Reviewed, UniProtKB/Swiss-Prot Q16342 (PDCD2_HUMAN)

Names and origin

Protein names

Recommended name:
    Programmed cell death protein 2
Alternative name(s):
    Zinc finger protein Rp-8
    Zinc finger MYND domain-containing protein 7

Gene names

Name:	PDCD2
Synonyms:	RP8, ZMYND7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
Subcellular location	Nucleus Potential.
Tissue specificity	Ubiquitous.
Sequence similarities	Contains 1 MYND-type zinc finger.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM8	O95777	1	EBI-359462,EBI-347779

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Programmed cell death protein 2		PRO_0000218304
Regions
	Zinc finger	135 – 172	38	MYND-type
Experimental info
	Sequence conflict	226	1	E → G in AAB34865. Ref.1
	Sequence conflict	317	1	V → A in AAB34865. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q16342-1 [UniParc]. Last modified February 1, 2003. Version 2. Checksum: F3E7BA2C9FBAFD0E	FASTA	344	38,592
	10 20 30 40 50 60 MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA CELCGRPLSF 70 80 90 100 110 120 LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL PRKNDFYSYE PPSENPPPET 130 140 150 160 170 180 GESVCLQLKS GAHLCRVCGC LGPKTCSRCH KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH 190 200 210 220 230 240 IIPDHNFLFP EFEIVIETED EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI 250 260 270 280 290 300 FQKFKTQIAL EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY 310 320 330 340 LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death." Kawakami T., Furukawa Y., Sudo K., Saito H., Takami S., Takahashi E., Nakamura Y. Cytogenet. Cell Genet. 71:41-43(1995) [PubMed: 7606924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal lung.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S78085 mRNA. Translation: AAB34865.1. AL031259 Genomic DNA. Translation: CAA20285.1. BC008378 mRNA. Translation: AAH08378.1.
IPI	IPI00001427.
PIR	I52969.
RefSeq	NP_002589.2. NP_659005.1.
UniGene	Hs.367900
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:27594N.
IntAct	Q16342. 2 interactions.
PTM databases
PhosphoSite	Q16342.
Proteomic databases
PRIDE	Q16342.
Genome annotation databases
Ensembl	ENSG00000071994. Homo sapiens. [Contig view]
GeneID	5134.
KEGG	hsa:5134.
UCSC	uc003qxw.1. human.
Organism-specific databases
GeneCards	GC06M170804.
HGNC	HGNC:8762. PDCD2.
MIM	600866. gene.
PharmGKB	PA33112.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q16342.
HOVERGEN	Q16342.
OMA	Q16342. DSMAKHE.
Gene expression databases
ArrayExpress	Q16342.
Bgee	Q16342.
CleanEx	HS_PDCD2.
GermOnline	ENSG00000071994. Homo sapiens.
Family and domain databases
InterPro	IPR007320. PDCD2_C. IPR002893. Znf_MYND. [Graphical view]
Pfam	PF04194. PDCD2_C. 1 hit. PF01753. zf-MYND. 1 hit. [Graphical view]
PROSITE	PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	19796.
SOURCE	Search...

Entry information

Entry name

PDCD2_HUMAN

Accession

Primary (citable) accession number: Q16342
Secondary accession number(s): Q9UH12

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	February 1, 2003
Last modified:	July 7, 2009
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)