ID PDCD2_HUMAN Reviewed; 344 AA. AC Q16342; E9PCU7; F5GYS7; Q58HM9; Q58HN0; Q9UH12; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-2003, sequence version 2. DT 24-JAN-2024, entry version 192. DE RecName: Full=Programmed cell death protein 2; DE AltName: Full=Zinc finger MYND domain-containing protein 7; DE AltName: Full=Zinc finger protein Rp-8; GN Name=PDCD2; Synonyms=RP8, ZMYND7; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Fetal lung; RX PubMed=7606924; DOI=10.1159/000134058; RA Kawakami T., Furukawa Y., Sudo K., Saito H., Takami S., Takahashi E., RA Nakamura Y.; RT "Isolation and mapping of a human gene (PDCD2) that is highly homologous to RT Rp8, a rat gene associated with programmed cell death."; RL Cytogenet. Cell Genet. 71:41-43(1995). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). RA Chen Q., Qian K.X.; RT "Cloning of cDNAs with PDCD_2 domain and their expression during apoptosis RT of HEK293T cells."; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP UBIQUITINATION BY PRKN. RX PubMed=19146857; DOI=10.1016/j.febslet.2008.12.055; RA Fukae J., Sato S., Shiba K., Sato K., Mori H., Sharp P.A., Mizuno Y., RA Hattori N.; RT "Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased RT in the substantia nigra of patients with autosomal recessive Parkinson's RT disease."; RL FEBS Lett. 583:521-525(2009). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: May be a DNA-binding protein with a regulatory function. May CC play an important role in cell death and/or in regulation of cell CC proliferation. CC -!- INTERACTION: CC Q16342; P08574: CYC1; NbExp=3; IntAct=EBI-359462, EBI-1224514; CC Q16342; Q92993: KAT5; NbExp=3; IntAct=EBI-359462, EBI-399080; CC Q16342; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-359462, EBI-11742507; CC Q16342; O60260: PRKN; NbExp=5; IntAct=EBI-359462, EBI-716346; CC Q16342; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-359462, EBI-9090795; CC Q16342; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-359462, EBI-12018146; CC Q16342; P61981: YWHAG; NbExp=3; IntAct=EBI-359462, EBI-359832; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=Q16342-1; Sequence=Displayed; CC Name=2; CC IsoId=Q16342-2; Sequence=VSP_042828, VSP_042829; CC Name=3; CC IsoId=Q16342-3; Sequence=VSP_042828; CC Name=4; CC IsoId=Q16342-4; Sequence=VSP_055159, VSP_055162; CC Name=5; CC IsoId=Q16342-5; Sequence=VSP_042828, VSP_055160, VSP_055161; CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- PTM: Ubiquitinated by PRKN, promoting proteasomal degradation. CC {ECO:0000269|PubMed:19146857}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S78085; AAB34865.1; -; mRNA. DR EMBL; AY948416; AAX51225.1; -; mRNA. DR EMBL; AY948417; AAX51226.1; -; mRNA. DR EMBL; AK297343; BAG59795.1; -; mRNA. DR EMBL; AL031259; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC008378; AAH08378.1; -; mRNA. DR CCDS; CCDS47521.1; -. [Q16342-4] DR CCDS; CCDS5316.1; -. [Q16342-1] DR CCDS; CCDS56460.1; -. [Q16342-2] DR CCDS; CCDS56461.1; -. [Q16342-3] DR CCDS; CCDS56462.1; -. [Q16342-5] DR PIR; I52969; I52969. DR RefSeq; NP_001186391.1; NM_001199462.1. [Q16342-3] DR RefSeq; NP_001186392.1; NM_001199463.1. [Q16342-2] DR RefSeq; NP_001186393.1; NM_001199464.1. [Q16342-5] DR RefSeq; NP_002589.2; NM_002598.3. [Q16342-1] DR RefSeq; NP_659005.1; NM_144781.2. [Q16342-4] DR AlphaFoldDB; Q16342; -. DR BioGRID; 111161; 52. DR CORUM; Q16342; -. DR DIP; DIP-27594N; -. DR IntAct; Q16342; 17. DR MINT; Q16342; -. DR STRING; 9606.ENSP00000439467; -. DR iPTMnet; Q16342; -. DR PhosphoSitePlus; Q16342; -. DR BioMuta; PDCD2; -. DR DMDM; 28202261; -. DR EPD; Q16342; -. DR jPOST; Q16342; -. DR MassIVE; Q16342; -. DR MaxQB; Q16342; -. DR PaxDb; 9606-ENSP00000439467; -. DR PeptideAtlas; Q16342; -. DR ProteomicsDB; 19518; -. DR ProteomicsDB; 24829; -. DR ProteomicsDB; 60856; -. [Q16342-1] DR ProteomicsDB; 60857; -. [Q16342-2] DR ProteomicsDB; 60858; -. [Q16342-3] DR Pumba; Q16342; -. DR Antibodypedia; 20097; 143 antibodies from 26 providers. DR DNASU; 5134; -. DR Ensembl; ENST00000392090.6; ENSP00000375940.2; ENSG00000071994.11. [Q16342-3] DR Ensembl; ENST00000443345.2; ENSP00000397272.2; ENSG00000071994.11. [Q16342-2] DR Ensembl; ENST00000453163.6; ENSP00000402524.2; ENSG00000071994.11. [Q16342-4] DR