q16348.
PharmGKBi PA35812.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3104.
GeneTreei ENSGT00530000062961.
HOGENOMi HOG000285186.
HOVERGENi HBG052962.
InParanoidi Q16348.
KOi K14637.
OMAi QCFGEDC.
OrthoDBi EOG7M3J0R.
PhylomeDBi Q16348.
TreeFami TF330897.

Enzyme and pathway databases

Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

Miscellaneous databases

GeneWikii SLC15A2.
GenomeRNAii 6565.
NextBioi 25543.
PROi Q16348.
SOURCEi Search...

Gene expression databases

Bgeei Q16348.
CleanExi HS_SLC15A2.
ExpressionAtlasi Q16348. baseline and differential.
Genevestigatori Q16348.

Family and domain databases

InterProi IPR029028. Alpha/beta_knot_MTases.
IPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsi TIGR00926. 2A1704. 1 hit.
PROSITEi PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney."
    Liu W., Liang R., Ramamoorthy S., Fei Y.J., Ganapathy M.E., Hediger M.A., Ganapathy V., Leibach F.H.
    Biochim. Biophys. Acta 1235:461-466(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Trachea.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiS15A2_HUMAN
AccessioniPrimary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5, B4E2A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3