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Protein

Programmed cell death protein 2

Gene

PDCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 172MYND-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • enzyme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic process Source: ProtInc
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of hematopoietic stem cell proliferation Source: UniProtKB
  • regulation of hematopoietic progenitor cell differentiation Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2
Alternative name(s):
Zinc finger MYND domain-containing protein 7
Zinc finger protein Rp-8
Gene namesi
Name:PDCD2
Synonyms:RP8, ZMYND7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000071994.10.
HGNCiHGNC:8762. PDCD2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5134.
OpenTargetsiENSG00000071994.
PharmGKBiPA33112.

Polymorphism and mutation databases

BioMutaiPDCD2.
DMDMi28202261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183041 – 344Programmed cell death protein 2Add BLAST344

Post-translational modificationi

Ubiquitinated by PRKN, promoting proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ16342.
MaxQBiQ16342.
PaxDbiQ16342.
PeptideAtlasiQ16342.
PRIDEiQ16342.

PTM databases

iPTMnetiQ16342.
PhosphoSitePlusiQ16342.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000071994.
CleanExiHS_PDCD2.
ExpressionAtlasiQ16342. baseline and differential.
GenevisibleiQ16342. HS.

Organism-specific databases

HPAiHPA026713.
HPA075534.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKNO602605EBI-359462,EBI-716346

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111161. 12 interactors.
CORUMiQ16342.
DIPiDIP-27594N.
IntActiQ16342. 8 interactors.
MINTiMINT-1133310.
STRINGi9606.ENSP00000439467.

Structurei

3D structure databases

ProteinModelPortaliQ16342.
SMRiQ16342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 172MYND-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
GeneTreeiENSGT00530000063570.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiQ16342.
KOiK14801.
OMAiRYFPSKL.
OrthoDBiEOG091G0F9T.
PhylomeDBiQ16342.
TreeFamiTF313722.

Family and domain databases

Gene3Di2.30.320.10. 1 hit.
InterProiView protein in InterPro
IPR007320. PDCD2_C.
IPR035948. YwqG-like_sf.
IPR002893. Znf_MYND.
PfamiView protein in Pfam
PF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
PROSITEiView protein in PROSITE
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16342-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA
60 70 80 90 100
CELCGRPLSF LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL
110 120 130 140 150
PRKNDFYSYE PPSENPPPET GESVCLQLKS GAHLCRVCGC LGPKTCSRCH
160 170 180 190 200
KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH IIPDHNFLFP EFEIVIETED
210 220 230 240 250
EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI FQKFKTQIAL
260 270 280 290 300
EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY
310 320 330 340
LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP
Length:344
Mass (Da):38,592
Last modified:February 1, 2003 - v2
Checksum:iF3E7BA2C9FBAFD0E
GO
Isoform 2 (identifier: Q16342-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-63: Missing.
     221-344: EALEEELDSM...VWKQDVTDTP → KQFQDFIH

Show »
Length:195
Mass (Da):22,230
Checksum:i2A29B0D0A276CB6D
GO
Isoform 3 (identifier: Q16342-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-63: Missing.

Show »
Length:311
Mass (Da):35,290
Checksum:i2690DDD960B82B1C
GO
Isoform 4 (identifier: Q16342-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-228: EALEEELD → KQFQDFIH
     229-344: Missing.

Note: No experimental confirmation available. Gene prediction based on partial EST data.
Show »
Length:228
Mass (Da):25,532
Checksum:i7BE1A0F6BE9306FD
GO
Isoform 5 (identifier: Q16342-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-63: Missing.
     221-221: E → I
     222-344: Missing.

Note: No experimental confirmation available. Gene prediction based on partial EST data.
Show »
Length:188
Mass (Da):21,299
Checksum:iDE1D2BC8F2529930
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226E → G in AAB34865 (PubMed:7606924).Curated1
Sequence conflicti317V → A in AAB34865 (PubMed:7606924).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04282831 – 63Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_042829221 – 344EALEE…VTDTP → KQFQDFIH in isoform 2. 2 PublicationsAdd BLAST124
Alternative sequenceiVSP_055159221 – 228EALEEELD → KQFQDFIH in isoform 4. Curated8
Alternative sequenceiVSP_055160221E → I in isoform 5. Curated1
Alternative sequenceiVSP_055161222 – 344Missing in isoform 5. CuratedAdd BLAST123
Alternative sequenceiVSP_055162229 – 344Missing in isoform 4. CuratedAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78085 mRNA. Translation: AAB34865.1.
AY948416 mRNA. Translation: AAX51225.1.
AY948417 mRNA. Translation: AAX51226.1.
AK297343 mRNA. Translation: BAG59795.1.
AL031259 Genomic DNA. No translation available.
BC008378 mRNA. Translation: AAH08378.1.
CCDSiCCDS47521.1. [Q16342-4]
CCDS5316.1. [Q16342-1]
CCDS56460.1. [Q16342-2]
CCDS56461.1. [Q16342-3]
CCDS56462.1. [Q16342-5]
PIRiI52969.
RefSeqiNP_001186391.1. NM_001199462.1. [Q16342-3]
NP_001186392.1. NM_001199463.1. [Q16342-2]
NP_001186393.1. NM_001199464.1. [Q16342-5]
NP_002589.2. NM_002598.3. [Q16342-1]
NP_659005.1. NM_144781.2. [Q16342-4]
UniGeneiHs.367900.

Genome annotation databases

EnsembliENST00000392090; ENSP00000375940; ENSG00000071994. [Q16342-3]
ENST00000443345; ENSP00000397272; ENSG00000071994. [Q16342-2]
ENST00000453163; ENSP00000402524; ENSG00000071994. [Q16342-4]
ENST00000537445; ENSP00000440572; ENSG00000071994. [Q16342-5]
ENST00000541970; ENSP00000439467; ENSG00000071994. [Q16342-1]
GeneIDi5134.
KEGGihsa:5134.
UCSCiuc003qxv.4. human. [Q16342-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDCD2_HUMAN
AccessioniPrimary (citable) accession number: Q16342
Secondary accession number(s): E9PCU7
, F5GYS7, Q58HM9, Q58HN0, Q9UH12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 2003
Last modified: October 25, 2017
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot