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Protein

Solute carrier family 15 member 2

Gene

SLC15A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

GO - Molecular functioni

GO - Biological processi

  • drug transport Source: UniProtKB
  • ion transport Source: Reactome
  • protein transport Source: UniProtKB-KW
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163406-MONOMER.
ReactomeiR-HSA-427975. Proton/oligopeptide cotransporters.

Protein family/group databases

TCDBi2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:SLC15A2
Synonyms:PEPT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:10921. SLC15A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6565.
OpenTargetsiENSG00000163406.
PharmGKBiPA35812.

Chemistry databases

ChEMBLiCHEMBL1743125.
DrugBankiDB00855. Aminolevulinic acid.
DB01060. Amoxicillin.
DB00415. Ampicillin.
DB08795. Azidocillin.
DB00542. Benazepril.
DB01053. Benzylpenicillin.
DB00833. Cefaclor.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00535. Cefdinir.
DB01413. Cefepime.
DB00671. Cefixime.
DB00274. Cefmetazole.
DB00493. Cefotaxime.
DB01333. Cefradine.
DB00438. Ceftazidime.
DB01415. Ceftibuten.
DB01212. Ceftriaxone.
DB01112. Cefuroxime.
DB00567. Cephalexin.
DB00672. Chlorpropamide.
DB01340. Cilazapril.
DB01147. Cloxacillin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00492. Fosinopril.
DB01016. Glyburide.
DB00691. Moexipril.
DB00731. Nateglinide.
DB00713. Oxacillin.
DB00790. Perindopril.
DB00881. Quinapril.
DB00178. Ramipril.
DB01348. Spirapril.
DB01124. Tolbutamide.
DB00519. Trandolapril.
DB00302. Tranexamic Acid.
DB00577. Valaciclovir.
DB01610. Valganciclovir.

Polymorphism and mutation databases

BioMutaiSLC15A2.
DMDMi209572672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643081 – 729Solute carrier family 15 member 2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Modified residuei9PhosphoserineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi472N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ16348.
PaxDbiQ16348.
PeptideAtlasiQ16348.
PRIDEiQ16348.

PTM databases

iPTMnetiQ16348.
PhosphoSitePlusiQ16348.

Expressioni

Gene expression databases

BgeeiENSG00000163406.
CleanExiHS_SLC15A2.
ExpressionAtlasiQ16348. baseline and differential.
GenevisibleiQ16348. HS.

Interactioni

Protein-protein interaction databases

BioGridi112453. 1 interactor.
STRINGi9606.ENSP00000417085.

Chemistry databases

BindingDBiQ16348.

Structurei

3D structure databases

ProteinModelPortaliQ16348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ16348.
KOiK14637.
OMAiFHLKYHN.
OrthoDBiEOG091G0M1S.
PhylomeDBiQ16348.
TreeFamiTF330897.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16348-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVIKSL GALPILGGQV VHTVLSLIGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSVFYLS INAGSLISTF
210 220 230 240 250
ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK IYNKPPPEGN
260 270 280 290 300
IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL
360 370 380 390 400
LVLIFIPLFD FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK
410 420 430 440 450
INEMAPAQPG PQEVFLQVLN LADDEVKVTV VGNENNSLLI ESIKSFQKTP
460 470 480 490 500
HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS VQEKNWYSLV IREDGNSISS
510 520 530 540 550
MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG EDYGVSAYRT
560 570 580 590 600
VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED
610 620 630 640 650
IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTIAVGNIIV LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK
710 720
TEDMRGPADK HIPHIQGNMI KLETKKTKL
Length:729
Mass (Da):81,783
Last modified:October 14, 2008 - v2
Checksum:i0169DC150BD35BC3
GO
Isoform 2 (identifier: Q16348-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-143: Missing.

Note: No experimental confirmation available.
Show »
Length:698
Mass (Da):78,527
Checksum:i5FBE321D4F1911D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278 – 279QH → HD in AAB34388 (PubMed:7756356).Curated2
Sequence conflicti396A → R in AAB34388 (PubMed:7756356).Curated1
Sequence conflicti609A → R in AAB34388 (PubMed:7756356).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04700157R → H.Corresponds to variant rs1920305dbSNPEnsembl.1
Natural variantiVAR_04700273Y → C.Corresponds to variant rs1143667dbSNPEnsembl.1
Natural variantiVAR_047003350L → F.Corresponds to variant rs2257212dbSNPEnsembl.1
Natural variantiVAR_047004409P → S.Corresponds to variant rs1143671dbSNPEnsembl.1
Natural variantiVAR_047005509R → K.Corresponds to variant rs1143672dbSNPEnsembl.1
Natural variantiVAR_047006609A → G.Corresponds to variant rs1143668dbSNPEnsembl.1
Natural variantiVAR_047007609A → P.Corresponds to variant rs1143673dbSNPEnsembl.1
Natural variantiVAR_047008704M → L.Corresponds to variant rs1920314dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043084113 – 143Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78203 mRNA. Translation: AAB34388.1.
AK289820 mRNA. Translation: BAF82509.1.
AK304189 mRNA. Translation: BAG65069.1.
AC072031 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79496.1.
CCDSiCCDS3007.1. [Q16348-1]
CCDS54631.1. [Q16348-2]
PIRiI52481.
RefSeqiNP_001139470.1. NM_001145998.1. [Q16348-2]
NP_066568.3. NM_021082.3. [Q16348-1]
UniGeneiHs.518089.