Ensembl; ENST00000537445.5; ENSP00000440572.1; ENSG00000071994.11. [Q16342-5] DR Ensembl; ENST00000541970.6; ENSP00000439467.1; ENSG00000071994.11. [Q16342-1] DR GeneID; 5134; -. DR KEGG; hsa:5134; -. DR MANE-Select; ENST00000541970.6; ENSP00000439467.1; NM_002598.4; NP_002589.2. DR UCSC; uc003qxv.4; human. [Q16342-1] DR AGR; HGNC:8762; -. DR CTD; 5134; -. DR DisGeNET; 5134; -. DR GeneCards; PDCD2; -. DR HGNC; HGNC:8762; PDCD2. DR HPA; ENSG00000071994; Low tissue specificity. DR MIM; 600866; gene. DR neXtProt; NX_Q16342; -. DR OpenTargets; ENSG00000071994; -. DR PharmGKB; PA33112; -. DR VEuPathDB; HostDB:ENSG00000071994; -. DR eggNOG; KOG2061; Eukaryota. DR GeneTree; ENSGT00940000156603; -. DR HOGENOM; CLU_034893_2_0_1; -. DR InParanoid; Q16342; -. DR OMA; HQVIRYS; -. DR OrthoDB; 5397827at2759; -. DR PhylomeDB; Q16342; -. DR TreeFam; TF313722; -. DR PathwayCommons; Q16342; -. DR SignaLink; Q16342; -. DR BioGRID-ORCS; 5134; 533 hits in 1135 CRISPR screens. DR ChiTaRS; PDCD2; human. DR GeneWiki; PDCD2; -. DR GenomeRNAi; 5134; -. DR Pharos; Q16342; Tbio. DR PRO; PR:Q16342; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q16342; Protein. DR Bgee; ENSG00000071994; Expressed in primordial germ cell in gonad and 195 other cell types or tissues. DR ExpressionAtlas; Q16342; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB. DR GO; GO:0006915; P:apoptotic process; TAS:ProtInc. DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB. DR GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IMP:UniProtKB. DR GO; GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; IMP:UniProtKB. DR Gene3D; 6.10.140.2220; -; 1. DR InterPro; IPR007320; PDCD2_C. DR InterPro; IPR002893; Znf_MYND. DR PANTHER; PTHR12298; PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED; 1. DR PANTHER; PTHR12298:SF4; PROGRAMMED CELL DEATH PROTEIN 2; 1. DR Pfam; PF04194; PDCD2_C; 1. DR Pfam; PF01753; zf-MYND; 1. DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1. DR PROSITE; PS01360; ZF_MYND_1; 1. DR PROSITE; PS50865; ZF_MYND_2; 1. DR Genevisible; Q16342; HS. PE 1: Evidence at protein level; KW Alternative splicing; Apoptosis; DNA-binding; Metal-binding; Nucleus; KW Reference proteome; Ubl conjugation; Zinc; Zinc-finger. FT CHAIN 1..344 FT /note="Programmed cell death protein 2" FT /id="PRO_0000218304" FT ZN_FING 135..172 FT /note="MYND-type; atypical" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 135 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 138 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 146 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 149 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 155 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 159 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 168 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT BINDING 172 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134" FT VAR_SEQ 31..63 FT /note="Missing (in isoform 2, isoform 3 and isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2" FT /id="VSP_042828" FT VAR_SEQ 221..344 FT /note="EALEEELDSMAKHESREDKIFQKFKTQIALEPEQILRYGRGIAPIWISGENI FT PQEKDIPDCPCGAKRILEFQVMPQLLNYLKADRLGKSIDWGILAVFTCAESCSLGTGYT FT EEFVWKQDVTDTP -> KQFQDFIH (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2" FT /id="VSP_042829" FT VAR_SEQ 221..228 FT /note="EALEEELD -> KQFQDFIH (in isoform 4)" FT /evidence="ECO:0000305" FT /id="VSP_055159" FT VAR_SEQ 221 FT /note="E -> I (in isoform 5)" FT /evidence="ECO:0000305" FT /id="VSP_055160" FT VAR_SEQ 222..344 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000305" FT /id="VSP_055161" FT VAR_SEQ 229..344 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000305" FT /id="VSP_055162" FT CONFLICT 226 FT /note="E -> G (in Ref. 1; AAB34865)" FT /evidence="ECO:0000305" FT CONFLICT 317 FT /note="V -> A (in Ref. 1; AAB34865)" FT /evidence="ECO:0000305" SQ SEQUENCE 344 AA; 38592 MW; F3E7BA2C9FBAFD0E CRC64; MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA CELCGRPLSF LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL PRKNDFYSYE PPSENPPPET GESVCLQLKS GAHLCRVCGC LGPKTCSRCH KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH IIPDHNFLFP EFEIVIETED EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI FQKFKTQIAL EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP //