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Q162K5

- THIM_ROSDO

UniProt

Q162K5 - THIM_ROSDO

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Substrate; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171ATPUniRule annotation
    Binding sitei163 – 1631ATPUniRule annotation
    Binding sitei190 – 1901Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRDEN375451:GJIZ-3404-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:RD1_3610
    OrganismiRoseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) (Roseobacter denitrificans)
    Taxonomic identifieri375451 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
    ProteomesiUP000007029: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Hydroxyethylthiazole kinasePRO_0000336569Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi375451.RD1_3610.

    Structurei

    3D structure databases

    ProteinModelPortaliQ162K5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiNACTQLA.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q162K5-1 [UniParc]FASTAAdd to Basket

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    MAPHDLLTAL RDQNPLVHCI TNYVAMNIAA NVVLAAGASP AMVHAPEEIA    50
    EFTPICGALT INIGTISTPW QASMMAAAAT ASAQNIPWVL DPVAHFISVY 100
    RREAAQQLLA QRPTILRGNA SEILALTGET GAGKGADSGD SVDAAQGAAK 150
    KLAAQFGTVV AITGPVDYLT DGTREAQVSG GSSLMPQVTA LGCSQTALMG 200
    AYAATGPAFD AALAALAHFK VAGSTAAQRA DGPGSFQMHF LDALANTQPF 250
    ELAQVIR 257
    Length:257
    Mass (Da):26,310
    Last modified:July 25, 2006 - v1
    Checksum:iCA5B990BE05FA6EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG33088.1.
    RefSeqiYP_683774.1. NC_008209.1.

    Genome annotation databases

    EnsemblBacteriaiABG33088; ABG33088; RD1_3610.
    GeneIDi4195087.
    KEGGirde:RD1_3610.
    PATRICi23365175. VBIRosDen86677_3453.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000362 Genomic DNA. Translation: ABG33088.1 .
    RefSeqi YP_683774.1. NC_008209.1.

    3D structure databases

    ProteinModelPortali Q162K5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 375451.RD1_3610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG33088 ; ABG33088 ; RD1_3610 .
    GeneIDi 4195087.
    KEGGi rde:RD1_3610.
    PATRICi 23365175. VBIRosDen86677_3453.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi NACTQLA.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci RDEN375451:GJIZ-3404-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33942 / OCh 114.

    Entry informationi

    Entry nameiTHIM_ROSDO
    AccessioniPrimary (citable) accession number: Q162K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3