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Q16322

- KCA10_HUMAN

UniProt

Q16322 - KCA10_HUMAN

Protein

Potassium voltage-gated channel subfamily A member 10

Gene

KCNA10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.1 Publication

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. intracellular cyclic nucleotide activated cation channel activity Source: ProtInc

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. protein homooligomerization Source: InterPro
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily A member 10
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv1.8
    Gene namesi
    Name:KCNA10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6219. KCNA10.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30020.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Potassium voltage-gated channel subfamily A member 10PRO_0000308275Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Lipidationi293 – 2931S-palmitoyl cysteineSequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ16322.
    PRIDEiQ16322.

    Expressioni

    Tissue specificityi

    Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.1 Publication

    Gene expression databases

    ArrayExpressiQ16322.
    CleanExiHS_KCNA10.
    GenevestigatoriQ16322.

    Organism-specific databases

    HPAiCAB022564.
    HPA015061.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.1 Publication

    Protein-protein interaction databases

    BioGridi109946. 1 interaction.
    STRINGi9606.ENSP00000358786.

    Structurei

    3D structure databases

    ProteinModelPortaliQ16322.
    SMRiQ16322. Positions 86-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei218 – 23821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29222Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei339 – 35820Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi421 – 4266Selectivity filterBy similarity

    Domaini

    The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231015.
    HOVERGENiHBG052230.
    InParanoidiQ16322.
    KOiK04881.
    OMAiKQNIPGE.
    OrthoDBiEOG7M0NRD.
    PhylomeDBiQ16322.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q16322-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVCGWKEME VALVNFDNSD EIQEEPGYAT DFDSTSPKGR PGGSSFSNGK    50
    ILISESTNHE TAFSKLPGDY ADPPGPEPVV LNEGNQRVII NIAGLRFETQ 100
    LRTLSQFPET LLGDREKRMQ FFDSMRNEYF FDRNRPSFDG ILYYYQSGGK 150
    IRRPANVPID IFADEISFYE LGSEAMDQFR EDEGFIKDPE TLLPTNDIHR 200
    QFWLLFEYPE SSSAARAVAV VSVLVVVISI TIFCLETLPE FREDRELKVV 250
    RDPNLNMSKT VLSQTMFTDP FFMVESTCIV WFTFELVLRF VVCPSKTDFF 300
    RNIMNIIDII SIIPYFATLI TELVQETEPS AQQNMSLAIL RIIRLVRVFR 350
    IFKLSRHSKG LQILGQTLKA SMRELGLLIF FLFIGVILFS SAVYFAEVDE 400
    PESHFSSIPD GFWWAVVTMT TVGYGDMCPT TPGGKIVGTL CAIAGVLTIA 450
    LPVPVIVSNF NYFYHRETEN EEKQNIPGEI ERILNSVGSR MGSTDSLNKT 500
    NGGCSTEKSR K 511
    Length:511
    Mass (Da):57,785
    Last modified:November 1, 1998 - v2
    Checksum:i1B09B1CD68745F29
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti200 – 2001R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036778
    Natural varianti220 – 2201V → M.
    Corresponds to variant rs34970857 [ dbSNP | Ensembl ].
    VAR_036779
    Natural varianti258 – 2581S → N.
    Corresponds to variant rs3748729 [ dbSNP | Ensembl ].
    VAR_036780

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96110 Genomic DNA. Translation: AAC51333.1.
    AL358215 Genomic DNA. Translation: CAH74103.1.
    CH471122 Genomic DNA. Translation: EAW56454.1.
    BC074990 mRNA. Translation: AAH74990.1.
    CCDSiCCDS826.1.
    RefSeqiNP_005540.1. NM_005549.2.
    UniGeneiHs.248140.
    Hs.622910.

    Genome annotation databases

    EnsembliENST00000369771; ENSP00000358786; ENSG00000143105.
    GeneIDi3744.
    KEGGihsa:3744.
    UCSCiuc001dzt.1. human.

    Polymorphism databases

    DMDMi74739879.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96110 Genomic DNA. Translation: AAC51333.1 .
    AL358215 Genomic DNA. Translation: CAH74103.1 .
    CH471122 Genomic DNA. Translation: EAW56454.1 .
    BC074990 mRNA. Translation: AAH74990.1 .
    CCDSi CCDS826.1.
    RefSeqi NP_005540.1. NM_005549.2.
    UniGenei Hs.248140.
    Hs.622910.

    3D structure databases

    ProteinModelPortali Q16322.
    SMRi Q16322. Positions 86-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109946. 1 interaction.
    STRINGi 9606.ENSP00000358786.

    Chemistry

    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 545.

    Polymorphism databases

    DMDMi 74739879.

    Proteomic databases

    PaxDbi Q16322.
    PRIDEi Q16322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369771 ; ENSP00000358786 ; ENSG00000143105 .
    GeneIDi 3744.
    KEGGi hsa:3744.
    UCSCi uc001dzt.1. human.

    Organism-specific databases

    CTDi 3744.
    GeneCardsi GC01M111059.
    H-InvDB HIX0200074.
    HGNCi HGNC:6219. KCNA10.
    HPAi CAB022564.
    HPA015061.
    MIMi 602420. gene.
    neXtProti NX_Q16322.
    PharmGKBi PA30020.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231015.
    HOVERGENi HBG052230.
    InParanoidi Q16322.
    KOi K04881.
    OMAi KQNIPGE.
    OrthoDBi EOG7M0NRD.
    PhylomeDBi Q16322.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNA10.
    GenomeRNAii 3744.
    NextBioi 14651.
    PROi Q16322.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q16322.
    CleanExi HS_KCNA10.
    Genevestigatori Q16322.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic localization of the human gene for KCNA10, a cGMP-activated K channel."
      Orias M., Bray-Ward P., Curran M.E., Keating M.T., Desir G.V.
      Genomics 42:33-37(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels."
      Lang R., Lee G., Liu W., Tian S., Rafi H., Orias M., Segal A.S., Desir G.V.
      Am. J. Physiol. 278:F1013-F1021(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit."
      Tian S., Liu W., Wu Y., Rafi H., Segal A.S., Desir G.V.
      Am. J. Physiol. 283:F142-F149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH POMP, REGULATION BY CAMP.
    7. "Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule."
      Yao X., Tian S., Chan H.-Y., Biemesderfer D., Desir G.V.
      J. Am. Soc. Nephrol. 13:2831-2839(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-200.

    Entry informationi

    Entry nameiKCA10_HUMAN
    AccessioniPrimary (citable) accession number: Q16322
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3