Genome annotation databases

EnsembliENST00000295605; ENSP00000295605; ENSG00000163406. [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406. [Q16348-1]
GeneIDi6565.
KEGGihsa:6565.
UCSCiuc003eep.3. human. [Q16348-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78203 mRNA. Translation: AAB34388.1.
AK289820 mRNA. Translation: BAF82509.1.
AK304189 mRNA. Translation: BAG65069.1.
AC072031 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79496.1.
CCDSiCCDS3007.1. [Q16348-1]
CCDS54631.1. [Q16348-2]
PIRiI52481.
RefSeqiNP_001139470.1. NM_001145998.1. [Q16348-2]
NP_066568.3. NM_021082.3. [Q16348-1]
UniGeneiHs.518089.

3D structure databases

ProteinModelPortaliQ16348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112453. 1 interactor.
STRINGi9606.ENSP00000417085.

Chemistry databases

BindingDBiQ16348.
ChEMBLiCHEMBL1743125.
DrugBankiDB00855. Aminolevulinic acid.
DB01060. Amoxicillin.
DB00415. Ampicillin.
DB08795. Azidocillin.
DB00542. Benazepril.
DB01053. Benzylpenicillin.
DB00833. Cefaclor.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00535. Cefdinir.
DB01413. Cefepime.
DB00671. Cefixime.
DB00274. Cefmetazole.
DB00493. Cefotaxime.
DB01333. Cefradine.
DB00438. Ceftazidime.
DB01415. Ceftibuten.
DB01212. Ceftriaxone.
DB01112. Cefuroxime.
DB00567. Cephalexin.
DB00672. Chlorpropamide.
DB01340. Cilazapril.
DB01147. Cloxacillin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00492. Fosinopril.
DB01016. Glyburide.
DB00691. Moexipril.
DB00731. Nateglinide.
DB00713. Oxacillin.
DB00790. Perindopril.
DB00881. Quinapril.
DB00178. Ramipril.
DB01348. Spirapril.
DB01124. Tolbutamide.
DB00519. Trandolapril.
DB00302. Tranexamic Acid.
DB00577. Valaciclovir.
DB01610. Valganciclovir.

Protein family/group databases

TCDBi2.A.17.4.8. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

iPTMnetiQ16348.
PhosphoSitePlusiQ16348.

Polymorphism and mutation databases

BioMutaiSLC15A2.
DMDMi209572672.

Proteomic databases

EPDiQ16348.
PaxDbiQ16348.
PeptideAtlasiQ16348.
PRIDEiQ16348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295605; ENSP00000295605; ENSG00000163406. [Q16348-2]
ENST00000489711; ENSP00000417085; ENSG00000163406. [Q16348-1]
GeneIDi6565.
KEGGihsa:6565.
UCSCiuc003eep.3. human. [Q16348-1]

Organism-specific databases

CTDi6565.
DisGeNETi6565.
GeneCardsiSLC15A2.
H-InvDBHIX0024323.
HGNCiHGNC:10921. SLC15A2.
MIMi602339. gene.
neXtProtiNX_Q16348.
OpenTargetsiENSG00000163406.
PharmGKBiPA35812.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ16348.
KOiK14637.
OMAiFHLKYHN.
OrthoDBiEOG091G0M1S.
PhylomeDBiQ16348.
TreeFamiTF330897.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163406-MONOMER.
ReactomeiR-HSA-427975. Proton/oligopeptide cotransporters.

Miscellaneous databases

GeneWikiiSLC15A2.
GenomeRNAii6565.
PROiQ16348.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163406.
CleanExiHS_SLC15A2.
ExpressionAtlasiQ16348. baseline and differential.
GenevisibleiQ16348. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS15A2_HUMAN
AccessioniPrimary (citable) accession number: Q16348
Secondary accession number(s): A8K1A5, B4E2A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.