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Q16322 (KCA10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily A member 10
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.8
Gene names
Name:KCNA10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Ref.5

Subunit structure

Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP. Ref.6

Subcellular location

Membrane; Multi-pass membrane protein Ref.5.

Tissue specificity

Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells. Ref.7

Domain

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Potassium voltage-gated channel subfamily A member 10
PRO_0000308275

Regions

Transmembrane218 – 23821Helical; Name=Segment S1; Potential
Transmembrane271 – 29222Helical; Name=Segment S2; Potential
Transmembrane303 – 32321Helical; Name=Segment S3; Potential
Transmembrane339 – 35820Helical; Voltage-sensor; Name=Segment S4; Potential
Transmembrane375 – 39521Helical; Name=Segment S5; Potential
Transmembrane436 – 45621Helical; Name=Segment S6; Potential
Motif421 – 4266Selectivity filter By similarity

Amino acid modifications

Lipidation2931S-palmitoyl cysteine Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Potential
Glycosylation4981N-linked (GlcNAc...) Potential

Natural variations

Natural variant2001R → H in a colorectal cancer sample; somatic mutation. Ref.8
VAR_036778
Natural variant2201V → M.
Corresponds to variant rs34970857 [ dbSNP | Ensembl ].
VAR_036779
Natural variant2581S → N.
Corresponds to variant rs3748729 [ dbSNP | Ensembl ].
VAR_036780

Sequences

Sequence LengthMass (Da)Tools
Q16322 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: 1B09B1CD68745F29

FASTA51157,785
        10         20         30         40         50         60 
MDVCGWKEME VALVNFDNSD EIQEEPGYAT DFDSTSPKGR PGGSSFSNGK ILISESTNHE 

        70         80         90        100        110        120 
TAFSKLPGDY ADPPGPEPVV LNEGNQRVII NIAGLRFETQ LRTLSQFPET LLGDREKRMQ 

       130        140        150        160        170        180 
FFDSMRNEYF FDRNRPSFDG ILYYYQSGGK IRRPANVPID IFADEISFYE LGSEAMDQFR 

       190        200        210        220        230        240 
EDEGFIKDPE TLLPTNDIHR QFWLLFEYPE SSSAARAVAV VSVLVVVISI TIFCLETLPE 

       250        260        270        280        290        300 
FREDRELKVV RDPNLNMSKT VLSQTMFTDP FFMVESTCIV WFTFELVLRF VVCPSKTDFF 

       310        320        330        340        350        360 
RNIMNIIDII SIIPYFATLI TELVQETEPS AQQNMSLAIL RIIRLVRVFR IFKLSRHSKG 

       370        380        390        400        410        420 
LQILGQTLKA SMRELGLLIF FLFIGVILFS SAVYFAEVDE PESHFSSIPD GFWWAVVTMT 

       430        440        450        460        470        480 
TVGYGDMCPT TPGGKIVGTL CAIAGVLTIA LPVPVIVSNF NYFYHRETEN EEKQNIPGEI 

       490        500        510 
ERILNSVGSR MGSTDSLNKT NGGCSTEKSR K 

« Hide

References

« Hide 'large scale' references
[1]"Genomic localization of the human gene for KCNA10, a cGMP-activated K channel."
Orias M., Bray-Ward P., Curran M.E., Keating M.T., Desir G.V.
Genomics 42:33-37(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels."
Lang R., Lee G., Liu W., Tian S., Rafi H., Orias M., Segal A.S., Desir G.V.
Am. J. Physiol. 278:F1013-F1021(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit."
Tian S., Liu W., Wu Y., Rafi H., Segal A.S., Desir G.V.
Am. J. Physiol. 283:F142-F149(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH POMP, REGULATION BY CAMP.
[7]"Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule."
Yao X., Tian S., Chan H.-Y., Biemesderfer D., Desir G.V.
J. Am. Soc. Nephrol. 13:2831-2839(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-200.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U96110 Genomic DNA. Translation: AAC51333.1.
AL358215 Genomic DNA. Translation: CAH74103.1.
CH471122 Genomic DNA. Translation: EAW56454.1.
BC074990 mRNA. Translation: AAH74990.1.
CCDSCCDS826.1.
RefSeqNP_005540.1. NM_005549.2.
UniGeneHs.248140.
Hs.622910.

3D structure databases

ProteinModelPortalQ16322.
SMRQ16322. Positions 86-468.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109946. 1 interaction.
STRING9606.ENSP00000358786.

Chemistry

ChEMBLCHEMBL2362996.
GuidetoPHARMACOLOGY545.

Polymorphism databases

DMDM74739879.

Proteomic databases

PaxDbQ16322.
PRIDEQ16322.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369771; ENSP00000358786; ENSG00000143105.
GeneID3744.
KEGGhsa:3744.
UCSCuc001dzt.1. human.

Organism-specific databases

CTD3744.
GeneCardsGC01M111059.
H-InvDBHIX0200074.
HGNCHGNC:6219. KCNA10.
HPACAB022564.
HPA015061.
MIM602420. gene.
neXtProtNX_Q16322.
PharmGKBPA30020.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231015.
HOVERGENHBG052230.
InParanoidQ16322.
KOK04881.
OMAKQNIPGE.
OrthoDBEOG7M0NRD.
PhylomeDBQ16322.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ16322.
CleanExHS_KCNA10.
GenevestigatorQ16322.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNA10.
GenomeRNAi3744.
NextBio14651.
PROQ16322.
SOURCESearch...

Entry information

Entry nameKCA10_HUMAN
AccessionPrimary (citable) accession number: Q16322
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM